Best TWAS P=1.47e-10 · Best GWAS P=5.5e-07 conditioned to 0.189
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | STAG3L2 | 0.33 | 0.09 | enet | 3 | 0.18 | 7.3e-21 | 3.0 | -5.1 | 3.0e-07 | -0.02 | 0.25 | 0.22 | FALSE |
| 2 | GTEx | Adipose Subcutaneous | STAG3L2 | 0.16 | 0.03 | enet | 11 | 0.09 | 1.0e-07 | 4.3 | -5.7 | 9.8e-09 | -0.01 | 0.01 | 0.97 | FALSE |
| 3 | GTEx | Artery Coronary | PMS2P5 | 0.15 | -0.01 | enet | 13 | 0.08 | 1.4e-03 | 4.3 | -5.4 | 7.6e-08 | -0.02 | 0.01 | 0.41 | FALSE |
| 4 | GTEx | Artery Tibial | PMS2P5 | 0.21 | 0.08 | lasso | 5 | 0.07 | 1.9e-06 | 4.3 | -5.4 | 8.0e-08 | -0.02 | 0.02 | 0.91 | FALSE |
| 5 | GTEx | Brain Cerebellum | PMS2P5 | 0.62 | 0.08 | lasso | 6 | 0.22 | 3.3e-07 | 4.3 | -6.0 | 1.5e-09 | -0.03 | 0.01 | 0.85 | FALSE |
| 6 | GTEx | Brain Frontal Cortex BA9 | STAG3L2 | 0.28 | 0.07 | lasso | 4 | 0.11 | 9.7e-04 | 5.0 | -5.3 | 9.9e-08 | -0.02 | 0.00 | 0.74 | FALSE |
| 7 | GTEx | Brain Nucleus accumbens basal ganglia | PMS2P5 | 0.27 | 0.00 | enet | 20 | 0.03 | 6.6e-02 | 4.3 | -5.6 | 2.1e-08 | -0.03 | 0.01 | 0.31 | FALSE |
| 8 | GTEx | Cells Transformed fibroblasts | PMS2P5 | 0.31 | 0.16 | lasso | 5 | 0.18 | 2.1e-13 | 4.3 | -5.5 | 4.9e-08 | -0.02 | 0.03 | 0.89 | FALSE |
| 9 | GTEx | Esophagus Gastroesophageal Junction | PMS2P5 | 0.23 | 0.19 | lasso | 2 | 0.18 | 5.4e-07 | 5.0 | -5.7 | 1.5e-08 | -0.03 | 0.00 | 0.98 | FALSE |
| 10 | GTEx | Esophagus Mucosa | PMS2P5 | 0.14 | 0.03 | lasso | 4 | 0.04 | 1.7e-03 | 5.0 | -5.4 | 7.6e-08 | -0.03 | 0.00 | 0.88 | FALSE |
| 11 | GTEx | Esophagus Muscularis | STAG3L2 | 0.23 | 0.09 | enet | 33 | 0.15 | 1.9e-09 | 4.3 | -5.7 | 1.2e-08 | 0.00 | 0.03 | 0.90 | FALSE |
| 12 | GTEx | Heart Left Ventricle | PMS2P5 | 0.34 | 0.13 | lasso | 4 | 0.19 | 2.9e-10 | 5.0 | -5.3 | 1.0e-07 | -0.02 | 0.00 | 0.99 | FALSE |
| 13 | GTEx | Lung | STAG3L2 | 0.13 | 0.11 | enet | 11 | 0.09 | 1.4e-07 | 4.3 | -5.2 | 2.4e-07 | 0.00 | 0.03 | 0.91 | FALSE |
| 14 | GTEx | Muscle Skeletal | PMS2P5 | 0.34 | 0.04 | enet | 22 | 0.14 | 1.6e-13 | 4.3 | -5.4 | 6.6e-08 | -0.01 | 0.00 | 0.99 | FALSE |
| 15 | GTEx | Nerve Tibial | PMS2P5 | 0.16 | 0.04 | enet | 34 | 0.08 | 3.5e-06 | 4.3 | -5.5 | 3.2e-08 | 0.00 | 0.02 | 0.87 | FALSE |
| 16 | GTEx | Nerve Tibial | STAG3L2 | 0.36 | 0.09 | enet | 13 | 0.24 | 9.5e-17 | 4.3 | -6.0 | 1.6e-09 | -0.02 | 0.02 | 0.94 | FALSE |
| 17 | GTEx | Skin Sun Exposed Lower leg | STAG3L2 | 0.15 | 0.05 | enet | 8 | 0.08 | 2.8e-07 | 4.3 | -6.2 | 6.8e-10 | -0.02 | 0.01 | 0.92 | FALSE |
| 18 | GTEx | Thyroid | MLXIPL | 0.23 | 0.14 | lasso | 7 | 0.15 | 2.1e-11 | -4.7 | -5.2 | 2.5e-07 | 0.88 | 0.02 | 0.97 | TRUE |
| 19 | GTEx | Thyroid | STAG3L2 | 0.26 | 0.13 | enet | 20 | 0.16 | 1.4e-12 | 4.3 | -6.4 | 1.5e-10 | -0.03 | 0.04 | 0.89 | TRUE |