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chr10:114,740,745-116,183,647

Best TWAS P=2.67e-11 · Best GWAS P=1.87e-10 conditioned to 0.0361

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
7	GTEx	Heart Atrial Appendage	CASP7	0.26	0.03	enet	27	0.13	2.3e-06	-6.2	-6.7	2.7e-11	0.75	0.01	0.98	TRUE
3	GTEx	Brain Nucleus accumbens basal ganglia	CASP7	0.42	0.21	lasso	13	0.21	2.5e-06	-5.3	-6.5	6.2e-11	0.75	0.04	0.93	FALSE
9	GTEx	Pancreas	CASP7	0.40	0.25	lasso	10	0.35	2.2e-15	-6.3	-6.3	3.5e-10	0.87	0.01	0.99	FALSE
15	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	CASP7	0.12	0.04	blup	107	0.07	3.6e-04	5.5	-5.9	3.6e-09	0.56	0.09	0.64	FALSE
10	GTEx	Prostate	CASP7	0.59	0.12	lasso	11	0.12	5.4e-04	-5.3	-5.8	5.9e-09	0.53	0.21	0.54	FALSE
11	GTEx	Whole Blood	CASP7	0.14	0.05	lasso	7	0.03	4.4e-04	3.7	-5.8	7.1e-09	0.56	0.09	0.85	FALSE
5	GTEx	Cells Transformed fibroblasts	CASP7	0.41	0.36	enet	27	0.45	1.9e-37	3.5	-5.7	1.2e-08	0.45	1.00	0.00	FALSE
8	GTEx	Muscle Skeletal	CASP7	0.24	0.12	lasso	5	0.25	5.8e-24	3.7	-5.7	1.4e-08	0.52	0.76	0.24	FALSE
19	The Cancer Genome Atlas	Prostate Adenocarcinoma	CASP7	0.18	0.10	lasso	7	0.13	2.2e-13	3.5	-5.7	1.4e-08	0.56	0.97	0.03	FALSE
1	CommonMind	Brain Pre-frontal Cortex	CASP7	0.28	0.24	lasso	7	0.33	5.6e-41	-5.3	-5.6	2.0e-08	0.45	0.69	0.31	FALSE
6	GTEx	Esophagus Mucosa	CASP7	0.23	0.06	enet	24	0.16	1.4e-10	-6.1	-5.5	3.7e-08	0.75	0.02	0.98	FALSE
12	ROSMAP	Brain Pre-frontal Cortex	CASP7	0.37	0.24	bslmm	598	0.38	2.5e-51	-5.3	-5.5	4.0e-08	0.62	0.70	0.30	FALSE
13	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	CASP7	0.07	0.01	blup	107	0.03	9.9e-04	4.1	-5.4	5.4e-08	0.58	0.03	0.49	FALSE
4	GTEx	Breast Mammary Tissue (Male)	CASP7	0.10	-0.01	enet	15	0.04	4.3e-02	2.5	-5.4	7.5e-08	0.09	0.05	0.10	FALSE
17	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	CASP7	0.12	0.03	blup	107	0.09	5.1e-05	3.7	-5.3	9.4e-08	0.54	0.27	0.49	FALSE
18	The Cancer Genome Atlas	Lung Adenocarcinoma	CASP7	0.05	0.02	blup	107	0.04	3.3e-05	-5.2	-5.3	1.2e-07	0.74	0.01	0.94	FALSE
14	The Cancer Genome Atlas	Breast Invasive Carcinoma	CASP7	0.07	0.08	lasso	6	0.08	2.6e-16	3.5	-5.2	2.6e-07	0.34	1.00	0.00	FALSE
16	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	CASP7	0.12	0.01	blup	107	0.10	1.9e-11	-6.1	-5.1	2.7e-07	0.56	0.05	0.93	FALSE
2	GTEx	Adipose Visceral Omentum	CASP7	0.39	0.12	enet	23	0.26	6.5e-14	3.7	-5.1	2.8e-07	0.59	0.19	0.81	FALSE