Hub : Traits :

Pulse rate, automated reading

2151 significantly associated models · 506 unique genes.

Significant Loci

#	chr	p0	p1	# assoc genes	# joint genes	best TWAS P	best SNP P	cond SNP P	% var exp	joint genes
1	1	5611729	7016109	2	1	2.6e-11	9.0e-18	6.2e-08	60	ICMT
2	1	25615377	26988026	3	1	2.0e-08	1.8e-09	2.8e-02	87	SLC30A2
3	1	28011854	29594563	3	1	6.1e-09	1.6e-08	3.5e-02	86	SNHG12
4	1	39258674	40737589	5	1	1.8e-11	5.8e-09	2.3e-01	96	BMP8A
5	1	44779991	46844530	6	2	1.5e-09	2.3e-42	6.2e-40	6	GPBP1L1 ZSWIM5
6	1	66304567	67938108	3	2	2.0e-17	5.0e-25	8.5e-09	69	SGIP1 TCTEX1D1
7	1	71163715	73435171	1	1	2.4e-08	9.4e-09	4.9e-04	63	NEGR1
8	1	87215608	87884808	1	1	1.0e-07	1.2e-08	5.5e-08	9	LOC339524
9	1	155739430	157406190	2	2	8.1e-09	3.4e-12	1.2e-03	78	MEF2D MRPL24
10	1	173331762	175860452	3	2	1.7e-11	3.3e-09	3.8e-01	98	ANKRD45 KIAA0040
11	1	201099275	202607593	4	1	2.2e-10	3.9e-09	9.2e-01	100	IPO9
12	1	206802184	208664733	3	2	1.6e-18	2.1e-51	1.4e-30	42	CD34 CD55
13	1	236170665	237625236	1	1	5.1e-12	2.8e-07	1.4e-01	92	ACTN2
14	2	16998604	18537483	3	1	1.4e-19	1.2e-15	3.9e-01	99	RAD51AP2
15	2	26653457	28414302	16	1	7.5e-29	1.2e-27	1.0e+00	100	FNDC4
16	2	47224927	48727280	1	1	5.8e-11	8.8e-10	8.9e-02	92	MSH6
17	2	53583159	54976770	1	1	1.6e-07	3.8e-08	4.9e-02	87	HMGB1P31
18	2	64168232	65573478	1	1	2.2e-07	5.6e-06	8.7e-03	67	SERTAD2
19	2	135972093	137435625	2	1	3.7e-08	3.0e-08	1.0e+00	100	DARS
20	2	159577307	160334363	1	1	7.0e-09	2.4e-14	6.8e-07	58	TANC1
21	2	178280031	180379917	9	10	6.2e-20	2.4e-117	NaN	NaN	AC009948.5 FKBP7 OSBPL6 PRKRA RBM45 RP11-171I2.5 TTN TTN-AS1
22	2	187360440	189122229	3	1	2.2e-24	2.5e-24	1.0e+00	100	CALCRL
23	2	190357442	192254289	6	1	6.4e-12	4.5e-11	2.9e-02	89	TMEM194B
24	2	200134004	202036478	2	1	1.9e-09	8.6e-13	7.9e-05	70	C2orf47
25	2	219403022	221058583	6	3	2.3e-18	1.0e-29	3.3e-11	66	DES OBSL1 RP11-316O14.1
26	2	227498520	228912778	1	1	1.6e-13	4.8e-12	7.3e-01	100	MFF
27	2	231564626	234168951	5	3	7.5e-22	3.2e-23	1.0e+00	100	B3GNT7 EFHD1
28	3	14781364	16261420	5	1	6.5e-11	3.9e-10	1.5e-04	63	EAF1-AS1
29	3	40537829	41986787	1	1	5.5e-08	5.9e-08	1.1e-01	91	CTNNB1
30	3	46919379	51077419	46	7	1.4e-28	1.5e-26	NaN	NaN	AMT CSPG5 MST1 RBM6 TRAIP
31	3	51306844	54077726	15	12	1.1e-15	4.9e-17	NaN	NaN	DCP1A GLT8D1 GNL3 NEK4 RFT1 RP11-155D18.12 TKT TMEM110
32	3	65739897	67250048	1	1	1.1e-08	8.4e-11	1.7e-03	76	LRIG1
33	3	121346656	122929314	5	2	8.1e-14	2.9e-14	1.0e+00	100	CSTA WDR5B
34	3	140350567	141867638	1	1	2.4e-16	3.9e-17	1.0e+00	100	ZBTB38
35	3	156300190	157010086	1	1	7.8e-08	7.9e-08	1.4e-07	4	LEKR1
36	3	171513388	172365832	1	1	4.2e-08	3.3e-21	3.9e-22	-5	FNDC3B
37	3	178356269	179864765	4	1	4.4e-25	4.3e-25	1.0e+00	100	AC007620.3
38	3	182942402	184700426	4	1	9.6e-10	3.3e-12	2.0e-05	62	PSMD2
39	4	507001	2058475	7	1	5.1e-10	4.8e-12	1.6e-03	79	LOC100130872
40	4	5575751	7002344	1	1	8.5e-09	4.1e-10	2.7e-03	77	WFS1
41	4	77938810	79439935	1	1	7.8e-08	1.1e-05	2.1e-01	92	CNOT6L
42	4	82578407	83991529	1	1	1.5e-07	2.1e-09	3.8e-03	77	HNRNPD
43	4	158997448	160525502	1	1	3.6e-11	6.3e-11	1.0e+00	100	FNIP2
44	5	44129083	45516364	2	1	4.5e-08	2.9e-08	1.0e-01	91	RP11-53O19.3
45	5	74731732	75253311	1	1	8.1e-08	8.2e-09	7.2e-03	78	POC5
46	5	86867897	88427942	1	1	2.0e-09	1.1e-09	9.4e-02	92	TMEM161B-AS1
47	5	122045488	123432250	3	1	6.5e-14	1.2e-13	3.2e-01	98	CEP120
48	5	136262454	139475611	11	10	3.9e-30	3.9e-30	1.0e+00	100	CDC25C DNAJC18 HNRNPA0 MYOT REEP2 RP11-381K20.5
49	5	171876084	173289036	2	2	1.2e-10	1.2e-16	1.5e-10	40	ATP6V0E1 BNIP1
50	6	6701209	8115492	2	1	2.3e-17	4.5e-14	5.6e-02	94	DSP
51	6	25296606	26689223	1	1	1.7e-07	6.7e-11	2.3e-06	48	U91328.19
52	6	33856903	35549670	3	1	2.0e-11	2.8e-10	1.0e+00	100	C6orf106
53	6	36014161	37590303	3	2	1.1e-13	5.5e-23	2.1e-10	59	PPIL1
54	6	41058968	42587818	2	1	6.2e-09	1.8e-14	4.2e-12	18	MED20
55	6	53184508	54821152	2	1	9.8e-12	1.7e-13	1.6e-03	82	C6orf142
56	6	105033213	106549398	1	1	8.1e-09	2.0e-09	1.0e+00	100	PREP
57	6	118089396	120041948	5	5	2.3e-56	5.1e-74	3.1e-05	95	C6orf204 MCM9 RP11-351A11.1
58	6	120704438	122457698	3	6	2.3e-46	7.6e-109	4.0e-10	92	C6orf170 GJA1 TBC1D32
59	6	133961374	134468561	1	1	1.2e-16	1.4e-16	5.6e-03	89	TCF21
60	7	34711663	35471882	2	1	6.1e-13	7.6e-13	2.1e-02	90	DPY19L2P1
61	7	75059331	75803132	1	1	1.9e-07	1.8e-06	1.0e+00	100	POM121C
62	7	93345774	93883599	1	1	2.0e-07	3.4e-29	4.5e-24	19	BET1
63	7	98244565	101185166	45	14	1.8e-82	4.7e-76	NaN	NaN	AP4M1 ARPC1A CYP3A5 GATS GIGYF1 MEPCE PPP1R35 TFR2 TRIM56 ZKSCAN5
64	7	115619298	117135212	1	1	6.2e-13	1.2e-13	1.0e+00	100	MET
65	7	122624770	124081532	4	1	6.1e-13	4.0e-14	1.0e+00	100	WASL
66	7	130101373	131880252	2	1	9.1e-12	9.7e-25	1.6e-14	44	MKLN1-AS2
67	7	134650544	136074356	4	1	9.1e-10	7.8e-09	1.0e+00	100	SLC13A4
68	9	16448628	18201083	1	1	2.2e-07	9.4e-07	1.0e-01	89	CNTLN
69	9	35213538	36597142	2	1	2.8e-15	2.9e-15	1.0e+00	100	LINC00961
