Hub : Genes

PPA2

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0820 0.0330 1.7e-04 0.029 0.037 0.030 0.037 0.032 1.7e-04 2.6e-05 1.1e-04 2.2e-05 7.6e-05
2 GTEx Adipose Subcutaneous 0.1470 0.0480 8.4e-05 0.020 NA 0.063 NA 0.016 8.5e-03 NA 7.0e-06 NA 1.8e-02
3 GTEx Adipose Visceral Omentum 0.1480 0.0530 9.5e-04 0.045 NA 0.029 NA 0.054 2.3e-03 NA 1.1e-02 NA 9.1e-04
4 GTEx Artery Aorta 0.1110 0.0480 2.1e-03 -0.005 NA 0.005 NA -0.003 9.9e-01 NA 1.6e-01 NA 5.1e-01
5 GTEx Artery Tibial 0.0764 0.0346 6.0e-03 0.024 NA 0.039 NA 0.036 5.4e-03 NA 5.0e-04 NA 7.8e-04
6 GTEx Brain Cerebellum 0.2190 0.0890 3.8e-03 0.006 NA 0.005 NA 0.033 2.0e-01 NA 2.3e-01 NA 3.7e-02
7 GTEx Brain Cortex 0.1450 0.0600 7.5e-03 0.089 NA 0.040 NA 0.093 2.0e-03 NA 2.9e-02 NA 1.6e-03
8 GTEx Breast Mammary Tissue 0.2580 0.0780 3.4e-04 0.060 NA 0.020 NA 0.044 5.2e-04 NA 3.1e-02 NA 2.7e-03
9 GTEx Breast Mammary Tissue (Female) 0.1493 0.0838 4.7e-02 0.019 NA 0.001 NA 0.002 8.7e-02 NA 3.1e-01 NA 2.8e-01
10 GTEx Cells Transformed fibroblasts 0.1130 0.0600 3.9e-03 0.028 NA -0.001 NA 0.009 3.5e-03 NA 4.2e-01 NA 6.5e-02
11 GTEx Esophagus Gastroesophageal Junction 0.2890 0.0910 1.6e-04 0.148 NA 0.098 NA 0.141 5.1e-06 NA 2.1e-04 NA 8.8e-06
12 GTEx Esophagus Mucosa 0.1820 0.0580 5.0e-06 0.056 NA 0.119 NA 0.113 1.2e-04 NA 2.5e-08 NA 5.5e-08
13 GTEx Heart Atrial Appendage 0.1450 0.0600 1.3e-03 0.046 NA 0.049 NA 0.065 3.8e-03 NA 3.0e-03 NA 7.4e-04
14 GTEx Lung 0.0892 0.0372 2.0e-03 0.018 NA 0.033 NA 0.021 1.5e-02 NA 1.4e-03 NA 9.1e-03
15 GTEx Muscle Skeletal 0.1904 0.0479 7.4e-08 0.060 NA 0.109 NA 0.083 1.6e-06 NA 8.7e-11 NA 1.4e-08
16 GTEx Nerve Tibial 0.1289 0.0573 1.0e-03 0.072 NA 0.065 NA 0.059 8.3e-06 NA 2.1e-05 NA 5.3e-05
17 GTEx Ovary 0.1820 0.0780 9.4e-03 0.099 NA 0.113 NA 0.144 2.0e-03 NA 1.0e-03 NA 2.2e-04
18 GTEx Skin Sun Exposed Lower leg 0.0870 0.0340 1.1e-03 0.066 NA 0.012 NA 0.037 3.9e-06 NA 3.0e-02 NA 4.3e-04
19 GTEx Testis 0.3490 0.0820 2.9e-08 0.249 NA 0.204 NA 0.203 2.1e-11 NA 2.0e-09 NA 2.1e-09
20 GTEx Thyroid 0.2240 0.0650 1.1e-05 0.013 NA 0.117 NA 0.071 3.4e-02 NA 2.9e-09 NA 3.9e-06
21 METSIM Adipose 0.0821 0.0282 2.6e-05 0.050 0.027 0.040 0.026 0.043 4.6e-08 5.3e-05 9.7e-07 6.9e-05 3.7e-07
22 ROSMAP Brain Pre-frontal Cortex 0.3204 0.0439 0.0e+00 0.378 0.294 0.368 0.366 0.380 2.2e-51 3.7e-38 9.9e-50 2.1e-49 1.1e-51
23 YFS Blood 0.2155 0.0343 0.0e+00 0.053 0.118 0.119 0.114 0.122 6.5e-17 2.2e-36 1.1e-36 2.6e-35 9.7e-38
24 TCGA Breast Invasive Carcinoma 0.0257 0.0176 7.7e-03 0.008 0.007 0.003 NA 0.010 8.5e-03 9.7e-03 8.0e-02 NA 2.8e-03
25 TCGA Kidney Renal Clear Cell Carcinoma 0.1115 0.0580 1.6e-05 0.028 0.027 0.018 NA 0.016 3.7e-04 4.6e-04 3.6e-03 NA 5.4e-03
26 TCGA Kidney Renal Papillary Cell Carcinoma 0.2900 0.0990 3.7e-06 0.011 0.095 0.086 NA 0.049 7.3e-02 4.3e-06 1.3e-05 NA 9.0e-04
27 TCGA Brain Lower Grade Glioma 0.1106 0.0586 1.2e-03 0.019 0.022 0.018 NA 0.017 2.7e-03 1.5e-03 3.2e-03 NA 4.2e-03
28 TCGA Thyroid Carcinoma 0.0410 0.0210 6.4e-04 0.021 0.042 0.025 NA 0.030 3.7e-03 6.1e-05 1.6e-03 NA 6.5e-04

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28
Bipolar Disorder (2018) 1.7 2.6 8.3 -1.8 -1.6 -1.3 -2.4 -0.3 -1.3 -2.3 -0.9 -1.0 -1.6 -2.8 -2.9 -1.4 -1.6 -1.7 -2.9 -2.0 -1.3 0.5 -0.7 1.4 -1.4 1.2 -0.1 -0.9 -0.7 -1.2 -1.8
Bipolar Disorder or Schizophrenia 1.8 4.5 11.4 -2.4 -1.6 -1.3 -3.4 -0.4 -2.0 -3.2 -1.3 -2.1 -2.2 -3.1 -3.2 -2.3 -1.8 -2.2 -2.5 -2.8 -1.3 1.6 -1.3 1.1 -1.5 2.6 -1.0 -1.6 -1.1 -1.6 -2.6
Depressed Affect (Nagel 2018) 0.5 1.0 6.8 -0.1 -1.0 0.4 -0.7 -1.2 0.1 0.7 0.1 -1.8 -0.2 0.3 0.9 -0.8 0.3 -0.2 0.4 0.9 1.5 1.0 -0.1 -2.0 1.4 -0.8 -2.6 -0.2 -1.3 -0.7 -0.4
Depression (Nagel 2018) 2.6 3.9 10.0 -2.8 -2.0 -1.2 -1.5 -3.2 -2.2 -1.2 -2.1 -3.1 -1.7 -1.3 -1.0 -2.0 -1.5 -2.1 -2.0 -1.4 -0.5 1.1 -2.6 -0.3 -0.9 1.1 -2.9 -2.9 -2.3 -1.9 -2.5
Intelligence (Savage-Jansen 2018) 8.4 25.7 72.6 -7.9 -2.6 -3.1 -5.2 -4.0 -4.6 -8.5 -3.1 -3.7 -5.6 -8.2 -6.9 -6.8 -5.3 -5.3 -5.8 -6.1 -2.8 3.0 -3.9 1.7 -3.2 5.0 -2.5 -5.4 -2.2 -1.4 -7.2
Neuroticism (Nagel 2018) 1.6 3.9 13.2 -2.5 -1.3 0.3 -2.1 -2.3 -1.6 -1.8 -0.9 -3.6 -2.3 -2.0 -1.1 -2.7 -0.4 -1.8 -1.4 -0.9 1.3 2.3 -1.5 -2.0 0.8 0.4 -3.6 -1.7 -2.6 -1.8 -2.7
Schizophrenia (2018) 1.0 2.1 6.1 -1.6 -0.7 -0.6 -2.4 -0.2 -1.5 -2.3 -1.0 -1.8 -1.5 -1.7 -1.8 -1.8 -1.0 -1.5 -1.0 -1.9 -0.6 1.6 -1.0 0.3 -0.8 2.5 -1.2 -1.4 -0.9 -1.1 -1.9
Schizophrenia vs Biploar Disorder 0.2 0.3 1.5 0.5 0.6 0.5 1.2 0.4 0.5 1.0 -0.4 0.2 0.6 0.7 1.2 0.4 -0.1 0.3 0.1 0.4 0.1 0.2 0.4 -0.5 0.2 -0.1 -0.5 -0.7 0.4 0.7 0.5
Worry (Nagel 2018) 0.4 0.9 3.9 -1.4 0.6 1.0 -0.4 -0.3 -0.2 -0.4 -0.3 -1.8 -0.2 -0.2 0.3 -0.7 0.3 -0.3 -0.2 0.8 1.8 1.6 -0.2 -2.0 1.6 -0.2 -1.9 -0.2 -0.4 -0.9 -0.5
Alzheimer’s Disease (in mother) 0.6 0.7 3.5 -1.1 -0.0 0.6 -0.3 -0.3 -0.5 -0.9 -1.7 -1.2 0.1 -1.8 -0.4 -0.6 -0.3 -1.3 -0.6 -0.5 0.5 0.9 -0.4 -0.3 0.4 -0.3 -0.8 -1.0 -0.1 -1.9 -0.8
Alzheimer’s Disease (in father) 0.8 0.9 3.0 0.2 1.4 0.7 0.1 1.3 0.9 0.3 0.8 0.3 0.3 0.8 0.8 0.5 0.7 0.4 0.7 1.4 1.7 1.2 1.1 -1.2 1.6 -0.1 0.2 1.3 1.4 0.3 0.7
Alzheimer’s Disease (including proxy) 0.3 0.4 1.8 0.2 0.4 0.8 -0.4 0.8 0.4 -0.1 -0.5 0.0 0.7 -0.2 0.0 0.5 0.3 -0.0 0.4 0.7 1.3 0.4 0.8 -1.0 1.3 -0.3 0.2 0.6 1.1 -0.0 0.6
Crohns Disease (2017) 0.2 0.4 2.7 1.1 0.1 -0.4 0.3 -0.9 -0.4 0.7 0.1 -0.8 -0.6 0.5 1.4 -0.3 0.6 0.3 -0.7 0.1 0.2 0.7 -0.3 -0.7 -0.2 1.1 -1.6 -0.5 -0.5 0.1 -0.3
Irritable Bowel Disease (IBD) 0.8 1.9 7.6 2.7 2.1 0.2 1.9 0.3 0.1 2.7 0.9 0.1 0.3 2.6 2.7 1.8 2.3 1.6 0.4 1.1 0.4 0.0 0.6 -0.5 0.1 0.3 -0.4 1.0 0.2 0.7 1.4
Ulcerative Colitis (UC) 2.5 4.7 15.1 3.6 2.9 0.8 2.8 1.5 1.0 3.9 1.6 1.6 1.3 3.8 3.2 2.8 3.1 2.2 1.4 1.8 0.6 -1.0 1.5 -0.2 0.5 -1.2 1.2 2.5 0.8 1.0 2.8
Major Depression (MDD) 2.2 2.7 11.0 -2.6 -2.6 -2.0 -2.9 -1.6 -0.8 -1.4 -0.7 -0.3 -0.1 -1.5 -2.2 -1.9 -3.3 -1.6 -1.2 -1.4 -1.1 -0.3 -1.0 0.4 -1.2 0.4 -1.3 -2.5 -0.9 0.2 -1.6
Reaction Time 2.7 5.2 14.1 -3.8 -0.5 -1.5 -2.2 -1.5 -2.6 -3.2 -1.6 -3.2 -2.7 -3.4 -2.4 -2.6 -2.0 -1.8 -1.6 -2.9 -0.3 1.7 -2.0 0.4 -1.0 3.1 -1.6 -2.1 -2.4 -2.2 -3.0
Verbal and Numeric Reasoning (VNR) 5.8 14.0 45.0 -6.1 -1.6 -0.9 -3.4 -2.5 -2.7 -6.7 -1.3 -3.1 -4.4 -6.2 -4.6 -5.8 -3.0 -4.4 -4.1 -4.3 -1.3 2.6 -2.5 0.3 -1.5 3.1 -2.7 -4.0 -2.3 -2.1 -5.9
Breast Cancer 1.5 3.5 15.3 3.9 2.2 0.1 2.3 -0.3 0.1 2.6 0.5 0.9 0.9 3.0 2.8 1.4 1.7 3.2 1.8 2.0 -0.3 -2.3 0.6 -0.5 0.2 -0.8 0.6 2.9 -1.0 1.8 2.1
Ovarian Cancer 0.9 1.2 5.6 -1.1 -0.5 -0.6 -0.8 -0.2 -0.5 -1.4 -1.0 -1.0 -0.2 -1.4 -0.1 -2.3 -1.4 -1.4 -0.8 -0.4 0.3 1.4 0.4 -0.8 -0.2 0.6 -2.4 -2.0 -0.3 0.0 -1.7
Prostate Cancer 5.7 8.1 28.8 3.7 2.6 0.2 2.9 0.6 0.4 3.7 2.9 3.1 0.3 3.3 1.3 4.7 3.9 3.3 1.9 0.2 -1.7 -4.3 0.6 3.1 -1.2 -1.3 5.4 4.9 -0.2 1.0 3.4
Age at First Birth 2.0 2.9 7.6 -2.7 -0.6 -1.5 -1.0 -1.9 -2.4 -2.0 -1.1 -1.7 -2.4 -1.9 -2.3 -1.0 -1.5 -0.4 -1.6 -2.4 -2.0 0.3 -2.4 1.5 -1.8 2.7 -0.0 -1.1 -0.9 -0.6 -1.7
Bipolar Disorder (2011) 5.6 5.4 16.1 -2.5 -1.0 -3.1 -3.4 -1.1 -2.9 -3.4 -1.1 -1.1 -2.2 -2.9 -4.0 -1.3 -3.2 0.1 -2.4 -2.5 -3.2 -0.4 -1.7 2.6 -3.0 3.3 0.5 -1.5 -0.1 1.2 -1.6
Body Mass Index (BMI) (2010) 0.6 0.8 3.4 0.3 0.5 1.0 0.7 0.5 1.2 -0.3 0.7 0.6 0.7 0.1 0.7 -0.7 0.2 0.2 1.4 0.9 1.5 0.7 0.8 -1.8 1.8 -1.5 -0.5 0.9 0.0 -0.2 0.3
Coronary Artery Disease (CAD) 0.5 0.5 3.9 -0.3 -1.0 1.1 0.7 -0.9 0.5 -0.4 0.3 -0.4 -0.5 -0.2 0.3 -1.3 0.3 -0.8 1.1 -0.2 -0.1 -0.1 -0.7 -0.4 0.0 -0.1 -0.3 -0.4 -2.0 -1.2 -0.8
Crohns Disease (2012) 0.4 0.6 2.7 0.4 -0.9 -0.6 0.1 -0.1 -0.4 1.1 -1.1 -0.9 0.5 1.1 1.6 0.1 -0.2 1.1 -0.6 0.4 -0.2 0.9 0.1 -0.1 -0.7 1.2 -1.4 -0.6 0.3 0.5 0.2
Mean Putamen Volume 0.5 0.6 3.2 -0.6 -1.4 -0.4 -0.5 -0.1 -0.2 -0.8 -0.8 -0.3 -0.2 -1.5 -0.9 -0.1 -1.0 -0.0 -1.8 -0.6 -0.8 -0.6 -0.1 0.6 -0.7 0.1 -0.1 -0.9 0.9 0.4 -0.4
Fasting Glucose 0.2 0.3 0.9 -0.0 -0.1 0.4 -0.9 -0.0 -0.3 -0.1 -0.3 -0.4 0.6 -0.9 0.1 -0.3 -0.9 -0.5 0.2 0.4 0.6 0.1 0.3 -0.7 0.6 -0.5 -0.5 0.6 -0.0 -0.7 0.7
