Best TWAS P=1.68e-09 · Best GWAS P=2.13e-08 conditioned to 0.145
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Brain Cerebellum | ARL14EP | 0.33 | 0.25 | lasso | 10 | 0.26 | 3.7e-08 | 5.1 | -5.2 | 1.7e-07 | -0.83 | 0.02 | 0.98 | FALSE |
2 | GTEx | Colon Sigmoid | ARL14EP | 0.16 | 0.05 | lasso | 13 | 0.10 | 2.6e-04 | 5.2 | -5.8 | 6.3e-09 | -0.65 | 0.06 | 0.68 | FALSE |
3 | GTEx | Esophagus Mucosa | ARL14EP | 0.09 | 0.03 | enet | 11 | 0.05 | 1.8e-04 | 5.2 | -5.5 | 3.1e-08 | -0.72 | 0.04 | 0.89 | FALSE |
4 | GTEx | Esophagus Muscularis | ARL14EP | 0.18 | 0.20 | lasso | 8 | 0.19 | 9.5e-12 | 4.9 | -5.1 | 2.9e-07 | -0.88 | 0.02 | 0.98 | FALSE |
5 | GTEx | Nerve Tibial | ARL14EP | 0.19 | 0.17 | enet | 22 | 0.18 | 4.2e-13 | 4.9 | -6.0 | 1.7e-09 | -0.78 | 0.03 | 0.97 | TRUE |
6 | GTEx | Ovary | ARL14EP | 0.35 | 0.21 | enet | 31 | 0.18 | 2.8e-05 | 4.9 | -5.4 | 8.0e-08 | -0.78 | 0.03 | 0.83 | FALSE |
7 | GTEx | Pancreas | ARL14EP | 0.16 | 0.08 | lasso | 6 | 0.07 | 1.0e-03 | 5.6 | -5.6 | 1.8e-08 | -0.95 | 0.01 | 0.97 | FALSE |
8 | GTEx | Thyroid | ARL14EP | 0.20 | 0.05 | lasso | 6 | 0.09 | 1.0e-07 | -4.0 | -5.7 | 1.4e-08 | -0.52 | 0.60 | 0.35 | FALSE |
9 | ROSMAP | Brain Pre-frontal Cortex | ARL14EP | 0.08 | 0.07 | enet | 13 | 0.08 | 5.3e-10 | 4.9 | -5.6 | 1.6e-08 | -0.85 | 0.02 | 0.98 | FALSE |