70	9	98302535	99734369	3	1	1.8e-07	1.1e-07	1.7e-02	80	HSD17B3
71	9	122669622	124303632	4	1	9.8e-10	1.5e-09	3.7e-01	98	RP11-27I1.4
72	9	127035761	129422783	3	1	1.8e-24	3.4e-25	7.0e-04	89	MAPKAP1
73	10	29001607	30716397	2	1	4.2e-12	3.4e-14	1.1e-16	-20	SVIL
74	10	42607692	43946295	1	1	2.7e-07	1.1e-09	8.6e-04	70	AL022344.7
75	10	49667361	51094660	1	1	7.0e-08	5.8e-09	4.9e-05	51	C10orf128
76	10	62920670	63459183	1	1	1.3e-08	2.2e-12	3.8e-05	66	TMEM26
77	10	74714177	76323150	10	1	5.3e-12	2.4e-10	9.0e-03	83	FUT11
78	10	100679684	103018321	8	3	6.3e-12	4.4e-12	7.2e-03	85	NDUFB8 SEC31B SLC25A28
79	10	112157994	112846298	1	1	9.9e-11	2.9e-11	6.2e-03	83	RBM20
80	10	114740745	116183647	1	1	2.7e-11	1.9e-10	3.6e-02	89	CASP7
81	11	10089027	10577397	1	1	6.1e-08	3.1e-07	8.3e-01	100	ADM
82	11	13288698	14975818	1	1	2.9e-12	9.1e-12	1.0e+00	100	SPON1
83	11	32168691	32702734	1	1	2.0e-07	1.3e-11	1.2e-07	39	WT1
84	11	47305669	48783497	1	1	2.8e-07	2.8e-07	2.4e-03	65	PTPRJ
85	11	56742853	58166421	1	1	1.4e-07	7.6e-07	7.3e-01	100	ZDHHC5
86	11	60465487	63110149	17	3	5.2e-38	1.3e-38	2.6e-02	97	EML3 FADS1 TMEM216
87	11	63295034	66184140	5	2	1.1e-09	1.7e-09	1.4e-03	72	FKBP2 RNASEH2C
88	11	77231939	78828001	1	1	5.2e-08	1.2e-07	1.0e+00	100	GAB2
89	11	101404645	102797829	1	1	2.2e-09	2.2e-09	1.0e+00	100	RP11-864G5.3
90	11	122700789	123312063	1	1	7.5e-08	1.7e-07	5.7e-01	99	ASAM
91	12	19826892	21533355	1	1	3.6e-09	3.8e-15	4.6e-08	52	PDE3A
92	12	24273423	27168878	3	2	1.1e-15	1.3e-80	2.2e-74	8	BCAT1 SSPN
93	12	27234999	28643213	4	1	3.3e-11	7.7e-11	8.7e-02	93	LOC100133893
94	12	32831091	34826574	2	5	1.9e-35	4.0e-65	NaN	NaN	ALG10 SYT10
95	12	38044044	39998144	2	1	4.5e-17	7.0e-19	9.4e-04	86	ALG10B
96	12	48605088	50364707	8	1	1.2e-11	1.6e-08	9.9e-02	92	RP11-302B13.5
97	12	64762194	65335717	1	1	1.5e-13	1.8e-26	4.7e-15	46	RASSF3
98	12	80954858	82853038	1	1	2.5e-12	4.0e-12	1.0e+00	100	PPFIA2
99	12	109591369	111699146	9	1	8.2e-12	1.4e-11	1.0e+00	100	GPN3
100	12	122318723	124162750	3	1	2.3e-12	9.9e-11	3.0e-04	69	ABCB9
101	13	41092698	42640341	2	1	2.8e-08	4.1e-08	1.0e+00	100	NAA16
102	14	20843889	22255090	1	1	9.3e-19	6.4e-32	1.3e-18	44	ARHGEF40
103	14	22670975	25605046	16	12	7.1e-79	4.0e-169	2.9e-34	81	CBLN3 CMTM5 HOMEZ NGDN PSMB5 RBM23 RP11-66N24.4 SLC22A17 SLC7A8 THTPA
104	14	51775331	53232305	1	1	1.6e-07	1.7e-08	4.1e-03	74	NID2
105	14	77570478	79097679	1	1	1.3e-09	5.1e-10	9.1e-03	82	ADCK1
106	14	85303548	86791228	1	1	5.5e-50	3.1e-50	1.0e+00	100	FLRT2
107	14	90643934	92390620	2	1	4.1e-13	1.6e-15	4.0e-09	46	C14orf159
108	14	101850676	103494612	2	1	7.2e-08	9.7e-09	1.7e-02	83	ZNF839
109	15	62636766	64056437	2	1	8.5e-09	1.6e-08	8.8e-02	91	LACTB
110	15	71418503	74291976	7	10	6.1e-49	3.9e-59	0.0e+00	-537	HCN4 HEXA MYO9A NEO1 NR2E3 RP11-1006G14.4
111	15	83167559	84434423	2	1	2.4e-10	9.9e-09	1.2e-03	68	BTBD1
112	15	98944630	100367846	2	1	1.6e-07	3.6e-07	1.8e-01	93	RP11-6O2.4
113	16	86671	934180	1	1	2.7e-07	4.9e-05	7.6e-01	99	LA16c-OS12.2
114	16	3608256	5479168	3	2	9.4e-08	5.4e-10	5.1e-09	11	NUDT16L1 RP11-95P2.1
115	16	15369019	16832414	1	1	7.2e-08	1.8e-30	3.7e-26	15	ABCC1
116	16	29905882	31860399	7	1	4.4e-10	4.7e-09	9.0e-01	100	RNF40
117	16	52772129	54235440	2	1	8.3e-16	3.0e-14	9.4e-01	100	RBL2
118	16	66143181	68210165	2	2	6.4e-09	2.8e-09	2.8e-03	75	ATP6V0D1 NAE1
119	16	69354963	69975360	1	1	2.8e-07	3.3e-09	2.6e-03	74	NFAT5
120	17	4156620	5556453	2	1	4.2e-08	5.9e-07	8.9e-01	100	INCA1
121	17	14509122	16109675	3	1	5.9e-14	4.4e-12	4.4e-09	28	TEKT3
122	17	16419425	18325085	9	2	5.1e-13	4.1e-12	8.3e-01	100	FLCN SREBF1
123	17	26716917	28172357	1	1	9.1e-08	8.3e-08	1.0e+00	100	MYO18A
124	17	36211659	37605364	2	1	8.1e-11	4.9e-10	1.0e+00	100	PCGF2
125	17	44788310	45876022	2	1	4.7e-09	1.7e-11	7.2e-04	75	GOSR2
126	17	73972187	75405078	3	1	4.7e-09	6.4e-10	1.0e+00	100	MXRA7
127	19	35807727	37300554	3	1	4.8e-10	4.7e-08	4.0e-02	86	CLIP3
128	19	38444944	39951086	4	1	2.4e-16	5.1e-17	1.0e-02	91	ACTN4
129	19	40000075	41953928	4	3	1.6e-13	1.8e-14	2.8e-01	98	C19orf47 C19orf54
130	20	35835657	37654024	4	5	9.9e-51	4.1e-116	2.3e-17	86	KIAA1755 TGM2 VSTM2L
131	20	39114404	40516054	1	1	1.6e-07	1.9e-11	9.1e-06	56	RP3-511B24.6
132	20	60781573	62912463	2	2	3.4e-09	2.7e-10	3.2e-04	68	PRPF6 TCFL5
133	22	38192452	40338284	16	6	2.5e-20	2.9e-20	1.0e+00	100	AL021707.1 CBX6 CBY1 GTPBP1 RP3-508I15.9 SUN2

Pleiotropic Associations

Trait	chisq ratio	# genes⁺	# genes⁺⁺	% genes⁺⁺	corr	corr P	genes
Pulse rate	11.96	77	40	88.9	0.99	3.5e-82	AC007620.3 AC009948.5 ACTN4 AL021707.1 ALG10 ALG10B AMT ARHGEF40 ATP6V0E1 B3GNT7 BCAT1 C6orf170 C6orf204 CALCRL CBY1 CD34 CEP120 CMTM5 CTNNB1 DCP1A DES DSP EML3 FADS1 FKBP7 FLRT2 FNDC4 FNIP2 FUT11 GIGYF1 GJA1 GTPBP1 HCN4 HOMEZ IPO9 KIAA1755 LINC00961 LOC339524 MAPKAP1 MCM9 MEPCE MFF MKLN1-AS2 MXRA7 NAA16 NEK4 NEO1 NGDN OSBPL6 POC5 PPFIA2 PPP1R35 PREP RAD51AP2 RBL2 RBM23 REEP2 RP11-171I2.5 RP11-381K20.5 RP11-66N24.4 RP3-508I15.9 SLC22A17 SPON1 SREBF1 SUN2 SVIL TBC1D32 TCF21 TCTEX1D1 TEKT3 TFR2 TGM2 THTPA TKT TRAIP VSTM2L ZBTB38
