Hub : Traits :

Type 2 Diabetes (T2D) (2012)

17 significantly associated models · 8 unique genes.

Significant Loci

#	chr	p0	p1	# assoc genes	# joint genes	best TWAS P	best SNP P	cond SNP P	% var exp	joint genes
1	3	185112300	185786406	1	1	1.6e-07	2.0e-11	5.4e-07	44	IGF2BP2
2	4	5575751	7002344	1	1	5.7e-08	1.1e-07	1.0e+00	100	WFS1
3	7	27623776	28468319	1	1	2.5e-08	7.3e-11	7.7e-04	73	JAZF1
4	10	93657148	95151622	3	1	1.7e-15	2.2e-16	1.0e+00	100	EIF2S2P3
5	10	113511441	115622375	2	1	4.3e-10	1.9e-10	3.6e-03	79	TCF7L2

Pleiotropic Associations

Trait	chisq ratio	# genes⁺	# genes⁺⁺	% genes⁺⁺	corr	corr P	genes
Type 2 Diabetes (T2D) (2018)	64.93	5	5	11.1	0.96	0.0085	EIF2S2P3 IGF2BP2 JAZF1 TCF7L2 WFS1
Diabetes diagnosed by doctor	58.64	5	5	11.1	0.96	0.0104	EIF2S2P3 IGF2BP2 JAZF1 TCF7L2 WFS1
Diabetes (self-reported)	53.63	5	5	11.1	0.96	0.0082	EIF2S2P3 IGF2BP2 JAZF1 TCF7L2 WFS1
Medication: Metformin	46.44	5	5	11.1	0.96	0.0096	EIF2S2P3 IGF2BP2 JAZF1 TCF7L2 WFS1
Diabetes (father)	36.80	5	3	6.7	0.94	0.0179	EIF2S2P3 IGF2BP2 JAZF1 TCF7L2 WFS1
Diabetes (mother)	28.51	5	2	4.4	0.93	0.0201	EIF2S2P3 IGF2BP2 JAZF1 TCF7L2 WFS1
Medication: Gliclazide	24.75	4	2	4.4	1.00	0.0048	IGF2BP2 JAZF1 TCF7L2 WFS1
Illnesses of siblings: Diabetes	18.79	4	2	4.4	0.92	0.0832	EIF2S2P3 IGF2BP2 TCF7L2 WFS1
Eye problems/disorders: Diabetes related eye disease	12.49	3	0	0.0	0.00	1.0000	IGF2BP2 TCF7L2 WFS1
Waist Hip Ratio (WHR)	10.32	4	4	8.9	0.96	0.0413	EIF2S2P3 IGF2BP2 JAZF1 TCF7L2
Medication: Cholesterol lowering	6.90	2	0	0.0	0.00	1.0000	IGF2BP2 TCF7L2
Height	6.50	2	1	2.2	0.00	1.0000	JAZF1 TCF7L2
Medication: Aspirin	6.48	2	0	0.0	0.00	1.0000	IGF2BP2 TCF7L2
Medication: Atorvastatin	6.43	2	0	0.0	0.00	1.0000	IGF2BP2 TCF7L2
Standing height	6.19	1	1	2.2	0.00	1.0000	JAZF1
Birth weight	5.87	2	1	2.2	0.00	1.0000	EIF2S2P3 TCF7L2
Breast Cancer	5.74	1	1	2.2	0.00	1.0000	TCF7L2
Fasting Glucose	5.58	2	0	0.0	0.00	1.0000	IGF2BP2 TCF7L2
Medication: Aspirin	5.56	1	0	0.0	0.00	1.0000	IGF2BP2
Comparative height size at age 10	5.23	2	1	2.2	0.00	1.0000	EIF2S2P3 JAZF1
Medication for cholesterol, blood pressure or diabetes	5.04	2	0	0.0	0.00	1.0000	IGF2BP2 JAZF1
Long-standing illness, disability or infirmity	4.90	1	0	0.0	0.00	1.0000	IGF2BP2
Forced expiratory volume in 1-second (FEV1), predicted	4.83	1	1	2.2	0.00	1.0000	JAZF1
