TWAS hub - PMS2P5

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.290	0.0560	1.2e-10	0.047	0.119	0.142	0.118	0.135	1.9e-06	2.9e-14	7.3e-17	3.7e-14	4.4e-16
2	GTEx	Artery Aorta	0.326	0.0810	1.1e-05	0.095	NA	0.130	NA	0.169	6.6e-06	NA	1.2e-07	NA	1.3e-09
3	GTEx	Artery Coronary	0.150	0.0730	5.7e-03	-0.005	NA	0.077	NA	0.026	5.4e-01	NA	1.4e-03	NA	4.5e-02
4	GTEx	Artery Tibial	0.205	0.0630	1.2e-05	0.077	NA	0.056	NA	0.074	1.2e-06	NA	3.6e-05	NA	1.9e-06
5	GTEx	Brain Cerebellar Hemisphere	0.400	0.1320	2.1e-03	0.071	NA	0.169	NA	0.125	6.9e-03	NA	4.1e-05	NA	4.4e-04
6	GTEx	Brain Cerebellum	0.621	0.1020	3.3e-06	0.081	NA	0.208	NA	0.223	2.2e-03	NA	8.8e-07	NA	3.3e-07
7	GTEx	Brain Frontal Cortex BA9	0.526	0.1036	1.1e-04	0.178	NA	0.210	NA	0.281	1.9e-05	NA	3.0e-06	NA	4.0e-08
8	GTEx	Brain Hippocampus	0.372	0.1386	4.0e-03	0.026	NA	0.048	NA	0.040	8.3e-02	NA	2.9e-02	NA	4.2e-02
9	GTEx	Brain Nucleus accumbens basal ganglia	0.270	0.1020	1.1e-03	0.003	NA	0.026	NA	-0.001	2.5e-01	NA	6.6e-02	NA	3.4e-01
10	GTEx	Cells EBV-transformed lymphocytes	0.156	0.0680	2.9e-03	0.063	NA	0.007	NA	0.041	4.2e-03	NA	1.8e-01	NA	1.7e-02
11	GTEx	Cells Transformed fibroblasts	0.306	0.0670	8.4e-11	0.161	NA	0.168	NA	0.179	4.1e-12	NA	1.3e-12	NA	2.1e-13
12	GTEx	Esophagus Gastroesophageal Junction	0.234	0.1010	2.0e-04	0.192	NA	0.154	NA	0.177	1.8e-07	NA	3.3e-06	NA	5.4e-07
13	GTEx	Esophagus Mucosa	0.138	0.0610	7.7e-04	0.029	NA	0.025	NA	0.036	4.6e-03	NA	7.7e-03	NA	1.7e-03
14	GTEx	Heart Atrial Appendage	0.118	0.0590	4.0e-03	0.029	NA	0.018	NA	0.072	1.8e-02	NA	5.2e-02	NA	3.8e-04
15	GTEx	Heart Left Ventricle	0.343	0.0885	9.3e-05	0.130	NA	0.095	NA	0.188	2.0e-07	NA	9.4e-06	NA	2.9e-10
16	GTEx	Muscle Skeletal	0.335	0.0619	5.7e-09	0.038	NA	0.139	NA	0.130	1.1e-04	NA	1.6e-13	NA	9.6e-13
17	GTEx	Nerve Tibial	0.160	0.0554	2.1e-05	0.044	NA	0.078	NA	0.071	4.5e-04	NA	3.5e-06	NA	1.0e-05
18	GTEx	Testis	0.224	0.1090	1.0e-02	0.133	NA	0.091	NA	0.126	1.7e-06	NA	7.5e-05	NA	3.1e-06

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18
Age when periods started (menarche)	15.8	37.9	51.3	6.0	5.4	6.0	6.7	6.1	5.9	4.9	4.6	5.5	6.4	6.2	7.1	7.2	5.7	7.1	6.9	6.2	6.4
Number of self-reported non-cancer illnesses	13.6	23.5	31.2	-4.6	-4.1	-4.8	-4.8	-3.5	-5.6	-4.1	-5.1	-5.5	-4.7	-4.9	-5.3	-5.0	-5.1	-4.8	-4.8	-5.6	-4.7
Alcohol intake frequency.	11.6	26.9	36.5	-4.9	-5.0	-5.4	-5.4	-4.1	-6.0	-4.7	-4.8	-5.6	-4.8	-5.5	-5.7	-5.4	-4.8	-5.3	-5.4	-5.5	-4.9
Diabetes (self-reported)	11.2	17.3	30.5	-3.2	-2.8	-3.4	-3.9	-3.0	-4.4	-3.5	-3.6	-4.0	-4.3	-3.9	-5.5	-4.8	-5.4	-5.0	-3.8	-3.8	-5.3
Other serious medical condition/disability diagnosed by doctor	10.8	14.0	17.9	-2.7	-3.3	-3.4	-4.1	-4.0	-3.6	-4.0	-3.9	-3.6	-4.2	-3.7	-3.7	-3.7	-3.4	-3.9	-4.2	-4.2	-3.4
Relative age voice broke	9.9	15.1	23.6	3.0	3.7	3.9	4.2	4.3	4.0	4.2	4.3	3.3	4.3	4.2	4.0	3.7	3.4	3.3	3.3	4.9	3.5
Diabetes diagnosed by doctor	9.7	15.9	28.3	-3.0	-2.8	-3.3	-3.7	-3.4	-4.3	-3.5	-3.6	-3.5	-4.1	-3.8	-5.3	-4.5	-5.0	-4.8	-3.4	-3.5	-5.2
Illnesses of siblings: Diabetes	9.2	11.3	16.6	-2.0	-2.4	-2.9	-3.5	-2.3	-3.7	-3.5	-3.9	-3.2	-4.1	-3.4	-3.9	-3.6	-3.8	-3.4	-3.1	-3.1	-3.8
Number of treatments/medications taken	8.9	16.1	30.9	-3.0	-3.6	-4.1	-4.0	-3.0	-4.6	-2.8	-4.9	-4.6	-3.8	-4.1	-3.9	-4.0	-4.5	-3.5	-3.8	-5.6	-3.4
Taking other prescription medications	8.8	13.5	20.0	-2.7	-2.9	-3.4	-3.5	-3.3	-3.8	-2.9	-3.5	-3.6	-3.6	-3.7	-4.5	-4.0	-4.0	-4.1	-4.0	-4.2	-4.2
Long-standing illness, disability or infirmity	8.7	13.4	23.3	-2.6	-2.3	-2.9	-3.5	-3.7	-3.8	-2.9	-3.8	-3.5	-4.1	-3.4	-4.3	-3.7	-4.1	-3.8	-3.4	-4.8	-4.2
Irritable Bowel Disease (IBD)	8.6	20.4	29.0	4.4	3.6	4.1	4.5	3.3	4.9	4.8	4.5	4.7	4.7	4.7	5.0	4.9	5.4	4.6	3.8	4.1	4.7
Cardiovascular Disease	8.4	27.8	40.4	-5.1	-4.5	-5.5	-5.7	-3.2	-5.5	-4.2	-5.4	-5.6	-5.6	-5.7	-5.8	-6.4	-5.9	-5.1	-4.8	-5.1	-5.1
Vascular/heart problems diagnosed by doctor	8.4	23.0	33.1	4.2	3.7	4.8	5.0	3.2	5.0	3.4	4.4	5.1	5.3	5.1	5.7	5.8	5.5	4.7	4.2	5.1	5.2
Pack years adult smoking proportion	8.3	12.6	22.0	-3.0	-1.8	-2.5	-3.2	-2.9	-3.6	-4.2	-3.2	-3.4	-3.7	-2.8	-4.7	-3.7	-4.1	-4.2	-4.1	-2.9	-4.6
Hypertension (Self-reported)	8.3	23.1	34.5	-4.3	-3.4	-4.6	-4.9	-3.0	-4.8	-3.8	-4.5	-5.0	-5.5	-5.0	-5.9	-5.8	-5.7	-4.7	-4.3	-4.7	-5.5
High blood pressure	8.2	22.9	33.5	-4.2	-3.5	-4.6	-5.0	-3.2	-4.8	-3.9	-4.5	-4.9	-5.5	-5.0	-5.8	-5.7	-5.5	-4.7	-4.2	-4.9	-5.4
Pack years of smoking	8.2	12.1	21.6	-3.0	-1.8	-2.5	-3.1	-3.0	-3.6	-3.9	-3.0	-3.4	-3.5	-2.8	-4.6	-3.6	-4.1	-4.1	-4.0	-2.8	-4.5
Mouth/teeth dental problems	8.1	12.5	24.8	2.2	1.7	2.7	3.1	4.0	3.9	3.8	3.2	3.2	4.0	3.5	4.6	4.1	5.0	3.2	2.2	2.6	4.6
Medication: Metformin	7.9	11.1	21.1	-2.3	-2.2	-2.5	-3.0	-2.4	-3.5	-3.7	-3.0	-2.7	-3.6	-3.0	-4.5	-3.5	-4.1	-4.3	-2.8	-2.6	-4.6
Overall health rating	7.8	16.8	25.7	-3.3	-3.0	-3.6	-4.0	-3.4	-3.7	-4.2	-4.3	-4.0	-4.4	-4.0	-5.1	-4.7	-4.4	-4.6	-3.7	-3.9	-4.9
