Best TWAS P=1.5e-08 · Best GWAS P=3.43e-07 conditioned to 0.395
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | NDUFA2 | 0.02 | 0.01 | bslmm | 343 | 0.01 | 7.8e-03 | 5.0 | -5.5 | 2.9e-08 | -0.90 | 0.08 | 0.70 | FALSE |
2 | GTEx | Artery Tibial | IK | 0.06 | 0.04 | enet | 13 | 0.05 | 1.3e-04 | 4.9 | 5.3 | 1.4e-07 | 0.89 | 0.08 | 0.92 | FALSE |
3 | GTEx | Brain Cerebellar Hemisphere | WDR55 | 0.11 | 0.07 | enet | 10 | -0.01 | 6.6e-01 | 4.6 | 5.2 | 2.6e-07 | 0.89 | 0.07 | 0.67 | FALSE |
4 | GTEx | Cells Transformed fibroblasts | ZMAT2 | 0.04 | 0.02 | lasso | 4 | 0.02 | 2.4e-02 | 5.1 | 5.3 | 1.4e-07 | 0.97 | 0.06 | 0.86 | FALSE |
5 | GTEx | Esophagus Muscularis | WDR55 | 0.05 | 0.01 | lasso | 4 | 0.03 | 6.6e-03 | 4.9 | 5.5 | 4.8e-08 | 0.90 | 0.08 | 0.73 | FALSE |
6 | GTEx | Vagina | IK | 0.27 | 0.09 | enet | 29 | 0.15 | 2.4e-04 | 4.8 | 5.7 | 1.5e-08 | 0.81 | 0.09 | 0.86 | TRUE |
7 | METSIM | Adipose | IK | 0.13 | 0.09 | enet | 17 | 0.12 | 1.2e-17 | 3.6 | 5.5 | 2.9e-08 | 0.67 | 0.77 | 0.21 | FALSE |
8 | The Cancer Genome Atlas | Stomach Adenocarcinoma | PCDHA4 | 0.03 | 0.01 | blup | 31 | 0.02 | 2.0e-02 | 4.8 | 5.2 | 1.7e-07 | 0.78 | 0.01 | 0.70 | FALSE |