Triglycerides	3.13	2	2	4.4	0.00	1.0e+00	FADS1 FNDC4
Pulse wave reflection index	2.42	3	1	2.2	0.00	1.0e+00	HOMEZ KIAA1755 VSTM2L
Diastolic blood pressure, automated reading	2.34	27	6	13.3	0.94	5.2e-15	ABCB9 AC007620.3 ARPC1A BNIP1 BTBD1 CEP120 CSPG5 CSTA CTNNB1 DARS GATS GIGYF1 MAPKAP1 MST1 MYO9A NR2E3 POC5 POM121C RBM6 RNF40 RP11-351A11.1 SEC31B SPON1 TMEM161B-AS1 TMEM194B TRAIP WDR5B
Waist Hip Ratio (WHR)	2.26	24	20	44.4	0.30	8.5e-02	ADM ALG10 AMT C14orf159 C6orf106 CALCRL CNOT6L EML3 GLT8D1 GNL3 MEF2D NEK4 PDE3A PTPRJ RBL2 REEP2 RFT1 RNASEH2C RP11-95P2.1 SREBF1 SSPN TMEM110 TRAIP ZBTB38
Trunk fat-free mass	2.09	30	24	53.3	-0.37	3.5e-02	ABCB9 ADM ARHGEF40 B3GNT7 BMP8A C2orf47 C6orf106 CEP120 CTNNB1 DNAJC18 EFHD1 FNDC3B FNDC4 GLT8D1 GNL3 GOSR2 HSD17B3 MED20 MYO9A NEK4 NUDT16L1 POC5 PRPF6 PSMD2 RBL2 RBM6 RFT1 SLC30A2 TMEM110 ZBTB38
Trunk predicted mass	2.09	32	23	51.1	-0.38	2.6e-02	ABCB9 ADM ARHGEF40 B3GNT7 BMP8A C2orf47 C6orf106 CEP120 CTNNB1 DNAJC18 EFHD1 FNDC3B FNDC4 GLT8D1 GNL3 GOSR2 GPN3 HSD17B3 MED20 MYO9A NEGR1 NEK4 NUDT16L1 POC5 PRPF6 PSMD2 RBL2 RBM6 RFT1 SLC30A2 TMEM110 ZBTB38
Whole body fat-free mass	2.09	31	25	55.6	-0.26	1.4e-01	ABCB9 ARHGEF40 B3GNT7 BMP8A C14orf159 C2orf47 C6orf106 CEP120 CTNNB1 DNAJC18 EFHD1 FNDC3B FNDC4 GLT8D1 GNL3 GOSR2 GPN3 HSD17B3 MED20 NEGR1 NUDT16L1 POC5 POM121C PRPF6 PSMD2 RBL2 RBM6 RFT1 SLC30A2 TMEM110 ZBTB38
Whole body water mass	2.09	32	25	55.6	-0.28	1.1e-01	ABCB9 ARHGEF40 B3GNT7 BMP8A C14orf159 C2orf47 C6orf106 CEP120 CTNNB1 DNAJC18 EFHD1 FNDC3B FNDC4 GLT8D1 GNL3 GOSR2 GPN3 HSD17B3 MED20 NEGR1 NEK4 NUDT16L1 POC5 POM121C PRPF6 PSMD2 RBL2 RBM6 RFT1 SLC30A2 TMEM110 ZBTB38
Basal metabolic rate	2.09	32	25	55.6	-0.24	1.6e-01	ABCB9 ARHGEF40 BMP8A C14orf159 C2orf47 C6orf106 CEP120 CTNNB1 DNAJC18 EFHD1 FNDC3B FNDC4 GLT8D1 GNL3 GPN3 HSD17B3 MED20 NEGR1 NUDT16L1 POC5 POM121C PSMD2 RBL2 RBM6 RFT1 RNF40 RP11-95P2.1 SLC30A2 TMEM110 TMEM161B-AS1 U91328.19 ZBTB38
Arm predicted mass (right)	2.07	30	19	42.2	-0.30	8.8e-02	ABCB9 ARHGEF40 B3GNT7 BMP8A C2orf47 C6orf106 CEP120 CTNNB1 DNAJC18 EFHD1 FNDC3B FNDC4 GLT8D1 GNL3 GPN3 HSD17B3 MED20 NEGR1 NUDT16L1 POC5 POM121C PSMD2 RBL2 RBM6 RFT1 RP11-864G5.3 SLC30A2 TMEM110 U91328.19 ZBTB38
Height	2.06	72	56	124.4	-0.31	5.6e-03	ADM AMT ANKRD45 ARHGEF40 ARPC1A ATP6V0E1 B3GNT7 BNIP1 C19orf54 C6orf106 CALCRL CBLN3 CBX6 CBY1 CEP120 CMTM5 CTNNB1 DNAJC18 DPY19L2P1 EFHD1 FADS1 FNDC3B FNDC4 GAB2 GIGYF1 GJA1 GNL3 GOSR2 GPBP1L1 GTPBP1 HMGB1P31 HNRNPD HSD17B3 LA16c-OS12.2 LOC339524 MAPKAP1 MED20 MEF2D MKLN1-AS2 MRPL24 MYO9A NFAT5 NGDN NR2E3 NUDT16L1 POM121C PRPF6 PSMD2 PTPRJ RBL2 REEP2 RFT1 RNF40 RP11-171I2.5 RP11-27I1.4 RP11-316O14.1 RP11-864G5.3 RP11-95P2.1 RP3-508I15.9 SLC13A4 SLC25A28 SLC30A2 SPON1 SREBF1 SSPN SUN2 TCTEX1D1 TMEM110 ZBTB38 ZDHHC5 ZKSCAN5 ZNF839
Weight	2.05	27	19	42.2	0.09	6.5e-01	ABCB9 BMP8A C14orf159 C6orf106 CEP120 CTNNB1 DNAJC18 EFHD1 FKBP2 FNDC4 GPN3 MED20 MST1 NEGR1 NEO1 NFAT5 NUDT16L1 POC5 POM121C PSMD2 RBM6 RFT1 RNF40 RP11-95P2.1 TMEM161B-AS1 U91328.19 ZBTB38
Arm fat-free mass (right)	2.05	31	18	40.0	-0.28	1.2e-01	ABCB9 ARHGEF40 B3GNT7 BMP8A C2orf47 C6orf106 CEP120 CTNNB1 DNAJC18 EFHD1 FNDC3B FNDC4 GLT8D1 GNL3 GOSR2 GPN3 HSD17B3 MED20 NEGR1 POC5 POM121C PSMD2 RBL2 RBM6 RFT1 RNASEH2C RP11-864G5.3 SLC30A2 TMEM110 U91328.19 ZBTB38
Arm fat-free mass (left)	2.05	27	17	37.8	-0.29	1.3e-01	ABCB9 ARHGEF40 BMP8A C2orf47 C6orf106 CEP120 CTNNB1 DNAJC18 EFHD1 FNDC3B FNDC4 GLT8D1 GNL3 GPN3 MED20 NEGR1 POC5 POM121C PSMD2 RBL2 RBM6 RFT1 RP11-864G5.3 SLC30A2 TMEM110 U91328.19 ZBTB38
Leg fat-free mass (left)	2.04	30	24	53.3	-0.18	3.2e-01	ABCB9 ARHGEF40 BMP8A C14orf159 C2orf47 C6orf106 CEP120 CTNNB1 DNAJC18 EFHD1 FNDC3B FNDC4 GLT8D1 GNL3 HSD17B3 MED20 NEGR1 NUDT16L1 POC5 POM121C PSMD2 RBL2 RBM6 RFT1 RNF40 SLC30A2 TMEM110 TMEM161B-AS1 VSTM2L ZBTB38
Leg predicted mass (left)	2.04	30	24	53.3	-0.18	3.1e-01	ABCB9 ARHGEF40 BMP8A C14orf159 C2orf47 C6orf106 CEP120 CTNNB1 DNAJC18 EFHD1 FNDC3B FNDC4 GLT8D1 GNL3 HSD17B3 MED20 NEGR1 NUDT16L1 POC5 POM121C PSMD2 RBL2 RBM6 RFT1 RNF40 SLC30A2 TMEM110 TMEM161B-AS1 VSTM2L ZBTB38
Arm predicted mass (left)	2.04	28	16	35.6	-0.29	1.2e-01	ABCB9 ARHGEF40 BMP8A C2orf47 C6orf106 CEP120 CTNNB1 DNAJC18 EFHD1 FNDC3B FNDC4 GLT8D1 GNL3 GPN3 HSD17B3 MED20 NEGR1 POC5 POM121C PSMD2 RBL2 RBM6 RFT1 RP11-864G5.3 SLC30A2 TMEM110 U91328.19 ZBTB38
Leg predicted mass (right)	2.02	31	23	51.1	-0.20	2.7e-01	ABCB9 ARHGEF40 BMP8A C14orf159 C2orf47 C6orf106 CEP120 CTNNB1 DNAJC18 EFHD1 FNDC3B FNDC4 GLT8D1 GNL3 HSD17B3 MED20 NEGR1 NUDT16L1 POC5 POM121C PSMD2 RBL2 RBM6 RFT1 RNF40 SLC13A4 SLC30A2 TMEM110 TMEM161B-AS1 VSTM2L ZBTB38
Leg fat-free mass (right)	2.01	32	23	51.1	-0.23	1.9e-01	ABCB9 ARHGEF40 BMP8A C14orf159 C2orf47 C6orf106 CEP120 CTNNB1 DNAJC18 EFHD1 FNDC3B FNDC4 GLT8D1 GNL3 HSD17B3 MED20 NEGR1 NUDT16L1 POC5 POM121C PSMD2 RBL2 RBM6 RFT1 RNF40 RP3-508I15.9 SLC13A4 SLC30A2 TMEM110 TMEM161B-AS1 VSTM2L ZBTB38