Type 2 Diabetes (T2D) (2018)	7.6	14.1	27.0	-2.5	-2.6	-2.8	-3.4	-3.5	-3.9	-3.5	-2.9	-3.0	-3.9	-3.5	-5.1	-4.2	-4.7	-5.0	-3.4	-2.8	-5.2
Mouth/teeth dental problems: Dentures	7.5	12.7	18.4	-2.4	-2.7	-3.4	-3.7	-3.2	-3.6	-3.5	-3.6	-3.6	-4.2	-3.9	-4.0	-4.2	-4.3	-3.2	-3.0	-3.1	-3.9
Mother’s age at death	7.3	9.1	15.6	3.4	2.8	2.9	3.1	3.3	2.5	3.3	2.9	2.7	2.7	2.7	3.1	2.9	1.8	3.2	3.8	3.9	2.6
Body mass index (BMI)	7.2	30.7	42.4	-4.9	-5.5	-6.4	-6.3	-3.3	-6.0	-5.2	-6.5	-6.3	-5.8	-6.3	-5.3	-6.1	-4.9	-4.3	-4.6	-6.5	-4.2
BMI	6.8	39.5	60.1	-5.5	-6.5	-7.4	-7.2	-3.7	-7.0	-5.4	-7.5	-7.2	-6.5	-7.2	-5.5	-6.7	-5.5	-4.8	-5.5	-7.8	-4.3
Medication: Ramipril	6.7	8.5	14.2	-3.8	-3.2	-3.4	-3.1	-1.1	-3.0	-1.9	-2.7	-3.4	-2.5	-3.3	-2.6	-3.3	-2.7	-2.9	-3.0	-3.5	-2.1
Crohns Disease (2017)	6.6	14.5	19.9	3.6	3.1	3.5	3.7	3.4	4.4	3.8	4.0	3.4	3.6	3.9	4.5	4.0	4.3	4.2	3.1	3.5	4.2
Ulcerative Colitis (UC)	6.1	11.5	18.5	3.4	2.5	3.0	3.4	1.8	3.6	3.9	3.4	4.3	3.7	3.4	3.5	3.7	4.1	3.0	3.1	3.1	3.2
Alcohol drinker status: Previous	6.1	7.0	11.3	-3.4	-3.0	-2.7	-3.1	-2.4	-1.8	-1.6	-1.3	-2.5	-2.9	-3.1	-2.6	-3.2	-1.6	-3.2	-3.2	-2.4	-2.4
Arm fat percentage (left)	5.8	23.2	35.6	-4.4	-4.6	-5.5	-5.3	-3.3	-5.3	-4.0	-5.7	-5.3	-5.0	-5.3	-5.0	-5.2	-4.2	-3.8	-4.0	-6.0	-4.0
Impedance of leg (right)	5.7	27.5	39.3	4.6	5.6	5.9	6.2	3.6	5.3	5.2	6.1	5.3	5.9	6.3	4.5	5.8	4.4	4.6	4.5	5.4	3.9
Medication: Blood pressure	5.6	9.8	14.6	-3.5	-3.0	-3.6	-3.3	-2.3	-3.0	-1.8	-3.4	-2.5	-3.0	-3.5	-3.7	-3.8	-2.8	-3.2	-2.5	-3.3	-3.2
Arm fat percentage (right)	5.5	21.6	34.1	-4.2	-4.6	-5.5	-5.2	-3.2	-5.2	-3.7	-5.6	-5.2	-4.7	-5.3	-4.7	-5.0	-3.9	-3.4	-3.5	-5.8	-3.7
Qualifications: O levels/GCSEs or equivalent	5.5	8.7	11.5	2.6	2.9	3.0	3.2	2.3	3.1	2.4	2.6	2.9	3.1	3.1	3.4	3.2	3.0	3.2	3.1	2.6	3.0
Medication: Lansoprazole	5.4	6.1	11.2	-2.0	-2.6	-2.9	-2.5	-1.5	-2.9	-2.0	-2.1	-1.5	-2.0	-2.8	-3.4	-2.9	-2.4	-3.0	-2.0	-2.1	-2.8
Medication for cholesterol, blood pressure or diabetes	5.4	9.0	15.4	3.3	2.8	3.4	3.1	2.0	2.8	1.7	3.9	2.6	3.0	3.4	3.3	3.5	2.9	2.9	2.2	3.3	2.9
Waist circumference	5.3	19.3	30.1	-3.8	-4.4	-5.2	-5.0	-2.8	-4.7	-3.9	-5.5	-5.2	-4.7	-5.1	-4.0	-4.8	-3.8	-3.0	-3.3	-5.4	-3.1
Handedness (chirality/laterality): Left-handed	5.3	6.3	8.1	2.7	2.3	2.4	2.5	2.3	2.7	2.8	2.4	2.0	2.4	2.6	2.7	2.6	2.4	2.7	2.6	2.6	2.5
Arm fat mass (left)	5.3	21.9	33.5	-4.3	-4.6	-5.4	-5.3	-2.7	-5.1	-3.9	-5.6	-5.4	-4.9	-5.2	-4.6	-5.1	-4.0	-3.6	-4.0	-5.8	-3.6
Cholesterol lowering medication	5.3	7.8	12.3	-3.0	-3.3	-3.4	-2.9	-3.1	-3.5	-2.7	-2.9	-1.5	-1.9	-3.3	-2.8	-3.1	-2.5	-2.9	-1.6	-2.6	-2.2
Impedance of leg (left)	5.2	25.2	36.5	4.6	5.3	5.6	6.0	3.5	5.2	4.8	5.5	5.0	5.7	5.9	4.4	5.5	4.3	4.6	4.6	5.2	3.7
Mean time to correctly identify matches	5.2	9.9	13.8	-2.9	-2.9	-3.2	-3.5	-2.1	-3.2	-2.4	-2.8	-3.4	-3.7	-3.6	-3.2	-3.7	-3.7	-3.2	-2.8	-2.9	-3.0
Osteoarthritis (self-reported)	5.2	6.8	11.3	-1.7	-1.7	-2.3	-2.6	-1.6	-3.0	-3.0	-3.4	-2.4	-3.2	-2.7	-3.2	-2.8	-3.2	-2.3	-1.6	-2.3	-3.0
Impedance of whole body	5.2	26.5	38.1	4.3	5.6	5.9	6.2	3.2	5.3	5.4	5.7	5.3	5.8	6.2	4.4	5.7	4.4	4.6	4.6	5.1	3.8
Systolic blood pressure, automated reading	5.1	14.9	22.9	-3.4	-2.3	-3.1	-4.0	-3.1	-3.6	-2.4	-2.8	-3.9	-4.6	-3.5	-4.8	-4.7	-4.7	-4.3	-4.2	-4.2	-4.5
Arm fat mass (right)	5.1	20.8	32.3	-4.2	-4.6	-5.4	-5.2	-2.6	-5.0	-3.8	-5.5	-5.3	-4.7	-5.2	-4.4	-4.9	-3.7	-3.4	-3.7	-5.7	-3.3
Medication: Blood pressure	5.1	9.7	14.4	-2.4	-2.2	-2.9	-3.2	-1.8	-3.5	-2.9	-3.2	-3.7	-3.4	-3.2	-3.5	-3.6	-3.8	-2.9	-2.8	-3.3	-3.2
Leg fat mass (left)	5.1	19.8	29.5	-3.8	-4.1	-5.0	-4.8	-2.4	-4.8	-4.3	-5.4	-5.1	-4.6	-4.8	-4.6	-4.9	-4.1	-3.4	-3.7	-5.3	-3.6
Illnesses of mother	4.9	6.0	12.6	1.1	0.6	1.3	1.9	3.2	2.0	2.9	3.0	1.4	3.3	2.3	3.0	3.0	3.5	2.5	1.3	1.3	3.5
Headache pain in last month	4.9	8.5	12.8	-1.9	-2.3	-2.5	-2.6	-3.4	-3.3	-3.2	-2.9	-3.3	-2.8	-3.1	-3.2	-3.0	-3.6	-2.9	-2.3	-2.4	-3.1
Medication for cholesterol	4.9	7.4	12.8	1.6	2.0	2.5	2.6	2.2	3.4	2.5	3.1	2.7	2.6	2.8	3.2	2.9	3.6	2.5	1.9	3.2	2.9
Relative age of first facial hair	4.8	10.0	15.9	2.4	2.5	2.9	3.1	3.7	3.5	3.2	3.7	2.6	3.1	2.9	3.6	3.0	3.1	3.2	2.6	4.0	3.2
Mouth/teeth dental problems: Bleeding gums	4.8	6.2	12.7	-1.6	-0.6	-1.5	-1.9	-3.0	-2.9	-3.2	-2.4	-2.4	-2.7	-2.0	-3.1	-2.5	-3.6	-2.1	-1.8	-2.3	-3.2
Leg fat mass (right)	4.8	18.7	27.5	-3.7	-3.8	-4.8	-4.7	-2.3	-4.8	-4.2	-5.2	-5.1	-4.5	-4.6	-4.5	-4.7	-4.2	-3.3	-3.6	-5.2	-3.6
Medication: Lisinopril	4.7	6.0	9.3	-1.8	-2.9	-3.1	-2.5	-2.1	-2.9	-2.0	-2.6	-2.4	-1.8	-3.0	-2.6	-2.7	-2.2	-2.6	-1.9	-2.4	-2.2
Unable to work because of sickness or disability	4.5	5.8	8.9	-2.1	-2.7	-3.0	-2.5	-2.0	-2.8	-1.9	-3.0	-3.0	-1.9	-2.9	-1.9	-2.4	-2.1	-1.6	-2.1	-3.0	-1.4
Diabetes (father)	4.4	5.5	9.5	-1.7	-1.6	-1.7	-2.0	-2.0	-2.3	-3.1	-2.7	-1.9	-2.2	-2.1	-2.5	-2.5	-3.0	-2.9	-2.5	-1.9	-2.6
Medication: Amlodipine	4.4	6.1	8.8	-2.4	-2.7	-2.9	-2.9	-2.2	-2.0	-1.9	-2.9	-1.9	-2.8	-3.0	-2.4	-2.8	-1.4	-2.3	-2.2	-2.9	-2.1