HbA1C 0.3 0.3 1.2 0.4 -0.8 -0.5 -0.7 0.1 0.0 -0.9 -0.2 1.0 0.3 -0.4 -0.7 -0.2 -0.5 -0.1 -0.2 -0.5 -0.6 -1.1 0.2 0.6 -0.7 0.0 0.6 -0.4 0.8 1.1 -0.1
HDL Cholesterol 0.8 1.4 5.8 2.4 0.2 0.9 1.6 0.2 0.4 2.0 0.5 0.0 0.1 1.9 1.8 1.4 2.0 1.4 0.3 1.3 1.0 -0.3 1.0 -1.0 1.1 -1.3 -0.2 1.1 0.4 0.5 1.2
LDL Cholesterol 0.9 1.4 6.9 -0.9 -2.6 -1.2 -2.0 -1.4 -0.6 -1.4 -0.4 -0.2 -0.5 -1.5 -1.8 -1.3 -1.4 -1.3 -0.3 -1.3 -1.1 0.2 -1.1 0.9 -1.2 0.3 -0.4 -0.8 -0.7 -0.4 -1.1
Lupus 0.9 1.3 3.7 1.6 0.6 0.4 0.9 1.6 1.4 1.2 1.8 1.2 1.4 1.0 0.9 0.7 0.4 1.1 1.0 1.5 1.0 -0.8 1.3 -0.8 1.1 -1.9 0.3 1.4 0.8 0.3 1.4
Neuroticism (2016) 3.8 5.5 18.1 -4.3 -2.5 -1.9 -3.0 -3.4 -2.7 -3.2 -1.5 -2.0 -2.2 -2.7 -2.5 -2.8 -3.0 -2.3 -2.0 -2.0 -0.6 0.8 -2.7 0.1 -1.0 0.9 -1.6 -2.6 -1.6 -0.1 -2.8
Primary Biliary Cirrhosis 1.0 1.4 6.7 1.0 0.9 -0.4 0.3 -0.2 0.0 1.0 1.7 1.5 -0.5 1.0 -0.0 1.5 1.3 0.6 0.6 -0.9 -1.7 -1.8 -0.1 1.8 -1.3 0.5 2.6 1.6 -1.4 -0.2 0.8
Rheumatoid Arthritis 0.4 0.6 2.2 1.0 0.6 -0.1 1.0 0.9 0.2 0.2 0.5 1.1 0.1 0.4 -0.3 0.3 -0.4 0.9 0.0 -0.1 -1.1 -1.1 0.8 0.9 -0.9 0.8 1.1 0.7 0.6 1.5 0.5
Schizophrenia (2014) 0.6 1.3 5.1 -1.3 0.5 0.2 -1.8 0.2 -0.8 -1.6 -0.6 -1.7 -1.4 -1.2 -1.2 -1.0 -0.0 -1.0 -0.5 -1.3 -0.1 1.9 -0.6 -0.3 0.0 2.3 -1.1 -0.9 -0.8 -1.2 -1.3
Triglycerides 1.1 1.8 4.4 1.2 2.0 1.1 1.4 1.8 2.1 0.7 1.8 1.3 1.2 1.3 1.4 0.5 1.6 0.5 1.9 1.5 1.4 0.5 1.3 -0.8 1.5 -0.5 0.9 1.9 1.5 -0.0 1.3
Type 2 Diabetes (T2D) (2012) 0.1 0.2 1.1 -0.2 -0.2 0.4 0.4 0.2 0.0 -0.2 0.1 0.5 -0.1 -0.2 0.5 -0.5 -0.3 0.2 0.2 -0.1 -0.1 0.0 0.8 0.3 -0.2 0.5 -0.2 -0.4 0.9 1.1 -0.1
Ulcerative Colitis 1.9 2.8 10.0 3.0 2.4 0.4 2.5 1.1 0.4 2.9 1.1 1.0 0.7 3.2 2.4 2.3 2.5 2.3 0.8 1.0 -0.1 -1.4 0.8 0.1 -0.1 -0.7 0.8 1.3 -0.2 1.2 1.9
Blood Eosinophil Count 0.3 2.2 8.3 -2.9 0.0 -1.1 -1.5 0.2 -1.1 -2.6 -0.8 -0.3 -1.6 -2.6 -2.5 -2.0 -0.8 -1.1 -0.1 -2.4 -1.3 1.4 -0.1 1.2 -1.0 2.5 1.1 0.8 0.0 -0.4 -1.4
Blood Platelet Count 0.3 3.3 26.6 -1.5 0.0 1.1 0.8 1.6 0.5 -1.5 0.0 0.1 0.1 -1.1 -1.0 -2.4 -1.0 -4.7 0.5 -1.8 -1.1 1.3 0.1 0.7 -0.3 -0.1 0.9 -0.0 -3.6 -5.2 -2.1
Blood Red Count 0.5 4.4 12.0 1.6 3.0 1.6 3.4 2.0 1.4 3.3 2.8 2.4 0.2 2.9 2.1 2.7 3.0 0.2 1.8 -0.0 -1.4 -0.9 1.4 1.4 -0.2 -0.5 3.5 2.8 -1.1 -1.5 1.7
Blood White Count 1.2 9.2 32.8 2.3 2.5 0.3 2.9 2.4 2.1 3.8 3.1 4.0 2.3 4.1 2.3 4.7 3.2 3.2 3.2 1.4 -2.4 -2.7 1.6 3.2 -1.2 0.5 5.7 4.9 1.3 1.5 4.0
Heel T-Score 0.7 5.3 17.8 -0.6 -1.1 1.7 0.5 3.8 3.5 -0.1 0.6 0.8 3.6 -0.4 1.3 -1.1 -1.8 -0.7 1.6 3.8 4.0 1.0 3.3 -3.2 3.2 -2.6 -2.3 -0.9 4.2 0.6 0.9
BMI 0.4 2.3 4.4 -0.6 -1.8 -1.7 -2.0 -2.1 -1.9 -1.7 -1.5 -1.8 -2.0 -2.0 -1.5 -1.7 -0.2 -1.5 -1.6 -2.0 -0.5 -0.2 -1.7 0.5 -1.0 1.2 -0.6 -0.7 -1.6 -1.2 -1.8
Height 5.4 103.8 289.0 -14.0 -8.0 -6.0 -11.1 -5.3 -10.0 -14.2 -5.5 -5.2 -11.4 -17.0 -17.0 -8.5 -8.4 -10.5 -12.3 -15.1 -9.7 1.2 -9.1 10.1 -10.5 8.8 2.1 -8.0 -6.0 -6.3 -12.2
Waist Hip Ratio (WHR) 0.4 1.8 8.7 0.3 -1.0 0.6 0.2 1.4 0.4 0.3 0.6 0.9 0.6 0.5 -2.9 2.3 -0.9 1.6 0.0 0.2 -2.3 -2.3 -0.4 2.2 -1.6 0.8 1.9 -0.2 1.5 0.9 1.1
Systolic Blood Pressure 0.4 2.1 11.1 0.6 0.6 -0.3 1.8 0.5 0.3 2.8 0.2 0.4 1.2 3.1 1.3 3.3 0.2 1.3 1.9 0.8 -1.4 -1.4 -0.2 1.5 -0.7 0.7 2.0 0.4 -0.7 -0.6 1.9
Smoking Status 1.5 3.5 16.6 -2.3 -2.0 -2.4 -3.5 -0.4 -1.5 -2.5 -0.8 -0.6 -1.3 -2.3 -4.1 -1.8 -2.9 -0.9 -1.7 -1.6 -1.6 0.5 -1.1 1.6 -2.0 2.3 -0.3 -1.3 0.5 0.8 -1.5
Allergy or Eczema 1.4 3.8 19.6 -0.3 -1.4 -1.4 -1.6 -2.5 -2.8 -0.8 -2.0 -2.3 -2.6 -1.2 -1.4 -0.7 0.5 -1.9 -1.6 -2.5 -0.7 -0.7 -3.8 0.7 -0.8 0.3 0.0 0.1 -4.4 -3.6 -1.6
Cardiovascular Disease 0.5 1.7 6.3 -1.4 -1.4 -2.0 -1.9 -0.8 -1.8 -1.2 -1.4 -0.9 -1.2 -1.5 -2.5 0.1 -1.5 -0.5 -0.7 -1.6 -1.2 -0.7 -1.4 1.6 -1.5 1.7 0.9 -1.0 -0.2 0.1 -0.8
Hypothyroidism (self reported) 0.6 1.4 5.0 -2.2 -0.4 -0.2 -1.5 -0.0 -0.9 -2.0 0.0 -1.3 -1.6 -1.9 -1.8 -1.8 -0.5 -0.6 -0.2 -1.7 -0.2 0.5 -0.1 0.0 -0.5 1.7 -0.6 -0.4 -1.4 -0.5 -1.6
Respiratory disease 0.6 1.3 4.3 -2.1 -1.0 -1.3 0.2 -1.9 -1.3 -0.8 0.1 -0.0 -1.6 -0.5 -0.5 -0.2 -0.8 -1.1 -1.3 -1.5 -1.4 0.2 -1.3 1.8 -1.8 1.5 0.9 -0.3 -0.9 -0.5 -0.9
Type 2 Diabetes (T2D) (2018) 0.3 0.6 3.0 1.2 -0.0 -0.3 0.0 1.4 0.8 -0.4 0.5 0.6 0.5 -0.9 0.5 -0.8 -0.3 -0.4 -0.4 0.3 0.8 0.9 1.7 -0.7 0.7 -1.4 -0.2 0.8 1.4 -0.2 0.1
Lung FEV1/FVC ratio 6.3 31.7 112.4 -3.8 -8.2 -4.2 -10.0 -1.7 -3.2 -8.5 -5.4 -3.1 -2.5 -10.6 -9.2 -8.2 -7.9 -5.7 -4.8 -5.1 -2.9 0.2 -2.0 1.7 -3.8 4.2 -3.4 -7.1 -0.5 0.2 -6.5
Lung FVC 1.2 6.3 28.3 1.1 -0.5 -3.2 -5.3 -0.7 -2.4 -3.2 -2.0 -2.1 -1.4 -4.4 -3.3 -3.0 -2.6 -1.5 -3.1 -2.6 -2.2 -1.2 -1.5 1.8 -2.8 2.1 -1.6 -3.2 -1.0 -0.7 -2.7
Neuroticism 1.4 3.4 10.2 -2.5 -2.0 -0.2 -2.3 -2.5 -1.7 -1.9 -0.9 -3.0 -2.0 -2.0 -1.5 -2.6 -1.2 -1.4 -1.4 -0.7 0.6 1.4 -1.6 -1.7 0.5 0.8 -3.2 -1.7 -2.3 -0.8 -2.4
Chronotype (morning person) 1.5 3.5 14.3 1.1 2.2 1.9 2.7 1.7 1.3 0.9 0.1 -1.5 0.7 1.9 3.0 0.0 2.3 0.3 1.4 2.1 3.8 2.4 1.4 -3.0 3.1 -1.3 -2.0 1.0 1.0 -1.4 0.5
Hair Pigment 0.2 4.8 16.1 -1.4 2.0 0.9 2.1 2.6 0.4 0.4 0.9 3.0 1.4 -0.9 -1.4 3.1 -0.7 3.3 0.1 -0.2 -3.4 -3.3 1.2 2.9 -1.6 0.9 4.0 1.3 3.0 3.5 2.3
Tanning 0.0 0.3 1.6 -0.4 -0.3 0.7 -0.6 -0.3 0.2 -0.9 0.1 -0.4 -0.3 -0.3 0.4 -0.9 -0.1 -0.6 -0.8 0.1 0.1 0.3 -0.0 -0.3 -0.0 0.6 -1.1 -1.2 -0.4 -0.2 -0.8
Hand grip strength (left) 0.3 0.8 5.0 -1.1 -0.6 -1.1 -1.4 0.6 1.0 0.0 2.2 1.6 -0.1 -0.6 -0.6 -0.3 -0.9 -0.4 -0.4 -0.4 -1.2 -0.0 0.5 1.1 -1.1 1.2 0.7 0.5 -0.4 0.5 0.0
Number of treatments/medications taken 1.6 2.8 7.4 -1.4 -0.1 -1.1 -1.4 -2.2 -2.7 -1.9 -0.7 -1.8 -2.7 -1.3 -2.3 -0.3 0.0 0.2 -1.9 -2.7 -2.0 -0.2 -2.2 1.8 -2.3 2.3 0.0 -1.0 -1.6 -0.7 -1.6
Average weekly spirits intake 1.6 1.9 6.9 -0.8 -1.3 -1.5 -2.6 -0.9 -1.8 -1.0 -1.0 -1.0 -1.6 -1.4 -2.6 -0.9 -0.2 -0.7 -1.5 -1.8 -1.6 -0.0 -1.6 1.7 -1.6 1.8 0.6 0.1 -1.3 -0.9 -1.2
Sensitivity / hurt feelings 3.2 5.5 13.9 -2.5 -0.6 -0.4 -2.3 -3.4 -3.0 -2.8 -1.7 -3.2 -3.7 -3.2 -1.6 -2.7 -0.2 -2.1 -2.5 -2.8 -0.2 1.2 -2.6 -0.4 -0.8 2.5 -2.4 -2.3 -3.1 -1.2 -3.4
Frequency of depressed mood in last 2 weeks 2.6 3.6 8.4 -2.7 -2.7 -1.4 -1.6 -2.9 -2.3 -1.6 -2.5 -2.8 -1.6 -1.5 -0.9 -2.0 -1.7 -2.0 -1.5 -1.5 -0.5 1.0 -2.4 0.1 -1.1 1.5 -2.2 -2.3 -1.9 -1.4 -2.3
Hearing difficulty/problems: Yes 0.4 0.6 3.5 -1.0 0.1 1.3 -0.0 0.1 0.7 -1.1 -0.0 -0.0 0.4 -1.1 -0.2 -1.1 -0.7 -0.8 -0.5 -0.0 0.5 0.7 0.3 -0.7 0.5 -0.3 -1.1 -1.9 0.3 0.1 -0.9
Relative age of first facial hair 0.3 0.7 4.9 -2.2 -1.0 0.6 -1.5 0.0 -0.2 -1.4 0.7 0.2 -0.3 -0.9 -1.8 -0.5 -0.9 -0.2 -0.4 -0.7 -0.7 -0.2 -0.5 0.6 -0.5 0.2 0.3 -0.6 -0.5 0.0 -0.8
Other serious medical condition/disability diagnosed by doctor 4.7 6.2 14.8 -3.9 -0.3 -2.4 -1.5 -1.4 -3.1 -3.8 -3.3 -2.4 -2.8 -3.7 -3.1 -2.0 -2.3 -2.0 -2.5 -3.3 -2.0 1.8 -2.1 1.9 -2.1 3.3 -0.1 -2.0 -0.6 -1.0 -3.0
Ever used hormone-replacement therapy (HRT) 1.1 1.4 5.1 0.7 0.5 0.7 0.6 1.9 1.3 0.9 0.1 0.4 1.8 1.0 1.0 -0.3 0.1 0.6 1.8 1.6 1.7 0.7 1.7 -1.9 1.8 -2.3 -1.1 0.2 0.9 0.2 0.9
Ever had hysterectomy (womb removed) 0.3 0.4 2.3 -0.1 1.2 -0.1 0.7 0.2 -1.5 -0.6 -1.3 -0.9 -0.7 -0.3 0.3 -0.4 -0.6 -0.3 -0.7 -0.2 0.4 1.1 -0.1 -0.0 0.1 0.4 -0.3 -0.1 0.5 -0.3 -0.3
Systolic blood pressure, automated reading 2.5 7.3 23.2 2.7 2.5 1.5 3.5 2.4 1.9 4.7 1.5 2.3 3.2 4.6 3.0 4.8 1.5 3.0 3.2 3.0 -0.1 -1.9 1.9 0.7 0.6 -1.6 2.7 2.3 1.5 0.7 4.1
Eye problems/disorders: Diabetes related eye disease 0.5 0.6 2.1 0.4 0.7 -0.6 -0.1 0.2 -1.2 -0.3 -0.5 -0.4 -1.0 -0.7 -1.2 -0.3 -0.2 -0.6 -0.9 -1.4 -0.8 0.2 -0.7 1.0 -1.0 -0.2 0.5 -0.1 -1.0 -1.4 -0.8
Angina 1.6 2.1 5.9 1.4 -0.2 0.5 0.9 2.2 1.6 2.0 -0.1 1.0 2.4 1.5 0.6 1.4 -0.3 1.2 2.1 2.4 1.2 -1.2 1.4 -0.8 1.5 -2.1 0.8 2.1 0.4 0.0 2.2
Medication for hormone replacement therapy 0.5 0.5 3.8 0.3 -0.9 0.0 -0.4 -0.0 -1.1 -0.2 -1.9 -0.5 -0.2 -0.2 -0.6 0.5 0.2 0.5 -0.8 -0.1 -0.9 0.1 -1.4 0.8 -0.9 0.8 0.2 -0.9 0.9 0.4 -0.0
Vitamin and mineral supplements 0.6 0.8 2.1 0.2 1.0 0.5 1.0 1.3 0.8 0.9 0.0 -0.2 0.9 1.2 1.5 0.4 0.9 0.5 1.0 1.3 1.4 0.5 0.8 -1.0 1.3 -0.5 -0.1 1.1 0.0 -0.6 0.7
