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chr3:87,495,550-88,911,119

Best TWAS P=1.23e-15 · Best GWAS P=1.34e-15 conditioned to 0.902

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
6	GTEx	Esophagus Mucosa	C3orf38	0.11	0.06	lasso	7	0.07	1.5e-05	7.7	-8.0	1.2e-15	-0.67	0.05	0.95	TRUE
20	The Cancer Genome Atlas	Thyroid Carcinoma	CGGBP1	0.30	0.07	enet	11	0.09	2.3e-09	8.0	5.9	3.2e-09	0.80	0.01	0.99	TRUE
8	GTEx	Skin Not Sun Exposed Suprapubic	ZNF654	0.09	0.01	lasso	7	0.06	2.7e-04	7.9	8.0	1.4e-15	0.64	0.04	0.74	FALSE
9	GTEx	Skin Not Sun Exposed Suprapubic	C3orf38	0.09	0.07	lasso	6	0.04	2.8e-03	7.6	-7.8	5.8e-15	-0.68	0.05	0.90	FALSE
3	GTEx	Artery Aorta	C3orf38	0.06	0.06	lasso	7	0.05	6.0e-04	7.7	-7.8	7.6e-15	-0.67	0.04	0.94	FALSE
7	GTEx	Nerve Tibial	C3orf38	0.09	0.05	lasso	4	0.04	6.3e-04	7.7	-7.8	8.3e-15	-0.68	0.04	0.94	FALSE
15	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	C3orf38	0.02	0.01	blup	24	0.02	2.0e-03	7.7	-7.7	1.6e-14	-0.65	0.02	0.73	FALSE
11	GTEx	Thyroid	C3orf38	0.12	0.08	lasso	18	0.07	1.0e-05	7.6	-7.7	1.7e-14	-0.68	0.05	0.95	FALSE
21	The Cancer Genome Atlas	Thyroid Carcinoma	ZNF654	0.03	0.04	lasso	3	0.03	4.6e-04	7.4	7.7	2.1e-14	0.69	0.02	0.92	FALSE
4	GTEx	Artery Tibial	C3orf38	0.11	0.03	lasso	6	0.04	3.7e-04	7.6	-7.6	2.4e-14	-0.66	0.05	0.91	FALSE
13	The Cancer Genome Atlas	Breast Invasive Carcinoma	C3orf38	0.01	0.01	lasso	3	0.01	1.2e-03	7.7	-7.6	4.1e-14	-0.65	0.02	0.67	FALSE
12	GTEx	Uterus	ZNF654	0.29	-0.01	lasso	4	0.01	1.7e-01	7.8	7.5	6.8e-14	0.66	0.03	0.70	FALSE
16	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	C3orf38	0.02	0.03	lasso	1	0.03	1.9e-04	7.4	-7.5	9.4e-14	-0.69	0.02	0.72	FALSE
18	The Cancer Genome Atlas	Prostate Adenocarcinoma	C3orf38	0.03	0.05	lasso	1	0.05	8.1e-06	7.4	-7.5	9.4e-14	-0.69	0.03	0.96	FALSE
5	GTEx	Cells Transformed fibroblasts	ZNF654	0.08	0.09	enet	6	0.10	3.1e-08	7.4	7.4	1.1e-13	0.57	0.24	0.76	FALSE
19	The Cancer Genome Atlas	Thyroid Carcinoma	C3orf38	0.05	0.05	blup	24	0.05	1.1e-05	7.8	-6.9	4.2e-12	-0.55	0.02	0.97	FALSE
10	GTEx	Testis	C3orf38	0.11	0.01	enet	12	0.00	1.9e-01	6.7	-6.8	1.5e-11	-0.72	0.09	0.39	FALSE
17	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	C3orf38	0.04	0.01	blup	24	0.03	5.7e-03	7.8	-6.3	3.6e-10	-0.44	0.01	0.60	FALSE
2	GTEx	Adipose Visceral Omentum	C3orf38	0.09	0.00	lasso	5	0.00	5.2e-01	3.2	-6.1	8.1e-10	-0.51	0.04	0.35	FALSE
14	The Cancer Genome Atlas	Colon Adenocarcinoma	C3orf38	0.08	0.01	blup	24	0.02	1.4e-02	7.8	-5.4	6.9e-08	-0.43	0.02	0.66	FALSE
1	CommonMind	Brain Pre-frontal Cortex	C3orf38	0.08	0.00	enet	14	0.04	2.3e-05	7.4	5.2	1.5e-07	0.56	0.06	0.90	FALSE