Breast Cancer	4.3	10.3	19.6	2.2	1.8	2.7	3.1	3.1	3.3	2.1	3.4	2.5	3.8	3.2	4.4	4.0	4.2	3.3	1.9	2.6	4.3
Leg fat percentage (left)	4.3	15.6	24.9	-3.3	-3.4	-4.3	-4.1	-2.7	-4.2	-3.9	-5.0	-4.5	-4.0	-4.3	-4.1	-4.4	-3.8	-2.9	-3.0	-4.8	-3.4
Medication: Atenolol	4.2	5.2	8.8	-2.4	-2.3	-2.5	-2.8	-0.6	-2.1	-2.6	-3.0	-1.6	-2.7	-2.5	-2.2	-2.4	-1.5	-2.3	-2.2	-2.5	-1.9
Heart disease (mother)	4.2	5.1	9.8	-1.6	-1.1	-1.5	-2.3	-2.3	-1.7	-2.2	-1.8	-2.3	-3.1	-2.1	-2.6	-2.8	-3.1	-2.4	-2.3	-1.6	-2.8
Number of operations (self-reported)	4.2	6.2	9.5	-2.8	-2.9	-2.8	-3.1	-1.9	-2.2	-1.9	-2.2	-2.5	-2.8	-2.8	-2.1	-2.4	-1.6	-2.6	-2.7	-3.0	-1.8
Whole body fat mass	4.1	17.3	26.4	-3.9	-3.9	-4.8	-4.6	-2.3	-4.5	-3.7	-5.1	-4.8	-4.2	-4.5	-4.2	-4.5	-3.7	-3.2	-3.4	-5.1	-3.3
Hip circumference	4.0	17.1	23.0	-3.5	-3.7	-4.5	-4.7	-2.7	-4.2	-3.8	-4.7	-4.6	-4.8	-4.5	-4.3	-4.8	-4.1	-3.4	-3.3	-4.5	-3.6
Diastolic blood pressure, automated reading	4.0	12.5	23.4	-2.4	-1.6	-2.7	-3.5	-3.0	-3.4	-2.2	-3.0	-3.2	-4.4	-3.3	-4.6	-4.5	-4.8	-3.6	-2.9	-3.9	-4.5
Diverticular disease/diverticulitis (self-reported)	3.9	4.6	8.5	-2.4	-2.4	-2.1	-2.1	-1.8	-1.6	-2.2	-1.8	-1.7	-1.5	-2.2	-2.4	-2.4	-1.6	-2.9	-2.9	-1.6	-2.2
Body fat percentage	3.9	15.3	25.6	-3.7	-3.6	-4.5	-4.2	-2.5	-4.3	-3.3	-4.8	-4.5	-3.9	-4.2	-4.2	-4.2	-3.5	-2.9	-3.1	-5.1	-3.2
Medication: Omeprazole	3.9	4.7	9.5	-1.5	-1.9	-1.9	-2.3	-1.5	-1.8	-1.1	-1.5	-2.4	-2.4	-2.2	-2.5	-2.4	-2.0	-2.7	-3.1	-2.4	-2.4
Serious illness, injury or assault of a close relative in last 2 years	3.7	4.3	6.5	2.4	2.2	2.1	2.3	2.0	2.2	2.3	1.6	1.6	1.8	2.0	2.2	1.9	1.3	2.3	2.5	2.3	1.7
Chest pain or discomfort	3.6	5.2	8.4	-2.1	-2.1	-2.3	-2.4	-1.8	-2.4	-1.6	-2.1	-2.9	-2.0	-2.3	-2.6	-2.5	-2.2	-2.3	-2.6	-2.3	-2.1
Diabetes (mother)	3.5	4.4	6.7	-1.7	-2.3	-2.3	-2.2	-1.1	-2.3	-2.6	-2.5	-2.6	-1.9	-2.3	-1.8	-2.2	-2.2	-2.1	-2.1	-1.7	-1.5
Impedance of arm (right)	3.5	16.2	25.1	3.3	4.4	4.5	4.8	2.2	4.1	5.0	4.5	4.0	4.5	4.8	3.3	4.3	3.4	3.8	3.8	3.8	2.9
Leg fat percentage (right)	3.5	12.8	20.1	-3.0	-2.9	-3.8	-3.7	-2.4	-4.0	-3.5	-4.5	-4.1	-3.7	-3.7	-3.9	-3.9	-3.7	-2.7	-2.8	-4.5	-3.2
High cholesterol (Self-reported)	3.5	6.2	10.4	-2.9	-2.3	-2.8	-2.4	-1.9	-2.8	-1.9	-3.2	-1.9	-1.9	-2.5	-2.8	-2.7	-2.5	-2.4	-2.0	-3.1	-2.2
Heel bone mineral density (BMD) T-score, automated (left)	3.3	7.4	12.5	2.1	2.3	2.6	2.7	3.5	3.0	2.4	2.3	2.0	2.9	3.0	3.5	3.0	2.8	3.1	1.8	1.5	3.4
Weight	3.3	16.3	26.6	-3.7	-3.8	-4.7	-4.6	-2.0	-4.5	-3.5	-4.9	-5.0	-4.2	-4.4	-3.8	-4.3	-3.5	-2.9	-3.5	-5.2	-2.8
Reaction Time	3.2	6.0	9.2	-2.1	-2.1	-2.3	-2.6	-1.5	-2.4	-2.1	-2.2	-3.0	-2.8	-2.7	-2.5	-2.9	-3.0	-2.6	-2.4	-1.8	-2.5
Heel bone mineral density (BMD) T-score, automated (right)	3.2	7.4	10.4	2.3	2.6	2.8	2.8	3.1	3.1	2.5	2.6	2.2	2.8	3.2	3.1	3.0	2.6	2.9	1.8	1.7	3.0
Illnesses of siblings	3.2	4.4	9.5	0.7	0.7	1.4	1.9	1.1	1.7	1.6	3.1	1.6	2.9	1.8	2.8	2.5	2.8	2.3	1.4	2.0	3.0
Alcohol drinker status: Never	3.2	3.9	6.7	-2.0	-2.3	-2.4	-2.2	-1.2	-2.1	-1.3	-1.9	-1.8	-1.8	-2.3	-2.0	-2.0	-1.3	-1.9	-2.2	-2.6	-1.6
Systolic Blood Pressure	3.1	15.5	25.6	-4.3	-3.1	-3.7	-4.4	-2.9	-3.2	-2.6	-3.0	-4.5	-4.2	-3.7	-4.1	-4.9	-3.9	-4.4	-5.1	-4.2	-3.6
Trunk fat mass	3.1	13.4	23.8	-3.6	-3.5	-4.3	-4.0	-1.9	-4.1	-3.0	-4.6	-4.3	-3.6	-3.9	-3.6	-3.9	-3.0	-2.6	-3.0	-4.9	-2.7
Qualifications: A levels/AS levels or equivalent	3.1	6.9	12.0	1.5	1.5	2.2	2.3	2.8	3.1	2.5	3.4	2.3	2.9	2.6	3.3	2.8	3.5	2.2	1.6	2.4	3.2
Impedance of arm (left)	3.1	14.1	22.2	3.1	4.3	4.5	4.5	2.0	4.0	4.5	4.3	3.7	4.1	4.7	3.0	4.1	3.0	3.2	3.0	3.7	2.5
Pulse rate, automated reading	3.1	10.1	17.7	-3.1	-2.9	-3.4	-3.2	-3.5	-4.1	-2.8	-3.1	-3.6	-3.0	-3.2	-3.4	-2.8	-2.7	-2.6	-2.3	-4.2	-2.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	3.1	3.7	6.3	-2.5	-2.5	-2.5	-2.4	-1.0	-1.8	-0.7	-1.2	-1.3	-1.7	-2.2	-2.2	-2.3	-1.0	-2.2	-2.0	-1.9	-1.5
Medication: Omeprazole (e.g. Zanprol)	3.1	3.8	7.1	-1.1	-1.4	-1.5	-1.9	-1.6	-1.7	-1.0	-1.5	-2.2	-2.1	-1.8	-2.3	-2.1	-2.2	-2.4	-2.7	-2.0	-2.4
Qualifications: None of the above	3.0	6.5	10.9	-1.5	-1.6	-2.4	-2.2	-2.3	-3.0	-2.3	-3.0	-2.8	-2.5	-2.7	-3.3	-2.8	-3.2	-2.0	-1.6	-2.7	-3.1
Age at last live birth	3.0	4.4	11.6	0.7	0.0	0.4	1.8	2.5	1.1	2.6	2.0	1.0	3.2	1.2	3.0	2.3	2.8	2.5	2.1	1.0	3.4
Supplements: Zinc	2.9	3.2	5.4	1.0	1.0	1.4	1.8	2.3	2.2	1.7	1.7	1.2	2.2	1.7	2.2	1.7	2.1	1.7	1.2	1.9	2.2
Trunk fat percentage	2.9	11.6	21.2	-3.4	-3.1	-4.0	-3.6	-2.1	-3.8	-2.6	-4.2	-4.0	-3.2	-3.6	-3.6	-3.7	-2.9	-2.4	-2.7	-4.6	-2.7
Medication: Simvastatin	2.9	4.3	9.3	-2.6	-2.1	-2.3	-2.0	-1.4	-2.0	-1.8	-3.0	-1.1	-1.6	-2.3	-2.1	-2.4	-2.0	-2.3	-1.5	-2.1	-1.9
Shortness of breath walking on level ground	2.9	3.4	5.5	-1.6	-1.9	-2.2	-2.0	-0.5	-2.2	-1.5	-2.1	-2.3	-1.8	-2.1	-1.8	-2.0	-1.7	-1.4	-1.8	-2.2	-1.4
Angina (self-reported)	2.9	3.9	7.4	-2.7	-2.4	-2.3	-2.2	-0.5	-1.8	-0.7	-1.7	-2.5	-1.4	-1.9	-1.6	-2.0	-1.2	-2.2	-2.7	-2.6	-1.1