Hip circumference	1.99	29	23	51.1	-0.13	5.1e-01	ABCB9 AL021707.1 BMP8A C14orf159 C6orf106 CBY1 CEP120 CTNNB1 DNAJC18 EFHD1 FNDC4 GPN3 MED20 NEGR1 NEO1 NFAT5 POC5 POM121C PSMD2 RBL2 RBM6 RNF40 RP11-95P2.1 RP3-508I15.9 SREBF1 SUN2 TMEM161B-AS1 U91328.19 ZBTB38
Standing height	1.98	42	34	75.6	-0.37	9.6e-03	AMT ARHGEF40 ATP6V0E1 B3GNT7 BNIP1 C6orf106 CBX6 CEP120 CTNNB1 DNAJC18 EFHD1 FADS1 FNDC3B FNDC4 GNL3 GPBP1L1 HMGB1P31 HNRNPD HSD17B3 LA16c-OS12.2 MAPKAP1 MED20 MYO9A NFAT5 NR2E3 NUDT16L1 PRPF6 PSMD2 PTPRJ RBL2 RFT1 RP11-171I2.5 RP11-27I1.4 RP11-316O14.1 RP11-95P2.1 RP3-508I15.9 SLC13A4 SLC25A28 SLC30A2 TMEM110 ZBTB38 ZKSCAN5
Leg fat mass (right)	1.98	25	15	33.3	0.46	1.3e-02	ABCB9 ARPC1A C6orf106 CNOT6L CTNNB1 DARS GPN3 HCN4 IPO9 MST1 NEGR1 NEO1 NFAT5 POC5 POM121C PSMD2 RBM6 RNF40 RP11-1006G14.4 RP11-95P2.1 RP3-511B24.6 TMEM161B-AS1 U91328.19 ZBTB38 ZKSCAN5
Leg fat mass (left)	1.98	28	15	33.3	0.36	4.4e-02	ABCB9 ARPC1A C6orf106 CNOT6L CTNNB1 DARS DNAJC18 FKBP2 FNDC4 GPN3 HCN4 IPO9 MST1 NEGR1 NEO1 NFAT5 POC5 POM121C PSMD2 RBM6 RNF40 RP11-1006G14.4 RP11-95P2.1 RP3-511B24.6 TMEM161B-AS1 U91328.19 ZBTB38 ZKSCAN5
Sitting height	1.97	39	27	60.0	-0.28	6.7e-02	ADM AMT ARHGEF40 ARPC1A BMP8A C2orf47 C6orf106 CALCRL CEP120 CTNNB1 DNAJC18 EFHD1 FADS1 FNDC3B FNDC4 GNL3 GOSR2 GPBP1L1 HSD17B3 KIAA1755 LA16c-OS12.2 MAPKAP1 MED20 MYO9A NEO1 NFAT5 NUDT16L1 PSMD2 RBL2 RFT1 RP11-171I2.5 RP11-95P2.1 SLC13A4 SLC30A2 TMEM110 VSTM2L ZBTB38 ZDHHC5 ZKSCAN5
Blood Red Count	1.96	43	31	68.9	0.31	3.4e-02	ADM AMT ARPC1A BMP8A C6orf106 C6orf170 CDC25C DARS FADS1 FNDC4 GAB2 GATS GIGYF1 GJA1 GLT8D1 GOSR2 GPBP1L1 GPN3 HNRNPA0 LA16c-OS12.2 MAPKAP1 MED20 MFF MST1 MYO9A NEK4 NFAT5 NR2E3 PPP1R35 PSMD2 RBM6 RNASEH2C RNF40 SERTAD2 SREBF1 TFR2 TMEM110 TMEM194B TRAIP TRIM56 ZBTB38 ZDHHC5 ZKSCAN5
BMI	1.94	38	26	57.8	0.35	1.9e-02	ABCB9 ANKRD45 AP4M1 ARPC1A BMP8A C14orf159 C6orf106 C6orf142 CEP120 CSPG5 CTNNB1 CYP3A5 DNAJC18 FKBP2 FNDC4 GAB2 GLT8D1 GPBP1L1 GPN3 HCN4 HEXA IPO9 MEF2D MST1 MYO9A NEGR1 NEK4 NEO1 NFAT5 POC5 POM121C PSMD2 RBM6 RNF40 RP11-1006G14.4 TMEM161B-AS1 ZKSCAN5 ZNF839
Leg fat percentage (left)	1.91	23	14	31.1	0.39	3.9e-02	ABCB9 ARPC1A C6orf106 CNOT6L DARS GPBP1L1 GPN3 HCN4 HSD17B3 MAPKAP1 MST1 NEGR1 NEO1 NFAT5 POC5 POM121C RBM6 RNF40 RP11-1006G14.4 RP11-95P2.1 RP3-511B24.6 U91328.19 ZKSCAN5
Whole body fat mass	1.90	28	15	33.3	0.35	5.4e-02	ABCB9 ARPC1A BMP8A C6orf106 C6orf142 CEP120 CNOT6L CTNNB1 DARS DNAJC18 FKBP2 GPN3 MST1 NEGR1 NEO1 NFAT5 POC5 POM121C PSMD2 RBM6 RNF40 RP11-1006G14.4 RP11-95P2.1 RP3-511B24.6 TMEM161B-AS1 U91328.19 ZBTB38 ZKSCAN5
Leg fat percentage (right)	1.89	21	15	33.3	0.53	4.9e-03	ABCB9 ARPC1A C6orf106 CNOT6L DARS GPBP1L1 HCN4 HSD17B3 MET MST1 NEGR1 NEO1 NFAT5 POC5 POM121C RBM6 RNF40 RP11-95P2.1 RP3-511B24.6 U91328.19 ZKSCAN5
Arm fat mass (left)	1.89	27	19	42.2	0.35	6.0e-02	ABCB9 ARPC1A BMP8A C6orf106 CEP120 CNOT6L CTNNB1 DNAJC18 FKBP2 FNDC4 GPN3 IPO9 MED20 MST1 NEGR1 NEO1 NFAT5 POC5 POM121C PSMD2 RBM6 RNF40 RP11-1006G14.4 TMEM161B-AS1 U91328.19 ZBTB38 ZKSCAN5
Trunk fat mass	1.88	27	16	35.6	0.40	3.4e-02	ABCB9 BMP8A C6orf106 C6orf142 CEP120 CNOT6L CTNNB1 DARS FKBP2 MST1 NEGR1 NEO1 NFAT5 NUDT16L1 POC5 POM121C PSMD2 RBM6 RNF40 RP11-1006G14.4 RP11-95P2.1 RP3-511B24.6 TMEM161B-AS1 TRAIP U91328.19 ZBTB38 ZKSCAN5
Arm fat mass (right)	1.87	27	18	40.0	0.27	1.6e-01	ABCB9 AC007620.3 ARPC1A BMP8A C6orf106 C6orf142 CEP120 CNOT6L CTNNB1 FKBP2 FNDC4 GPN3 IPO9 MED20 MST1 NEGR1 NEO1 NFAT5 POC5 POM121C PSMD2 RBM6 RNF40 TMEM161B-AS1 U91328.19 ZBTB38 ZKSCAN5
HDL Cholesterol	1.85	8	4	8.9	-0.43	2.5e-01	BMP8A C6orf106 FADS1 GNL3 LACTB PDE3A PTPRJ RBM6
Body mass index (BMI)	1.82	26	15	33.3	0.26	1.7e-01	ABCB9 ANKRD45 ARPC1A BMP8A C14orf159 C6orf106 C6orf142 CEP120 CSPG5 DARS FKBP2 FNDC4 GPN3 IPO9 MST1 NEGR1 NEK4 NFAT5 POC5 POM121C PSMD2 RBM6 RNF40 TMEM161B-AS1 U91328.19 ZKSCAN5
Waist circumference	1.82	19	14	31.1	0.47	2.9e-02	ABCB9 ARPC1A BMP8A C6orf106 CEP120 CNOT6L CTNNB1 NEGR1 NEO1 NFAT5 POC5 POM121C PSMD2 RBM6 RNASEH2C RNF40 TMEM161B-AS1 ZBTB38 ZKSCAN5
Diabetes diagnosed by doctor	1.79	8	3	6.7	0.08	8.5e-01	AMT BMP8A FNDC4 LOC100133893 NFAT5 RBL2 RBM6 WFS1
Heel T-Score	1.77	43	34	75.6	0.34	1.8e-02	AL021707.1 AMT ANKRD45 BMP8A C10orf128 C6orf204 CALCRL CBX6 CBY1 CEP120 CTNNB1 EML3 FADS1 FLCN GAB2 GIGYF1 GJA1 GLT8D1 GTPBP1 LEKR1 LOC100130872 MSH6 MST1 NAE1 NEGR1 PCGF2 PTPRJ RBM6 RFT1 RNASEH2C RNF40 RP11-95P2.1 RP3-508I15.9 RP3-511B24.6 SEC31B SERTAD2 SREBF1 SUN2 TANC1 TCTEX1D1 TRAIP ZBTB38 ZDHHC5
Body fat percentage	1.76	26	15	33.3	0.59	6.9e-04	ABCB9 ARPC1A C6orf106 CNOT6L CTNNB1 DARS EML3 FKBP2 HCN4 HNRNPD MST1 NEGR1 NEO1 NFAT5 POC5 POM121C RBM6 RNF40 RP11-1006G14.4 RP11-95P2.1 RP3-511B24.6 TMEM161B-AS1 TRAIP U91328.19 ZBTB38 ZKSCAN5
Alcohol intake frequency.	1.76	7	3	6.7	0.50	2.1e-01	CBY1 FNDC4 MST1 NFAT5 RBM6 SUN2 ZDHHC5
