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chr4:105,598,022-107,092,169
Best TWAS P=4.22e-10 · Best GWAS P=4.55e-12 conditioned to 0.00462
105.6M
105.8M
106M
106.2M
106.4M
106.6M
106.8M
107M
0
2
4
6
8
10
12
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
4
GTEx
Esophagus Gastroesophageal Junction
PPA2
0.29
0.15
lasso
5
0.14
8.8e-06
-6.7
-6.2
4.2e-10
0.88
0.01
0.98
TRUE
3
GTEx
Breast Mammary Tissue (Female)
PPA2
0.15
0.02
lasso
4
0.00
2.8e-01
-6.5
-5.7
9.1e-09
0.53
0.04
0.26
TRUE
2
GTEx
Brain Cortex
PPA2
0.14
0.09
lasso
9
0.09
1.6e-03
-5.8
-5.9
2.7e-09
0.81
0.05
0.62
FALSE
1
CommonMind
Brain Pre-frontal Cortex
PPA2
0.08
0.03
bslmm
429
0.04
2.2e-05
-4.7
-5.7
1.1e-08
0.69
0.02
0.97
FALSE
5
The Cancer Genome Atlas
Thyroid Carcinoma
PPA2
0.04
0.02
blup
84
0.04
6.1e-05
-5.0
-5.3
1.2e-07
0.73
0.01
0.96
FALSE