Lung FEV1/FVC ratio	2.8	14.3	24.6	-3.4	-3.8	-3.9	-4.4	-1.9	-3.5	-3.4	-3.1	-3.4	-4.4	-4.7	-3.4	-5.0	-4.5	-4.2	-3.8	-3.0	-3.3
Medication: Bendroflumethiazide	2.7	4.0	7.8	-1.8	-1.1	-1.7	-1.8	-1.8	-1.7	-2.0	-2.0	-1.5	-2.2	-2.1	-2.8	-2.6	-2.0	-2.1	-1.5	-1.9	-2.7
Prostate Cancer	2.6	3.7	6.1	1.0	1.6	1.7	2.0	1.6	2.1	2.5	2.3	2.2	2.5	2.0	1.8	1.6	2.0	1.4	1.7	2.1	1.7
Allergy	2.6	5.9	8.8	1.8	1.7	2.2	2.1	2.0	2.9	2.8	3.0	2.4	2.2	2.4	2.9	2.4	2.7	2.3	2.0	2.6	2.7
Noisy workplace	2.6	3.2	7.2	-2.2	-2.0	-2.2	-1.9	-1.1	-1.9	-0.8	-1.2	-2.2	-1.4	-2.1	-1.7	-1.8	-0.9	-1.6	-2.1	-2.7	-1.3
Age at first live birth	2.6	4.6	11.2	0.3	0.2	0.7	1.6	2.7	1.7	2.3	2.7	1.4	2.9	1.3	3.1	2.1	3.0	2.2	1.7	1.6	3.4
Ever had hysterectomy (womb removed)	2.5	2.8	4.5	-1.6	-1.3	-1.5	-1.5	-1.7	-1.5	-1.5	-1.7	-1.5	-1.3	-1.6	-2.1	-1.8	-1.5	-2.1	-1.7	-2.0	-2.0
High blood pressure (siblings)	2.5	3.6	10.5	-0.3	0.0	-0.9	-1.4	-1.0	-1.9	-1.4	-2.8	-1.9	-2.5	-1.4	-2.6	-2.1	-3.2	-1.7	-0.9	-1.8	-2.8
Angina	2.4	3.1	6.1	-2.4	-2.0	-2.0	-2.0	-0.5	-1.5	-0.4	-1.4	-2.2	-1.3	-1.7	-1.5	-1.9	-1.2	-2.0	-2.5	-2.4	-1.1
Birth weight	2.4	5.3	8.8	2.3	2.7	2.5	2.6	2.4	2.2	1.4	1.1	1.6	2.1	2.5	2.6	2.3	1.2	2.8	2.8	3.0	2.2
Wheeze or whistling in the chest in last year	2.4	4.3	10.0	-0.6	-0.7	-1.5	-1.2	-2.1	-2.8	-2.0	-2.7	-1.8	-1.6	-1.8	-3.2	-2.1	-3.0	-2.0	-0.8	-1.9	-3.1
Average weekly champagne plus white wine intake	2.4	3.3	9.4	0.8	1.0	1.4	1.5	3.1	2.1	1.5	1.4	0.9	2.0	1.9	2.5	1.9	2.0	1.5	1.1	1.9	2.5
Intelligence (Savage-Jansen 2018)	2.3	7.0	10.8	1.3	1.2	2.1	2.3	3.0	2.9	3.0	3.2	2.5	3.2	2.6	3.3	2.8	3.2	2.1	1.9	2.4	3.3
Heel T-Score	2.2	17.7	29.6	3.1	2.9	3.6	4.0	4.3	5.4	4.0	4.1	4.0	4.4	4.0	5.2	3.8	4.5	4.4	3.7	4.2	5.0
High blood pressure (mother)	2.2	3.1	6.2	-1.1	-0.5	-1.0	-1.3	-1.9	-1.5	-2.5	-1.9	-1.6	-1.9	-1.6	-2.1	-2.3	-2.5	-1.8	-1.4	-0.7	-2.4
Happiness	2.1	2.5	6.9	-1.4	-0.6	-0.8	-1.1	-1.9	-0.4	-2.0	-1.1	-0.5	-1.6	-1.3	-2.4	-2.2	-2.0	-2.1	-1.2	-0.6	-2.6
Townsend deprivation index at recruitment	2.0	2.8	5.7	-1.7	-2.4	-2.4	-1.8	-0.1	-2.1	-0.4	-1.8	-1.9	-1.0	-2.0	-1.6	-1.7	-1.3	-1.7	-1.2	-2.1	-1.1
Leg predicted mass (left)	2.0	10.3	17.0	-3.2	-3.2	-3.8	-3.8	-1.1	-3.6	-3.0	-3.9	-4.1	-3.4	-3.4	-2.6	-3.4	-2.6	-2.3	-3.0	-4.0	-1.8
Medication: Gliclazide	2.0	2.3	4.9	-0.3	-1.0	-1.0	-1.4	-1.3	-1.8	-1.8	-1.2	-0.6	-1.8	-1.6	-2.0	-1.6	-2.1	-2.0	-0.7	-0.5	-2.2
Basal cell carcinoma (self-reported)	2.0	2.3	4.6	-1.7	-1.6	-1.7	-1.9	-0.8	-2.1	-0.4	-1.3	-1.5	-1.8	-1.7	-1.3	-1.4	-1.5	-1.3	-1.4	-2.1	-1.1
Neuroticism (2016)	1.9	2.7	5.9	2.2	2.4	2.2	2.0	2.0	1.2	0.0	1.3	0.7	1.3	2.1	1.4	1.8	0.1	1.8	1.9	1.7	1.1
Leg fat-free mass (left)	1.9	9.9	15.8	-3.1	-3.1	-3.6	-3.8	-1.1	-3.5	-3.0	-3.8	-4.0	-3.4	-3.4	-2.6	-3.3	-2.5	-2.3	-2.9	-3.9	-1.8
Medication: Levothyroxine sodium	1.9	3.1	5.7	-1.7	-2.2	-2.2	-1.9	-1.5	-2.4	-1.4	-2.3	-1.6	-1.0	-1.8	-1.3	-1.4	-1.2	-1.5	-2.2	-2.3	-0.7
Average weekly red wine intake	1.9	2.8	6.0	1.7	1.7	1.7	1.5	1.9	1.8	2.4	1.8	1.1	1.3	1.8	2.3	1.5	1.1	1.6	1.3	1.2	1.9
Eye problems/disorders: Diabetes related eye disease	1.8	2.0	5.2	-0.7	-0.7	-1.0	-1.3	-0.8	-1.7	-0.4	-0.7	-1.4	-1.5	-1.2	-2.0	-1.7	-2.3	-1.8	-1.3	-1.0	-2.0
Serious illness, injury or assault to yourself	1.8	2.2	6.4	-0.9	-0.4	-0.9	-0.8	-1.8	-1.8	-1.8	-1.7	-2.5	-0.9	-1.0	-1.6	-1.3	-2.3	-1.0	-0.9	-1.6	-1.5
Nervous feelings	1.8	3.4	9.1	-1.2	-0.2	-0.6	-1.4	-1.0	-1.6	-2.1	-1.5	-2.0	-2.3	-1.2	-2.5	-2.1	-3.0	-2.1	-1.6	-0.6	-2.8
Number of live births	1.8	2.6	5.2	1.1	0.6	1.1	1.5	1.7	1.9	1.3	1.1	1.5	2.0	1.4	2.3	1.9	2.2	1.4	1.1	1.4	2.1
Leg fat-free mass (right)	1.8	9.4	15.7	-2.9	-3.0	-3.6	-3.6	-1.1	-3.3	-3.0	-4.0	-4.0	-3.3	-3.4	-2.4	-3.3	-2.4	-2.1	-2.7	-3.8	-1.7
Leg predicted mass (right)	1.8	9.5	15.9	-2.9	-3.0	-3.6	-3.6	-1.1	-3.3	-3.0	-4.0	-4.0	-3.3	-3.4	-2.4	-3.3	-2.4	-2.1	-2.8	-3.8	-1.7
Medication: Paracetamol	1.8	2.8	6.3	-1.1	-2.0	-2.0	-1.7	-1.5	-2.1	-1.4	-2.3	-2.5	-1.4	-2.2	-0.8	-1.3	-1.5	-0.7	-0.9	-2.4	-0.5
Medication for pain relief, constipation, heartburn	1.7	2.9	6.8	0.8	1.9	1.9	1.8	0.6	2.0	1.1	2.6	2.3	1.8	2.0	1.1	1.4	1.9	1.0	1.1	2.6	0.9
Hayfever, allergic rhinitis or eczema	1.6	3.4	6.1	-1.3	-1.1	-1.5	-1.8	-1.6	-2.0	-2.4	-2.2	-1.8	-2.0	-1.7	-2.1	-2.0	-2.5	-1.8	-1.5	-1.7	-2.0
Time employed in main current job	1.6	1.8	5.1	2.0	2.2	2.0	1.6	1.0	1.9	0.7	0.8	1.0	0.3	1.6	0.7	0.9	0.1	1.4	1.2	1.7	0.1
Alcohol intake versus 10 years previously	1.6	2.4	7.3	-1.8	-1.5	-1.8	-1.4	-1.2	-2.7	-1.5	-1.6	-1.8	-0.8	-1.6	-1.7	-1.2	-1.6	-1.3	-0.9	-1.6	-1.2
Birth weight of first child	1.6	2.8	6.1	1.6	1.7	1.9	1.7	2.5	1.8	1.6	1.8	0.8	1.2	1.8	1.8	1.9	1.3	1.6	1.4	2.0	1.4
Ever highly irritable/argumentative for 2 days	1.6	1.9	4.2	-0.4	-0.7	-1.2	-1.2	-0.4	-2.0	-1.3	-1.8	-1.4	-1.7	-1.5	-1.7	-1.2	-1.8	-0.7	-0.8	-2.0	-1.6
Medication: Paracetamol	1.6	2.6	6.4	-0.7	-1.9	-1.9	-1.5	-1.0	-2.1	-1.7	-2.5	-2.4	-1.4	-2.2	-0.7	-1.1	-1.6	-0.5	-0.4	-2.0	-0.5