Respiratory disease	4.51	2	1	2.2	0.00	1.0000	EIF2S2P3 JAZF1
Impedance of leg (left)	4.51	1	1	2.2	0.00	1.0000	JAZF1
Blood Eosinophil Count	4.41	2	2	4.4	0.00	1.0000	EIF2S2P3 JAZF1
Lung FVC	4.39	2	1	2.2	0.00	1.0000	IGF2BP2 JAZF1
Number of self-reported non-cancer illnesses	4.39	2	0	0.0	0.00	1.0000	IGF2BP2 JAZF1
Impedance of leg (right)	4.38	2	1	2.2	0.00	1.0000	JAZF1 TCF7L2
Cholesterol lowering medication	4.30	1	0	0.0	0.00	1.0000	TCF7L2
Asthma	4.28	2	0	0.0	0.00	1.0000	EIF2S2P3 JAZF1
Illnesses of mother	4.28	1	0	0.0	0.00	1.0000	IGF2BP2
Reproduciblity of spirometry measurement using ERS/ATS criteria	4.16	2	0	0.0	0.00	1.0000	EIF2S2P3 TCF7L2
Pulse rate, automated reading	4.10	4	1	2.2	0.99	0.0087	EIF2S2P3 JAZF1 TCF7L2 WFS1
Medication: Simvastatin	4.01	1	0	0.0	0.00	1.0000	TCF7L2
Impedance of whole body	3.99	2	1	2.2	0.00	1.0000	JAZF1 TCF7L2
Asthma (self-reported)	3.95	2	0	0.0	0.00	1.0000	EIF2S2P3 JAZF1
Number of treatments/medications taken	3.68	2	0	0.0	0.00	1.0000	IGF2BP2 WFS1
Forced expiratory volume in 1-second (FEV1), predicted percentage	3.68	2	0	0.0	0.00	1.0000	IGF2BP2 JAZF1
Hip circumference	3.42	1	1	2.2	0.00	1.0000	TCF7L2
Impedance of arm (left)	3.40	3	1	2.2	0.00	1.0000	JAZF1 TCF7L2 WFS1
Wheeze or whistling in the chest in last year	3.23	2	0	0.0	0.00	1.0000	IGF2BP2 JAZF1
Crohns Disease (2017)	3.11	2	0	0.0	0.00	1.0000	EIF2S2P3 JAZF1
Body mass index (BMI)	3.09	3	1	2.2	0.00	1.0000	JAZF1 TCF7L2 WFS1
Pulse rate	3.07	1	0	0.0	0.00	1.0000	WFS1
Body Mass Index (BMI) (2010)	2.96	1	0	0.0	0.00	1.0000	TCF7L2
Medication: Ramipril	2.96	1	0	0.0	0.00	1.0000	JAZF1
Impedance of arm (right)	2.85	2	1	2.2	0.00	1.0000	JAZF1 TCF7L2
BMI	2.79	2	2	4.4	0.00	1.0000	JAZF1 TCF7L2
Age at last live birth	2.79	1	0	0.0	0.00	1.0000	EIF2S2P3
Birth weight of first child	2.69	1	0	0.0	0.00	1.0000	IGF2BP2
Allergy	2.47	1	0	0.0	0.00	1.0000	JAZF1
Peak expiratory flow (PEF)	2.46	1	0	0.0	0.00	1.0000	IGF2BP2
Crohns Disease (2012)	2.44	1	0	0.0	0.00	1.0000	JAZF1
Medication for pain relief, constipation, heartburn	2.40	1	0	0.0	0.00	1.0000	IGF2BP2
Irritable Bowel Disease (IBD)	2.37	1	0	0.0	0.00	1.0000	EIF2S2P3
Leg fat mass (left)	2.35	1	1	2.2	0.00	1.0000	TCF7L2
Medication: Blood pressure	2.34	1	0	0.0	0.00	1.0000	JAZF1
Leg fat mass (right)	2.33	2	1	2.2	0.00	1.0000	TCF7L2 WFS1
