Best TWAS P=5.74e-08 · Best GWAS P=1.1e-07 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | WFS1 | 0.10 | 0.03 | lasso | 2 | 0.02 | 4.8e-04 | -5.3 | 5.4 | 5.7e-08 | -0.98 | 0.02 | 0.98 | TRUE |
| 2 | GTEx | Brain Cerebellum | WFS1 | 0.44 | 0.26 | lasso | 10 | 0.27 | 9.8e-09 | -4.9 | 5.3 | 8.8e-08 | -0.94 | 0.03 | 0.97 | FALSE |
| 3 | GTEx | Skin Not Sun Exposed Suprapubic | WFS1 | 0.35 | 0.25 | lasso | 7 | 0.28 | 7.6e-16 | -5.0 | 5.3 | 1.2e-07 | -0.93 | 0.03 | 0.97 | FALSE |
| 4 | GTEx | Thyroid | WFS1 | 0.19 | 0.12 | lasso | 4 | 0.10 | 2.9e-08 | -4.9 | 5.3 | 1.2e-07 | -0.95 | 0.04 | 0.96 | FALSE |
| 5 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | WFS1 | 0.07 | 0.10 | lasso | 3 | 0.10 | 2.6e-11 | -5.0 | 5.4 | 6.8e-08 | -0.97 | 0.01 | 0.99 | FALSE |
| 6 | The Cancer Genome Atlas | Thyroid Carcinoma | WFS1 | 0.04 | 0.01 | blup | 76 | 0.01 | 1.6e-02 | -5.4 | 5.3 | 1.4e-07 | -0.90 | 0.01 | 0.98 | FALSE |