Comparative height size at age 10	1.6	8.8	15.1	-3.3	-2.6	-3.1	-3.4	-1.9	-3.5	-1.9	-2.9	-3.5	-3.1	-2.7	-3.1	-2.9	-2.3	-2.8	-3.3	-3.9	-2.4
Back pain experienced in last month	1.6	2.4	5.3	-0.8	-1.4	-1.8	-1.4	-1.8	-2.0	-1.3	-2.3	-1.7	-1.4	-2.0	-1.4	-1.6	-1.5	-0.9	-0.3	-1.5	-1.3
Medication: Aspirin	1.6	2.1	4.7	-1.6	-2.1	-2.2	-1.8	-0.4	-1.4	-0.2	-1.6	-1.0	-1.4	-1.9	-1.4	-1.8	-1.1	-1.2	-0.8	-1.6	-0.9
HbA1C	1.5	1.7	5.0	0.7	1.0	1.4	1.2	1.0	1.1	1.3	1.8	2.2	1.2	1.6	0.7	1.6	1.4	0.3	1.0	1.8	0.5
Medication: Cholesterol lowering	1.5	2.4	8.7	-1.5	-0.9	-1.4	-1.3	-0.5	-1.5	-0.4	-3.0	-1.6	-1.5	-1.4	-1.6	-1.5	-2.1	-1.2	-0.9	-2.2	-1.5
Eye problems/disorders: Glaucoma	1.5	1.8	7.0	-0.3	0.5	0.3	-0.3	-1.6	-0.7	-2.0	-0.7	-0.2	-1.2	-0.3	-2.2	-1.2	-2.0	-2.0	-1.4	-0.2	-2.6
Average weekly beer plus cider intake	1.5	2.1	7.0	2.1	2.6	1.9	1.7	1.2	1.1	1.6	1.6	1.1	0.4	1.6	-0.5	0.9	0.1	1.1	2.0	1.3	-0.9
Fractured/broken bones in last 5 years	1.5	2.0	3.4	1.6	1.8	1.9	1.7	0.8	1.1	1.0	1.1	1.1	1.4	1.8	1.4	1.9	0.6	1.5	1.5	1.1	1.1
Ovarian Cancer	1.4	1.9	4.2	1.5	1.0	1.3	1.4	1.1	1.3	1.0	1.9	0.6	1.6	1.4	1.6	1.4	1.1	1.1	0.7	2.0	1.6
Mean Putamen Volume	1.4	1.7	5.3	0.0	0.2	0.6	1.3	0.0	1.0	0.0	0.0	0.9	2.3	0.0	1.9	1.7	2.2	1.5	0.0	1.3	2.2
Allergy or Eczema	1.4	3.8	8.1	-1.4	-0.9	-1.5	-1.7	-1.7	-2.2	-2.2	-2.0	-2.1	-2.1	-1.8	-2.4	-2.2	-2.8	-1.9	-1.4	-1.7	-2.4
Chronotype (morning person)	1.4	3.2	11.1	-2.0	-3.3	-2.6	-2.4	-1.6	-1.7	-1.1	-1.3	-1.8	-1.0	-2.2	-0.1	-1.0	0.4	-1.3	-2.4	-2.0	0.6
Arm predicted mass (right)	1.4	7.0	11.7	-2.8	-2.9	-3.1	-3.3	-0.6	-2.8	-2.9	-3.2	-3.4	-2.8	-2.9	-1.7	-2.6	-1.9	-1.9	-2.6	-3.1	-1.1
Osteoporosis (self-reported)	1.4	1.7	3.5	-0.7	-0.9	-1.0	-1.0	-1.6	-1.3	-1.7	-1.4	-0.9	-1.0	-1.2	-1.6	-1.4	-1.9	-1.5	-1.1	-0.8	-1.6
Medication: Atorvastatin	1.4	1.8	4.6	-0.5	-0.9	-1.1	-1.2	-0.4	-1.8	-0.5	-1.7	-1.9	-1.3	-1.2	-1.2	-1.1	-2.2	-1.2	-1.0	-1.8	-1.2
Basal metabolic rate	1.4	7.7	13.6	-2.8	-2.8	-3.3	-3.3	-0.8	-3.1	-2.6	-3.6	-3.7	-2.9	-3.0	-2.0	-2.8	-2.1	-1.8	-2.5	-3.6	-1.3
Commuting to job workplace: Cycle	1.4	1.7	4.5	-0.5	-0.9	-0.8	-1.1	-2.1	-0.9	-1.7	-0.9	0.1	-1.5	-1.5	-1.5	-1.4	-1.2	-1.8	-0.9	-0.9	-1.8
Stomach or abdominal pain in last month	1.3	1.6	3.7	-0.7	-0.8	-0.7	-1.2	-1.9	-0.3	-1.5	-1.0	-1.3	-1.7	-1.2	-1.2	-1.5	-1.2	-1.3	-1.7	-0.8	-1.4
Seen doctor (GP) for nerves, anxiety, tension or depression	1.3	1.9	7.6	-1.0	-0.2	-0.9	-0.8	1.1	-2.0	-0.1	-1.9	-2.8	-0.9	-0.7	-1.3	-1.0	-2.1	-0.5	-0.9	-2.2	-1.0
Illness, injury, bereavement, stress in last 2 years	1.3	1.6	3.8	-1.9	-1.9	-1.5	-1.5	-0.7	-1.3	-0.8	-0.1	-0.6	-0.8	-1.4	-1.1	-1.1	-0.0	-1.7	-1.7	-1.1	-0.8
Arm fat-free mass (right)	1.2	6.1	9.6	-2.4	-2.6	-2.9	-3.0	-0.4	-2.7	-2.8	-3.1	-3.1	-2.6	-2.7	-1.7	-2.5	-1.9	-1.9	-2.4	-2.9	-1.1
Emphysema/chronic bronchitis	1.2	1.4	4.2	-1.8	-1.4	-1.4	-1.1	-0.3	-1.4	-0.5	-0.6	-1.5	-0.5	-1.2	-1.0	-0.9	-0.5	-1.1	-1.5	-2.0	-0.6
Medication: Seretide 50 evohaler	1.2	1.4	3.2	-0.8	-0.4	-0.9	-0.9	-1.1	-1.3	-1.3	-1.2	-1.4	-1.3	-1.2	-1.5	-1.4	-1.8	-0.9	-0.7	-1.0	-1.6
Medication: Aspirin	1.2	1.5	3.5	-1.3	-1.8	-1.9	-1.4	-0.5	-1.1	-0.4	-1.9	-0.8	-1.0	-1.7	-1.1	-1.4	-1.0	-1.0	-0.5	-1.2	-0.7
Arm predicted mass (left)	1.2	6.1	10.6	-2.5	-2.6	-3.1	-3.0	-0.4	-2.8	-2.4	-3.2	-3.2	-2.5	-2.8	-1.6	-2.5	-1.8	-1.5	-2.0	-3.1	-1.0
Average weekly fortified wine intake	1.1	1.3	2.9	1.7	1.0	1.2	1.1	0.8	1.4	0.6	0.6	0.5	0.8	1.0	1.7	1.1	0.5	1.5	1.3	1.2	1.4
Qualifications: CSEs or equivalent	1.1	1.4	3.3	1.6	1.3	1.1	1.5	0.6	0.8	0.6	-0.0	0.6	1.4	1.2	1.2	1.6	1.1	1.8	1.6	0.4	1.2
Multivitamins +/- minerals	1.1	1.3	3.6	0.9	0.7	0.6	0.8	0.8	1.2	1.7	0.3	0.5	0.8	1.0	1.7	1.2	1.2	1.9	1.4	-0.1	1.8
Frequency of tenseness / restlessness in last 2 weeks	1.1	1.7	7.7	0.1	0.5	-0.1	-0.5	0.2	-1.4	-0.8	-2.1	-1.6	-1.6	-0.7	-1.4	-1.0	-2.8	-0.8	0.1	-1.2	-1.9
Fluid intelligence score	1.1	2.3	5.7	0.5	0.6	1.4	1.3	1.4	1.9	1.1	2.4	1.6	1.8	1.6	1.9	1.7	1.9	0.6	0.4	1.5	1.8
Qualifications: NVQ or HND or HNC or equivalent	1.1	1.3	3.8	0.9	0.9	0.8	1.2	2.0	1.0	1.6	0.5	0.5	1.4	1.1	1.1	1.2	1.4	1.2	0.9	0.9	1.1
Mineral and other dietary supplements	1.1	1.5	5.3	0.2	-0.3	-0.5	-0.9	-1.4	-1.1	-2.3	-1.6	0.0	-1.6	-1.1	-1.4	-1.1	-1.6	-1.1	-0.3	0.0	-1.7
Whole body water mass	1.1	6.4	11.5	-2.6	-2.6	-3.1	-3.1	-0.5	-2.8	-2.4	-3.2	-3.4	-2.7	-2.8	-1.6	-2.5	-1.8	-1.6	-2.4	-3.2	-1.0
Arm fat-free mass (left)	1.1	5.5	10.0	-2.3	-2.7	-3.0	-3.0	-0.5	-2.6	-2.3	-3.2	-3.0	-2.4	-2.7	-1.4	-2.3	-1.4	-1.3	-2.0	-3.0	-0.7
Age started oral contraceptive pill	1.1	1.4	3.4	-1.9	-1.6	-1.8	-1.6	-0.4	-1.3	0.4	-0.2	-1.6	-1.1	-1.6	-0.5	-1.4	-0.8	-0.4	-0.6	-1.1	-0.1
Ever depressed for a whole week	1.1	1.3	2.9	-0.8	-0.6	-0.8	-1.0	-0.0	-1.4	-1.2	-1.7	-1.5	-1.1	-1.0	-1.1	-1.1	-1.7	-1.0	-1.0	-1.3	-1.1
Alzheimer’s Disease (in mother)	1.0	1.1	3.0	1.7	1.6	1.5	1.4	-0.2	1.1	0.8	1.2	1.3	1.2	1.4	0.2	0.6	0.2	0.2	0.6	1.3	-0.1