Illnesses of siblings	2.30	1	0	0.0	0.00	1.0000	IGF2BP2
Systolic Blood Pressure	2.29	2	1	2.2	0.00	1.0000	JAZF1 TCF7L2
Allergy or Eczema	2.28	1	0	0.0	0.00	1.0000	JAZF1
Hypothyroidism (self reported)	2.28	1	0	0.0	0.00	1.0000	IGF2BP2
Age at first live birth	2.25	1	0	0.0	0.00	1.0000	EIF2S2P3
Leg fat percentage (left)	2.25	1	1	2.2	0.00	1.0000	TCF7L2
Leg fat percentage (right)	2.19	1	1	2.2	0.00	1.0000	TCF7L2
Breast cancer (self-reported)	2.19	1	0	0.0	0.00	1.0000	TCF7L2
Ever had stillbirth, spontaneous miscarriage or termination	2.16	1	0	0.0	0.00	1.0000	TCF7L2
Lupus	2.14	1	0	0.0	0.00	1.0000	JAZF1
Worrier / anxious feelings	2.13	1	0	0.0	0.00	1.0000	TCF7L2
Hypothyroidism/myxoedema (self-reported)	2.09	1	0	0.0	0.00	1.0000	IGF2BP2
Overall health rating	2.06	1	0	0.0	0.00	1.0000	IGF2BP2
Qualifications: nursing, teaching	2.06	1	0	0.0	0.00	1.0000	TCF7L2
Blood Platelet Count	2.03	1	1	2.2	0.00	1.0000	IGF2BP2
Comparative body size at age 10	1.99	2	0	0.0	0.00	1.0000	JAZF1 WFS1
Lung FEV1/FVC ratio	1.95	1	1	2.2	0.00	1.0000	IGF2BP2
Whole body fat mass	1.92	1	0	0.0	0.00	1.0000	TCF7L2
Forced expiratory volume in 1-second (FEV1), Best measure	1.90	1	0	0.0	0.00	1.0000	IGF2BP2
Vascular/heart problems diagnosed by doctor	1.85	1	0	0.0	0.00	1.0000	IGF2BP2
Weight	1.82	3	0	0.0	0.00	1.0000	JAZF1 TCF7L2 WFS1
Alcohol intake frequency.	1.81	1	0	0.0	0.00	1.0000	WFS1
Relative age of first facial hair	1.79	1	0	0.0	0.00	1.0000	JAZF1
High blood pressure	1.76	1	0	0.0	0.00	1.0000	IGF2BP2
Hypertension (Self-reported)	1.75	1	0	0.0	0.00	1.0000	IGF2BP2
Cardiovascular Disease	1.73	2	0	0.0	0.00	1.0000	IGF2BP2 JAZF1
Waist circumference	1.73	2	0	0.0	0.00	1.0000	TCF7L2 WFS1
High cholesterol (Self-reported)	1.72	1	0	0.0	0.00	1.0000	TCF7L2
Arm fat mass (right)	1.70	1	0	0.0	0.00	1.0000	TCF7L2
Trunk predicted mass	1.68	1	1	2.2	0.00	1.0000	JAZF1
Heel T-Score	1.66	3	1	2.2	0.00	1.0000	IGF2BP2 JAZF1 TCF7L2
Trunk fat mass	1.66	2	0	0.0	0.00	1.0000	JAZF1 TCF7L2
Forced expiratory volume in 1-second (FEV1)	1.66	1	0	0.0	0.00	1.0000	IGF2BP2
Trunk fat-free mass	1.65	1	1	2.2	0.00	1.0000	JAZF1
Hayfever, allergic rhinitis or eczema	1.63	1	0	0.0	0.00	1.0000	JAZF1
Arm fat-free mass (left)	1.62	3	0	0.0	0.00	1.0000	JAZF1 TCF7L2 WFS1
Heart disease (siblings)	1.58	1	0	0.0	0.00	1.0000	IGF2BP2
Arm fat percentage (right)	1.57	1	0	0.0	0.00	1.0000	TCF7L2