Fasting Glucose	1.74	3	2	4.4	0.00	1.0e+00	FADS1 FNDC4 RP3-511B24.6
Arm fat percentage (left)	1.73	21	13	28.9	0.63	1.1e-03	ABCB9 ARPC1A BMP8A C6orf106 C6orf142 CNOT6L CTNNB1 DARS FKBP2 MST1 NEGR1 NEO1 NFAT5 POC5 POM121C RBM6 RNF40 RP11-1006G14.4 TMEM161B-AS1 ZDHHC5 ZKSCAN5
Bipolar Disorder (2011)	1.72	2	1	2.2	0.00	1.0e+00	NEK4 RP11-302B13.5
Chronotype (morning person)	1.72	8	4	8.9	0.74	1.5e-02	ALG10 ALG10B HNRNPD MYO9A NR2E3 REEP2 SYT10 ZDHHC5
Overall health rating	1.72	7	3	6.7	0.27	5.1e-01	C6orf106 C6orf142 FNIP2 MST1 RBL2 RBM6 ZDHHC5
Type 2 Diabetes (T2D) (2018)	1.70	7	6	13.3	0.08	8.7e-01	BMP8A FNDC4 LOC100133893 NFAT5 RBL2 RBM6 WFS1
Trunk fat percentage	1.69	24	17	37.8	0.56	2.8e-03	ABCB9 C6orf106 C6orf142 CNOT6L CTNNB1 DARS EML3 FKBP2 HNRNPD MST1 NEGR1 NEO1 NFAT5 POC5 POM121C RBM6 RNF40 RP11-1006G14.4 RP11-95P2.1 RP3-511B24.6 TMEM161B-AS1 TRAIP ZBTB38 ZKSCAN5
Diabetes (self-reported)	1.69	6	3	6.7	0.08	8.8e-01	FNDC4 LOC100133893 NFAT5 RBL2 RBM6 WFS1
Age when periods started (menarche)	1.68	14	8	17.8	-0.52	3.1e-02	AMT GAB2 GATS GLT8D1 GNL3 MED20 MSH6 NEGR1 NEK4 NFAT5 POM121C RFT1 RNASEH2C TMEM110
Arm fat percentage (right)	1.68	21	12	26.7	0.63	1.1e-03	ABCB9 ARPC1A BMP8A C6orf106 C6orf142 CNOT6L CTNNB1 DARS FKBP2 MST1 NEGR1 NEO1 NFAT5 POC5 POM121C RBM6 RNF40 RP11-1006G14.4 TMEM161B-AS1 ZDHHC5 ZKSCAN5
Comparative height size at age 10	1.68	25	19	42.2	-0.39	4.2e-02	ARHGEF40 B3GNT7 C6orf106 CEP120 CTNNB1 DNAJC18 EFHD1 FNDC3B FNDC4 GPBP1L1 HNRNPD HSD17B3 LA16c-OS12.2 MYO9A NR2E3 NUDT16L1 PRPF6 PSMD2 RBL2 RFT1 RP11-171I2.5 RP11-27I1.4 SLC13A4 SLC30A2 ZBTB38
Impedance of arm (left)	1.66	24	15	33.3	0.51	9.0e-03	ADM AMT C2orf47 CEP120 DES DNAJC18 DPY19L2P1 EML3 FNDC4 FNIP2 GAB2 GLT8D1 GOSR2 HNRNPD NEGR1 NEK4 POC5 POM121C PSMD2 RBM6 REEP2 RP11-316O14.1 U91328.19 ZNF839
Heel bone mineral density (BMD) T-score, automated (right)	1.65	11	4	8.9	0.33	3.2e-01	ALG10 AMT ANKRD45 CBY1 LEKR1 RBM6 RNASEH2C SERTAD2 SUN2 TRAIP ZBTB38
Alcohol intake versus 10 years previously	1.65	5	2	4.4	0.98	4.4e-03	BMP8A FNDC4 MST1 NEGR1 RBM6
Lung FEV1/FVC ratio	1.64	35	18	40.0	-0.37	2.5e-02	ADM AP4M1 ATP6V0D1 BMP8A BTBD1 C6orf106 CALCRL CEP120 DCP1A DES EML3 GAB2 GJA1 GPBP1L1 HNRNPD KIAA0040 LOC100133893 MEF2D MET MFF NEGR1 NEK4 PCGF2 RAD51AP2 RFT1 RNF40 RP11-351A11.1 RP11-53O19.3 RP11-95P2.1 SERTAD2 SREBF1 TCF21 ZBTB38 ZDHHC5 ZSWIM5
Impedance of arm (right)	1.61	26	15	33.3	0.58	2.1e-03	ADM AMT C2orf47 CEP120 DES DPY19L2P1 EML3 FNDC4 FNIP2 GAB2 GLT8D1 GPN3 HNRNPD NEGR1 NEK4 POC5 POM121C PSMD2 RBM6 REEP2 RP11-302B13.5 RP11-316O14.1 RP11-864G5.3 U91328.19 ZDHHC5 ZNF839
Mineral and other dietary supplements	1.60	2	0	0.0	0.00	1.0e+00	ARPC1A CYP3A5
Impedance of whole body	1.60	24	18	40.0	0.36	7.1e-02	ADM AMT BMP8A C14orf159 C2orf47 C6orf106 CBX6 CEP120 DNAJC18 EML3 FNDC4 GAB2 GLT8D1 HNRNPD NEGR1 NEK4 POC5 POM121C PSMD2 RBM6 RFT1 RP11-316O14.1 TMEM110 ZNF839
Medication: Metformin	1.59	3	2	4.4	0.00	1.0e+00	FNDC4 RBL2 WFS1
Major Depression (MDD)	1.58	2	1	2.2	0.00	1.0e+00	NEGR1 ZDHHC5
Qualifications: College or University degree	1.57	11	4	8.9	-0.31	3.3e-01	AMT CSPG5 DCP1A FNIP2 MST1 NEGR1 POM121C RBL2 RBM6 RP11-864G5.3 ZDHHC5
Schizophrenia (2014)	1.56	8	3	6.7	0.75	1.9e-02	EFHD1 GIGYF1 GLT8D1 NEK4 REEP2 RP11-53O19.3 SREBF1 ZDHHC5
Forced expiratory volume in 1-second (FEV1), predicted	1.56	4	2	4.4	-0.23	7.7e-01	C6orf106 MYO9A NUDT16L1 ZBTB38
Systolic Blood Pressure	1.55	33	19	42.2	-0.14	4.3e-01	C2orf47 C6orf142 CD34 CEP120 CSPG5 CSTA CTNNB1 DNAJC18 FNDC4 FUT11 GOSR2 HOMEZ MAPKAP1 MEF2D MKLN1-AS2 MST1 NAA16 NUDT16L1 POM121C PTPRJ RNASEH2C RP3-511B24.6 SEC31B SGIP1 SLC13A4 SLC22A17 SNHG12 SREBF1 TCF21 TMEM161B-AS1 TMEM194B WASL ZDHHC5
Blood Platelet Count	1.54	48	36	80.0	0.39	6.1e-03	ACTN4 AL021707.1 AP4M1 ARPC1A BNIP1 C10orf128 C6orf106 CBY1 CEP120 CYP3A5 DNAJC18 FADS1 FKBP2 FNDC4 GIGYF1 GPBP1L1 GTPBP1 HSD17B3 ICMT KIAA1755 LA16c-OS12.2 LACTB MEF2D MEPCE MET MRPL24 MST1 POC5 PPP1R35 RNASEH2C RNF40 RP11-27I1.4 RP11-864G5.3 RP11-95P2.1 RP3-508I15.9 RP3-511B24.6 SERTAD2 SUN2 SVIL TFR2 TGM2 TMEM216 VSTM2L WASL WT1 ZDHHC5 ZKSCAN5 ZNF839
Heel bone mineral density (BMD) T-score, automated (left)	1.54	9	4	8.9	0.61	8.1e-02	AMT CBY1 LEKR1 MST1 RBM6 RNASEH2C SERTAD2 SUN2 TRAIP
Intelligence (Savage-Jansen 2018)	1.50	11	6	13.3	-0.51	9.0e-02	AMT CTNNB1 HSD17B3 MST1 NEGR1 NEK4 RBL2 RBM6 RP11-302B13.5 SREBF1 ZDHHC5
Body Mass Index (BMI) (2010)	1.50	3	1	2.2	0.00	1.0e+00	NEGR1 POM121C PSMD2
Impedance of leg (left)	1.50	26	15	33.3	0.38	4.9e-02	AMT ARHGEF40 BMP8A C14orf159 C2orf47 C6orf106 CEP120 FNDC4 GLT8D1 GNL3 HNRNPD MED20 NEGR1 NEK4 NFAT5 POC5 POM121C PSMD2 RBL2 RBM6 RFT1 RP11-302B13.5 SREBF1 TMEM110 TMEM161B-AS1 VSTM2L
Bipolar Disorder or Schizophrenia	1.49	6	5	11.1	0.76	4.9e-02	EFHD1 GIGYF1 GLT8D1 NEK4 REEP2 RP11-53O19.3
Age at First Birth	1.49	3	1	2.2	0.00	1.0e+00	MST1 RBM6 TMEM110