Blood Red Count	1.0	10.1	17.2	-4.0	-3.5	-3.6	-3.7	-3.2	-3.0	-2.7	-3.7	-2.8	-3.1	-3.2	-2.8	-3.0	-1.5	-2.8	-3.1	-4.2	-1.9
Alcohol usually taken with meals	1.0	1.7	5.8	0.2	0.1	0.6	0.7	1.1	1.1	1.8	1.3	0.3	1.5	1.1	2.3	1.4	1.9	1.0	-0.0	0.7	2.4
Had other major operations	1.0	1.3	4.9	-1.4	-1.4	-1.1	-1.4	-0.3	-0.3	-0.2	-0.2	-1.7	-0.9	-0.9	-0.3	-1.2	-0.4	-1.3	-2.2	-1.7	-0.1
Father’s age at death	1.0	1.4	4.7	0.6	1.3	1.3	1.5	0.6	0.6	1.2	2.2	1.0	1.5	1.4	0.6	1.4	0.9	1.1	1.2	0.9	0.7
Depression (self-reported)	1.0	1.2	3.7	-1.0	-0.4	-1.0	-0.8	0.2	-1.9	-0.0	-1.0	-1.7	-0.7	-0.7	-1.4	-1.0	-1.9	-0.5	-0.8	-1.7	-1.0
Blood clot in the leg (DVT)	1.0	1.3	4.0	-0.7	-1.1	-0.9	-1.3	-1.1	-1.4	-1.0	-0.4	-1.1	-1.2	-1.0	-1.3	-0.9	-0.6	-1.5	-2.0	-1.2	-1.2
Whole body fat-free mass	1.0	5.8	10.8	-2.5	-2.5	-2.9	-3.0	-0.4	-2.7	-2.4	-3.0	-3.3	-2.6	-2.6	-1.6	-2.5	-1.8	-1.6	-2.4	-3.0	-1.0
Hearing aid user	1.0	1.1	3.8	0.6	0.1	0.4	0.8	0.3	1.1	-0.2	-0.1	2.0	0.9	0.5	1.1	1.0	1.6	1.2	1.6	1.4	1.1
Financial situation satisfaction	1.0	1.3	3.1	-0.7	-0.4	-0.8	-0.8	-1.5	-1.4	-1.4	-0.8	-0.5	-1.2	-1.2	-1.6	-1.3	-1.6	-1.2	-0.3	-0.3	-1.8
Deep venous thrombosis (DVT) (self-reported)	1.0	1.3	3.2	-0.6	-0.7	-0.7	-1.1	-1.1	-1.4	-1.4	-0.5	-1.0	-1.2	-0.9	-1.4	-0.9	-0.9	-1.5	-1.8	-1.1	-1.4
Primary Biliary Cirrhosis	0.9	1.3	3.0	0.8	1.0	1.3	1.3	1.7	0.7	1.7	0.0	1.3	0.0	1.6	1.2	1.4	0.9	0.5	0.0	1.2	1.2
Standing height	0.9	9.4	15.8	1.9	3.4	3.4	3.2	3.0	3.0	3.5	3.1	2.1	3.2	4.0	3.4	3.5	2.9	3.1	2.0	2.3	3.2
Forced expiratory volume in 1-second (FEV1), predicted	0.9	1.8	5.7	-0.0	0.3	0.6	0.8	1.6	1.0	0.7	0.7	1.0	1.3	1.2	2.1	1.7	2.1	1.8	1.4	0.8	2.4
Commuting to job workplace: Walk	0.9	1.0	2.0	-0.4	-0.6	-0.6	-1.1	-1.4	-1.3	-1.1	-0.2	-0.0	-1.4	-0.8	-1.3	-0.8	-1.1	-1.4	-1.1	-0.4	-1.4
Guilty feelings	0.9	1.3	7.1	1.1	1.3	1.2	1.0	2.7	1.0	1.9	0.7	-0.6	0.4	1.1	1.1	1.1	-0.1	1.1	0.6	0.1	0.8
Supplements: Fish oil (including cod liver oil)	0.9	1.2	5.5	-0.1	0.2	0.3	0.6	1.0	0.6	2.3	1.3	-0.3	1.3	1.0	1.1	1.1	1.4	1.1	0.1	-0.8	1.6
Lung FVC	0.8	4.1	9.3	-0.9	-0.7	-1.4	-1.6	-2.5	-2.3	-1.9	-2.1	-2.3	-2.4	-1.8	-2.6	-2.0	-3.0	-1.4	-0.7	-2.1	-2.6
Exposure to tobacco smoke outside home	0.8	1.1	2.8	-0.6	-0.3	-0.5	-0.5	-1.0	-0.4	-0.5	-0.6	-1.1	-0.7	-0.7	-1.6	-1.4	-1.6	-1.5	-1.2	-0.6	-1.7
Health satisfaction	0.8	1.1	1.8	-0.8	-1.0	-1.0	-1.1	-1.1	-0.6	-0.5	-0.6	-0.5	-1.2	-1.2	-1.3	-1.3	-0.7	-1.3	-1.0	-1.3	-1.3
Breast cancer (self-reported)	0.8	1.0	2.8	-1.1	-1.0	-1.0	-0.9	-0.7	-0.9	-0.2	0.3	-1.7	-0.4	-0.7	-0.9	-0.9	-0.6	-1.4	-1.6	-1.3	-0.7
Pain experienced in last month	0.8	1.3	3.3	0.9	1.2	1.4	0.7	1.3	1.6	1.0	1.8	1.4	0.3	1.4	0.5	0.8	1.1	0.0	-0.3	1.8	0.2
Worry (Nagel 2018)	0.7	1.6	8.8	0.5	1.6	1.0	0.3	0.9	-0.5	-1.6	-1.6	-1.4	-1.0	0.3	-1.1	-0.8	-3.0	-0.9	-0.3	0.4	-1.8
Hypothyroidism (self reported)	0.7	1.5	3.4	-1.0	-1.8	-1.6	-1.3	-1.2	-1.6	-1.3	-1.6	-1.1	-0.3	-1.2	-0.6	-0.8	-0.4	-1.1	-1.7	-1.6	-0.0
Ever used hormone-replacement therapy (HRT)	0.7	0.9	2.5	-0.3	-0.7	-0.6	-0.8	-0.8	-0.8	-1.0	-1.0	-0.8	-0.7	-0.6	-1.1	-0.7	-1.0	-1.1	-1.4	-1.6	-1.0
Had menopause	0.7	0.9	3.0	0.3	0.7	0.8	-0.3	-1.1	0.6	-0.6	0.9	0.7	-1.4	0.1	-1.1	-0.7	-1.0	-1.4	-1.1	-0.1	-1.7
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.9	2.4	1.3	0.7	0.7	0.9	1.5	0.2	1.1	0.2	-0.4	0.7	0.7	1.2	1.2	0.0	1.5	1.2	-0.1	1.1
Glaucoma (self-reported)	0.7	0.8	3.5	0.3	0.8	0.7	0.2	-1.3	-0.3	-1.0	0.2	0.0	-0.5	0.3	-1.5	-0.4	-1.3	-1.3	-1.0	0.1	-1.9
Migraine (self-reported)	0.7	0.9	1.9	-1.1	-0.6	-0.7	-1.0	-1.3	-1.2	-0.7	-0.4	-0.7	-1.0	-0.7	-1.2	-0.6	-0.6	-0.9	-1.1	-1.4	-1.0
Illnesses of father: High blood pressure	0.7	0.8	2.4	0.5	1.4	1.1	0.4	-0.9	1.0	0.4	1.4	1.2	-0.6	0.6	-0.7	-0.3	-0.1	-0.2	0.8	1.6	-1.1
Verbal and Numeric Reasoning (VNR)	0.6	1.5	4.6	-0.2	-0.1	0.5	0.5	1.5	1.3	1.4	1.7	0.8	1.2	1.0	1.9	1.4	2.1	0.9	0.0	0.1	2.1
Fasting Glucose	0.6	0.8	1.9	-0.8	-0.6	-0.9	-1.1	-0.9	-0.2	-1.2	-0.8	-0.5	-1.4	-0.9	-1.0	-1.1	-0.5	-0.5	-0.8	-0.7	-0.9
Neuroticism	0.6	1.4	5.0	1.1	2.2	1.7	1.2	2.1	0.5	1.5	0.3	-0.9	0.1	1.5	0.6	0.7	-1.5	0.8	0.7	0.7	0.1
Hand grip strength (left)	0.6	1.5	4.1	1.7	2.0	1.7	1.6	0.5	0.9	0.3	1.1	1.3	1.1	1.7	0.6	1.3	0.5	1.0	0.9	1.1	0.3
Sensitivity / hurt feelings	0.6	1.0	3.5	1.0	1.2	1.8	0.7	0.8	1.9	0.6	0.7	0.5	0.0	1.4	1.0	0.7	0.0	-0.2	-0.7	1.7	0.3
Medication for hormone replacement therapy	0.6	0.7	2.6	0.5	0.4	0.2	-0.5	-1.0	-0.5	-0.1	-0.7	-0.3	-1.3	-0.1	-1.2	-0.4	-1.0	-0.7	-1.1	-1.6	-1.3
Chronic bronchitis/emphysema (father)	0.6	0.7	2.1	1.4	1.5	1.0	0.7	-0.8	-0.0	-0.6	-0.6	1.1	-0.5	0.5	-0.4	0.3	-0.7	0.5	1.3	0.3	-0.9
Heart attack	0.6	0.8	2.3	-0.9	-1.2	-1.2	-0.9	-0.2	-0.4	0.3	-1.5	-1.1	-0.5	-1.0	-0.4	-0.9	-0.6	-0.6	-0.7	-1.4	-0.2
Frequency of tiredness / lethargy in last 2 weeks	0.6	1.0	6.1	0.2	0.5	-0.1	-0.2	-0.4	-0.8	-1.5	-2.5	-0.7	-1.1	-0.5	-0.9	-0.6	-1.4	-0.3	0.3	-0.9	-1.3
Falls in the last year	0.6	0.9	3.2	-0.6	-0.6	-0.5	-0.9	-0.2	-0.6	-0.1	-0.1	-1.1	-0.8	-0.6	-1.1	-1.1	-1.2	-1.6	-1.8	-0.7	-1.1
