Hub : Traits :

Type 2 Diabetes (T2D) (2012)

17 significantly associated models · 8 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 3 185112300 185786406 1 1 1.6e-07 2.0e-11 5.4e-07 44 IGF2BP2
2 4 5575751 7002344 1 1 5.7e-08 1.1e-07 1.0e+00 100 WFS1
3 7 27623776 28468319 1 1 2.5e-08 7.3e-11 7.7e-04 73 JAZF1
4 10 93657148 95151622 3 1 1.7e-15 2.2e-16 1.0e+00 100 EIF2S2P3
5 10 113511441 115622375 2 1 4.3e-10 1.9e-10 3.6e-03 79 TCF7L2

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Crohns Disease (2017) 3.11 2 0 0.0 0.00 1.0000 EIF2S2P3 JAZF1
Irritable Bowel Disease (IBD) 2.37 1 0 0.0 0.00 1.0000 EIF2S2P3
Ulcerative Colitis (UC) 1.55 1 0 0.0 0.00 1.0000 EIF2S2P3
Breast Cancer 5.74 1 1 2.2 0.00 1.0000 TCF7L2
Body Mass Index (BMI) (2010) 2.96 1 0 0.0 0.00 1.0000 TCF7L2
Crohns Disease (2012) 2.44 1 0 0.0 0.00 1.0000 JAZF1
Fasting Glucose 5.58 2 0 0.0 0.00 1.0000 IGF2BP2 TCF7L2
Lupus 2.14 1 0 0.0 0.00 1.0000 JAZF1
Blood Eosinophil Count 4.41 2 2 4.4 0.00 1.0000 EIF2S2P3 JAZF1
Blood Platelet Count 2.03 1 1 2.2 0.00 1.0000 IGF2BP2
Blood Red Count 1.26 2 0 0.0 0.00 1.0000 EIF2S2P3 IGF2BP2
Blood White Count 0.38 1 0 0.0 0.00 1.0000 IGF2BP2
Heel T-Score 1.66 3 1 2.2 0.00 1.0000 IGF2BP2 JAZF1 TCF7L2
BMI 2.79 2 2 4.4 0.00 1.0000 JAZF1 TCF7L2
Height 6.50 2 1 2.2 0.00 1.0000 JAZF1 TCF7L2
Waist Hip Ratio (WHR) 10.32 4 4 8.9 0.96 0.0413 EIF2S2P3 IGF2BP2 JAZF1 TCF7L2
Systolic Blood Pressure 2.29 2 1 2.2 0.00 1.0000 JAZF1 TCF7L2
Allergy or Eczema 2.28 1 0 0.0 0.00 1.0000 JAZF1
Cardiovascular Disease 1.73 2 0 0.0 0.00 1.0000 IGF2BP2 JAZF1
Hypothyroidism (self reported) 2.28 1 0 0.0 0.00 1.0000 IGF2BP2
Respiratory disease 4.51 2 1 2.2 0.00 1.0000 EIF2S2P3 JAZF1
Type 2 Diabetes (T2D) (2018) 64.93 5 5 11.1 0.96 0.0085 EIF2S2P3 IGF2BP2 JAZF1 TCF7L2 WFS1
Lung FEV1/FVC ratio 1.95 1 1 2.2 0.00 1.0000 IGF2BP2
Lung FVC 4.39 2 1 2.2 0.00 1.0000 IGF2BP2 JAZF1
Hair Pigment 1.47 1 1 2.2 0.00 1.0000 JAZF1
Tanning 1.28 1 1 2.2 0.00 1.0000 JAZF1
Number of treatments/medications taken 3.68 2 0 0.0 0.00 1.0000 IGF2BP2 WFS1
Relative age of first facial hair 1.79 1 0 0.0 0.00 1.0000 JAZF1
Eye problems/disorders: Diabetes related eye disease 12.49 3 0 0.0 0.00 1.0000 IGF2BP2 TCF7L2 WFS1
Medication: Metformin 46.44 5 5 11.1 0.96 0.0096 EIF2S2P3 IGF2BP2 JAZF1 TCF7L2 WFS1
Diabetes (father) 36.80 5 3 6.7 0.94 0.0179 EIF2S2P3 IGF2BP2 JAZF1 TCF7L2 WFS1
Diabetes (mother) 28.51 5 2 4.4 0.93 0.0201 EIF2S2P3 IGF2BP2 JAZF1 TCF7L2 WFS1
Impedance of leg (right) 4.38 2 1 2.2 0.00 1.0000 JAZF1 TCF7L2
Leg fat-free mass (left) 1.05 2 0 0.0 0.00 1.0000 TCF7L2 WFS1
Trunk fat percentage 1.02 1 0 0.0 0.00 1.0000 TCF7L2
High blood pressure 1.76 1 0 0.0 0.00 1.0000 IGF2BP2
Hayfever, allergic rhinitis or eczema 1.63 1 0 0.0 0.00 1.0000 JAZF1
Sitting height 1.35 1 1 2.2 0.00 1.0000 JAZF1
Body mass index (BMI) 3.09 3 1 2.2 0.00 1.0000 JAZF1 TCF7L2 WFS1
