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chr7:72,674,074-74,494,207

Best TWAS P=1.47e-10 · Best GWAS P=5.5e-07 conditioned to 0.189

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
19	GTEx	Thyroid	STAG3L2	0.26	0.13	enet	20	0.16	1.4e-12	4.3	-6.4	1.5e-10	-0.03	0.04	0.89	TRUE
18	GTEx	Thyroid	MLXIPL	0.23	0.14	lasso	7	0.15	2.1e-11	-4.7	-5.2	2.5e-07	0.88	0.02	0.97	TRUE
17	GTEx	Skin Sun Exposed Lower leg	STAG3L2	0.15	0.05	enet	8	0.08	2.8e-07	4.3	-6.2	6.8e-10	-0.02	0.01	0.92	FALSE
5	GTEx	Brain Cerebellum	PMS2P5	0.62	0.08	lasso	6	0.22	3.3e-07	4.3	-6.0	1.5e-09	-0.03	0.01	0.85	FALSE
16	GTEx	Nerve Tibial	STAG3L2	0.36	0.09	enet	13	0.24	9.5e-17	4.3	-6.0	1.6e-09	-0.02	0.02	0.94	FALSE
2	GTEx	Adipose Subcutaneous	STAG3L2	0.16	0.03	enet	11	0.09	1.0e-07	4.3	-5.7	9.8e-09	-0.01	0.01	0.97	FALSE
11	GTEx	Esophagus Muscularis	STAG3L2	0.23	0.09	enet	33	0.15	1.9e-09	4.3	-5.7	1.2e-08	0.00	0.03	0.90	FALSE
9	GTEx	Esophagus Gastroesophageal Junction	PMS2P5	0.23	0.19	lasso	2	0.18	5.4e-07	5.0	-5.7	1.5e-08	-0.03	0.00	0.98	FALSE
7	GTEx	Brain Nucleus accumbens basal ganglia	PMS2P5	0.27	0.00	enet	20	0.03	6.6e-02	4.3	-5.6	2.1e-08	-0.03	0.01	0.31	FALSE
15	GTEx	Nerve Tibial	PMS2P5	0.16	0.04	enet	34	0.08	3.5e-06	4.3	-5.5	3.2e-08	0.00	0.02	0.87	FALSE
8	GTEx	Cells Transformed fibroblasts	PMS2P5	0.31	0.16	lasso	5	0.18	2.1e-13	4.3	-5.5	4.9e-08	-0.02	0.03	0.89	FALSE
14	GTEx	Muscle Skeletal	PMS2P5	0.34	0.04	enet	22	0.14	1.6e-13	4.3	-5.4	6.6e-08	-0.01	0.00	0.99	FALSE
3	GTEx	Artery Coronary	PMS2P5	0.15	-0.01	enet	13	0.08	1.4e-03	4.3	-5.4	7.6e-08	-0.02	0.01	0.41	FALSE
10	GTEx	Esophagus Mucosa	PMS2P5	0.14	0.03	lasso	4	0.04	1.7e-03	5.0	-5.4	7.6e-08	-0.03	0.00	0.88	FALSE
4	GTEx	Artery Tibial	PMS2P5	0.21	0.08	lasso	5	0.07	1.9e-06	4.3	-5.4	8.0e-08	-0.02	0.02	0.91	FALSE
6	GTEx	Brain Frontal Cortex BA9	STAG3L2	0.28	0.07	lasso	4	0.11	9.7e-04	5.0	-5.3	9.9e-08	-0.02	0.00	0.74	FALSE
12	GTEx	Heart Left Ventricle	PMS2P5	0.34	0.13	lasso	4	0.19	2.9e-10	5.0	-5.3	1.0e-07	-0.02	0.00	0.99	FALSE
13	GTEx	Lung	STAG3L2	0.13	0.11	enet	11	0.09	1.4e-07	4.3	-5.2	2.4e-07	0.00	0.03	0.91	FALSE
1	CommonMind	Brain Pre-frontal Cortex	STAG3L2	0.33	0.09	enet	3	0.18	7.3e-21	3.0	-5.1	3.0e-07	-0.02	0.25	0.22	FALSE