Qualifications: A levels/AS levels or equivalent	1.49	4	3	6.7	-0.32	6.0e-01	MST1 NEGR1 POM121C RBM6
Mother's age at death	1.49	1	0	0.0	0.00	1.0e+00	MAPKAP1
Supplements: Fish oil (including cod liver oil)	1.49	2	0	0.0	0.00	1.0e+00	ARPC1A CYP3A5
Forced expiratory volume in 1-second (FEV1), Best measure	1.48	15	9	20.0	-0.69	2.9e-03	BTBD1 C6orf106 CEP120 CTNNB1 DARS EML3 FNDC3B HSD17B3 MYO9A NFAT5 NR2E3 PCGF2 RFT1 SLC30A2 ZBTB38
Crohns Disease (2017)	1.47	7	4	8.9	0.45	2.7e-01	FADS1 FNDC4 FUT11 MST1 RBM6 RFT1 ZBTB38
Average weekly spirits intake	1.47	1	0	0.0	0.00	1.0e+00	MST1
Forced expiratory volume in 1-second (FEV1)	1.47	18	11	24.4	-0.52	2.2e-02	AMT BTBD1 C6orf106 CEP120 CTNNB1 DARS EML3 FNDC3B HSD17B3 MYO9A NFAT5 NR2E3 PCGF2 RFT1 SLC30A2 U91328.19 ZBTB38 ZDHHC5
Smoking status: Previous	1.47	1	0	0.0	0.00	1.0e+00	MSH6
Verbal and Numeric Reasoning (VNR)	1.46	7	5	11.1	-0.52	1.9e-01	MST1 NEGR1 NEK4 RAD51AP2 RBL2 RBM6 SREBF1
Systolic blood pressure, automated reading	1.46	11	2	4.4	-0.22	5.2e-01	GOSR2 MAPKAP1 MKLN1-AS2 NFAT5 POM121C RBM23 SEC31B SGIP1 SLC22A17 TMEM194B ZDHHC5
Impedance of leg (right)	1.46	23	16	35.6	0.37	7.4e-02	ARHGEF40 BMP8A C14orf159 C2orf47 C6orf106 CEP120 FNDC4 GLT8D1 HNRNPD MED20 NEGR1 NEK4 POC5 POM121C PSMD2 RBL2 RBM6 RFT1 RP11-302B13.5 SREBF1 TMEM110 TMEM161B-AS1 VSTM2L
Ever smoked	1.46	4	2	4.4	-0.14	8.2e-01	ARPC1A CSPG5 MSH6 ZKSCAN5
Irritable Bowel Disease (IBD)	1.45	6	3	6.7	-0.10	8.1e-01	AMT FNDC4 GIGYF1 MST1 RBM6 TCTEX1D1
Forced vital capacity (FVC), Best measure	1.45	17	10	22.2	-0.65	3.7e-03	BTBD1 C6orf106 CEP120 CTNNB1 DARS EML3 FNDC3B HSD17B3 MYO9A NFAT5 NR2E3 NUDT16L1 RFT1 RNASEH2C SLC13A4 SLC30A2 ZBTB38
Relative age of first facial hair	1.44	6	3	6.7	-0.18	7.3e-01	C6orf106 FNDC4 MED20 MKLN1-AS2 RP11-381K20.5 ZBTB38
Forced vital capacity (FVC)	1.44	15	10	22.2	-0.60	1.4e-02	BTBD1 C6orf106 CEP120 CTNNB1 DARS EML3 FNDC3B HSD17B3 MYO9A NFAT5 NR2E3 NUDT16L1 RFT1 SLC30A2 ZBTB38
Frequency of unenthusiasm / disinterest in last 2 weeks	1.43	1	0	0.0	0.00	1.0e+00	ZDHHC5
Seen doctor (GP) for nerves, anxiety, tension or depression	1.43	2	2	4.4	0.00	1.0e+00	NEGR1 SGIP1
Gout (self-reported)	1.43	2	1	2.2	0.00	1.0e+00	FNDC4 NFAT5
Mean time to correctly identify matches	1.43	4	1	2.2	-0.03	9.7e-01	LA16c-OS12.2 MXRA7 RP11-302B13.5 SREBF1
Long-standing illness, disability or infirmity	1.43	3	0	0.0	0.00	1.0e+00	NEGR1 NFAT5 TMEM161B-AS1
Qualifications: nursing, teaching	1.43	3	1	2.2	0.00	1.0e+00	MST1 NEGR1 RBM6
Schizophrenia (2018)	1.42	7	1	2.2	0.89	7.1e-03	EFHD1 GIGYF1 GLT8D1 NEK4 REEP2 RP11-53O19.3 SREBF1
Smoking Status	1.42	7	4	8.9	-0.48	1.9e-01	AMT ARPC1A CSPG5 LA16c-OS12.2 MAPKAP1 MSH6 ZKSCAN5
Past tobacco smoking	1.42	5	0	0.0	0.33	5.9e-01	ARPC1A CSPG5 MSH6 TMEM161B-AS1 ZKSCAN5
Medication: Gliclazide	1.42	1	0	0.0	0.00	1.0e+00	WFS1
Medication: Atorvastatin	1.42	1	1	2.2	0.00	1.0e+00	FNDC4
Coronary Artery Disease (CAD)	1.41	2	0	0.0	0.00	1.0e+00	SREBF1 TCF21
Reaction Time	1.38	7	0	0.0	-0.36	4.3e-01	ALG10 C2orf47 FKBP2 LA16c-OS12.2 MXRA7 RP11-302B13.5 SREBF1
Crohns Disease (2012)	1.38	3	2	4.4	0.96	4.0e-02	FADS1 MST1 RBM6
Fed-up feelings	1.38	4	1	2.2	1.00	1.7e-04	MST1 RBM6 TMEM216 ZDHHC5
Fluid intelligence score	1.38	5	2	4.4	-0.67	2.2e-01	MST1 NEGR1 RBL2 RBM6 SREBF1
Headache pain in last month	1.38	1	1	2.2	0.00	1.0e+00	MEF2D
Comparative body size at age 10	1.38	6	5	11.1	-0.30	5.7e-01	ATP6V0D1 CSPG5 HNRNPD NEGR1 RNF40 RP11-302B13.5
Cholesterol lowering medication	1.38	2	1	2.2	0.00	1.0e+00	CALCRL FNDC4
Age at first live birth	1.37	1	1	2.2	0.00	1.0e+00	RBM6
Qualifications: None of the above	1.36	5	2	4.4	0.33	5.8e-01	AMT MST1 NEGR1 RBM6 ZDHHC5
Pack years adult smoking proportion	1.35	1	0	0.0	0.00	1.0e+00	AMT
Hand grip strength (right)	1.35	9	3	6.7	-0.40	2.8e-01	C6orf106 DARS GNL3 MEPCE NFAT5 PSMD2 RFT1 RP11-171I2.5 ZBTB38
Ever had prostate specific antigen (PSA) test	1.35	1	0	0.0	0.00	1.0e+00	ZBTB38
Hand grip strength (left)	1.34	7	3	6.7	0.13	7.8e-01	C2orf47 DARS MEPCE NFAT5 NUDT16L1 RP11-171I2.5 ZBTB38
Medication: Paracetamol	1.34	1	0	0.0	0.00	1.0e+00	MEF2D
Lung FVC	1.33	24	16	35.6	-0.17	4.1e-01	ATP6V0D1 B3GNT7 BTBD1 C6orf106 C6orf204 CD55 CEP120 DARS EFHD1 EML3 GATS LA16c-OS12.2 MEF2D MSH6 NFAT5 RNASEH2C RP11-171I2.5 RP11-316O14.1 SLC30A2 SREBF1 TCF21 TMEM194B WDR5B ZBTB38
Birth weight of first child	1.33	5	2	4.4	0.65	2.3e-01	POM121C RP11-864G5.3 SVIL WT1 ZBTB38
Medication for cholesterol, blood pressure or diabetes	1.33	2	0	0.0	0.00	1.0e+00	GATS TCF21
LDL Cholesterol	1.32	5	2	4.4	0.08	9.0e-01	C6orf106 DARS FADS1 POC5 TMEM216
Alcohol usually taken with meals	1.31	3	1	2.2	0.00	1.0e+00	ANKRD45 NEGR1 ZDHHC5
Heart attack	1.31	1	0	0.0	0.00	1.0e+00	TCF21
Leg pain on walking	1.31	1	1	2.2	0.00	1.0e+00	RBM6
Number of treatments/medications taken	1.30	1	1	2.2	0.00	1.0e+00	RBM6
High cholesterol (Self-reported)	1.30	2	1	2.2	0.00	1.0e+00	FNDC4 POC5
Medication: Paracetamol	1.30	1	0	0.0	0.00	1.0e+00	AMT