Supplements: Zinc 4.9 5.4 13.2 -1.3 -2.5 -2.2 -2.4 -1.7 -2.8 -2.7 -1.9 -0.9 -2.4 -2.2 -3.5 -1.1 -1.8 -0.9 -2.9 -3.3 -3.6 -0.9 -2.7 3.3 -3.6 2.6 1.0 -2.0 -1.2 0.2 -2.1
Medication: Co-codamol 0.4 0.5 4.3 0.6 0.9 0.2 -0.5 -0.1 -0.4 -0.0 0.1 -0.0 -0.1 0.6 -0.0 0.6 0.4 1.6 0.4 -0.2 -0.9 0.4 -0.5 0.7 -0.8 2.1 0.2 0.6 0.0 0.4 0.6
Medication: Metformin 0.6 0.8 4.5 0.7 0.1 -0.4 0.3 1.8 1.0 0.1 0.7 1.4 1.2 -0.3 0.3 0.2 -0.6 0.5 -0.2 0.8 0.5 0.4 1.9 -0.2 0.4 -1.3 0.4 0.5 2.1 1.0 0.8
Diabetes (father) 0.7 0.9 3.3 -0.0 -0.2 -0.3 -0.3 -1.8 -1.5 -0.5 -1.6 -0.6 -1.1 -0.6 -0.0 -1.0 -0.4 -1.1 -0.6 -1.5 -1.2 -0.5 -1.0 0.8 -1.3 0.7 -0.1 -1.0 -1.4 -0.2 -1.1
Diabetes (mother) 0.2 0.3 1.6 -0.0 1.3 -0.2 -0.9 -0.0 0.4 -0.2 1.2 -0.1 -0.6 -0.4 -0.2 -0.1 0.4 0.0 -0.4 -0.5 0.3 0.4 0.1 -0.7 0.5 0.3 -0.4 0.2 -0.4 -0.5 -0.3
Severe depression (siblings) 2.6 2.9 8.4 -0.8 -0.0 -0.5 -0.9 -1.8 -1.7 -2.3 -2.4 -2.0 -1.5 -1.5 -1.1 -2.3 -0.6 -2.9 -1.6 -1.8 -0.4 0.7 -2.6 0.5 -1.0 1.4 -1.1 -2.1 -2.5 -2.2 -2.4
Pack years adult smoking proportion 0.8 1.2 3.7 -1.9 -0.8 0.2 -0.7 -0.2 -0.2 -1.8 -0.3 -1.0 -0.8 -1.6 -1.9 -1.1 -0.6 -1.0 -1.2 -1.3 -0.5 1.6 -1.2 0.7 -0.7 1.1 -0.3 -0.1 -0.6 -1.8 -1.2
Impedance of leg (right) 1.3 6.2 19.4 2.7 1.1 1.5 3.7 1.7 1.4 3.6 1.9 3.2 2.3 4.2 1.3 4.4 1.5 2.9 2.0 1.9 -1.5 -2.5 0.9 1.8 -0.4 -2.0 3.8 2.7 1.8 1.4 3.7
Leg fat-free mass (left) 5.5 29.4 81.9 -6.5 -4.1 -3.8 -6.6 -4.2 -5.5 -8.1 -3.3 -4.6 -7.0 -9.1 -7.9 -6.2 -3.3 -5.2 -6.3 -7.8 -3.3 1.7 -5.1 2.9 -4.1 5.3 -1.2 -3.7 -4.4 -3.4 -7.1
Trunk fat percentage 0.3 1.3 6.8 0.5 0.8 -0.6 1.4 0.2 -0.9 0.6 -0.0 0.3 -0.6 0.6 -0.5 2.2 1.1 1.1 -0.2 -0.9 -1.7 -1.4 -0.8 2.3 -1.3 0.9 2.6 1.5 0.2 -0.7 1.0
Hand grip strength (right) 0.2 0.6 3.2 -0.1 -1.4 -1.0 -1.1 -0.3 0.8 0.0 1.8 1.8 -0.0 -0.2 -0.6 -0.3 -0.4 -0.3 -0.4 -0.7 -1.1 -0.8 -0.1 1.0 -1.0 -0.0 1.0 0.3 -0.8 -0.0 -0.1
Townsend deprivation index at recruitment 1.1 1.5 7.9 -1.6 0.4 -1.0 0.0 -0.1 -1.1 -0.8 0.3 0.5 -0.8 -0.2 -1.8 1.0 -1.1 0.6 -0.7 -1.1 -2.4 -0.0 -0.9 2.3 -2.1 2.8 1.5 -0.6 1.0 0.7 -0.0
Current tobacco smoking 1.6 2.6 9.1 -2.7 -2.1 -2.5 -2.9 -0.7 -1.3 -1.7 -1.5 -0.8 -0.4 -1.4 -3.0 -1.5 -3.0 -0.3 -0.8 -0.9 -1.3 0.2 -1.1 1.3 -1.6 2.3 -0.3 -0.6 0.1 1.0 -0.8
Average weekly fortified wine intake 0.4 0.4 2.0 0.5 0.7 1.2 1.1 0.7 -0.1 -1.1 0.6 0.4 -0.5 -1.0 -0.4 0.4 0.8 0.2 -0.9 -0.4 0.0 -0.0 0.3 0.4 0.0 0.1 0.9 0.4 1.4 0.0 0.0
Maternal smoking around birth 0.7 0.9 4.5 -1.5 -0.0 0.5 -0.6 0.6 0.1 -1.8 -0.1 -0.5 -0.6 -2.1 -1.0 -1.1 -0.2 -1.4 -0.9 -0.4 1.2 1.8 0.1 -0.5 0.7 -0.1 -0.2 -0.5 1.4 -0.9 -1.0
Fed-up feelings 0.3 0.6 4.4 -0.5 -2.1 0.5 -0.5 -0.9 0.3 0.3 0.3 -0.6 0.2 0.6 0.2 0.0 0.1 0.8 1.2 1.2 1.1 -0.5 -0.1 -1.3 1.1 -0.5 -1.0 0.3 -0.2 0.8 0.4
Frequency of unenthusiasm / disinterest in last 2 weeks 2.3 3.0 9.1 -2.8 -2.4 0.0 -0.6 -2.6 -1.9 -1.4 -2.8 -3.0 -1.2 -1.1 -0.4 -1.9 -0.7 -1.7 -1.3 -0.7 0.3 0.8 -2.1 -0.9 -0.0 0.2 -2.7 -2.5 -1.8 -1.6 -2.1
Relative age voice broke 0.7 1.0 2.9 -1.0 -0.6 -0.1 -1.5 -0.8 -1.1 -1.2 -0.3 -0.2 -1.0 -1.1 -1.7 -0.2 -0.3 0.2 -1.3 -1.1 -1.5 -0.2 -1.4 1.5 -1.6 1.7 0.7 -0.6 0.1 0.2 -0.8
Taking other prescription medications 1.1 1.7 6.4 -2.5 0.2 -0.4 -1.4 -1.5 -1.7 -1.8 -0.3 -1.9 -2.4 -1.1 -1.8 0.0 0.3 0.4 -1.2 -1.7 -0.2 1.5 -1.2 0.2 -0.3 2.3 -0.2 -0.2 -0.9 -0.6 -1.2
Age when periods started (menarche) 1.4 3.4 12.2 2.4 0.9 -0.8 1.1 1.7 0.6 1.9 1.3 2.3 1.2 2.7 -0.1 3.3 1.7 2.8 1.6 0.9 -1.3 -2.1 0.5 2.1 -0.8 -0.6 3.5 2.2 1.8 1.9 2.3
Bilateral oophorectomy (both ovaries removed) 0.9 1.0 5.2 2.3 1.4 0.1 1.0 1.0 0.6 0.6 0.4 0.2 0.5 1.7 0.6 0.1 0.4 1.6 1.6 1.4 0.9 -0.1 0.7 -1.0 1.2 -0.5 -0.2 0.9 0.6 1.0 1.0
Heel bone mineral density (BMD) T-score, automated (left) 1.3 3.0 8.5 1.0 -0.2 0.8 1.8 2.2 2.8 1.4 0.8 1.7 2.9 1.2 2.3 0.2 -0.2 0.1 1.5 2.7 2.2 0.2 2.7 -1.8 2.0 -2.4 -0.6 0.0 2.7 0.9 1.4
Tinnitus: Yes, but not now, but have in the past 0.2 0.2 2.0 0.6 1.4 -0.2 0.1 0.8 0.2 -0.2 0.5 -0.2 -0.4 0.1 -0.4 0.0 0.5 0.8 -0.3 -0.1 -0.0 0.4 0.6 -0.0 -0.0 -0.2 -0.3 -0.7 0.7 0.6 -0.2
Qualifications: CSEs or equivalent 0.7 0.9 3.7 0.6 1.5 0.6 1.7 -0.6 0.1 1.0 0.6 0.8 0.1 1.9 1.4 1.2 1.2 0.3 1.1 -0.0 -0.3 -1.1 -0.8 0.8 -0.3 0.1 1.4 0.5 -1.0 -0.3 0.8
Serious illness, injury or assault to yourself 3.3 4.0 8.8 -2.8 -2.5 -2.6 -2.5 -2.1 -2.0 -2.0 -1.2 -1.3 -1.9 -2.1 -3.0 -1.0 -1.9 -1.1 -2.5 -2.6 -1.9 -0.8 -2.2 2.2 -2.3 1.4 0.2 -1.7 -1.7 -0.8 -1.9
High blood pressure 0.2 0.5 1.7 -0.3 -1.0 -0.8 -1.1 -0.6 -0.9 0.4 -1.1 -0.7 -0.2 0.0 -1.3 0.7 -0.6 -0.4 -0.0 -0.4 -0.4 -0.7 -1.0 0.5 -0.5 0.4 0.2 -0.9 -0.8 -0.9 -0.2
Hayfever, allergic rhinitis or eczema 1.8 4.0 21.6 -0.5 -3.0 -1.0 -1.9 -2.7 -2.3 -1.0 -2.1 -2.2 -2.2 -1.8 -1.4 -1.5 0.4 -2.4 -1.8 -2.3 -0.2 -0.9 -3.4 -0.1 -0.3 -0.4 -0.7 -0.4 -4.7 -3.1 -2.0
Multivitamins +/- minerals 0.4 0.5 2.3 0.3 -1.2 -0.9 -1.5 -0.8 -0.3 -0.3 0.3 0.6 -0.3 -0.7 -1.5 0.0 -0.6 0.0 -0.2 -0.8 -1.3 -0.5 -0.5 0.8 -1.2 0.5 0.3 -0.4 -0.1 0.7 -0.1
Stomach or abdominal pain in last month 5.8 7.2 20.2 -3.0 -1.4 -0.8 -2.8 -4.5 -2.9 -3.4 -2.8 -3.2 -3.3 -3.7 -1.6 -3.5 -1.1 -3.2 -2.8 -2.7 0.5 1.7 -2.9 -1.2 -0.1 0.2 -3.0 -3.4 -2.7 -1.4 -4.0
Supplements: Glucosamine 0.5 0.6 3.0 0.4 0.3 -0.6 0.6 0.1 -1.1 -0.9 -0.8 0.2 -0.7 -0.6 0.1 -1.0 -0.2 -0.6 -1.7 -0.7 -0.8 0.0 0.3 0.6 -1.2 -0.3 -0.5 -1.7 0.9 0.9 -1.0
Diverticular disease/diverticulitis (self-reported) 0.3 0.3 2.4 -0.4 -0.3 0.4 -0.0 -1.6 -0.8 0.2 -1.1 -0.4 -0.1 0.7 0.0 0.5 0.1 0.6 0.8 0.3 0.0 0.3 -0.8 -0.3 0.2 -0.1 -0.2 -0.6 0.1 0.6 -0.0
Medication: Atenolol 0.5 0.6 4.0 0.5 -0.2 0.7 0.2 -0.1 0.1 0.6 -0.1 0.2 0.4 0.7 0.2 1.4 1.1 0.5 0.3 0.1 -0.7 -2.0 -0.9 1.1 -0.3 -0.2 1.3 0.3 -1.1 -0.9 0.6
Medication: Levothyroxine sodium 0.2 0.4 1.8 -1.0 0.2 0.3 -0.8 0.3 -0.5 -1.1 -0.4 -0.4 -0.4 -1.3 -0.9 -0.9 -0.5 -0.0 -0.0 -1.0 -0.3 0.5 0.4 0.1 -0.3 1.2 -0.1 -0.1 -0.0 -0.1 -0.6
Sitting height 7.9 56.1 151.3 -9.5 -5.3 -4.7 -8.9 -5.0 -7.8 -10.9 -3.9 -4.8 -9.6 -12.3 -12.2 -6.8 -5.1 -6.5 -8.9 -11.1 -6.4 2.2 -7.5 6.5 -7.1 7.7 1.0 -4.6 -4.9 -4.0 -9.1
Chronic bronchitis/emphysema (father) 0.2 0.3 1.8 -1.4 0.1 0.5 0.2 0.1 -0.7 -0.1 -0.9 -0.8 -0.4 -0.3 0.3 1.0 -0.0 -0.2 -0.0 -0.1 0.2 0.7 -0.4 0.1 0.0 0.1 0.3 -1.1 0.3 -0.5 -0.1
High blood pressure (mother) 0.6 0.8 3.9 -0.4 -2.0 -0.6 -0.5 -0.3 0.3 -0.2 0.7 1.4 0.5 -1.4 -1.1 -0.1 -1.6 -0.0 -0.3 -0.6 -1.2 -1.6 0.3 1.1 -1.2 -0.1 0.7 -0.6 0.2 1.0 0.2
Body mass index (BMI) 0.1 0.2 1.1 0.2 -0.0 -1.1 -0.4 -0.6 -0.5 0.3 -0.4 -0.6 -0.5 -0.2 0.1 0.1 0.7 -0.2 -0.2 -0.5 -0.0 -0.4 -0.5 0.4 -0.3 0.6 0.3 0.7 -0.6 -0.8 0.1
Impedance of leg (left) 1.8 8.8 28.3 2.8 1.7 1.5 4.4 2.7 1.9 4.2 2.3 3.7 2.9 4.7 2.1 5.3 1.8 3.4 2.3 2.7 -1.2 -2.5 1.6 1.9 -0.1 -2.6 4.3 3.0 2.8 1.8 4.3
Leg predicted mass (left) 5.6 29.9 83.7 -6.6 -4.1 -3.7 -6.7 -4.3 -5.6 -8.2 -3.4 -4.8 -7.1 -9.2 -7.8 -6.3 -3.2 -5.3 -6.3 -7.8 -3.2 1.9 -5.2 2.8 -4.0 5.2 -1.4 -3.8 -4.4 -3.5 -7.2
Trunk fat mass 0.9 3.8 10.7 -1.7 -0.9 -1.9 -1.1 -1.0 -2.5 -1.9 -0.9 -0.8 -2.6 -2.4 -3.2 0.0 -0.4 -0.7 -2.3 -3.2 -2.8 -0.9 -2.3 3.3 -2.8 2.3 2.2 0.1 -1.0 -1.5 -1.3
Waist circumference 0.7 2.6 8.2 -1.0 -0.8 -1.3 -1.1 -1.1 -2.0 -1.5 -0.8 -1.2 -2.2 -1.9 -2.9 -0.1 -0.0 -0.6 -1.6 -2.5 -2.1 -0.8 -2.3 2.5 -2.1 1.8 1.3 -0.1 -1.1 -1.7 -1.1
Number of incorrect matches in round 2.7 4.4 14.7 3.0 2.4 0.2 1.5 1.2 0.4 3.1 0.6 2.1 1.7 3.0 2.4 3.1 0.9 3.8 2.1 1.5 -0.5 -1.1 1.6 0.5 -0.1 0.2 2.0 2.3 2.0 3.5 3.3
Past tobacco smoking 1.1 2.0 5.9 1.5 0.7 0.7 1.4 0.2 1.6 2.3 1.4 1.3 1.9 2.4 2.4 1.7 0.8 2.1 1.8 1.6 0.3 -0.9 1.1 -0.6 0.8 -1.1 0.4 1.0 0.4 1.0 1.8
Alcohol usually taken with meals 0.5 0.8 4.8 0.4 0.1 -0.9 -0.5 0.8 0.5 -1.6 0.5 0.5 0.3 -0.6 -0.6 -2.2 -1.8 -0.7 -0.2 -0.1 0.1 0.2 1.3 -0.2 -0.3 -0.1 -1.2 -1.4 0.7 0.8 -1.1
Nervous feelings 0.3 0.5 2.6 -0.0 1.5 0.4 0.2 0.5 -0.7 0.7 0.4 -0.3 -0.3 0.5 0.2 1.0 0.8 1.3 0.2 0.6 0.2 -0.6 0.6 -0.1 0.3 0.2 0.7 1.6 -0.3 0.9 0.7