Impedance of leg (left) 4.51 1 1 2.2 0.00 1.0000 JAZF1
Leg predicted mass (left) 1.06 2 0 0.0 0.00 1.0000 TCF7L2 WFS1
Trunk fat mass 1.66 2 0 0.0 0.00 1.0000 JAZF1 TCF7L2
Waist circumference 1.73 2 0 0.0 0.00 1.0000 TCF7L2 WFS1
Forced vital capacity (FVC) 1.09 1 0 0.0 0.00 1.0000 IGF2BP2
Allergy 2.47 1 0 0.0 0.00 1.0000 JAZF1
Diabetes (self-reported) 53.63 5 5 11.1 0.96 0.0082 EIF2S2P3 IGF2BP2 JAZF1 TCF7L2 WFS1
Medication: Ramipril 2.96 1 0 0.0 0.00 1.0000 JAZF1
Medication: Simvastatin 4.01 1 0 0.0 0.00 1.0000 TCF7L2
Illnesses of siblings 2.30 1 0 0.0 0.00 1.0000 IGF2BP2
Weight 1.82 3 0 0.0 0.00 1.0000 JAZF1 TCF7L2 WFS1
Impedance of arm (right) 2.85 2 1 2.2 0.00 1.0000 JAZF1 TCF7L2
Arm fat percentage (right) 1.57 1 0 0.0 0.00 1.0000 TCF7L2
Trunk fat-free mass 1.65 1 1 2.2 0.00 1.0000 JAZF1
Hip circumference 3.42 1 1 2.2 0.00 1.0000 TCF7L2
Worrier / anxious feelings 2.13 1 0 0.0 0.00 1.0000 TCF7L2
Forced expiratory volume in 1-second (FEV1) 1.66 1 0 0.0 0.00 1.0000 IGF2BP2
Pulse rate 3.07 1 0 0.0 0.00 1.0000 WFS1
Asthma 4.28 2 0 0.0 0.00 1.0000 EIF2S2P3 JAZF1
Medication: Cholesterol lowering 6.90 2 0 0.0 0.00 1.0000 IGF2BP2 TCF7L2
Illnesses of mother 4.28 1 0 0.0 0.00 1.0000 IGF2BP2
Forced expiratory volume in 1-second (FEV1), Best measure 1.90 1 0 0.0 0.00 1.0000 IGF2BP2
Impedance of arm (left) 3.40 3 1 2.2 0.00 1.0000 JAZF1 TCF7L2 WFS1
Arm fat mass (right) 1.70 1 0 0.0 0.00 1.0000 TCF7L2
Trunk predicted mass 1.68 1 1 2.2 0.00 1.0000 JAZF1
Standing height 6.19 1 1 2.2 0.00 1.0000 JAZF1
Birth weight of first child 2.69 1 0 0.0 0.00 1.0000 IGF2BP2
Peak expiratory flow (PEF) 2.46 1 0 0.0 0.00 1.0000 IGF2BP2
Medication for cholesterol, blood pressure or diabetes 5.04 2 0 0.0 0.00 1.0000 IGF2BP2 JAZF1
Hypothyroidism/myxoedema (self-reported) 2.09 1 0 0.0 0.00 1.0000 IGF2BP2
Birth weight 5.87 2 1 2.2 0.00 1.0000 EIF2S2P3 TCF7L2
Forced vital capacity (FVC), Best measure 1.37 1 0 0.0 0.00 1.0000 JAZF1
Body fat percentage 1.39 1 0 0.0 0.00 1.0000 TCF7L2
Leg fat percentage (right) 2.19 1 1 2.2 0.00 1.0000 TCF7L2
Arm fat-free mass (right) 1.53 2 0 0.0 0.00 1.0000 JAZF1 TCF7L2
Comparative body size at age 10 1.99 2 0 0.0 0.00 1.0000 JAZF1 WFS1
Wheeze or whistling in the chest in last year 3.23 2 0 0.0 0.00 1.0000 IGF2BP2 JAZF1
Age at first live birth 2.25 1 0 0.0 0.00 1.0000 EIF2S2P3
Medication for pain relief, constipation, heartburn 2.40 1 0 0.0 0.00 1.0000 IGF2BP2
Medication: Blood pressure 2.34 1 0 0.0 0.00 1.0000 JAZF1
Reproduciblity of spirometry measurement using ERS/ATS criteria 4.16 2 0 0.0 0.00 1.0000 EIF2S2P3 TCF7L2
Whole body fat mass 1.92 1 0 0.0 0.00 1.0000 TCF7L2
Leg fat mass (right) 2.33 2 1 2.2 0.00 1.0000 TCF7L2 WFS1
Arm predicted mass (right) 1.52 2 0 0.0 0.00 1.0000 JAZF1 WFS1
Pulse rate, automated reading 4.10 4 1 2.2 0.99 0.0087 EIF2S2P3 JAZF1 TCF7L2 WFS1
