Best TWAS P=5.65e-14 · Best GWAS P=1.16e-12 conditioned to 0.00768
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | MED28 | 0.07 | 0.09 | enet | 9 | 0.11 | 7.1e-13 | 4.8 | -5.3 | 1.0e-07 | 0.25 | 1.00 | 0.00 | TRUE |
| 2 | GTEx | Artery Aorta | DCAF16 | 0.10 | 0.01 | enet | 6 | 0.02 | 4.7e-02 | 6.5 | -7.5 | 5.6e-14 | 0.61 | 0.08 | 0.68 | TRUE |
| 3 | GTEx | Artery Tibial | DCAF16 | 0.16 | 0.16 | lasso | 5 | 0.13 | 1.5e-10 | -5.0 | -5.8 | 7.5e-09 | 0.84 | 0.07 | 0.93 | FALSE |
| 4 | GTEx | Breast Mammary Tissue | DCAF16 | 0.12 | 0.08 | lasso | 4 | 0.10 | 6.4e-06 | -5.2 | -6.6 | 4.4e-11 | 0.71 | 0.12 | 0.70 | FALSE |
| 5 | GTEx | Breast Mammary Tissue (Male) | DCAF16 | 0.24 | 0.03 | enet | 18 | -0.01 | 4.4e-01 | 6.2 | -6.4 | 1.9e-10 | 0.50 | 0.06 | 0.43 | FALSE |
| 6 | GTEx | Esophagus Mucosa | DCAF16 | 0.10 | 0.02 | lasso | 4 | 0.02 | 8.3e-03 | -5.2 | -6.1 | 1.3e-09 | 0.77 | 0.04 | 0.80 | FALSE |
| 7 | GTEx | Esophagus Muscularis | DCAF16 | 0.16 | 0.14 | lasso | 3 | 0.14 | 9.3e-09 | -5.1 | -5.2 | 2.5e-07 | 0.79 | 0.83 | 0.17 | FALSE |
| 8 | GTEx | Nerve Tibial | DCAF16 | 0.16 | 0.14 | lasso | 3 | 0.14 | 2.8e-10 | -5.1 | -5.8 | 7.5e-09 | 0.78 | 0.96 | 0.04 | FALSE |
| 9 | GTEx | Skin Not Sun Exposed Suprapubic | DCAF16 | 0.16 | 0.08 | lasso | 5 | 0.12 | 4.4e-07 | -4.8 | -5.7 | 1.6e-08 | 0.75 | 0.27 | 0.59 | FALSE |
| 10 | GTEx | Skin Sun Exposed Lower leg | DCAF16 | 0.14 | 0.12 | enet | 14 | 0.12 | 5.4e-10 | -5.2 | -5.5 | 4.4e-08 | 0.80 | 0.43 | 0.57 | FALSE |
| 11 | GTEx | Spleen | DCAF16 | 0.35 | 0.02 | lasso | 5 | 0.11 | 8.5e-04 | -5.1 | -6.8 | 1.4e-11 | 0.74 | 0.03 | 0.75 | FALSE |
| 12 | GTEx | Stomach | DCAF16 | 0.21 | 0.04 | lasso | 6 | 0.02 | 5.6e-02 | -5.0 | -5.7 | 1.5e-08 | 0.90 | 0.02 | 0.91 | FALSE |
| 13 | GTEx | Thyroid | DCAF16 | 0.11 | 0.02 | lasso | 5 | 0.03 | 2.3e-03 | -5.1 | -6.6 | 3.9e-11 | 0.79 | 0.03 | 0.95 | FALSE |
| 14 | ROSMAP | Brain Pre-frontal Cortex | MED28 | 0.02 | 0.01 | bslmm | 411 | 0.00 | 1.9e-01 | 4.6 | -5.9 | 4.0e-09 | 0.27 | 0.23 | 0.02 | FALSE |
| 15 | The Cancer Genome Atlas | Colon Adenocarcinoma | NCAPG | 0.08 | 0.04 | blup | 34 | 0.09 | 1.1e-05 | 6.2 | 5.5 | 3.4e-08 | 0.01 | 0.02 | 0.97 | FALSE |
| 16 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | NCAPG | 0.14 | 0.07 | lasso | 3 | 0.07 | 5.2e-08 | 6.2 | 6.0 | 2.0e-09 | -0.19 | 0.04 | 0.96 | FALSE |
| 17 | The Cancer Genome Atlas | Brain Lower Grade Glioma | DCAF16 | 0.09 | 0.02 | lasso | 3 | 0.04 | 5.2e-05 | -5.0 | -7.0 | 3.3e-12 | 0.72 | 0.04 | 0.90 | FALSE |
| 18 | The Cancer Genome Atlas | Brain Lower Grade Glioma | NCAPG | 0.02 | 0.03 | lasso | 1 | 0.02 | 9.0e-04 | 6.2 | 6.2 | 5.5e-10 | -0.24 | 0.02 | 0.69 | FALSE |
| 19 | The Cancer Genome Atlas | Prostate Adenocarcinoma | DCAF16 | 0.04 | 0.04 | blup | 31 | 0.04 | 2.2e-05 | -5.1 | -6.9 | 4.9e-12 | 0.72 | 0.23 | 0.35 | FALSE |
| 20 | The Cancer Genome Atlas | Prostate Adenocarcinoma | NCAPG | 0.02 | 0.02 | blup | 34 | 0.02 | 3.4e-03 | 6.0 | 5.5 | 3.7e-08 | -0.03 | 0.01 | 0.80 | FALSE |
| 21 | The Cancer Genome Atlas | Thyroid Carcinoma | DCAF16 | 0.07 | 0.04 | blup | 31 | 0.07 | 4.9e-07 | -5.0 | -6.1 | 1.0e-09 | 0.68 | 0.17 | 0.74 | FALSE |