Frequency of tenseness / restlessness in last 2 weeks 1.0 1.6 4.4 -1.8 -2.1 -0.8 -1.9 -2.0 -1.6 -1.2 -1.4 -1.6 -1.1 -0.4 -0.6 -1.9 -0.9 -1.0 -0.3 -0.8 0.4 0.7 -1.1 -1.0 0.2 0.2 -1.8 -0.7 -1.8 -0.1 -1.5
Hearing difficulty/problems with background noise 0.6 1.0 3.7 -1.5 -0.3 -0.0 -1.1 -0.1 -0.7 -1.9 -0.1 -0.0 -1.0 -1.7 -1.5 -1.0 -1.0 -0.2 -1.4 -1.0 -0.6 0.2 -0.4 0.8 -1.0 0.8 -0.2 -1.8 0.8 1.3 -1.3
Hair/balding pattern: Pattern 2 0.9 1.2 3.5 0.1 0.7 1.3 -0.3 1.1 1.3 1.1 0.7 0.3 1.0 0.6 1.2 1.3 0.8 -0.1 1.4 1.6 1.9 1.2 1.1 -0.9 1.7 -1.1 0.4 1.1 1.6 -0.5 1.4
Had menopause 0.3 0.4 1.7 0.7 1.3 0.5 1.2 0.1 -0.3 0.4 0.2 -0.5 -0.6 0.5 1.0 -0.0 0.9 0.1 0.2 -0.2 0.3 1.1 0.5 -0.8 0.6 -0.2 -0.8 -0.0 -0.1 -0.6 -0.2
Had other major operations 8.5 10.4 23.8 -4.9 -2.9 -1.7 -4.0 -3.1 -2.4 -4.3 -3.1 -3.8 -3.1 -4.7 -3.4 -4.2 -2.4 -4.3 -3.1 -3.1 0.2 3.1 -2.8 -0.8 -0.4 1.4 -3.5 -3.6 -2.2 -2.7 -4.4
Forced vital capacity (FVC) 7.2 27.8 69.6 -4.0 -4.0 -5.7 -8.0 -3.3 -5.7 -6.9 -2.9 -3.4 -5.8 -8.3 -8.3 -5.2 -4.7 -4.2 -6.6 -7.2 -5.4 -0.4 -4.8 4.8 -5.9 5.1 -0.5 -4.2 -3.5 -2.0 -6.0
Heel bone mineral density (BMD) T-score, automated (right) 0.8 1.9 5.0 0.5 -0.9 0.3 1.1 1.3 2.2 0.8 0.7 1.2 2.2 0.7 1.7 -0.7 -0.8 -0.9 1.0 2.1 2.2 0.6 2.1 -1.8 1.7 -2.1 -1.0 -0.6 1.9 0.2 0.5
Ever unenthusiastic/disinterested for a whole week 1.6 2.0 5.7 -2.4 -0.5 -2.2 -1.6 -0.7 -1.7 -2.0 -0.9 -1.1 -1.9 -1.7 -1.7 -1.4 -1.5 -1.1 -1.9 -1.5 -0.6 1.0 -1.0 0.7 -1.1 1.5 -0.5 -1.6 -0.3 -0.0 -1.7
Qualifications: None of the above 5.0 10.7 35.2 3.4 3.9 1.7 5.0 3.4 2.3 4.8 2.7 3.1 2.7 4.9 2.9 5.9 3.0 4.1 3.1 2.8 0.0 -1.6 2.4 0.9 0.9 -1.5 3.8 3.7 2.2 1.2 4.7
Financial difficulties in last 2 years 2.4 3.2 10.7 -2.7 -2.0 -3.3 -2.7 -1.0 -0.7 -2.0 -0.4 -0.5 -0.7 -2.4 -2.7 -1.9 -3.2 -1.6 -1.8 -1.8 -1.4 0.9 -1.1 1.0 -1.5 1.3 -0.8 -1.9 -0.1 -0.6 -1.7
Mouth/teeth dental problems 0.3 0.5 2.9 1.0 -1.7 0.3 0.4 -0.5 0.1 1.0 0.3 0.2 0.3 0.4 0.1 0.2 0.5 1.0 0.3 0.6 -1.0 -1.1 0.3 0.1 -0.4 -0.1 -0.1 1.2 -0.0 1.0 1.0
Heart attack 1.5 1.9 10.3 -0.3 -1.6 -0.3 0.5 1.1 2.2 1.4 1.0 2.1 3.2 0.8 0.4 0.6 -1.9 -0.2 1.2 1.6 0.6 -1.9 1.7 -0.2 0.6 -2.8 0.4 0.3 0.0 -0.3 1.4
Allergy 0.8 1.9 15.0 -0.0 2.1 0.1 0.5 1.9 1.5 0.3 0.8 1.5 1.8 0.6 0.6 0.4 -1.4 1.1 0.6 1.6 0.1 1.0 2.4 -0.1 0.2 0.3 -0.1 -0.8 3.9 2.5 0.9
Pain all over the body in last month 1.7 1.8 7.1 -0.5 2.6 1.9 0.6 0.3 -0.9 -2.1 -0.4 -2.3 -2.0 -1.2 0.1 -1.4 1.7 -0.4 -0.5 -0.9 0.8 2.7 -0.3 -0.9 0.7 1.3 -1.4 -0.1 -0.1 -1.4 -1.6
Diabetes (self-reported) 0.3 0.4 1.7 0.7 1.2 -0.0 1.0 1.3 0.3 -0.3 0.6 0.3 -0.2 -0.1 0.6 -0.1 0.4 0.5 0.2 0.1 0.4 1.1 1.2 -0.1 0.2 0.1 0.2 0.6 1.3 -0.0 0.0
Hayfever/allergic rhinitis (self-reported) 1.3 1.7 5.0 0.0 -0.3 -0.9 -0.9 -1.2 -2.2 -1.1 -0.9 -1.8 -2.2 -0.8 -1.6 -0.4 0.5 0.5 -1.0 -2.2 -1.3 -0.9 -2.1 1.1 -1.5 1.5 0.2 -0.3 -2.2 -1.2 -1.2
Medication: Ramipril 0.8 1.0 5.7 -0.4 -1.7 -1.3 -0.2 -0.4 0.7 0.8 -0.4 0.4 1.7 0.5 -0.1 -0.6 -2.4 -1.3 0.4 0.5 -0.1 -1.1 0.2 -0.4 -0.1 -2.2 -1.1 -1.7 -0.8 -0.8 -0.3
Medication: Simvastatin 2.2 3.2 8.8 -2.0 -2.0 -0.9 -2.7 -1.2 -2.0 -2.2 -1.8 -1.8 -1.9 -2.6 -3.0 -1.9 -1.0 -1.9 -1.3 -2.4 -1.0 0.2 -2.0 0.9 -1.3 1.2 -0.4 -0.8 -2.2 -1.5 -2.1
Fluid intelligence score 9.2 19.2 51.0 -6.6 -3.0 -1.2 -4.5 -3.4 -3.0 -6.9 -2.6 -3.9 -4.1 -7.1 -4.8 -6.3 -4.3 -5.8 -4.9 -4.8 -1.3 3.0 -3.1 0.3 -1.9 2.8 -3.9 -6.1 -2.7 -2.8 -6.7
Illnesses of siblings 0.4 0.6 3.1 -0.4 -1.6 -1.4 -1.1 -1.5 0.3 0.6 0.4 0.0 0.4 0.6 -0.1 -0.6 -0.7 -0.6 -0.3 -0.0 -0.3 -0.6 -0.6 -0.1 -0.3 -0.9 -0.7 0.2 -1.8 -1.2 -0.1
Neuroticism score 2.5 5.2 11.4 -3.2 -2.7 -0.8 -2.8 -3.1 -2.4 -2.7 -1.8 -3.4 -2.6 -2.8 -2.0 -3.0 -1.4 -2.0 -2.0 -1.6 0.2 1.1 -2.6 -0.9 -0.3 1.7 -3.0 -2.3 -2.5 -1.1 -3.0
Weight 3.1 15.1 37.8 -4.3 -3.0 -3.3 -4.6 -2.9 -4.4 -5.1 -2.4 -2.8 -5.0 -6.2 -6.0 -3.5 -2.2 -3.5 -4.6 -5.9 -3.3 0.5 -4.0 3.5 -3.8 3.8 0.5 -2.0 -3.0 -2.8 -4.5
Impedance of arm (right) 0.4 2.1 8.7 1.0 1.3 0.8 3.0 1.4 0.4 1.3 0.7 1.8 1.0 2.4 0.3 2.6 0.1 2.1 1.2 0.7 -1.6 -1.1 0.5 1.3 -0.5 -0.9 2.3 1.0 1.4 0.9 1.8
Arm fat percentage (right) 0.1 0.6 1.9 0.0 0.3 -0.9 0.7 -0.4 -1.0 0.4 -0.6 -0.4 -0.5 0.3 -0.4 0.9 0.2 0.3 -0.3 -0.9 -1.2 -0.7 -1.1 1.4 -1.0 0.9 1.1 0.5 -0.5 -1.3 0.3
Trunk fat-free mass 7.1 41.0 114.5 -7.7 -5.6 -4.5 -8.4 -4.6 -6.2 -9.1 -3.6 -4.8 -7.6 -10.7 -9.7 -7.3 -4.7 -6.5 -7.5 -9.0 -4.3 1.7 -5.8 4.0 -5.2 5.5 -1.3 -4.8 -5.1 -4.0 -8.3
Hip circumference 1.6 7.0 19.1 -2.1 -1.2 -2.6 -2.5 -2.8 -3.6 -2.9 -2.1 -2.3 -3.9 -3.6 -3.1 -2.2 -0.5 -2.5 -3.2 -4.4 -2.3 0.1 -3.3 2.6 -2.8 2.2 0.6 -0.9 -2.9 -2.7 -3.0
Time employed in main current job 0.4 0.4 2.3 0.6 -0.1 0.8 0.4 0.2 0.2 -0.4 0.5 0.4 0.1 0.5 0.9 0.3 1.5 0.9 1.2 -0.0 0.2 -1.0 0.3 -0.0 0.2 -0.8 0.8 0.7 -0.2 0.8 0.2
Alcohol intake versus 10 years previously 0.7 1.1 3.6 1.6 -0.3 -0.8 -0.4 0.9 1.4 0.9 1.4 1.2 0.9 0.6 0.5 0.9 0.5 1.7 1.1 0.9 0.3 -0.1 1.3 0.1 0.2 -0.3 0.5 1.4 1.9 1.9 1.4
Father’s age at death 0.3 0.4 1.3 0.6 -0.6 -0.6 -0.1 -0.7 -1.0 -0.0 -0.8 -0.4 0.0 -0.2 -0.9 0.1 -0.7 0.1 -0.9 -0.1 -0.5 -1.0 -0.8 0.6 -0.8 -1.0 -0.2 -1.1 0.3 0.3 -0.2
Worrier / anxious feelings 1.1 2.2 8.2 -1.3 0.4 1.4 -1.0 -1.6 -0.7 -1.0 -0.6 -2.4 -1.3 -0.6 0.8 -1.8 0.9 -1.3 -0.4 -0.1 2.0 2.4 -1.0 -2.4 1.6 0.2 -2.9 -1.5 -1.5 -1.6 -1.7
Frequency of tiredness / lethargy in last 2 weeks 1.6 2.6 6.7 -1.5 -0.4 -0.2 -1.3 -2.4 -1.5 -1.8 -0.8 -2.3 -2.5 -1.6 -0.7 -1.9 0.2 -1.8 -1.8 -2.0 0.4 1.7 -1.8 -0.7 -0.1 0.6 -1.9 -1.4 -2.1 -1.9 -2.6
Falls in the last year 0.7 0.9 3.6 -1.3 0.8 -0.1 -0.8 0.4 -0.3 -1.9 -1.2 -0.7 -0.0 -1.3 -0.3 -1.6 -1.3 -0.3 0.3 -0.1 0.8 1.9 0.6 -0.5 0.6 0.8 -0.8 -0.9 1.6 0.4 -0.8
Hair/balding pattern: Pattern 3 1.4 2.0 10.9 1.1 1.1 -0.8 1.5 1.1 -1.0 -0.1 0.2 1.3 -0.3 -0.4 -0.9 0.8 0.4 1.7 -1.2 -1.1 -2.8 -3.3 -0.0 2.6 -2.3 0.6 2.2 0.4 0.8 1.8 0.3
Number of live births 0.8 1.1 7.2 -0.6 1.2 0.7 0.5 -0.6 -0.6 0.2 -1.0 -2.2 -0.9 0.4 0.1 0.3 1.3 -1.1 -0.5 -0.3 0.9 1.6 -1.2 -1.0 1.1 0.1 -1.0 -0.1 -1.5 -2.7 -0.7
Forced expiratory volume in 1-second (FEV1) 10.0 33.7 97.0 -4.1 -5.7 -6.2 -9.4 -3.2 -5.3 -8.0 -3.6 -3.2 -5.2 -9.8 -9.1 -6.9 -6.4 -5.2 -6.9 -7.3 -5.4 -0.7 -4.2 4.3 -6.1 5.2 -1.4 -5.4 -3.1 -1.1 -6.8
Pulse rate 0.3 0.6 2.0 -1.3 0.2 0.2 0.2 1.0 0.1 0.0 0.8 0.5 0.4 0.3 -1.0 1.0 -0.3 1.4 0.5 0.4 -0.9 -0.7 0.5 0.7 -0.4 1.2 0.8 0.7 1.2 1.1 0.8
Happiness 1.7 2.1 7.1 -1.1 -1.3 -1.6 -2.7 -1.8 -1.4 -1.6 -0.1 -1.0 -2.2 -1.4 -2.5 -0.8 -1.0 -0.6 -1.3 -2.0 -1.1 0.2 -1.8 0.9 -1.2 2.2 0.1 -0.3 -1.6 -0.2 -1.1
Noisy workplace 3.8 4.6 10.9 3.3 2.4 0.1 2.0 2.2 1.8 2.4 2.2 2.6 1.4 2.4 1.2 3.3 2.2 3.1 2.6 1.4 0.1 -1.6 1.7 0.8 0.5 -1.2 3.2 3.0 1.5 1.6 2.9
Qualifications: A levels/AS levels or equivalent 4.5 9.9 26.0 -2.9 -2.9 -2.5 -3.4 -3.2 -2.8 -4.5 -2.4 -2.9 -3.5 -4.1 -2.7 -5.1 -2.5 -4.1 -3.7 -3.9 -1.5 1.6 -2.4 0.7 -2.2 2.5 -2.5 -3.6 -2.8 -1.9 -4.9
Serious illness, injury or assault of a close relative in last 2 years 0.4 0.4 1.7 0.5 0.3 -0.7 -0.4 -0.1 0.4 -1.2 0.1 -0.1 -0.8 -0.6 -0.1 -1.3 -0.1 -0.3 -0.8 -0.6 0.1 1.3 0.2 0.0 -0.2 0.9 -0.6 -0.6 1.0 0.6 -0.9
Mouth/teeth dental problems: Dentures 0.6 1.0 2.6 0.2 1.4 0.9 1.5 0.8 0.8 0.6 0.3 1.4 1.5 1.2 1.1 1.6 0.3 0.9 0.7 1.0 0.8 -0.4 0.8 0.1 0.7 -1.3 1.2 0.5 1.6 0.4 1.1
Asthma 0.3 0.5 2.6 -1.6 -1.2 0.0 1.2 -0.7 0.0 0.5 0.1 0.2 -0.1 0.1 0.6 1.0 0.5 -0.6 0.2 -0.3 -0.4 -0.5 -0.5 0.8 -0.5 0.5 1.0 0.8 -1.0 -1.2 0.3
Medication: Ibuprofen (e.g. Nurofen) 0.6 0.8 3.2 0.3 -0.1 -0.7 -0.8 -0.9 -1.3 -0.7 -0.6 -1.6 -1.5 -0.4 -0.7 -0.7 0.4 -0.7 -0.8 -0.9 -0.0 0.2 -1.5 0.0 -0.3 0.4 -0.9 -0.4 -1.2 -1.8 -1.1
Medication: Cholesterol lowering 0.5 0.8 4.2 -0.6 -1.4 -1.6 -2.0 -0.3 -0.5 -0.3 -0.1 0.2 -0.1 -0.8 -2.1 0.0 -1.0 -0.3 -0.1 -0.9 -1.1 -1.0 -0.5 1.4 -1.3 -0.2 0.7 -0.2 -0.5 -0.1 -0.4
Depression (self-reported) 1.7 2.0 5.3 -2.3 -1.3 -1.2 -0.9 -1.7 -1.9 -1.8 -1.8 -1.6 -1.4 -1.6 -1.0 -0.8 -1.6 -1.1 -1.3 -1.4 -0.4 1.5 -1.9 0.8 -1.0 2.3 -0.7 -1.6 0.2 -0.5 -1.4
