Best TWAS P=1.9e-10 · Best GWAS P=1.1e-21 conditioned to 6.35e-22
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | LRRC34 | 0.08 | 0.09 | lasso | 3 | 0.08 | 4.5e-10 | -5.3 | 5.2 | 2.3e-07 | -0.04 | 1.00 | 0.00 | FALSE |
| 2 | GTEx | Adipose Subcutaneous | LRRC34 | 0.08 | 0.07 | lasso | 6 | 0.06 | 1.1e-05 | -5.1 | 5.4 | 7.5e-08 | -0.03 | 0.95 | 0.00 | FALSE |
| 3 | GTEx | Adrenal Gland | LRRC34 | 0.23 | 0.08 | lasso | 7 | 0.09 | 4.4e-04 | -5.3 | 5.5 | 4.4e-08 | -0.03 | 0.25 | 0.15 | FALSE |
| 4 | GTEx | Artery Aorta | LRRC34 | 0.21 | 0.08 | enet | 29 | 0.07 | 7.5e-05 | -5.3 | 6.2 | 4.0e-10 | -0.24 | 0.75 | 0.04 | FALSE |
| 5 | GTEx | Nerve Tibial | LRRC34 | 0.18 | 0.11 | lasso | 7 | 0.10 | 1.8e-07 | -5.1 | 5.3 | 1.3e-07 | -0.01 | 0.99 | 0.00 | FALSE |
| 6 | GTEx | Testis | MYNN | 0.12 | 0.13 | lasso | 5 | 0.13 | 1.8e-06 | -6.3 | -6.4 | 1.9e-10 | -0.01 | 0.86 | 0.02 | TRUE |
| 7 | GTEx | Testis | RP11-362K14.5 | 0.12 | 0.16 | lasso | 3 | 0.14 | 1.0e-06 | -6.3 | -6.3 | 3.9e-10 | -0.01 | 0.87 | 0.02 | FALSE |
| 8 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | ARPM1 | 0.04 | 0.02 | blup | 27 | 0.02 | 3.4e-03 | -5.9 | 6.1 | 1.2e-09 | 0.02 | 0.05 | 0.83 | FALSE |
| 9 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | ARPM1 | 0.02 | 0.04 | lasso | 1 | 0.04 | 6.9e-05 | -6.1 | 6.1 | 1.0e-09 | 0.02 | 0.02 | 0.91 | FALSE |
| 10 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | LRRIQ4 | 0.06 | 0.07 | lasso | 3 | 0.12 | 2.4e-05 | -3.1 | -5.1 | 2.9e-07 | 0.01 | 0.02 | 0.90 | FALSE |