Arm fat mass (left)	1.57	1	0	0.0	0.00	1.0000	TCF7L2
Ulcerative Colitis (UC)	1.55	1	0	0.0	0.00	1.0000	EIF2S2P3
Arm fat-free mass (right)	1.53	2	0	0.0	0.00	1.0000	JAZF1 TCF7L2
Basal metabolic rate	1.53	3	0	0.0	0.00	1.0000	JAZF1 TCF7L2 WFS1
Arm predicted mass (left)	1.53	3	0	0.0	0.00	1.0000	JAZF1 TCF7L2 WFS1
Arm predicted mass (right)	1.52	2	0	0.0	0.00	1.0000	JAZF1 WFS1
Arm fat percentage (left)	1.48	1	0	0.0	0.00	1.0000	TCF7L2
Hair Pigment	1.47	1	1	2.2	0.00	1.0000	JAZF1
Body fat percentage	1.39	1	0	0.0	0.00	1.0000	TCF7L2
Whole body fat-free mass	1.39	2	0	0.0	0.00	1.0000	JAZF1 WFS1
Forced vital capacity (FVC), Best measure	1.37	1	0	0.0	0.00	1.0000	JAZF1
Sitting height	1.35	1	1	2.2	0.00	1.0000	JAZF1
Whole body water mass	1.33	2	0	0.0	0.00	1.0000	JAZF1 WFS1
Tanning	1.28	1	1	2.2	0.00	1.0000	JAZF1
Blood Red Count	1.26	2	0	0.0	0.00	1.0000	EIF2S2P3 IGF2BP2
Diastolic blood pressure, automated reading	1.21	1	0	0.0	0.00	1.0000	TCF7L2
Forced vital capacity (FVC)	1.09	1	0	0.0	0.00	1.0000	IGF2BP2
Leg predicted mass (left)	1.06	2	0	0.0	0.00	1.0000	TCF7L2 WFS1
Leg fat-free mass (left)	1.05	2	0	0.0	0.00	1.0000	TCF7L2 WFS1
Trunk fat percentage	1.02	1	0	0.0	0.00	1.0000	TCF7L2
Leg fat-free mass (right)	1.00	2	0	0.0	0.00	1.0000	TCF7L2 WFS1
Leg predicted mass (right)	1.00	2	0	0.0	0.00	1.0000	TCF7L2 WFS1
Blood White Count	0.38	1	0	0.0	0.00	1.0000	IGF2BP2

Associations by panel

study	tissue	# hits	% hits/tests	avg chisq
GTEx	Brain Cortex	0	0.000	1.4
GTEx	Brain Hippocampus	0	0.000	1.4
GTEx	Prostate	1	0.131	1.4
GTEx	Spleen	1	0.076	1.4
GTEx	Adipose Subcutaneous	0	0.000	1.3
GTEx	Adipose Visceral Omentum	0	0.000	1.3
GTEx	Adrenal Gland	0	0.000	1.3
GTEx	Artery Aorta	1	0.036	1.3
GTEx	Artery Coronary	0	0.000	1.3
GTEx	Artery Tibial	0	0.000	1.3
GTEx	Brain Caudate basal ganglia	0	0.000	1.3
GTEx	Brain Cerebellar Hemisphere	0	0.000	1.3
GTEx	Brain Cerebellum	1	0.055	1.3
GTEx	Brain Frontal Cortex BA9	0	0.000	1.3
GTEx	Brain Hypothalamus	0	0.000	1.3
GTEx	Brain Nucleus accumbens basal ganglia	0	0.000	1.3
GTEx	Brain Putamen basal ganglia	0	0.000	1.3
GTEx	Breast Mammary Tissue (Female)	0	0.000	1.3
GTEx	Cells EBV-transformed lymphocytes	0	0.000	1.3
GTEx	Cells Transformed fibroblasts	0	0.000	1.3
GTEx	Colon Sigmoid	0	0.000	1.3
GTEx	Colon Transverse	0	0.000	1.3