Medication: Lansoprazole 0.8 0.9 3.3 1.2 1.1 1.0 1.2 0.7 0.7 1.3 1.1 0.8 0.8 1.8 1.2 1.6 0.7 0.9 0.4 1.0 -0.2 -0.6 0.7 0.5 -0.0 0.0 0.8 0.9 0.0 -0.3 1.4
Prospective memory result 1.4 1.7 6.2 2.5 0.3 0.6 1.6 -0.1 0.5 2.5 -0.6 0.2 1.0 2.2 2.1 1.2 2.1 1.5 1.2 1.6 0.5 -0.6 0.1 -1.0 1.0 -1.5 -0.2 1.2 0.5 1.0 1.5
Lung cancer (father) 0.9 1.1 5.3 -2.3 0.7 0.6 -0.2 0.3 -0.8 -1.6 -1.5 -1.5 -0.7 -1.8 -0.7 -1.1 -0.5 -1.0 0.0 -0.8 1.0 1.6 -0.4 -0.5 0.3 1.4 -0.7 -1.2 0.1 -0.6 -1.2
Illnesses of mother 0.1 0.1 0.9 0.2 -0.5 -0.9 -0.4 0.3 0.2 -0.1 0.3 0.4 -0.1 0.1 -0.5 -0.2 -0.1 0.4 -0.2 0.2 -0.1 0.1 0.2 0.2 -0.1 -0.1 0.2 0.4 0.6 0.8 0.1
Forced expiratory volume in 1-second (FEV1), Best measure 10.8 34.6 110.2 -4.8 -5.7 -5.8 -9.2 -2.6 -5.4 -8.4 -4.2 -3.9 -5.1 -10.5 -9.0 -7.2 -6.6 -5.5 -7.2 -7.2 -4.5 0.3 -4.1 3.7 -5.5 4.8 -2.1 -5.8 -2.5 -1.7 -7.2
Pulse wave Arterial Stiffness index 0.6 0.7 4.7 -0.6 -0.6 -0.4 -1.4 0.6 -0.0 -1.1 1.4 0.3 -0.6 -1.1 -2.2 -0.7 -1.3 -0.0 -0.5 -0.9 -0.9 -0.1 0.0 0.8 -0.9 0.8 0.0 -0.5 0.2 0.0 -0.5
Impedance of arm (left) 0.5 2.3 9.5 1.7 1.5 1.0 3.1 1.2 0.5 1.8 0.4 1.3 1.2 3.1 1.2 2.5 0.9 2.3 1.5 1.2 -0.8 -0.8 0.5 0.5 0.0 -0.6 1.6 1.2 1.4 1.0 2.1
Arm fat mass (right) 0.9 3.6 9.4 -1.7 -1.1 -2.1 -1.5 -1.6 -2.5 -1.9 -1.4 -1.5 -2.5 -2.4 -2.8 -0.9 -0.7 -1.3 -2.2 -3.1 -2.1 -0.3 -2.4 2.3 -2.2 2.0 0.8 -0.4 -1.8 -2.1 -1.7
Trunk predicted mass 7.2 41.1 114.5 -7.8 -5.6 -4.5 -8.4 -4.6 -6.3 -9.2 -3.6 -4.8 -7.6 -10.7 -9.8 -7.4 -4.7 -6.5 -7.5 -9.0 -4.3 1.7 -5.8 4.0 -5.2 5.4 -1.2 -4.7 -5.2 -4.0 -8.3
Standing height 6.7 66.2 185.0 -9.9 -6.5 -4.9 -9.1 -5.2 -8.6 -12.0 -4.4 -5.0 -10.2 -13.2 -13.6 -7.7 -6.0 -7.1 -9.8 -12.0 -7.6 1.7 -7.8 7.1 -8.0 7.3 0.7 -5.7 -5.2 -4.1 -10.1
Length of working week for main job 1.2 1.4 5.2 1.2 1.4 2.0 0.9 -0.3 1.4 0.0 1.7 0.4 -0.0 0.7 1.9 -0.7 2.3 0.1 1.4 0.7 1.7 0.1 0.3 -1.8 1.8 -1.1 -0.7 0.7 -0.9 -0.7 -0.0
Exposure to tobacco smoke at home 0.4 0.5 1.9 0.0 1.2 -0.0 0.3 1.1 -0.7 0.8 -1.3 -0.9 -0.1 1.0 0.2 1.1 0.2 0.4 0.6 0.4 0.2 1.4 -0.0 0.2 0.2 0.5 0.4 -0.1 0.8 -0.7 0.3
Breastfed as a baby 0.4 0.5 2.7 -1.6 -0.8 0.1 -0.3 0.2 -0.2 -1.2 -0.3 -0.4 -0.4 -1.2 -1.2 -0.6 -1.1 -0.5 -0.4 -0.7 -0.2 -0.2 -0.0 0.6 -0.4 0.3 0.2 -0.6 -0.6 -0.3 -0.7
Tense / ‘highly strung’ 1.6 2.7 11.0 -3.3 -2.2 -1.2 -2.5 -1.0 -1.2 -2.8 -0.5 -1.7 -1.3 -2.3 -2.4 -1.9 -2.0 -1.1 -1.4 -0.6 0.7 1.1 -1.3 -0.7 0.1 1.3 -1.6 -1.6 -0.3 0.0 -1.8
Seen doctor (GP) for nerves, anxiety, tension or depression 3.2 4.9 13.7 -3.7 -0.5 -0.6 -1.2 -2.1 -2.2 -2.7 -2.4 -3.4 -1.9 -2.3 -1.3 -2.0 -1.7 -2.9 -1.8 -2.0 0.5 3.1 -2.2 -0.4 -0.2 1.2 -2.5 -3.4 -1.1 -3.2 -2.9
Hair/balding pattern: Pattern 4 0.6 1.6 4.6 1.2 -0.1 -2.0 -0.3 -1.8 -0.9 1.2 0.4 0.9 -1.1 1.1 -1.2 1.9 0.1 1.5 0.0 -0.9 -2.1 -1.2 -1.6 2.0 -1.7 0.5 2.0 0.6 -0.4 1.0 0.5
Birth weight of first child 9.4 17.0 49.8 -5.6 -5.5 -4.2 -5.9 -2.3 -3.2 -5.5 -4.2 -2.5 -2.4 -7.1 -6.6 -5.2 -6.2 -4.6 -5.0 -3.7 -1.8 1.4 -2.4 1.0 -2.5 2.3 -2.4 -4.2 -0.9 -0.4 -4.5
Peak expiratory flow (PEF) 2.5 5.9 20.0 -1.6 -3.2 -3.1 -3.5 -0.7 -1.5 -3.2 -0.5 0.5 -1.4 -4.3 -4.5 -2.5 -3.1 -1.3 -2.1 -2.9 -3.1 -2.2 -1.3 2.7 -3.1 1.6 1.1 -1.4 -0.6 1.2 -2.1
Pulse wave reflection index 0.9 1.2 4.1 0.4 -1.2 -0.3 -1.9 -0.8 -0.4 -0.9 0.4 -0.4 -1.1 -1.5 -1.1 -2.0 -0.5 -2.0 -1.4 -1.0 0.0 0.1 -0.6 -0.1 -0.5 -0.2 -1.4 -1.6 -1.0 -0.7 -1.5
Ever highly irritable/argumentative for 2 days 1.2 1.4 4.9 -0.8 -2.0 -1.2 -1.8 -1.1 -0.9 -1.6 -0.2 -0.5 -1.4 -2.2 -1.6 -1.2 -0.6 -1.5 -1.9 -1.5 -0.7 0.1 -0.8 0.8 -0.9 -0.6 0.0 -1.1 -0.4 -0.2 -1.5
Loud music exposure frequency 3.0 3.3 8.7 -1.7 -2.5 -2.0 -1.8 -0.9 -2.0 -1.4 -2.0 0.2 -0.8 -2.1 -2.4 0.2 -2.2 -0.4 -2.0 -2.1 -3.0 -1.6 -1.6 2.9 -2.8 2.3 1.9 -1.1 0.0 1.1 -0.7
Qualifications: O levels/GCSEs or equivalent 1.0 1.7 6.2 -0.6 -1.8 -0.3 -0.3 -1.1 -1.0 -2.3 -0.8 -0.6 -1.2 -1.8 -0.7 -2.5 -1.4 -2.2 -1.8 -1.4 -0.8 -0.2 -0.1 0.4 -1.1 0.1 -0.7 -1.8 -0.9 -0.6 -2.1
Mouth/teeth dental problems: Bleeding gums 5.2 6.7 16.2 -2.6 -1.8 -2.1 -2.7 -2.4 -2.4 -4.0 -2.3 -2.5 -3.0 -3.6 -2.2 -3.5 -2.0 -3.7 -3.1 -3.3 -0.7 1.8 -2.4 0.6 -1.5 2.0 -1.7 -3.3 -1.7 -1.5 -3.8
Blood clot in the leg (DVT) 0.6 0.7 4.1 1.3 0.8 -0.2 0.2 2.0 0.9 0.4 1.4 0.1 0.7 0.4 0.0 1.0 0.6 1.3 1.5 0.6 0.3 -0.0 1.1 0.1 0.3 -0.0 0.5 1.4 0.9 -0.3 0.9
Medication: Paracetamol 0.8 1.4 4.3 -1.1 0.1 -0.6 -1.1 -2.1 -1.5 -1.2 -0.7 -1.4 -2.0 -0.7 -0.8 -0.1 0.2 -0.9 -0.4 -1.8 -0.4 0.1 -2.0 0.6 -0.7 1.8 0.2 -0.6 -2.0 -1.3 -1.2
Headache pain in last month 0.8 1.4 5.1 0.2 -0.2 -0.2 -0.8 -2.0 -0.5 0.0 -0.9 -1.5 -0.8 0.5 1.3 -1.3 0.8 -1.0 0.4 0.2 2.3 1.4 -1.3 -2.2 1.6 -0.5 -2.0 0.1 -1.8 -1.1 -0.8
Medication for cholesterol, blood pressure or diabetes 1.2 2.0 8.5 0.9 1.2 2.2 2.0 0.7 1.5 1.0 0.7 0.2 1.0 0.9 2.9 0.1 1.8 0.3 0.9 1.8 2.2 0.8 1.2 -2.3 2.5 -1.3 -1.1 0.7 1.0 0.4 0.9
Glaucoma (self-reported) 1.1 1.3 5.4 1.0 1.4 -0.7 0.8 0.2 -0.1 -0.6 1.4 1.6 -0.4 0.5 -0.2 0.5 0.8 1.8 0.7 -0.4 -1.1 -0.5 0.7 1.4 -1.0 0.8 2.3 2.1 1.4 1.9 0.9
Gout (self-reported) 0.9 1.2 4.6 -1.7 -0.6 -0.9 -1.6 -1.0 -1.0 -0.2 -2.1 -1.7 -0.5 -0.2 -0.8 -0.9 -0.8 -1.6 -0.6 -0.7 0.7 1.4 -1.3 -0.5 0.3 0.5 -1.0 -0.6 -1.6 -1.7 -1.2
Hypothyroidism/myxoedema (self-reported) 0.8 1.5 6.2 -2.0 -0.5 0.5 -2.0 -0.2 -0.4 -2.0 -0.0 -1.5 -1.3 -2.5 -1.4 -2.1 -0.1 -0.7 -0.1 -1.4 0.6 1.0 0.1 -1.0 0.3 1.2 -1.6 -0.6 -1.1 -0.3 -1.6
Medication: Amlodipine 0.4 0.6 2.7 -0.2 -0.9 -1.0 -1.6 -0.5 -0.4 -0.8 -0.9 -0.7 -0.5 -0.6 -1.2 -0.5 -1.4 -0.5 -0.2 -0.6 -0.1 0.1 -1.1 0.1 -0.3 1.3 -0.3 -0.5 -0.5 -0.5 -0.5
Medication: Ventolin 100micrograms inhaler 0.2 0.2 1.4 -0.6 -0.2 -0.1 1.2 -0.0 0.2 0.2 0.4 0.5 0.2 0.5 0.8 0.9 -0.1 0.0 -0.2 -0.0 -0.3 -0.2 0.0 0.8 -0.4 0.3 1.1 0.4 0.3 0.0 0.5
Birth weight 4.1 8.9 24.8 -4.6 -2.6 -1.2 -2.7 -0.7 -2.1 -3.7 -2.9 -2.7 -1.9 -5.0 -4.4 -4.6 -3.7 -4.0 -3.6 -3.0 -1.1 2.7 -1.4 -0.0 -1.2 1.8 -2.9 -3.2 -1.6 -2.4 -4.0
Chronic bronchitis/emphysema (mother) 0.7 0.8 2.8 1.1 1.1 -0.6 1.0 -0.6 -0.5 0.3 -1.6 -1.0 -0.2 1.6 1.7 -0.2 0.6 -0.4 0.9 0.8 1.2 1.3 -0.5 -1.2 0.9 0.7 -1.0 -0.4 0.5 0.3 -0.1
High blood pressure (siblings) 1.1 1.6 5.8 -2.3 0.3 0.6 0.2 0.1 -1.4 -2.4 -1.4 -1.3 -1.5 -2.1 -1.3 -0.5 -0.3 -0.3 -1.1 -0.6 0.0 1.2 -0.8 0.3 -0.4 2.3 -0.2 -2.1 1.5 1.0 -1.5
Forced vital capacity (FVC), Best measure 7.6 27.9 75.9 -4.5 -4.1 -5.5 -7.7 -3.0 -5.7 -7.2 -3.0 -3.7 -5.7 -8.7 -8.1 -5.4 -5.1 -4.2 -6.6 -7.1 -5.0 0.0 -4.7 4.4 -5.7 4.9 -0.9 -4.6 -3.2 -2.1 -6.3
Body fat percentage 0.3 1.3 6.0 0.7 0.8 -0.5 1.5 0.3 -0.5 1.1 0.3 0.6 -0.2 1.0 -0.2 2.4 1.1 1.3 -0.1 -0.5 -1.5 -1.6 -0.6 2.0 -1.1 0.6 2.4 1.5 0.3 -0.6 1.3
Leg fat percentage (right) 0.4 1.6 6.5 1.1 0.5 -0.5 1.4 0.2 0.1 1.8 0.9 1.1 0.5 1.3 0.1 2.6 1.0 1.4 0.4 0.1 -1.1 -2.1 -0.3 1.7 -0.8 -0.2 2.4 2.0 0.2 -0.5 1.9
Arm fat-free mass (right) 5.1 26.1 75.4 -6.2 -4.0 -3.8 -6.5 -3.6 -5.1 -7.3 -2.6 -3.9 -6.6 -8.7 -7.6 -5.7 -2.8 -5.2 -6.3 -7.4 -3.3 1.4 -4.7 3.3 -4.1 4.6 -0.7 -3.2 -4.1 -3.5 -6.6
Exposure to tobacco smoke outside home 1.6 2.1 6.5 -2.1 -0.6 -0.8 -1.6 -2.6 -2.3 -1.4 -1.7 -1.0 -1.8 -1.8 -1.2 -0.8 -0.7 -1.3 -1.9 -1.9 -0.9 0.5 -1.7 0.7 -1.1 1.6 -0.1 -1.7 -1.0 -0.3 -1.6
Comparative body size at age 10 0.7 2.1 11.1 -1.2 -0.2 -0.3 0.1 -0.6 0.9 -0.3 0.2 -0.9 0.7 -0.4 1.2 -2.0 -1.9 -1.5 -0.7 1.1 2.4 1.5 0.8 -3.2 2.2 -1.3 -3.3 -1.4 -0.6 -0.9 -0.7
Number of full brothers 0.3 0.4 1.7 1.1 -0.7 0.1 0.4 -0.8 0.1 1.1 -0.5 0.9 0.7 0.8 0.2 1.3 0.2 0.2 0.3 0.4 -0.5 -0.6 -0.7 0.2 -0.2 -0.6 1.0 0.4 0.4 0.7 1.0
Worry too long after embarrassment 5.5 9.2 21.6 -3.6 -2.8 -1.3 -3.3 -2.6 -3.3 -4.6 -2.1 -3.7 -4.1 -4.4 -4.2 -3.7 -1.7 -2.5 -3.3 -3.5 -1.5 1.5 -3.1 0.8 -1.8 2.6 -2.0 -3.2 -2.3 -1.6 -4.5
Seen a psychiatrist for nerves, anxiety, tension or depression 4.3 5.5 12.7 -3.3 -1.8 -2.2 -2.7 -2.6 -2.8 -3.6 -2.3 -2.5 -2.9 -3.0 -2.6 -2.5 -2.0 -2.3 -2.2 -3.0 -0.9 1.4 -2.7 0.9 -1.5 2.3 -1.0 -2.3 -1.5 -1.1 -3.1