Alcohol intake frequency. 1.81 1 0 0.0 0.00 1.0000 WFS1
Comparative height size at age 10 5.23 2 1 2.2 0.00 1.0000 EIF2S2P3 JAZF1
Overall health rating 2.06 1 0 0.0 0.00 1.0000 IGF2BP2
Age at last live birth 2.79 1 0 0.0 0.00 1.0000 EIF2S2P3
Medication: Aspirin 5.56 1 0 0.0 0.00 1.0000 IGF2BP2
Hypertension (Self-reported) 1.75 1 0 0.0 0.00 1.0000 IGF2BP2
Illnesses of siblings: Diabetes 18.79 4 2 4.4 0.92 0.0832 EIF2S2P3 IGF2BP2 TCF7L2 WFS1
Forced expiratory volume in 1-second (FEV1), predicted 4.83 1 1 2.2 0.00 1.0000 JAZF1
Whole body fat-free mass 1.39 2 0 0.0 0.00 1.0000 JAZF1 WFS1
Leg fat-free mass (right) 1.00 2 0 0.0 0.00 1.0000 TCF7L2 WFS1
Arm fat percentage (left) 1.48 1 0 0.0 0.00 1.0000 TCF7L2
Long-standing illness, disability or infirmity 4.90 1 0 0.0 0.00 1.0000 IGF2BP2
Diabetes diagnosed by doctor 58.64 5 5 11.1 0.96 0.0104 EIF2S2P3 IGF2BP2 JAZF1 TCF7L2 WFS1
Ever had stillbirth, spontaneous miscarriage or termination 2.16 1 0 0.0 0.00 1.0000 TCF7L2
Qualifications: nursing, teaching 2.06 1 0 0.0 0.00 1.0000 TCF7L2
Breast cancer (self-reported) 2.19 1 0 0.0 0.00 1.0000 TCF7L2
Asthma (self-reported) 3.95 2 0 0.0 0.00 1.0000 EIF2S2P3 JAZF1
Medication: Aspirin 6.48 2 0 0.0 0.00 1.0000 IGF2BP2 TCF7L2
Medication: Gliclazide 24.75 4 2 4.4 1.00 0.0048 IGF2BP2 JAZF1 TCF7L2 WFS1
Forced expiratory volume in 1-second (FEV1), predicted percentage 3.68 2 0 0.0 0.00 1.0000 IGF2BP2 JAZF1
Whole body water mass 1.33 2 0 0.0 0.00 1.0000 JAZF1 WFS1
Leg predicted mass (right) 1.00 2 0 0.0 0.00 1.0000 TCF7L2 WFS1
Arm fat mass (left) 1.57 1 0 0.0 0.00 1.0000 TCF7L2
Number of self-reported non-cancer illnesses 4.39 2 0 0.0 0.00 1.0000 IGF2BP2 JAZF1
High cholesterol (Self-reported) 1.72 1 0 0.0 0.00 1.0000 TCF7L2
Medication: Atorvastatin 6.43 2 0 0.0 0.00 1.0000 IGF2BP2 TCF7L2
Basal metabolic rate 1.53 3 0 0.0 0.00 1.0000 JAZF1 TCF7L2 WFS1
Leg fat percentage (left) 2.25 1 1 2.2 0.00 1.0000 TCF7L2
Arm fat-free mass (left) 1.62 3 0 0.0 0.00 1.0000 JAZF1 TCF7L2 WFS1
Diastolic blood pressure, automated reading 1.21 1 0 0.0 0.00 1.0000 TCF7L2
Vascular/heart problems diagnosed by doctor 1.85 1 0 0.0 0.00 1.0000 IGF2BP2
Cholesterol lowering medication 4.30 1 0 0.0 0.00 1.0000 TCF7L2
Heart disease (siblings) 1.58 1 0 0.0 0.00 1.0000 IGF2BP2
Impedance of whole body 3.99 2 1 2.2 0.00 1.0000 JAZF1 TCF7L2
Leg fat mass (left) 2.35 1 1 2.2 0.00 1.0000 TCF7L2
Arm predicted mass (left) 1.53 3 0 0.0 0.00 1.0000 JAZF1 TCF7L2 WFS1

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 0 0.000 1.3
GTEx Adipose Visceral Omentum 0 0.000 1.3
GTEx Adrenal Gland 0 0.000 1.3
GTEx Artery Aorta 1 0.036 1.3
GTEx Artery Coronary 0 0.000 1.3
GTEx Artery Tibial 0 0.000 1.3
GTEx Brain Caudate basal ganglia 0 0.000 1.3
GTEx Brain Cerebellar Hemisphere 0 0.000 1.3
GTEx Brain Cerebellum 1 0.055 1.3
GTEx Brain Cortex 0 0.000 1.4
