Best TWAS P=9.24e-09 · Best GWAS P=9.88e-12 conditioned to 1.36e-09
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Cells EBV-transformed lymphocytes | TBCK | 0.24 | 0.21 | lasso | 10 | 0.19 | 8.8e-07 | 5.2 | 5.2 | 1.7e-07 | -0.07 | 0.94 | 0.05 | FALSE |
2 | GTEx | Cells EBV-transformed lymphocytes | AIMP1 | 0.32 | 0.19 | lasso | 16 | 0.16 | 7.8e-06 | 5.1 | 5.6 | 1.7e-08 | -0.16 | 0.85 | 0.08 | FALSE |
3 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | TBCK | 0.05 | 0.05 | blup | 123 | 0.04 | 1.5e-04 | 5.1 | 5.1 | 2.7e-07 | -0.08 | 0.04 | 0.95 | FALSE |
4 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | TBCK | 0.13 | 0.14 | blup | 123 | 0.14 | 3.9e-15 | 5.2 | 5.2 | 2.4e-07 | -0.20 | 0.03 | 0.96 | FALSE |
5 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | TBCK | 0.06 | 0.05 | blup | 123 | 0.04 | 7.6e-06 | 5.1 | 5.2 | 2.6e-07 | -0.18 | 0.04 | 0.96 | FALSE |
6 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | TBCK | 0.05 | 0.03 | blup | 123 | 0.03 | 7.0e-03 | 5.1 | 5.7 | 9.2e-09 | -0.14 | 0.03 | 0.71 | TRUE |
7 | The Cancer Genome Atlas | Lung Adenocarcinoma | TBCK | 0.05 | 0.08 | lasso | 1 | 0.07 | 1.0e-08 | 5.2 | 5.2 | 1.9e-07 | -0.06 | 0.03 | 0.97 | FALSE |
8 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | TBCK | 0.09 | 0.14 | enet | 18 | 0.13 | 2.4e-14 | 5.1 | 5.2 | 1.5e-07 | -0.11 | 0.04 | 0.96 | FALSE |
9 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | TBCK | 0.09 | 0.06 | blup | 123 | 0.06 | 8.1e-05 | 5.1 | 5.4 | 7.0e-08 | -0.14 | 0.03 | 0.95 | FALSE |
10 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | TBCK | 0.18 | 0.12 | lasso | 1 | 0.08 | 6.3e-04 | 5.2 | 5.2 | 1.9e-07 | -0.06 | 0.03 | 0.95 | FALSE |
11 | The Cancer Genome Atlas | Prostate Adenocarcinoma | TBCK | 0.09 | 0.14 | lasso | 3 | 0.14 | 1.2e-14 | 5.2 | 5.2 | 2.7e-07 | -0.07 | 0.03 | 0.96 | FALSE |