GTEx	Esophagus Mucosa	0	0.000	1.3
GTEx	Esophagus Muscularis	1	0.034	1.3
GTEx	Heart Atrial Appendage	0	0.000	1.3
GTEx	Heart Left Ventricle	0	0.000	1.3
GTEx	Muscle Skeletal	0	0.000	1.3
GTEx	Nerve Tibial	0	0.000	1.3
GTEx	Ovary	0	0.000	1.3
GTEx	Pancreas	0	0.000	1.3
GTEx	Pituitary	0	0.000	1.3
GTEx	Skin Not Sun Exposed Suprapubic	1	0.043	1.3
GTEx	Skin Sun Exposed Lower leg	0	0.000	1.3
GTEx	Stomach	0	0.000	1.3
GTEx	Testis	1	0.034	1.3
GTEx	Thyroid	2	0.054	1.3
GTEx	Uterus	0	0.000	1.3
GTEx	Vagina	0	0.000	1.3
GTEx	Whole Blood	0	0.000	1.3
METSIM	Adipose	0	0.000	1.3
ROSMAP	Brain Pre-frontal Cortex	0	0.000	1.3
The Cancer Genome Atlas	Bladder Urothelial Carcinoma	0	0.000	1.3
The Cancer Genome Atlas	Breast Invasive Carcinoma	0	0.000	1.3
The Cancer Genome Atlas	Esophageal Carcinoma	0	0.000	1.3
The Cancer Genome Atlas	Glioblastoma Multiforme	0	0.000	1.3
The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	1	0.041	1.3
The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	0	0.000	1.3
The Cancer Genome Atlas	Brain Lower Grade Glioma	0	0.000	1.3
The Cancer Genome Atlas	Prostate Adenocarcinoma	0	0.000	1.3
The Cancer Genome Atlas	Rectum Adenocarcinoma	0	0.000	1.3
The Cancer Genome Atlas	Soft Tissue Sarcoma	0	0.000	1.3
The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	0	0.000	1.3
GTEx	Breast Mammary Tissue	0	0.000	1.2
GTEx	Breast Mammary Tissue (Male)	0	0.000	1.2
GTEx	Esophagus Gastroesophageal Junction	0	0.000	1.2
GTEx	Liver	0	0.000	1.2
GTEx	Lung	0	0.000	1.2
GTEx	Small Intestine Terminal Ileum	0	0.000	1.2
NTR	Blood	2	0.086	1.2
YFS	Blood	0	0.000	1.2
CommonMind	Brain Pre-frontal Cortex	1	0.020	1.2
The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Colon Adenocarcinoma	0	0.000	1.2
The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Lung Adenocarcinoma	1	0.038	1.2
The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	1	0.045	1.2
The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	0	0.000	1.2
The Cancer Genome Atlas	Pancreatic Adenocarcinoma	0	0.000	1.2
The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	0	0.000	1.2
The Cancer Genome Atlas	Skin Cutaneous Melanoma	0	0.000	1.2
The Cancer Genome Atlas	Stomach Adenocarcinoma	0	0.000	1.2
The Cancer Genome Atlas	Testicular Germ Cell Tumors	0	0.000	1.2
The Cancer Genome Atlas	Thyroid Carcinoma	2	0.044	1.2