Wheeze or whistling in the chest in last year 0.3 0.5 2.2 -1.1 0.9 1.4 1.0 -0.2 -0.5 -0.8 0.1 -1.0 -1.3 0.1 0.2 0.4 1.5 0.1 -0.1 -0.5 0.0 0.3 -0.7 -0.0 0.2 0.7 0.3 0.4 -0.9 -1.0 -0.4
Number of children fathered 1.7 2.0 8.6 -0.7 -1.9 -0.9 -1.9 -1.5 -0.0 -0.9 -0.8 -1.1 -0.3 -1.5 -0.4 -2.6 -1.4 -2.9 -1.0 -0.5 0.8 0.9 -1.0 -0.8 0.1 -0.0 -2.1 -1.4 -1.8 -1.9 -1.9
Reason for reducing amount of alcohol drunk: Health precaution 3.5 4.1 12.1 3.2 1.2 1.4 2.0 1.6 1.9 3.2 1.2 1.2 2.4 3.5 2.6 2.3 1.5 2.0 2.3 2.9 1.6 -1.1 1.9 -1.6 1.9 -1.6 -0.0 1.6 1.3 0.7 2.7
Age at first live birth 2.1 3.7 9.2 -1.8 -1.3 -1.4 -1.6 -2.5 -2.7 -2.0 -1.8 -1.7 -3.0 -2.1 -1.8 -1.0 -0.3 -0.7 -1.9 -2.8 -2.2 -0.6 -3.0 2.1 -2.5 2.2 0.4 -1.5 -1.7 -0.0 -2.2
Pulse wave peak to peak time 0.3 0.4 3.1 -0.1 0.1 0.1 0.9 -1.1 -0.6 0.3 -1.8 -0.7 -0.1 0.4 1.2 0.2 0.8 -0.5 -0.3 0.1 0.3 0.2 -0.7 -0.2 0.3 -0.2 0.1 -0.0 -0.6 -0.3 -0.2
Health satisfaction 1.8 2.3 5.9 -1.1 -0.9 -2.4 -2.0 -1.8 -2.3 -0.8 -1.3 -1.2 -2.1 -0.8 -2.2 0.3 -1.3 -0.7 -1.9 -1.8 -1.8 0.5 -2.4 1.5 -1.5 2.1 0.6 -0.6 -1.1 -0.6 -0.9
Shortness of breath walking on level ground 0.6 0.7 2.2 -1.1 1.2 1.3 -0.1 -0.6 0.1 -0.8 0.5 -0.0 -1.4 -0.3 0.0 0.6 1.5 -0.7 -0.1 -0.6 1.4 1.5 -0.4 -0.5 1.2 0.1 1.1 0.6 -0.2 -0.8 -0.4
Qualifications: College or University degree 7.5 23.5 53.6 -5.6 -5.1 -3.9 -5.8 -4.6 -3.5 -6.9 -3.1 -4.0 -4.1 -7.1 -4.9 -7.3 -5.5 -6.7 -6.0 -4.9 -1.7 2.7 -3.7 0.4 -2.7 3.0 -4.5 -6.4 -2.9 -2.7 -7.0
Eye problems/disorders: None of the above 0.2 0.2 1.3 0.3 -1.0 0.3 0.2 0.4 -0.6 0.4 -0.5 -0.3 -0.3 -0.2 -0.2 0.4 0.6 0.1 0.6 -0.1 -0.1 -0.6 -0.0 0.5 -0.1 0.4 0.9 1.1 -0.2 -0.1 0.4
Mouth/teeth dental problems: Loose teeth 1.1 1.3 6.9 1.2 -0.0 0.9 1.1 1.6 1.4 1.7 -0.6 0.7 2.1 1.0 0.8 0.6 -0.5 -0.3 0.8 1.8 1.4 -0.3 0.9 -0.9 1.2 -2.6 -0.1 -0.2 0.5 -0.4 1.0
Emphysema/chronic bronchitis 1.0 1.1 4.1 -1.5 -0.2 0.2 -1.0 -1.6 -1.8 -1.7 -1.1 -0.6 -2.0 -1.7 -1.0 -0.3 -0.2 -0.6 -1.0 -1.4 -0.2 1.0 -1.0 0.6 -0.5 1.0 0.9 -0.1 0.3 0.8 -0.7
Medication for pain relief, constipation, heartburn 0.8 1.3 4.9 0.2 -1.1 -0.0 1.2 0.6 1.6 1.0 0.9 2.2 2.1 0.1 0.8 0.6 -1.2 0.3 0.2 1.3 -0.8 -1.4 1.2 0.4 -0.2 -1.5 0.8 0.2 1.7 1.7 1.4
Neck or shoulder pain in last month 0.3 0.4 1.1 -0.9 -0.3 -0.6 -0.7 -0.5 0.2 -0.1 -0.5 -0.2 0.0 -0.5 0.3 -0.9 -0.7 -0.4 -0.3 0.2 0.7 0.8 0.6 -0.9 0.4 -0.7 -1.0 -0.9 0.6 1.0 -0.6
Medication: Blood pressure 1.2 2.1 8.3 -0.9 -1.8 -2.4 -2.1 -0.6 -1.4 -0.6 -1.4 -0.3 -0.6 -0.6 -2.9 0.2 -2.4 -0.6 -1.2 -1.5 -2.0 -0.9 -1.4 2.2 -2.2 1.0 1.0 -1.1 -1.0 -1.0 -0.7
Angina (self-reported) 1.6 2.1 6.4 1.2 -0.3 0.7 1.0 2.0 1.7 1.9 -0.2 0.9 2.5 1.4 0.7 1.0 -0.4 1.0 2.0 2.5 1.4 -1.1 1.5 -1.1 1.7 -2.2 0.4 1.9 0.4 0.0 2.0
Migraine (self-reported) 0.8 0.9 3.3 -0.3 0.8 -0.7 -0.4 -1.2 -0.6 -0.8 -0.4 -1.1 -1.5 0.0 -0.3 -1.1 0.5 -1.8 -0.5 -1.2 0.5 1.7 -1.0 -0.5 0.4 0.6 -0.5 -0.5 -1.4 -1.8 -1.4
Medication: Ibuprofen 0.2 0.3 1.4 0.6 0.3 -0.4 -0.2 -0.4 -1.0 -0.0 -0.2 -0.9 -0.8 -0.0 -0.3 -0.2 0.2 -0.1 -0.5 -0.5 -0.0 -0.1 -1.0 0.0 -0.2 -0.2 -0.5 -0.1 -0.7 -1.2 -0.5
Medication: Allopurinol 1.3 1.7 5.2 -2.3 -1.2 -1.3 -1.5 -1.7 -1.5 -0.8 -2.0 -1.4 -0.9 -1.1 -1.7 -0.9 -1.6 -1.6 -1.1 -1.4 0.0 0.2 -1.7 0.2 -0.4 0.5 -0.4 -1.2 -1.7 -0.9 -1.5
Medication: Omeprazole 1.2 1.4 4.9 -1.5 1.4 1.2 0.3 -0.5 -2.0 -1.7 -1.4 -2.0 -2.2 -1.1 -0.9 -0.4 0.8 -0.5 -1.1 -1.3 0.4 1.9 -0.9 -0.0 0.2 0.1 -0.2 -0.6 -0.9 -1.3 -1.7
Medication: Seretide 50 evohaler 0.6 0.7 3.0 -0.2 0.2 0.9 0.5 -0.1 1.0 0.9 1.1 0.7 -0.0 1.7 1.1 0.5 1.0 0.4 1.5 0.6 1.1 0.7 0.5 -1.1 1.1 0.1 0.2 1.0 -0.7 0.2 0.5
Mean time to correctly identify matches 2.3 4.4 11.7 -3.4 -0.4 -0.5 -1.6 -1.0 -2.7 -2.9 -2.0 -3.1 -2.2 -3.4 -2.2 -2.1 -1.9 -1.7 -1.7 -2.6 -0.1 1.9 -1.4 0.1 -0.7 2.5 -1.7 -2.3 -1.6 -2.4 -2.7
Heart disease (mother) 3.3 4.0 10.7 -2.6 -0.5 -1.9 -3.3 -1.1 -2.2 -2.9 -1.7 -2.3 -2.3 -1.9 -2.9 -2.1 -1.8 -2.0 -2.5 -2.0 -0.9 1.7 -1.7 0.5 -1.1 2.1 -1.3 -2.2 -1.3 -1.5 -2.6
Reproduciblity of spirometry measurement using ERS/ATS criteria 2.5 3.0 7.5 1.7 0.3 -0.0 2.5 1.7 1.2 2.7 1.3 2.5 1.9 2.4 1.6 2.6 0.1 2.1 0.5 1.7 -0.8 -2.5 2.1 0.8 -0.6 -0.8 1.5 0.9 1.2 2.7 2.2
Whole body fat mass 0.9 3.6 9.7 -1.6 -1.1 -2.1 -1.2 -1.3 -2.5 -1.8 -1.0 -0.9 -2.5 -2.3 -3.1 -0.1 -0.5 -0.7 -2.3 -3.1 -2.7 -1.0 -2.3 3.1 -2.7 2.1 1.9 -0.1 -1.0 -1.4 -1.3
Leg fat mass (right) 0.6 2.5 7.4 -1.1 -1.1 -2.0 -1.1 -1.2 -1.7 -1.1 -0.4 -0.6 -1.9 -1.8 -2.7 0.2 -0.2 -0.5 -2.0 -2.4 -2.2 -1.3 -2.0 2.6 -2.2 1.5 1.7 0.4 -1.1 -1.5 -0.8
Arm predicted mass (right) 4.7 23.8 72.8 -6.2 -3.8 -3.1 -6.2 -3.3 -4.6 -7.1 -2.4 -4.1 -6.2 -8.5 -7.2 -5.7 -2.6 -5.2 -5.9 -6.9 -2.6 1.9 -4.3 2.7 -3.5 4.3 -1.2 -3.3 -3.9 -3.7 -6.5
Pulse rate, automated reading 0.6 2.0 7.8 0.1 0.9 -0.1 0.3 1.7 0.6 1.2 1.9 1.0 0.2 1.4 -1.2 2.8 1.8 2.4 0.5 0.5 -1.4 -1.2 0.2 1.5 -0.6 0.9 2.5 2.6 1.0 0.7 1.7
Alcohol intake frequency. 4.1 9.6 23.4 3.4 2.8 2.2 3.8 2.3 3.6 4.4 2.2 1.5 3.4 4.8 4.7 3.1 2.5 3.1 4.0 4.2 3.1 -0.0 3.1 -2.9 3.6 -2.9 -0.4 2.4 1.6 0.7 3.6
Comparative height size at age 10 2.2 12.0 30.7 -4.0 -2.7 -1.4 -3.2 -2.1 -4.1 -5.2 -2.9 -2.9 -4.5 -5.3 -5.5 -3.5 -1.3 -3.0 -3.9 -5.2 -3.4 0.9 -3.8 2.6 -3.2 3.4 -0.3 -2.2 -2.6 -2.1 -4.4
Number of full sisters 1.7 2.0 6.7 -0.7 0.2 -0.4 -1.3 -1.1 -2.1 -2.0 -1.2 -0.8 -2.5 -1.7 -2.2 -0.4 1.0 -0.6 -1.3 -2.6 -1.1 0.1 -1.9 1.9 -1.6 2.0 1.5 -0.2 -0.4 -0.3 -1.3
Suffer from ‘nerves’ 1.1 1.7 4.6 -1.7 -0.2 0.2 -1.2 -1.0 -1.6 -2.2 -1.2 -2.0 -1.8 -1.9 -1.2 -1.9 -0.4 -1.0 -1.4 -1.1 0.6 1.7 -1.0 -0.8 0.3 0.7 -1.4 -0.9 -0.8 -0.6 -1.8
Overall health rating 1.7 3.7 8.3 -2.7 -0.8 -2.3 -1.2 -2.4 -2.5 -1.7 -1.3 -1.4 -1.9 -1.3 -2.4 -0.1 -1.7 -1.5 -1.4 -2.6 -2.3 -0.4 -2.9 2.5 -2.4 2.2 1.1 -1.4 -2.0 -1.8 -1.7
Chest pain or discomfort 2.3 3.4 8.7 -2.6 -1.9 -2.0 -0.5 -2.2 -1.6 -2.1 0.3 0.4 -1.6 -1.6 -2.5 -0.5 -2.4 -0.8 -2.3 -2.5 -2.8 -1.4 -1.6 2.6 -3.0 1.2 0.8 -2.1 -0.7 0.9 -1.6
Had major operations 1.9 2.2 6.6 -2.0 -0.1 -0.4 -1.2 -1.6 -1.8 -2.1 -0.3 -1.8 -2.5 -2.6 -2.3 -0.8 -0.4 -0.9 -2.2 -1.9 -0.7 1.3 -1.5 0.6 -0.8 1.8 -0.6 -1.2 -0.3 -0.5 -1.7
Age at last live birth 1.4 2.0 6.7 -0.3 -0.2 -0.7 -0.6 -1.4 -1.8 -1.1 -0.7 -1.1 -2.6 -0.6 -1.4 -0.3 0.6 -0.0 -1.2 -2.2 -2.0 -0.6 -2.5 1.8 -2.0 2.5 0.8 -0.1 -2.2 -0.6 -1.3
Family relationship satisfaction 1.2 1.5 6.3 -1.3 -0.7 -0.9 -2.5 -0.2 -1.0 -1.8 -0.3 -1.3 -1.7 -1.2 -1.9 -1.4 -1.2 -0.8 -1.4 -1.2 -0.1 1.4 -0.9 0.1 -0.5 1.9 -0.9 -0.9 -0.8 -0.8 -1.6
Leg pain on walking 0.3 0.4 1.6 0.3 0.3 -0.3 0.3 0.1 -0.4 -0.4 -0.2 -0.2 -1.0 -0.9 -0.8 0.5 0.7 -0.2 -0.6 -1.0 -0.9 0.2 -1.0 1.3 -0.9 -0.1 1.0 -0.2 0.1 -0.7 -0.4
Qualifications: NVQ or HND or HNC or equivalent 0.4 0.5 2.1 1.0 0.4 0.5 -0.7 0.3 0.7 0.2 0.8 0.3 0.4 0.5 -0.3 0.9 1.0 1.3 0.7 0.7 0.6 -0.6 0.4 -0.5 0.8 0.2 0.3 1.4 0.3 0.2 1.0
Commuting to job workplace: Car/motor vehicle 4.0 4.6 11.3 1.7 3.4 2.3 3.1 2.0 2.2 2.5 2.6 1.5 1.1 2.9 2.7 2.6 2.6 2.2 2.2 2.1 1.6 0.1 2.2 -0.9 1.8 -1.2 1.4 2.6 1.2 0.7 2.4
Illness, injury, bereavement, stress in last 2 years 1.3 1.6 5.0 0.8 2.2 1.9 1.7 0.6 0.3 1.3 0.9 0.1 0.2 1.4 1.9 0.9 1.9 1.1 1.5 1.5 1.6 0.7 1.1 -1.7 1.7 -1.2 -0.2 1.2 0.1 0.5 0.8
Medication: Aspirin 1.0 1.3 6.0 -0.9 -1.0 -1.4 -2.4 -0.9 -0.7 -1.4 -0.3 -1.0 -1.1 -1.1 -1.7 -1.8 -0.7 -0.9 -0.6 -1.3 0.5 0.3 -0.8 -0.4 -0.1 0.3 -1.2 -0.4 -1.9 -1.1 -1.5
Supplements: Vitamin C 0.6 0.8 5.7 0.2 1.1 2.4 1.4 -0.7 -0.0 -0.3 -0.2 -0.4 -1.0 0.1 1.1 0.7 1.9 0.5 0.5 0.2 1.0 0.9 -0.4 -0.7 0.9 0.1 0.1 -0.5 0.7 0.7 -0.1
Knee pain experienced in last month 0.5 0.7 3.8 0.7 1.2 -0.2 0.6 -0.5 -0.0 -0.2 1.1 1.5 -0.8 0.0 0.0 0.3 0.8 0.8 0.0 -0.9 -0.9 -0.5 0.0 1.5 -1.0 0.5 1.9 1.3 0.3 0.9 0.3
Hypertension (Self-reported) 0.2 0.6 2.1 -0.5 -1.0 -0.6 -1.3 -0.8 -1.0 0.0 -1.1 -0.8 -0.5 -0.3 -1.4 0.5 -0.4 -0.5 -0.1 -0.6 -0.5 -0.9 -1.1 0.6 -0.7 0.8 0.1 -1.0 -1.0 -0.9 -0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.8 1.0 8.6 0.7 1.6 2.3 1.0 -1.2 0.1 0.2 0.8 -0.2 -0.8 0.5 1.3 0.9 2.9 0.9 0.3 0.0 0.8 0.2 -0.2 -0.4 0.8 0.4 0.1 0.7 -0.0 -0.3 0.3