Lung cancer (father)	0.6	0.7	1.8	0.3	-0.2	-0.4	-0.6	-0.1	-0.7	-1.0	-1.2	-1.3	-1.3	-0.8	-0.8	-0.7	-1.2	-0.6	-0.5	-0.8	-1.1
Number of children fathered	0.6	0.6	1.8	1.1	0.4	0.3	0.6	-0.3	-0.0	0.6	-0.9	0.4	0.6	0.5	1.2	1.0	0.3	1.4	1.2	-0.1	1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.7	3.6	-1.4	-0.7	-0.6	-0.5	0.1	-0.6	-0.9	-0.6	-1.2	-0.0	-0.2	-0.7	-0.3	-0.2	-0.8	-1.9	-1.0	-0.3
Number of full sisters	0.6	0.7	2.0	0.6	0.1	0.3	0.7	0.4	0.8	1.0	0.6	0.4	1.2	0.6	1.2	1.0	1.4	1.1	0.4	-0.1	1.4
Mood swings	0.6	1.1	4.3	1.1	2.1	1.4	1.2	1.7	0.2	1.2	0.0	-0.9	0.7	1.5	0.3	0.7	-1.1	1.1	0.6	0.1	0.2
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.7	1.6	0.5	0.5	0.6	0.8	1.0	0.9	-0.6	-0.4	0.3	0.9	0.7	1.3	0.9	0.7	1.1	0.7	0.9	1.2
Wears glasses or contact lenses	0.6	0.7	1.5	1.0	1.2	1.2	0.6	1.1	1.1	1.1	0.9	1.2	0.1	1.1	0.3	0.5	-0.0	0.1	0.4	0.7	-0.0
Heart disease (siblings)	0.6	0.7	3.3	-0.1	0.0	0.2	0.2	1.8	1.5	1.5	0.2	0.3	0.4	0.5	0.8	0.3	1.5	0.4	0.1	0.2	0.9
Neuroticism (Nagel 2018)	0.5	1.2	4.1	1.2	2.0	1.5	0.7	1.8	0.2	-0.4	-1.1	-1.4	-0.5	1.0	-0.1	0.2	-2.0	0.0	-0.2	0.3	-0.8
Schizophrenia (2018)	0.5	1.1	9.0	0.0	0.0	-1.1	0.0	0.0	-2.3	0.0	0.0	0.0	0.0	0.0	0.0	-2.0	-3.0	0.0	0.0	0.0	0.0
HDL Cholesterol	0.5	0.9	3.1	0.0	1.6	1.6	0.0	0.0	1.6	0.0	0.0	0.0	0.0	0.0	0.0	1.3	0.9	1.6	0.0	1.8	0.5
Lupus	0.5	0.7	3.6	0.4	-0.6	-0.8	0.3	-0.2	-0.6	0.1	-1.9	-0.8	0.6	-0.6	0.5	0.1	-0.3	1.4	1.3	-1.1	0.8
Rheumatoid Arthritis	0.5	0.6	3.7	0.0	0.0	-1.7	0.0	0.0	-1.9	0.0	0.0	0.0	0.0	0.0	0.0	-1.4	-1.6	0.0	0.0	0.0	0.0
Height	0.5	9.4	17.5	2.3	4.1	3.8	3.8	3.9	2.5	3.8	2.7	0.9	3.6	4.2	2.7	3.1	1.1	2.8	2.2	2.8	2.4
Waist Hip Ratio (WHR)	0.5	2.1	5.8	1.3	0.7	0.7	1.4	1.3	0.8	1.1	0.3	0.3	1.8	1.0	2.4	1.8	1.5	2.2	1.6	1.0	2.4
Severe depression (siblings)	0.5	0.5	3.2	0.3	0.1	-0.4	-0.2	-0.4	-1.2	-0.0	-1.8	-1.1	-0.6	-0.4	-0.4	-0.1	-1.1	0.5	0.6	-0.3	-0.4
Fed-up feelings	0.5	1.0	3.8	0.7	1.9	1.2	1.2	1.9	-0.1	0.6	0.1	-0.9	0.7	1.2	0.2	0.6	-1.2	1.0	1.0	0.2	0.1
Number of incorrect matches in round	0.5	0.8	3.0	-0.7	0.1	-0.5	-0.5	-1.1	-1.4	-1.6	-1.7	-0.3	-0.9	-0.4	-1.0	-0.3	-0.8	-0.3	0.2	-0.8	-1.0
Neuroticism score	0.5	1.0	4.1	0.7	2.0	1.5	0.9	2.0	0.4	0.9	0.2	-1.2	0.1	1.2	0.2	0.3	-1.6	0.4	0.3	0.5	-0.3
Trunk fat-free mass	0.5	2.9	6.5	-1.8	-1.7	-2.0	-2.1	-0.0	-1.9	-1.6	-2.3	-2.5	-1.8	-1.7	-0.8	-1.6	-1.2	-1.0	-1.7	-2.2	-0.4
Hair/balding pattern: Pattern 3	0.5	0.7	1.5	-0.9	-0.7	-0.7	-1.0	-0.1	-0.5	-0.1	0.1	-0.5	-1.1	-0.9	-0.7	-1.2	-1.0	-1.2	-1.2	-0.2	-0.9
Prospective memory result	0.5	0.6	1.8	-0.1	0.3	0.4	0.6	0.8	0.6	-0.3	-0.1	-0.2	1.0	0.7	1.2	1.0	1.0	1.1	0.5	1.1	1.3
Trunk predicted mass	0.5	2.9	6.3	-1.8	-1.7	-2.0	-2.2	0.0	-1.9	-1.6	-2.2	-2.5	-1.8	-1.7	-0.8	-1.6	-1.1	-0.9	-1.7	-2.3	-0.3
Hypothyroidism/myxoedema (self-reported)	0.5	1.0	2.5	-0.7	-1.4	-1.3	-1.1	-0.5	-1.3	-0.9	-1.5	-1.0	-0.5	-0.9	-0.7	-0.7	-0.5	-0.9	-1.6	-1.4	-0.2
Family relationship satisfaction	0.5	0.6	2.5	-0.0	0.4	0.3	-0.0	-1.4	0.8	-1.6	-0.2	1.2	-0.7	-0.1	-1.0	-0.7	-0.3	-0.5	0.2	0.9	-1.3
Friendships satisfaction	0.5	0.6	3.7	-1.9	-0.8	-0.4	-0.5	-0.7	-0.1	-1.3	-0.1	0.5	-0.0	-0.2	-0.2	-0.3	0.5	-1.0	-1.3	-0.2	-0.1
Ever taken oral contraceptive pill	0.5	0.5	2.1	0.7	1.3	0.7	0.9	0.4	0.6	0.5	-0.4	-0.2	0.4	0.9	0.3	0.7	0.2	1.5	0.9	-0.1	0.4
Heart attack/myocardial infarction (self-reported)	0.5	0.6	1.7	-0.9	-1.1	-1.0	-0.8	-0.2	-0.3	0.3	-1.3	-1.1	-0.4	-0.9	-0.3	-0.8	-0.6	-0.6	-0.7	-1.2	-0.2
Depressed Affect (Nagel 2018)	0.4	0.8	2.9	0.8	1.7	1.0	0.5	1.3	-0.3	-0.3	-0.9	-1.6	-0.4	0.8	-0.1	0.3	-1.6	0.4	-0.1	-0.4	-0.4
Depression (Nagel 2018)	0.4	0.5	2.7	0.6	1.1	0.6	0.6	-0.3	-0.4	-1.3	-1.6	-0.3	-0.1	0.4	-0.0	0.5	-0.8	0.8	1.0	-0.3	-0.2
Alzheimer’s Disease (in father)	0.4	0.4	1.3	-0.7	-1.1	-0.8	-1.0	-0.2	-0.2	0.5	0.7	-0.2	-0.6	-0.6	0.1	-0.3	0.6	-0.2	-1.0	-0.8	0.4
Alzheimer’s Disease (including proxy)	0.4	0.6	2.7	1.3	0.6	0.8	0.6	-0.1	0.7	1.3	1.7	0.9	0.5	0.9	0.4	0.7	0.6	0.2	-0.1	0.4	0.4
Age at First Birth	0.4	0.6	1.6	-0.1	0.2	0.4	0.6	0.9	1.1	0.6	0.9	1.1	0.8	0.3	0.9	0.3	1.1	0.6	1.0	1.3	0.7
Schizophrenia (2014)	0.4	0.8	6.1	0.0	0.0	-1.0	0.0	0.0	-2.2	0.0	0.0	0.0	0.0	0.0	0.0	-1.5	-2.5	0.0	0.0	0.0	0.0
Maternal smoking around birth	0.4	0.6	5.1	-0.5	-0.7	-0.9	-0.5	0.6	-0.4	-0.3	-2.2	-0.8	-0.3	-0.6	-0.4	-0.4	-0.2	0.1	0.0	-1.6	-0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.5	2.9	0.6	1.0	0.6	0.9	0.9	0.3	0.2	-0.5	0.1	0.5	0.5	0.5	0.4	-0.3	1.0	1.7	0.9	0.3
Tinnitus: Yes, but not now, but have in the past	0.4	0.5	2.2	-0.3	-0.7	-0.7	-0.4	-1.5	-0.3	0.1	-0.3	-0.3	-0.4	-0.9	-0.6	-0.9	-0.8	-0.5	-0.3	-0.9	-0.6
Supplements: Glucosamine	0.4	0.6	1.9	0.0	0.1	0.5	0.7	1.1	1.1	0.3	0.6	1.3	1.0	0.7	0.6	0.7	1.4	0.2	0.6	0.2	0.6
Hair/balding pattern: Pattern 2	0.4	0.5	2.0	-0.6	-1.3	-1.0	-0.6	0.1	-0.5	-0.6	-0.8	-1.4	0.1	-0.9	-0.2	-0.7	-0.2	-0.6	-0.5	0.1	0.0