Heart attack/myocardial infarction (self-reported)	1.30	1	0	0.0	0.00	1.0e+00	TCF21
Cardiovascular Disease	1.29	11	5	11.1	0.42	2.0e-01	CSPG5 FNDC4 GOSR2 MAPKAP1 NEGR1 NFAT5 POM121C RNASEH2C RNF40 TCF21 TMEM161B-AS1
Taking other prescription medications	1.29	1	1	2.2	0.00	1.0e+00	RBM6
Medication: Blood pressure	1.29	1	0	0.0	0.00	1.0e+00	TCF21
Medication for cholesterol	1.29	1	1	2.2	0.00	1.0e+00	FNDC4
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.29	7	3	6.7	-0.44	3.3e-01	BTBD1 CEP120 EML3 GJA1 NFAT5 PCGF2 SLC30A2
Illness, injury, bereavement, stress in last 2 years	1.28	1	0	0.0	0.00	1.0e+00	BMP8A
Depressed Affect (Nagel 2018)	1.27	6	0	0.0	-0.49	3.2e-01	AL021707.1 CBY1 MST1 RBM6 RP3-508I15.9 SUN2
Medication: Cholesterol lowering	1.27	1	1	2.2	0.00	1.0e+00	FNDC4
Qualifications: NVQ or HND or HNC or equivalent	1.27	1	0	0.0	0.00	1.0e+00	RBM6
Average weekly red wine intake	1.27	2	1	2.2	0.00	1.0e+00	NEO1 ZDHHC5
Ulcerative Colitis (UC)	1.26	4	3	6.7	-0.73	1.6e-01	AMT MST1 RBM6 TCTEX1D1
Ulcerative Colitis	1.26	2	2	4.4	0.00	1.0e+00	MST1 RBM6
Birth weight	1.26	5	2	4.4	-0.63	2.6e-01	ARHGEF40 CEP120 PSMD2 RFT1 RP11-864G5.3
Medication: Allopurinol	1.26	1	1	2.2	0.00	1.0e+00	FNDC4
Mouth/teeth dental problems: Dentures	1.25	1	0	0.0	0.00	1.0e+00	RBM6
Smoking status: Current	1.25	2	1	2.2	0.00	1.0e+00	FNIP2 MAPKAP1
Miserableness	1.25	2	1	2.2	0.00	1.0e+00	AMT RBM6
Bipolar Disorder (2018)	1.24	1	0	0.0	0.00	1.0e+00	NEK4
Depression (Nagel 2018)	1.24	1	1	2.2	0.00	1.0e+00	ZDHHC5
Current tobacco smoking	1.24	1	1	2.2	0.00	1.0e+00	MAPKAP1
Frequency of tiredness / lethargy in last 2 weeks	1.24	3	2	4.4	-0.74	2.6e-01	AMT TRAIP ZDHHC5
Migraine (self-reported)	1.24	3	0	0.0	0.00	1.0e+00	MEF2D POC5 SVIL
Vascular/heart problems diagnosed by doctor	1.24	4	1	2.2	0.44	5.6e-01	NEGR1 PTPRJ TCF21 TMEM161B-AS1
Medication for pain relief, constipation, heartburn	1.23	1	1	2.2	0.00	1.0e+00	MEF2D
Irritability	1.23	1	0	0.0	0.00	1.0e+00	TMEM216
Worrier / anxious feelings	1.22	2	2	4.4	0.00	1.0e+00	NEK4 ZDHHC5
Peak expiratory flow (PEF)	1.22	4	2	4.4	0.38	6.2e-01	PCGF2 SLC30A2 TCF21 TMEM194B
Medication: Omeprazole	1.22	1	0	0.0	0.00	1.0e+00	C6orf106
Average weekly champagne plus white wine intake	1.22	1	0	0.0	0.00	1.0e+00	FADS1
Breast Cancer	1.21	3	2	4.4	0.00	1.0e+00	ADM RP11-53O19.3 ZBTB38
High blood pressure	1.21	7	1	2.2	0.50	2.5e-01	MAPKAP1 NEGR1 POM121C PTPRJ RBL2 TCF21 TMEM161B-AS1
Hypertension (Self-reported)	1.21	8	1	2.2	0.55	1.6e-01	CSPG5 GATS MAPKAP1 NEGR1 POM121C PTPRJ TCF21 TMEM161B-AS1
Number of self-reported non-cancer illnesses	1.21	3	2	4.4	0.00	1.0e+00	FNDC4 NEGR1 NFAT5
Diabetes (father)	1.19	1	0	0.0	0.00	1.0e+00	FNDC4
Hayfever/allergic rhinitis (self-reported)	1.19	1	0	0.0	0.00	1.0e+00	CYP3A5
Worry (Nagel 2018)	1.18	2	1	2.2	0.00	1.0e+00	GLT8D1 NEK4
Medication: Simvastatin	1.18	1	1	2.2	0.00	1.0e+00	FNDC4
Worry too long after embarrassment	1.18	2	1	2.2	0.00	1.0e+00	TMEM161B-AS1 ZDHHC5
Wheeze or whistling in the chest in last year	1.18	2	1	2.2	0.00	1.0e+00	HSD17B3 RBM6
Angina (self-reported)	1.18	1	1	2.2	0.00	1.0e+00	TCF21
Neuroticism	1.17	4	1	2.2	-0.25	7.5e-01	GAB2 SLC22A17 TMEM161B-AS1 ZDHHC5
Angina	1.17	1	1	2.2	0.00	1.0e+00	TCF21
Hayfever, allergic rhinitis or eczema	1.17	5	1	2.2	0.74	1.5e-01	C6orf106 CDC25C SREBF1 U91328.19 ZBTB38
Chronic bronchitis/emphysema (mother)	1.17	1	0	0.0	0.00	1.0e+00	SLC30A2
Pain experienced in last month	1.17	2	1	2.2	0.00	1.0e+00	BMP8A RBM6
Blood White Count	1.16	28	21	46.7	0.05	7.7e-01	ACTN4 ARPC1A C10orf128 C19orf54 C6orf106 C6orf204 CALCRL CEP120 FADS1 FNDC3B FNDC4 GNL3 HSD17B3 INCA1 KIAA1755 MXRA7 PTPRJ RBM6 RFT1 RNF40 RP11-864G5.3 SREBF1 SVIL TCTEX1D1 TGM2 TMEM110 ZKSCAN5 ZSWIM5
Back pain experienced in last month	1.16	1	0	0.0	0.00	1.0e+00	C6orf106
Relative age voice broke	1.15	2	0	0.0	0.00	1.0e+00	NFAT5 RP11-95P2.1
Guilty feelings	1.15	1	0	0.0	0.00	1.0e+00	ZDHHC5
Medication: Co-codamol	1.14	1	0	0.0	0.00	1.0e+00	ABCB9
Hypothyroidism/myxoedema (self-reported)	1.14	3	1	2.2	-0.97	2.8e-02	FADS1 GIGYF1 TMEM194B
Hypothyroidism (self reported)	1.13	3	2	4.4	-0.98	2.3e-02	FADS1 GIGYF1 TMEM194B
Eye problems/disorders: Diabetes related eye disease	1.13	1	0	0.0	0.00	1.0e+00	WFS1
Number of incorrect matches in round	1.13	1	0	0.0	0.00	1.0e+00	IPO9
Financial difficulties in last 2 years	1.13	1	0	0.0	0.00	1.0e+00	BMP8A
Neck or shoulder pain in last month	1.13	1	0	0.0	0.00	1.0e+00	BMP8A
Allergy or Eczema	1.12	9	4	8.9	0.25	5.2e-01	ARPC1A C6orf106 CALCRL CDC25C CYP3A5 MYOT NEGR1 SREBF1 ZBTB38
Hearing difficulty/problems: Yes	1.12	2	0	0.0	0.00	1.0e+00	GPBP1L1 TTN-AS1
Nervous feelings	1.12	1	1	2.2	0.00	1.0e+00	NEK4
Eye problems/disorders: Glaucoma	1.12	1	0	0.0	0.00	1.0e+00	PTPRJ
Allergy	1.11	4	1	2.2	-0.71	2.9e-01	C6orf106 CDC25C U91328.19 ZBTB38
Ever highly irritable/argumentative for 2 days	1.11	1	0	0.0	0.00	1.0e+00	RBM6
Osteoporosis (self-reported)	1.11	1	0	0.0	0.00	1.0e+00	CTNNB1