GTEx Brain Frontal Cortex BA9 0 0.000 1.3
GTEx Brain Hippocampus 0 0.000 1.4
GTEx Brain Hypothalamus 0 0.000 1.3
GTEx Brain Nucleus accumbens basal ganglia 0 0.000 1.3
GTEx Brain Putamen basal ganglia 0 0.000 1.3
GTEx Breast Mammary Tissue 0 0.000 1.2
GTEx Breast Mammary Tissue (Male) 0 0.000 1.2
GTEx Breast Mammary Tissue (Female) 0 0.000 1.3
GTEx Cells EBV-transformed lymphocytes 0 0.000 1.3
GTEx Cells Transformed fibroblasts 0 0.000 1.3
GTEx Colon Sigmoid 0 0.000 1.3
GTEx Colon Transverse 0 0.000 1.3
GTEx Esophagus Gastroesophageal Junction 0 0.000 1.2
GTEx Esophagus Mucosa 0 0.000 1.3
GTEx Esophagus Muscularis 1 0.034 1.3
GTEx Heart Atrial Appendage 0 0.000 1.3
GTEx Heart Left Ventricle 0 0.000 1.3
GTEx Liver 0 0.000 1.2
GTEx Lung 0 0.000 1.2
GTEx Muscle Skeletal 0 0.000 1.3
GTEx Nerve Tibial 0 0.000 1.3
GTEx Ovary 0 0.000 1.3
GTEx Pancreas 0 0.000 1.3
GTEx Pituitary 0 0.000 1.3
GTEx Prostate 1 0.131 1.4
GTEx Skin Not Sun Exposed Suprapubic 1 0.043 1.3
GTEx Skin Sun Exposed Lower leg 0 0.000 1.3
GTEx Small Intestine Terminal Ileum 0 0.000 1.2
GTEx Spleen 1 0.076 1.4
GTEx Stomach 0 0.000 1.3
GTEx Testis 1 0.034 1.3
GTEx Thyroid 2 0.054 1.3
GTEx Uterus 0 0.000 1.3
GTEx Vagina 0 0.000 1.3
GTEx Whole Blood 0 0.000 1.3
METSIM Adipose 0 0.000 1.3
NTR Blood 2 0.086 1.2
ROSMAP Brain Pre-frontal Cortex 0 0.000 1.3
YFS Blood 0 0.000 1.2
CommonMind Brain Pre-frontal Cortex 1 0.020 1.2
The Cancer Genome Atlas Bladder Urothelial Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Breast Invasive Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Cervical Squamous Cell Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Colon Adenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Esophageal Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Glioblastoma Multiforme 0 0.000 1.3
The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma 1 0.041 1.3
The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Brain Lower Grade Glioma 0 0.000 1.3
The Cancer Genome Atlas Liver Hepatocellular Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Lung Adenocarcinoma 1 0.038 1.2
The Cancer Genome Atlas Lung Squamous Cell Carcinoma 1 0.045 1.2
The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Pancreatic Adenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Pheochromocytoma and Paraganglioma 0 0.000 1.2
The Cancer Genome Atlas Prostate Adenocarcinoma 0 0.000 1.3
The Cancer Genome Atlas Rectum Adenocarcinoma 0 0.000 1.3
The Cancer Genome Atlas Soft Tissue Sarcoma 0 0.000 1.3
The Cancer Genome Atlas Skin Cutaneous Melanoma 0 0.000 1.2
The Cancer Genome Atlas Stomach Adenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Testicular Germ Cell Tumors 0 0.000 1.2
The Cancer Genome Atlas Thyroid Carcinoma 2 0.044 1.2
The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma 0 0.000 1.3