Illnesses of father: Heart disease 1.4 1.9 6.6 -1.3 -0.2 -0.8 -1.5 -0.3 -1.3 -2.6 -0.2 -0.8 -2.0 -2.6 -2.0 -1.6 -0.5 -1.3 -1.9 -2.4 -0.6 0.7 -0.5 1.0 -1.2 1.0 -0.2 -1.1 -0.7 -0.8 -2.1
Illnesses of siblings: Diabetes 0.4 0.4 2.0 -0.2 1.4 0.2 -0.4 1.2 0.4 -0.0 0.1 -0.3 0.2 -0.3 0.5 -0.2 -0.2 0.4 1.2 0.3 0.9 1.3 0.9 -1.0 1.0 0.1 -0.7 -0.0 0.6 0.3 0.1
Smoking status: Previous 0.4 0.6 2.6 -0.2 0.4 0.8 0.1 0.5 -0.6 -1.4 0.0 -0.3 -1.4 -1.6 -1.0 -0.9 0.7 -1.2 -1.0 -1.0 0.2 0.5 -0.1 0.1 -0.1 0.0 0.1 -0.3 -0.1 -0.9 -1.1
Forced expiratory volume in 1-second (FEV1), predicted 2.6 5.3 16.5 -3.1 -2.3 -1.6 -3.1 -1.3 -1.8 -3.1 0.1 -0.8 -2.6 -3.9 -4.1 -1.9 -1.9 -1.5 -2.0 -3.2 -2.7 -0.8 -2.1 2.5 -2.7 2.4 0.7 -1.3 -1.6 -0.7 -2.6
Whole body fat-free mass 6.5 37.2 106.1 -7.5 -5.0 -4.3 -7.7 -4.5 -6.1 -8.9 -3.5 -4.9 -7.6 -10.3 -9.0 -6.9 -4.0 -6.1 -7.2 -8.6 -3.9 1.9 -5.6 3.7 -4.8 5.5 -1.2 -4.4 -4.8 -3.8 -8.0
Leg fat-free mass (right) 5.3 28.2 84.3 -6.7 -3.9 -3.7 -6.5 -3.9 -5.3 -8.1 -3.3 -4.7 -6.9 -9.2 -7.5 -6.1 -3.2 -5.2 -6.3 -7.5 -2.9 2.2 -4.7 2.7 -3.8 5.1 -1.4 -3.9 -3.8 -3.1 -7.1
Arm fat percentage (left) 0.1 0.5 1.5 0.4 0.7 -0.6 0.9 -0.2 -0.6 0.8 -0.4 -0.4 -0.3 0.8 0.1 1.2 0.9 0.6 0.1 -0.4 -0.6 -0.6 -0.8 0.8 -0.5 0.7 0.9 0.9 -0.4 -1.2 0.6
Average weekly red wine intake 1.7 2.6 10.5 -2.0 -2.0 -0.6 -0.7 0.3 0.1 -2.7 -0.9 -0.7 0.4 -2.2 -1.2 -3.2 -2.8 -2.7 -1.4 -0.6 0.6 1.4 0.2 -0.7 0.1 -0.7 -2.1 -2.2 -0.0 -1.5 -2.1
Handedness (chirality/laterality): Left-handed 0.5 0.6 2.1 -1.2 -0.9 -0.7 -0.5 -0.8 -0.4 -0.5 -0.1 -0.4 -0.2 0.1 0.1 -0.5 -0.8 -1.3 -0.6 -0.4 -1.0 -0.8 -0.8 0.9 -0.9 1.1 0.1 -1.4 -1.4 -0.8 -0.8
Mood swings 0.3 0.6 2.5 -0.0 -0.5 0.1 0.2 -0.8 0.3 0.9 0.1 -1.1 0.4 1.1 1.1 -0.2 0.1 0.1 0.6 1.0 1.3 -0.0 -0.4 -1.6 1.2 -0.8 -1.6 0.0 -1.2 -0.8 0.1
Loneliness, isolation 4.8 6.6 12.9 -3.1 -2.9 -1.9 -2.7 -2.9 -3.1 -3.6 -2.8 -2.8 -2.9 -3.4 -3.0 -3.4 -2.6 -2.5 -2.0 -2.8 -1.4 0.7 -2.6 0.8 -1.9 2.5 -1.6 -2.2 -2.6 -0.6 -3.3
Long-standing illness, disability or infirmity 1.0 1.5 4.1 -1.6 -1.0 -1.5 -0.7 -0.4 -0.6 -1.8 -0.3 0.7 -0.3 -1.8 -1.9 -0.1 -1.9 -0.1 -1.1 -1.6 -1.8 -0.1 -0.5 2.0 -1.8 1.3 1.3 -0.5 1.2 0.6 -0.6
Ever had bowel cancer screening 0.3 0.4 1.3 -0.4 0.3 1.1 -0.1 -1.2 -0.7 -0.4 -0.8 -0.6 -0.3 -0.6 -0.4 0.1 -0.3 0.4 -0.6 -0.6 -0.7 0.4 -1.1 0.5 -0.5 0.0 -0.2 -0.9 -0.2 -1.0 -0.4
Diabetes diagnosed by doctor 0.7 1.2 4.9 1.6 0.9 -0.0 1.3 2.2 1.3 0.5 1.5 1.4 1.0 0.7 0.6 0.5 0.3 1.1 0.9 0.9 0.3 0.2 2.1 -0.0 0.3 -0.8 0.7 1.4 1.9 0.6 1.1
Ever had stillbirth, spontaneous miscarriage or termination 0.6 0.7 4.1 -0.9 -0.4 -0.4 -0.7 -1.1 -0.7 -0.8 -2.0 -1.1 -0.3 -0.9 -0.6 -0.4 -0.5 -0.4 -1.0 -0.3 0.5 1.0 -1.1 -0.5 0.2 0.5 -1.3 -1.1 0.8 -0.5 -0.6
Friendships satisfaction 2.6 3.2 10.4 -2.6 -0.9 -1.9 -2.1 -0.4 -1.1 -3.2 -0.1 -0.8 -1.8 -3.2 -2.2 -2.4 -2.5 -2.3 -2.7 -1.9 -0.9 0.9 -0.6 0.6 -1.1 1.4 -1.0 -2.1 0.1 -0.5 -2.3
Qualifications: nursing, teaching 4.6 7.2 21.3 -3.1 -1.7 -1.7 -2.9 -2.5 -1.6 -4.3 -0.6 -2.1 -2.8 -3.7 -2.3 -4.6 -2.5 -2.6 -3.2 -3.1 -1.4 1.3 -1.5 0.2 -1.9 2.4 -2.9 -3.8 -2.5 -1.3 -4.2
Commuting to job workplace: Walk 3.9 4.2 10.5 -2.6 -1.8 -0.1 -2.2 -1.5 -1.7 -3.0 -2.3 -2.3 -1.3 -3.0 -1.5 -3.0 -1.7 -3.2 -2.1 -2.1 -0.3 0.7 -1.7 0.0 -0.7 0.9 -2.2 -2.7 -1.8 -2.4 -2.9
Eye problems/disorders: Cataract 0.7 0.8 3.2 -0.1 -1.1 -1.3 -1.8 -1.4 0.3 -0.3 -0.3 -0.4 0.1 0.2 -0.6 -1.4 -1.1 -0.8 -0.7 0.2 0.3 0.0 -0.7 -1.0 0.5 -1.2 -1.6 -0.6 -1.3 -0.5 -0.8
Mouth/teeth dental problems: Mouth ulcers 0.8 1.2 9.2 -0.4 3.0 1.4 0.1 -0.2 -0.8 -1.0 0.5 -1.3 -1.9 0.1 0.4 -0.1 2.2 0.7 0.5 -1.1 0.6 1.3 -0.8 -0.2 0.3 1.3 -0.2 -0.6 -1.1 -0.9 -1.1
Medication for cholesterol 1.2 1.9 5.0 1.0 1.9 0.8 1.8 -0.0 1.8 1.4 1.9 1.1 0.9 1.5 2.2 0.6 1.6 0.5 1.6 1.5 1.7 0.5 1.5 -1.4 1.8 -1.7 0.0 1.6 0.7 0.2 1.2
Medication: Laxatives (e.g. Dulcolax, Senokot) 3.1 3.6 17.4 -4.2 -0.9 -0.6 -1.0 -0.3 -0.3 -2.9 -1.3 -2.0 -0.9 -2.7 -1.5 -2.5 -3.2 -2.2 -2.0 -1.4 -0.0 2.3 -0.1 -0.2 -0.3 1.2 -2.1 -3.2 0.1 -1.2 -2.7
Back pain experienced in last month 0.4 0.6 2.2 -0.6 0.4 0.5 -0.4 -0.8 -0.0 -1.4 0.0 -0.2 -0.7 -0.9 0.4 -1.5 -0.2 -1.3 -0.4 -0.7 1.0 0.7 0.5 -0.6 0.5 0.1 -0.8 -1.0 -0.5 -0.1 -1.3
Mineral and other dietary supplements 0.6 0.9 3.8 -0.7 0.7 1.1 0.4 -0.5 0.5 0.2 -0.1 -1.1 0.4 0.8 0.8 -0.0 0.9 0.7 1.3 1.1 1.8 1.0 -0.2 -1.9 1.9 -0.2 -1.2 0.9 -0.4 -0.6 0.3
Breast cancer (self-reported) 3.0 3.6 11.0 -2.0 -1.2 -0.4 -2.4 -2.1 -1.5 -2.4 -1.4 -1.9 -2.1 -1.9 -3.1 -1.1 -0.6 -2.5 -2.2 -2.4 -0.6 1.2 -2.7 1.0 -0.9 1.3 -0.3 -1.6 -1.8 -3.3 -2.3
Asthma (self-reported) 0.3 0.6 2.0 -1.3 -1.2 0.2 1.4 -0.7 0.1 0.7 0.1 0.3 0.1 0.5 0.8 1.1 0.5 -0.4 0.5 -0.1 -0.4 -0.6 -0.5 0.8 -0.4 0.4 1.1 1.0 -0.9 -1.1 0.6
Osteoporosis (self-reported) 1.6 2.0 6.0 -0.7 -1.4 -0.2 -1.5 -1.4 -1.1 -1.6 -1.4 -2.1 -1.2 -1.2 -0.8 -2.5 -0.5 -1.7 -1.4 -1.4 -0.0 1.5 -1.1 -0.8 -0.1 0.4 -2.4 -1.8 -1.4 -1.6 -2.1
Osteoarthritis (self-reported) 0.6 0.8 3.3 -0.1 -0.8 -1.8 -0.7 -1.4 -0.8 0.7 -1.2 -0.7 0.2 0.8 0.2 0.8 -0.9 0.6 -0.0 0.2 -1.2 -0.1 -1.5 1.3 -1.4 1.7 -0.0 -0.4 0.0 -0.3 0.3
Medication: Aspirin 0.9 1.1 3.6 -1.1 -1.0 -1.2 -1.8 -1.0 -0.5 -1.2 -0.6 -1.2 -0.7 -0.6 -1.1 -1.7 -0.8 -1.1 -0.3 -0.9 0.9 0.3 -0.8 -0.7 0.2 0.2 -1.5 -0.8 -1.9 -1.4 -1.4
Medication: Gliclazide 0.3 0.4 2.0 1.4 -0.2 -1.4 -0.8 0.1 0.0 0.1 -0.1 1.0 0.0 -0.2 -0.5 0.0 -0.1 0.2 -0.6 -0.4 -0.6 -0.5 0.4 0.9 -0.9 -0.0 0.9 0.7 0.3 0.6 0.3
Illnesses of father: None of the above (group 1) 0.9 1.2 4.0 -0.5 -1.1 -1.5 0.3 -1.4 -1.7 -0.2 -1.6 -0.5 -0.8 -0.5 -0.8 0.0 -0.5 0.1 -0.9 -1.2 -2.0 -0.9 -1.6 1.8 -1.8 1.3 1.0 0.0 -0.7 0.1 -0.2
Smoking status: Current 1.5 2.4 8.8 -2.1 -1.8 -2.6 -3.0 -0.8 -1.4 -1.5 -1.3 -0.9 -0.7 -1.1 -2.8 -1.4 -2.5 -0.4 -0.8 -1.0 -1.4 0.1 -1.2 1.4 -1.6 2.5 -0.1 -0.3 -0.3 0.8 -0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage 4.0 8.6 29.3 -1.4 -3.0 -3.8 -5.1 -0.8 -2.0 -3.9 -3.0 -1.8 -0.9 -5.4 -4.0 -4.3 -4.3 -3.1 -3.6 -2.4 -1.6 -0.2 -1.2 1.1 -2.3 1.7 -2.2 -3.7 -0.1 -0.8 -3.3
Whole body water mass 6.5 37.1 106.1 -7.5 -4.9 -4.2 -7.7 -4.5 -6.0 -8.9 -3.4 -4.9 -7.6 -10.3 -8.9 -7.0 -4.0 -6.2 -7.2 -8.6 -3.7 1.9 -5.5 3.5 -4.7 5.3 -1.4 -4.5 -4.8 -3.9 -8.1
Leg predicted mass (right) 5.3 28.1 83.9 -6.7 -3.9 -3.7 -6.6 -3.9 -5.3 -8.1 -3.3 -4.7 -6.9 -9.2 -7.5 -6.1 -3.2 -5.1 -6.2 -7.5 -2.9 2.2 -4.7 2.7 -3.8 5.1 -1.4 -3.8 -3.8 -3.1 -7.1
Arm fat mass (left) 0.8 3.1 8.2 -1.7 -1.0 -1.8 -1.7 -1.6 -2.3 -1.7 -1.3 -1.7 -2.5 -2.2 -2.5 -1.0 -0.4 -1.3 -1.9 -2.9 -1.7 -0.1 -2.3 1.8 -1.8 1.9 0.5 -0.4 -1.9 -2.1 -1.7
Number of self-reported non-cancer illnesses 1.2 2.0 7.4 -1.9 -0.3 -0.6 -1.1 -1.4 -2.1 -2.1 -0.3 -1.4 -2.3 -1.8 -2.1 -0.3 0.3 -0.0 -0.8 -2.3 -1.3 -0.3 -1.4 1.6 -1.6 2.7 0.7 -0.4 -1.2 -0.4 -1.4
Average weekly champagne plus white wine intake 2.8 3.9 10.9 -3.0 -1.2 -0.5 -2.3 -1.2 -1.7 -3.3 -2.0 -2.7 -1.9 -2.8 -2.5 -3.1 -1.6 -2.0 -1.3 -1.4 0.4 1.6 -1.3 -1.0 0.0 1.6 -2.1 -1.8 -1.7 -0.8 -2.8
Miserableness 0.9 1.6 5.7 -1.4 -1.3 0.1 -1.2 -1.6 -0.3 -1.2 0.2 -1.9 -1.1 -0.9 0.3 -2.1 0.1 -1.6 -0.6 -0.5 1.2 0.5 -0.9 -1.5 0.9 -0.3 -2.4 -0.8 -2.1 -1.8 -1.7
Guilty feelings 5.4 8.2 17.2 -3.9 -3.6 -1.6 -3.6 -4.2 -2.6 -2.9 -2.0 -3.1 -2.8 -3.0 -3.0 -3.3 -2.4 -3.1 -2.3 -2.9 -1.1 0.8 -3.4 0.2 -1.6 1.6 -2.9 -3.7 -3.6 -1.6 -4.0
Wears glasses or contact lenses 2.0 2.3 5.8 -2.3 -0.4 0.2 -0.9 -0.8 -2.2 -2.4 -2.0 -1.7 -1.8 -1.1 -2.1 -1.1 -0.7 -1.2 -1.6 -1.9 -0.8 0.9 -1.6 1.0 -1.3 1.3 -0.6 -2.4 -0.8 -1.0 -2.4
Ever taken oral contraceptive pill 3.9 4.3 10.2 -2.6 -2.1 -1.4 -2.6 -2.3 -1.8 -2.5 -2.4 -1.7 -1.7 -2.9 -2.0 -2.1 -2.2 -3.1 -2.1 -2.4 -0.6 1.1 -2.6 0.8 -1.2 1.3 -1.0 -3.2 -0.8 -1.3 -2.7
Hearing aid user 1.7 2.0 5.9 -0.1 1.0 1.3 2.0 1.9 2.4 1.7 2.1 1.7 2.4 0.9 1.0 0.7 -0.0 0.3 1.8 1.9 0.9 -0.6 2.1 -1.0 1.1 -1.8 -0.1 0.3 1.0 0.3 1.5