Age at last live birth	1.09	1	1	2.2	0.00	1.0e+00	RBM6
Medication: Bendroflumethiazide	1.09	1	0	0.0	0.00	1.0e+00	TCF21
Neuroticism (Nagel 2018)	1.08	2	1	2.2	0.00	1.0e+00	TMEM161B-AS1 ZDHHC5
Medication: Aspirin	1.08	1	0	0.0	0.00	1.0e+00	MEF2D
Knee pain experienced in last month	1.08	1	0	0.0	0.00	1.0e+00	RBM6
Frequency of depressed mood in last 2 weeks	1.07	1	0	0.0	0.00	1.0e+00	ZDHHC5
Respiratory disease	1.06	1	1	2.2	0.00	1.0e+00	FADS1
Alzheimer’s Disease (including proxy)	1.05	2	0	0.0	0.00	1.0e+00	GATS RNF40
Medication: Aspirin	1.05	1	0	0.0	0.00	1.0e+00	MEF2D
Medication: Levothyroxine sodium	1.04	1	0	0.0	0.00	1.0e+00	FADS1
Mouth/teeth dental problems	1.04	1	0	0.0	0.00	1.0e+00	SLC13A4
Illnesses of father: Heart disease	1.04	1	0	0.0	0.00	1.0e+00	TCF21
Asthma (self-reported)	1.04	1	0	0.0	0.00	1.0e+00	FADS1
Mood swings	1.03	1	0	0.0	0.00	1.0e+00	RBM6
Neuroticism score	1.02	2	1	2.2	0.00	1.0e+00	SLC22A17 ZDHHC5
Asthma	1.02	1	0	0.0	0.00	1.0e+00	FADS1
Hair/balding pattern: Pattern 4	1.02	6	4	8.9	-0.19	7.2e-01	ATP6V0D1 CTNNB1 FADS1 MKLN1-AS2 RP3-511B24.6 ZBTB38
Average weekly beer plus cider intake	0.98	1	0	0.0	0.00	1.0e+00	RBM6
Lupus	0.87	1	0	0.0	0.00	1.0e+00	TMEM194B
Blood Eosinophil Count	0.81	18	9	20.0	-0.10	7.0e-01	ABCB9 AMT CDC25C CSTA DARS FADS1 GPN3 NEK4 NFAT5 PTPRJ RBM6 RNF40 SLC13A4 SLC30A2 SLC7A8 SREBF1 TRAIP ZDHHC5
Hair Pigment	0.32	16	8	17.8	-0.24	3.1e-01	ADM BMP8A BTBD1 EFHD1 FADS1 FNDC4 GAB2 GIGYF1 MEPCE MSH6 NEO1 REEP2 RNASEH2C RP11-302B13.5 TRIM56 ZBTB38
Tanning	0.23	5	4	8.9	-0.71	1.8e-01	FNDC4 GAB2 LEKR1 NEK4 TCTEX1D1

Associations by panel

study	tissue	# hits	% hits/tests	avg chisq
GTEx	Heart Atrial Appendage	32	2.03	4.6
GTEx	Ovary	19	2.09	4.3
GTEx	Heart Left Ventricle	33	2.16	4.1
GTEx	Brain Putamen basal ganglia	9	1.44	4.0
GTEx	Liver	8	1.12	3.7
GTEx	Nerve Tibial	76	1.76	3.7
GTEx	Skin Not Sun Exposed Suprapubic	44	1.79	3.7
GTEx	Artery Aorta	41	1.38	3.5
GTEx	Artery Coronary	19	1.61	3.5
GTEx	Esophagus Gastroesophageal Junction	26	1.80	3.5
GTEx	Esophagus Mucosa	53	1.60	3.5
GTEx	Pancreas	30	1.84	3.5
GTEx	Prostate	12	1.44	3.5
GTEx	Skin Sun Exposed Lower leg	65	1.79	3.5
GTEx	Stomach	24	1.65	3.5
GTEx	Vagina	14	2.20	3.5
GTEx	Adipose Visceral Omentum	33	1.62	3.4
GTEx	Artery Tibial	55	1.46	3.4
GTEx	Colon Transverse	31	1.50	3.4
GTEx	Esophagus Muscularis	44	1.36	3.4
GTEx	Lung	38	1.32	3.4
GTEx	Muscle Skeletal	41	1.42	3.4
GTEx	Pituitary	14	1.26	3.4
GTEx	Thyroid	57	1.43	3.4
GTEx	Adipose Subcutaneous	47	1.35	3.3
GTEx	Brain Cerebellar Hemisphere	21	1.41	3.3
GTEx	Breast Mammary Tissue	31	1.57	3.3
GTEx	Breast Mammary Tissue (Female)	24	1.46	3.3
GTEx	Cells Transformed fibroblasts	63	1.50	3.3
GTEx	Spleen	20	1.42	3.3
GTEx	Testis	42	1.33	3.3
ROSMAP	Brain Pre-frontal Cortex	58	1.32	3.3
The Cancer Genome Atlas	Colon Adenocarcinoma	29	1.40	3.3
The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	14	1.27	3.3
The Cancer Genome Atlas	Testicular Germ Cell Tumors	15	1.17	3.3
GTEx	Adrenal Gland	21	1.44	3.2
GTEx	Brain Cerebellum	22	1.11	3.2
GTEx	Brain Nucleus accumbens basal ganglia	11	1.27	3.2
GTEx	Colon Sigmoid	15	1.03	3.2
GTEx	Uterus	9	1.59	3.2
GTEx	Whole Blood	28	1.40	3.2
NTR	Blood	33	1.37	3.2
The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	11	1.00	3.2
The Cancer Genome Atlas	Rectum Adenocarcinoma	7	1.01	3.2
The Cancer Genome Atlas	Soft Tissue Sarcoma	17	1.59	3.2
GTEx	Brain Hypothalamus	5	0.85	3.1
The Cancer Genome Atlas	Breast Invasive Carcinoma	60	1.36	3.1
The Cancer Genome Atlas	Glioblastoma Multiforme	10	0.98	3.1
The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	32	1.56	3.1
The Cancer Genome Atlas	Pancreatic Adenocarcinoma	25	1.51	3.1
The Cancer Genome Atlas	Thyroid Carcinoma	69	1.34	3.1
GTEx	Brain Caudate basal ganglia	10	1.09	3.0
GTEx	Brain Frontal Cortex BA9	10	1.08	3.0
GTEx	Breast Mammary Tissue (Male)	10	0.84	3.0
GTEx	Cells EBV-transformed lymphocytes	17	1.19	3.0
GTEx	Small Intestine Terminal Ileum	5	1.08	3.0
METSIM	Adipose	50	1.08	3.0
YFS	Blood	51	1.10	3.0
CommonMind	Brain Pre-frontal Cortex	62	1.15	3.0
The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	33	1.21	3.0
The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	57	1.39	3.0
The Cancer Genome Atlas	Lung Adenocarcinoma	42	1.43	3.0
The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	20	1.26	3.0
The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	11	0.83	3.0
The Cancer Genome Atlas	Prostate Adenocarcinoma	59	1.28	3.0
The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	4	0.79	3.0
GTEx	Brain Cortex	9	0.87	2.9
The Cancer Genome Atlas	Bladder Urothelial Carcinoma	22	1.33	2.9
The Cancer Genome Atlas	Esophageal Carcinoma	9	1.31	2.9
The Cancer Genome Atlas	Brain Lower Grade Glioma	57	1.32	2.9
The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	21	0.84	2.9
The Cancer Genome Atlas	Skin Cutaneous Melanoma	8	1.50	2.9
The Cancer Genome Atlas	Stomach Adenocarcinoma	25	1.48	2.9
GTEx	Brain Hippocampus	2	0.38	2.6