Best TWAS P=4.22e-10 · Best GWAS P=4.55e-12 conditioned to 0.00462
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | PPA2 | 0.08 | 0.03 | bslmm | 429 | 0.04 | 2.2e-05 | -4.7 | -5.7 | 1.1e-08 | 0.69 | 0.02 | 0.97 | FALSE |
| 2 | GTEx | Brain Cortex | PPA2 | 0.14 | 0.09 | lasso | 9 | 0.09 | 1.6e-03 | -5.8 | -5.9 | 2.7e-09 | 0.81 | 0.05 | 0.62 | FALSE |
| 3 | GTEx | Breast Mammary Tissue (Female) | PPA2 | 0.15 | 0.02 | lasso | 4 | 0.00 | 2.8e-01 | -6.5 | -5.7 | 9.1e-09 | 0.53 | 0.04 | 0.26 | TRUE |
| 4 | GTEx | Esophagus Gastroesophageal Junction | PPA2 | 0.29 | 0.15 | lasso | 5 | 0.14 | 8.8e-06 | -6.7 | -6.2 | 4.2e-10 | 0.88 | 0.01 | 0.98 | TRUE |
| 5 | The Cancer Genome Atlas | Thyroid Carcinoma | PPA2 | 0.04 | 0.02 | blup | 84 | 0.04 | 6.1e-05 | -5.0 | -5.3 | 1.2e-07 | 0.73 | 0.01 | 0.96 | FALSE |