Mother’s age at death 0.3 0.4 2.0 0.1 -0.3 0.7 0.8 -0.8 -0.3 -0.7 -0.3 0.1 -0.3 -0.6 0.5 -1.1 -0.2 -0.1 -0.8 -0.6 -0.3 -0.0 -0.2 -0.2 -0.5 0.5 -1.3 -1.4 0.6 0.7 -0.6
Financial situation satisfaction 6.4 8.0 14.7 -2.5 -1.3 -3.1 -3.2 -3.7 -3.0 -3.3 -1.7 -2.7 -3.7 -2.4 -2.9 -3.3 -1.9 -3.1 -3.2 -3.8 -1.6 2.4 -3.5 0.8 -2.0 2.9 -2.0 -2.8 -3.0 -2.5 -3.8
Tinnitus: Yes, now most or all of the time 1.4 1.7 3.6 0.4 1.3 1.3 1.8 1.6 1.5 1.5 1.5 1.9 1.6 1.1 1.0 1.5 0.4 1.6 1.6 1.2 0.3 -0.7 1.9 -0.3 0.6 -1.2 1.1 1.2 1.0 1.3 1.6
Commuting to job workplace: Public transport 5.7 6.8 15.0 -2.7 -3.3 -2.3 -3.9 -3.0 -2.1 -3.3 -2.6 -2.6 -1.9 -3.5 -2.7 -3.6 -2.8 -3.5 -2.1 -2.5 -0.5 0.6 -2.5 -0.3 -1.0 0.5 -2.6 -3.2 -3.0 -1.7 -3.5
Eye problems/disorders: Glaucoma 2.0 2.4 7.0 1.5 2.5 0.1 1.6 1.4 0.7 0.6 2.1 2.1 0.2 1.4 0.5 1.4 1.5 2.4 1.5 0.6 -0.4 -0.3 1.4 0.9 -0.2 0.2 2.5 2.6 2.1 2.4 1.7
Medication: Blood pressure 0.2 0.4 1.5 0.3 -1.2 -0.4 -1.1 -0.7 -0.8 -0.0 -0.6 -0.4 -0.3 -0.2 -0.9 -0.1 -0.5 -0.2 0.0 -0.6 -0.7 -1.2 -0.9 0.3 -0.6 0.7 -0.1 -0.4 -1.2 -0.2 -0.2
Pain type(s) experienced in last month: Hip pain 1.6 2.0 6.5 -1.0 0.1 0.1 0.0 -2.2 -1.5 -2.0 -1.2 -2.1 -2.6 -1.3 -0.5 -1.7 1.0 -1.1 -1.2 -1.7 0.1 0.9 -2.0 0.1 -0.5 0.9 -1.2 -1.4 -2.0 -1.3 -2.4
Supplements: Fish oil (including cod liver oil) 0.7 0.9 3.7 0.7 -0.6 -1.4 -0.4 1.1 0.0 0.3 -0.1 1.4 0.6 -0.6 -0.6 0.5 -1.3 -0.5 -0.9 -0.6 -1.6 -0.7 0.5 1.9 -1.8 0.6 1.3 -0.8 1.3 1.1 0.4
High cholesterol (Self-reported) 1.4 2.5 8.1 -2.7 -2.2 -0.7 -2.8 -0.7 -1.3 -1.8 -1.8 -1.3 -0.6 -2.4 -2.9 -1.5 -1.8 -1.9 -0.8 -1.7 -0.9 0.0 -1.4 0.9 -1.2 1.0 -0.4 -1.5 -1.2 -1.2 -1.6
Medication: Bendroflumethiazide 0.5 0.7 4.1 -0.3 0.6 0.1 -2.0 0.2 -0.1 -0.3 0.9 -0.5 -1.0 -0.2 -1.5 1.1 0.9 1.6 0.3 -0.3 -0.2 -0.0 -0.5 0.5 -0.1 1.7 0.9 1.0 0.3 0.6 0.4
Medication: Paracetamol 0.5 0.8 3.2 -1.2 0.4 -0.1 -0.8 -1.8 -1.5 -0.3 -1.3 -1.3 -1.2 -0.3 -0.1 0.3 -0.1 -0.6 0.0 -1.0 -0.3 -0.1 -1.8 0.4 -0.4 1.0 0.1 -0.8 -1.7 -0.7 -0.7
Medication: Lisinopril 0.6 0.8 2.6 0.4 -0.3 -0.3 0.5 0.8 -0.6 0.6 -1.0 0.3 0.8 0.7 -0.6 1.4 -1.4 1.5 0.6 0.4 -1.1 -0.8 -0.1 1.3 -1.0 0.7 1.1 -0.1 1.6 1.2 1.1
Medication: Atorvastatin 1.6 1.9 6.0 -0.2 -1.5 -2.5 -2.2 -1.3 -1.5 -1.0 -1.6 -0.1 -0.3 -0.8 -1.6 -0.9 -2.4 -1.2 -1.3 -1.6 -1.7 -0.6 -1.2 2.0 -2.3 0.9 0.4 -1.1 -1.1 -0.6 -0.9
Illnesses of father: High blood pressure 0.5 0.6 3.0 -0.2 0.1 0.8 -0.2 0.1 0.6 -0.1 0.3 -0.9 -0.1 0.5 0.3 -0.4 0.6 0.1 0.1 0.4 1.6 1.4 0.2 -1.7 1.3 -0.4 -1.6 -0.2 -0.5 -0.6 -0.4
Alcohol drinker status: Never 4.8 5.7 14.8 2.0 2.7 2.5 2.7 2.2 2.7 2.7 1.2 0.2 2.3 3.0 3.4 1.6 1.8 1.4 2.5 3.4 3.4 0.4 2.7 -3.5 3.8 -2.2 -1.2 1.9 0.9 -0.5 2.2
Ever smoked 3.5 6.1 15.2 -3.3 -2.0 -1.3 -2.8 -1.1 -2.7 -3.7 -3.3 -2.5 -2.4 -3.9 -3.5 -3.0 -2.5 -3.2 -3.0 -2.3 -0.8 1.5 -2.2 0.9 -1.5 2.3 -1.4 -2.6 -0.5 -1.0 -3.0
Basal metabolic rate 5.9 32.5 91.2 -6.9 -4.6 -4.1 -7.1 -4.2 -5.8 -8.2 -3.2 -4.5 -7.2 -9.6 -8.4 -6.3 -3.6 -5.6 -6.7 -8.2 -3.8 1.6 -5.3 3.6 -4.6 5.2 -0.9 -4.0 -4.6 -3.7 -7.4
Leg fat percentage (left) 0.6 2.1 9.2 1.2 1.1 -0.5 1.8 0.9 0.4 2.2 1.2 1.4 0.8 1.5 0.5 3.0 1.2 1.7 0.5 0.5 -0.9 -2.0 0.2 1.7 -0.6 -0.5 2.8 2.2 0.9 -0.1 2.2
Arm fat-free mass (left) 5.5 28.1 80.6 -6.4 -4.0 -3.7 -6.8 -3.6 -5.2 -7.7 -2.5 -4.0 -6.7 -9.0 -7.9 -6.1 -3.3 -5.5 -6.3 -7.7 -3.4 1.7 -4.7 3.4 -4.3 4.6 -0.8 -3.5 -4.3 -3.7 -7.0
Number of operations (self-reported) 10.8 16.0 39.0 -5.7 -1.0 -0.4 -3.6 -3.3 -4.3 -5.9 -3.9 -5.7 -5.1 -6.2 -4.8 -4.0 -1.8 -3.7 -4.7 -4.2 -0.5 4.1 -4.1 0.1 -1.0 4.1 -3.4 -4.2 -1.7 -4.0 -5.3
Average weekly beer plus cider intake 0.5 0.7 2.8 -0.7 1.5 1.4 1.4 0.7 0.1 0.1 0.8 0.2 -0.3 0.8 1.1 0.7 1.4 0.1 0.2 -0.0 0.6 1.7 0.9 -0.0 0.6 0.5 0.7 0.7 0.8 -0.2 0.2
Irritability 2.2 3.8 9.8 -2.6 -2.2 -1.4 -2.0 -0.8 -2.6 -2.9 -1.7 -2.6 -2.4 -3.1 -2.6 -2.4 -2.2 -1.0 -2.3 -1.4 0.0 1.5 -1.5 0.1 -0.9 1.9 -1.9 -1.9 0.6 0.4 -2.3
Risk taking 1.5 2.1 6.6 -1.2 -1.2 0.0 -1.0 1.8 2.1 -1.1 1.6 1.7 1.4 -1.3 -0.8 -2.0 -1.5 -0.9 -0.3 0.9 1.8 1.4 2.6 -1.5 1.2 -1.9 -1.0 -0.4 2.6 1.8 -0.3
Ever had prostate specific antigen (PSA) test 0.9 1.0 4.0 -0.4 -1.8 -0.6 -1.1 -0.7 -0.3 -0.8 -1.2 0.0 0.7 -1.4 -0.9 -0.7 -2.0 -0.4 -1.1 -0.4 -1.5 -1.4 -0.8 1.2 -1.5 0.9 -0.3 -1.4 0.2 0.2 -0.4
Fractured/broken bones in last 5 years 3.2 4.1 13.8 -3.3 -1.0 -0.5 -1.6 -1.7 -1.7 -3.7 -0.6 -2.3 -3.1 -3.4 -1.9 -3.0 -0.4 -1.7 -2.3 -2.5 -0.1 2.2 -1.2 -0.3 -0.4 1.9 -1.7 -1.6 -1.4 -0.7 -3.1
Age started oral contraceptive pill 1.0 1.3 3.1 -1.8 -0.8 -1.6 -1.0 -1.3 -1.5 -1.4 -1.1 -1.3 -1.3 -1.0 -1.1 -1.1 -1.3 -0.8 -0.5 -1.3 -1.1 0.3 -1.1 0.7 -0.9 1.0 -0.4 -0.7 -1.4 -0.6 -1.3
Diastolic blood pressure, automated reading 0.3 1.0 4.5 -0.1 0.6 -0.4 0.2 1.1 0.4 1.4 1.1 1.2 0.8 1.1 -0.3 2.1 -0.3 1.0 0.5 0.4 -1.1 -0.8 0.6 1.4 -0.7 0.7 1.9 1.0 0.4 0.2 1.4
Ever depressed for a whole week 1.8 2.2 6.1 -2.5 -0.3 -2.0 -2.1 -0.8 -1.7 -2.1 -1.1 -1.3 -1.5 -2.0 -2.2 -1.1 -1.6 -0.9 -2.1 -1.9 -0.9 0.5 -1.4 1.1 -1.2 1.0 -0.1 -1.7 -0.6 -0.8 -1.8
Unable to work because of sickness or disability 0.3 0.4 3.3 0.4 0.2 -0.4 -0.1 -0.0 0.1 1.2 -1.0 0.0 0.9 0.3 0.9 0.8 -0.1 -0.3 1.1 0.3 0.8 0.5 0.2 -0.6 0.7 -1.8 0.1 -0.0 0.0 -0.1 0.6
Commuting to job workplace: Cycle 1.0 1.2 5.3 -1.2 -2.3 -1.2 -1.7 -0.8 -0.4 -0.5 -1.2 -1.0 0.1 -1.1 -1.1 -1.5 -1.1 -1.7 -1.1 -0.4 0.4 0.8 -0.6 -0.5 0.2 -0.7 -1.3 -0.6 -0.8 -1.8 -0.9
Myopia 2.4 3.5 8.7 -0.7 -3.0 -1.9 -1.7 -2.5 -2.2 -1.9 -1.6 -1.0 -1.6 -1.7 -2.3 -0.7 -1.8 -0.8 -2.2 -2.1 -2.7 -1.3 -2.3 2.3 -2.7 1.5 0.0 -2.4 -0.8 0.2 -1.7
Vascular/heart problems diagnosed by doctor 0.1 0.3 0.9 0.4 0.9 0.2 0.6 -0.1 0.3 -0.9 0.9 0.2 -0.6 -0.6 0.8 -1.0 0.6 -0.2 -0.7 -0.4 -0.2 0.5 0.2 -0.1 -0.0 0.2 -0.2 0.6 0.1 0.3 -0.3
Cholesterol lowering medication 2.6 3.9 7.5 -2.7 -2.0 0.1 -2.1 -0.9 -2.1 -2.7 -2.2 -2.4 -1.9 -2.7 -2.1 -2.5 -1.6 -1.8 -1.9 -2.5 -0.8 0.7 -1.9 0.6 -1.4 2.2 -1.3 -2.2 -2.5 -1.3 -2.6
Medication: Omeprazole (e.g. Zanprol) 1.6 2.0 6.5 -1.9 1.6 1.6 1.1 -0.5 -2.1 -1.9 -1.5 -2.5 -2.5 -1.3 -0.5 -0.4 1.3 -0.5 -1.3 -1.5 0.4 2.2 -1.0 -0.0 0.2 0.8 -0.5 -0.9 -0.8 -1.7 -1.9
Pain experienced in last month 0.6 0.9 2.6 -0.3 -0.7 -0.2 0.3 1.5 0.7 0.8 0.7 1.4 1.6 0.9 -0.4 1.6 -0.8 1.0 0.4 0.7 -1.1 -1.4 0.9 0.9 -0.6 -0.0 1.2 0.1 1.4 1.0 1.3
Supplements: Calcium 3.8 4.2 8.6 -2.1 -2.1 -1.6 -2.4 -2.3 -2.3 -2.7 -1.4 -1.9 -2.3 -2.6 -2.6 -2.1 -1.2 -2.3 -2.9 -2.8 -1.8 0.4 -2.2 1.2 -1.7 1.2 -0.9 -1.7 -1.8 -2.1 -2.5
Basal cell carcinoma (self-reported) 0.4 0.5 2.0 0.1 0.3 1.2 0.4 -0.0 0.8 0.8 0.5 -0.1 0.2 1.1 0.3 0.5 1.1 0.4 0.7 0.4 1.3 0.1 -0.1 -1.2 1.4 -1.0 -0.2 0.5 -1.0 -0.8 0.2
Heart attack/myocardial infarction (self-reported) 1.3 1.7 8.6 -0.3 -1.5 -0.6 0.2 0.9 2.0 1.2 1.0 2.1 2.9 0.7 0.1 0.7 -2.0 -0.2 1.1 1.3 0.2 -2.2 1.4 0.1 0.3 -2.5 0.7 0.4 -0.3 -0.2 1.3
Deep venous thrombosis (DVT) (self-reported) 0.8 1.0 4.5 1.5 0.8 -0.0 0.1 2.1 1.1 0.7 1.4 0.2 0.9 0.8 0.4 1.0 0.7 1.4 1.9 1.0 0.6 0.0 1.2 -0.2 0.6 -0.3 0.3 1.6 0.8 -0.2 1.1
Heart disease (siblings) 0.7 0.9 6.0 0.9 1.7 0.7 0.7 2.4 0.4 0.5 1.0 0.8 0.1 -0.2 -0.3 1.3 0.6 1.1 0.2 0.1 -0.7 -0.5 1.1 1.0 -0.2 -0.1 1.8 1.6 0.4 0.3 0.8
Alcohol drinker status: Previous 3.0 3.4 9.5 1.5 2.4 1.8 3.1 1.4 1.3 2.1 -0.1 0.3 2.0 2.9 3.0 1.0 1.2 0.7 2.3 2.7 2.4 1.0 1.8 -2.2 2.3 -2.1 -1.0 0.0 1.3 0.1 1.4
Pack years of smoking 0.9 1.3 4.1 -1.6 -0.9 0.1 -0.6 -0.3 -0.5 -1.7 -0.5 -1.0 -0.8 -1.5 -2.0 -1.1 -0.7 -0.9 -1.5 -1.4 -0.9 1.4 -1.4 1.0 -1.0 1.1 -0.2 -0.0 -0.7 -2.0 -1.1
Impedance of whole body 1.2 6.2 19.0 2.8 1.9 1.3 4.2 2.1 1.3 3.3 1.6 3.0 2.2 4.4 1.9 4.3 1.3 3.2 2.1 2.0 -1.3 -2.1 1.2 1.5 -0.2 -1.7 3.4 2.3 2.2 1.6 3.5
Leg fat mass (left) 0.5 2.0 6.6 -1.0 -0.8 -2.0 -0.8 -0.8 -1.5 -0.9 -0.2 -0.3 -1.7 -1.7 -2.4 0.5 -0.1 -0.3 -1.7 -2.1 -2.0 -1.2 -1.6 2.6 -2.0 1.2 1.9 0.5 -0.6 -1.2 -0.5
Arm predicted mass (left) 5.8 29.4 82.4 -6.7 -4.2 -3.9 -6.8 -3.9 -5.4 -7.7 -2.8 -4.2 -6.8 -9.1 -7.9 -6.1 -3.5 -5.7 -6.4 -7.9 -3.5 1.5 -5.0 3.4 -4.4 4.6 -1.0 -3.9 -4.6 -3.9 -7.1