Pain all over the body in last month	0.4	0.4	2.6	-0.2	-0.6	-0.7	-0.0	0.6	-0.7	0.4	-1.6	-0.9	0.7	-0.1	0.3	0.2	0.1	0.3	-0.0	-1.0	0.7
Asthma	0.4	0.9	3.6	-0.4	-0.1	-0.6	-0.1	-0.2	-1.6	-1.2	-1.9	-1.2	-0.1	-0.6	-1.1	-0.5	-1.1	-0.5	0.0	-1.3	-1.1
Tense / ‘highly strung’	0.4	0.7	3.3	0.9	1.5	1.1	0.8	0.6	-0.4	-0.4	-0.6	-0.8	-0.1	0.5	-0.5	0.0	-1.8	0.0	0.7	0.7	-1.0
Chronic bronchitis/emphysema (mother)	0.4	0.5	3.6	0.3	-0.2	-0.5	-0.2	-0.7	-0.5	-0.8	-1.9	-0.2	-0.5	-0.6	0.2	0.3	0.3	0.8	0.8	-0.9	0.2
Comparative body size at age 10	0.4	1.0	2.3	1.0	0.7	0.8	0.7	1.2	0.9	1.1	0.4	0.7	0.5	0.7	1.5	1.0	0.8	1.5	1.2	0.6	1.4
Worry too long after embarrassment	0.4	0.7	4.0	1.0	2.0	1.6	1.0	0.5	0.4	0.0	-0.2	-0.1	-0.2	1.1	-0.2	0.4	-1.3	0.1	0.3	0.1	-0.8
Eye problems/disorders: None of the above	0.4	0.5	2.4	-0.4	-1.3	-0.8	-0.4	0.2	0.2	0.4	0.2	0.3	0.3	-0.7	0.9	0.2	1.5	0.4	0.2	-0.3	1.1
Commuting to job workplace: Car/motor vehicle	0.4	0.5	1.3	0.4	0.6	0.6	0.8	0.7	0.3	1.0	0.3	-0.3	1.1	1.0	0.6	1.0	0.7	0.8	-0.1	-0.4	0.9
Knee pain experienced in last month	0.4	0.6	1.5	0.2	-1.2	-1.1	-0.7	-0.6	-0.7	-1.1	-0.9	-0.6	-0.6	-1.2	-0.9	-0.8	-0.5	-0.7	0.0	-0.6	-0.8
Loneliness, isolation	0.4	0.5	1.5	0.2	1.2	1.0	1.1	0.7	1.2	0.1	-0.3	-0.2	0.9	1.0	0.6	0.3	-0.0	0.5	0.5	0.8	0.3
Asthma (self-reported)	0.4	0.8	3.3	-0.5	-0.0	-0.5	0.0	-0.1	-1.5	-1.2	-1.8	-1.2	0.1	-0.5	-1.1	-0.5	-1.0	-0.4	0.2	-1.2	-1.0
Ever smoked	0.4	0.7	3.2	0.0	-0.7	-0.4	-0.9	-1.8	-0.1	0.1	-0.7	0.2	-1.3	-0.7	-0.5	-0.6	-0.4	-1.2	-0.9	-0.9	-0.8
Risk taking	0.4	0.6	1.5	0.9	0.5	0.5	0.8	1.2	0.3	0.5	0.4	0.7	0.9	0.8	0.4	1.2	1.1	1.0	1.2	-0.3	0.6
Ever had prostate specific antigen (PSA) test	0.4	0.4	1.2	-0.8	-1.1	-1.0	-0.7	-0.2	-0.7	0.4	-0.9	-0.7	-0.0	-0.5	0.1	-0.4	-0.1	-0.3	-0.8	-0.9	0.5
Myopia	0.4	0.5	1.5	-0.4	0.2	0.5	0.6	0.5	0.2	0.9	1.1	1.0	1.2	0.8	0.8	0.9	1.1	0.2	-0.1	0.1	0.9
Supplements: Calcium	0.4	0.5	1.7	-0.6	-0.4	0.1	0.1	-0.5	1.2	0.6	1.0	1.3	0.3	0.0	0.6	0.1	1.3	0.2	0.4	0.8	0.6
Smoking Status	0.3	0.6	1.3	0.9	0.9	0.8	1.0	0.2	1.0	0.5	-0.4	1.1	0.9	1.1	0.6	0.9	0.8	0.8	0.9	0.5	0.5
Respiratory disease	0.3	0.6	2.7	-0.4	-0.0	-0.4	-0.0	-0.5	-1.3	-1.4	-1.6	-0.8	0.1	-0.2	-0.7	-0.1	-0.6	-0.4	-0.2	-1.4	-0.6
Bilateral oophorectomy (both ovaries removed)	0.3	0.4	1.7	0.2	0.1	0.0	0.6	1.3	-0.4	1.1	-0.5	-0.7	1.0	0.2	0.3	0.4	-0.2	0.2	0.4	-0.7	0.4
Sitting height	0.3	2.4	5.1	0.6	1.1	1.1	1.4	2.1	1.3	2.2	1.3	0.8	1.9	1.7	1.9	1.7	2.0	1.6	1.1	0.3	2.1
Ever unenthusiastic/disinterested for a whole week	0.3	0.3	1.1	0.9	1.0	0.8	0.5	0.8	-0.1	0.1	-0.7	0.3	0.1	0.7	-0.1	0.3	-0.9	0.1	0.1	-0.4	-0.2
Hayfever/allergic rhinitis (self-reported)	0.3	0.3	2.4	-0.2	-0.7	-0.6	-0.5	0.2	-0.3	-1.5	-0.6	-0.8	-0.3	-0.7	0.5	-0.1	0.1	0.4	-0.3	-0.2	0.6
Worrier / anxious feelings	0.3	0.5	2.9	-0.1	0.9	0.7	-0.0	-0.0	-0.2	0.2	-0.2	-0.6	-0.7	0.5	-0.8	-0.5	-1.7	-1.0	-0.6	0.0	-1.1
Pulse wave Arterial Stiffness index	0.3	0.3	0.8	-0.4	-0.7	-0.5	-0.7	0.0	0.1	0.0	0.5	0.3	-0.6	-0.6	-0.8	-0.9	-0.1	-0.9	-0.5	0.1	-0.7
Exposure to tobacco smoke at home	0.3	0.3	1.1	-1.0	-0.4	-0.5	-0.6	-0.9	-0.5	0.1	0.2	-0.5	-0.5	-0.4	-0.7	-0.6	-0.6	-0.5	-0.3	-0.2	-0.5
Peak expiratory flow (PEF)	0.3	0.6	1.9	0.4	0.6	0.3	0.5	1.2	0.0	0.9	0.1	-1.4	0.9	0.8	0.8	0.6	0.0	0.9	-0.5	-1.2	1.2
Loud music exposure frequency	0.3	0.3	1.4	-0.2	0.1	-0.2	-0.1	-0.4	-0.5	-0.1	-0.1	-0.4	-0.4	-0.7	-1.0	-0.8	-0.9	-0.3	0.1	-0.6	-1.2
Medication: Ventolin 100micrograms inhaler	0.3	0.4	1.2	0.9	0.9	0.9	0.8	-0.1	0.2	0.1	0.1	1.1	0.5	0.6	0.3	0.7	0.1	0.3	1.1	0.6	0.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.3	1.4	0.0	0.3	-0.2	-0.1	0.4	-0.8	0.4	-0.9	-1.2	-0.4	-0.3	-0.5	-0.4	-1.2	0.1	0.3	-0.8	-0.4
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.4	1.7	-0.6	-0.5	-0.4	-0.3	-1.3	-0.6	0.1	-1.0	-0.8	-0.0	-0.5	-0.1	-0.3	-0.7	-0.3	-0.1	-1.2	-0.1
Pulse wave peak to peak time	0.3	0.3	0.8	0.4	0.9	0.7	0.8	0.2	0.1	0.0	-0.3	-0.4	0.6	0.7	0.8	0.9	0.0	0.8	0.3	0.0	0.7
Qualifications: College or University degree	0.3	1.1	4.2	-1.9	-2.0	-1.2	-1.0	-0.3	-0.1	0.1	1.4	0.6	0.4	-0.9	1.0	-0.2	1.6	-0.3	-0.4	0.2	1.5
Suffer from ‘nerves’	0.3	0.5	1.7	0.5	1.2	0.9	0.4	1.2	0.4	0.1	-0.3	-0.6	-0.5	0.4	0.1	-0.2	-1.3	0.2	0.8	0.9	-0.5
Leg pain on walking	0.3	0.4	0.9	0.1	-0.5	-0.6	-0.4	-0.5	-1.0	-0.6	-1.0	-0.4	-0.5	-0.8	-0.5	-0.4	-0.8	-0.2	0.4	-0.8	-0.5
Supplements: Vitamin C	0.3	0.3	1.4	0.0	0.0	-0.3	0.1	0.2	-0.7	-0.6	-0.8	-1.1	0.0	-0.5	-0.6	-0.7	-1.2	-0.2	0.4	-0.1	-0.7
Qualifications: nursing, teaching	0.3	0.4	2.0	-0.0	-0.3	0.1	0.2	0.6	0.6	0.2	1.4	0.7	0.9	0.4	0.6	0.5	1.3	0.1	-0.1	0.7	0.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.3	1.2	-0.9	-1.0	-0.5	-0.5	-0.6	0.7	-0.0	-0.3	-0.0	-0.1	-0.3	0.2	-0.2	0.7	-0.5	-1.1	-0.6	0.3
Illnesses of father: None of the above (group 1)	0.3	0.4	1.6	-0.9	-1.3	-0.9	-0.2	0.8	-0.7	0.2	0.2	-0.7	0.9	-0.6	0.3	0.1	0.5	-0.2	-0.3	-0.5	0.7
Smoking status: Current	0.3	0.4	2.2	0.9	0.7	0.3	0.5	-1.5	-0.2	-0.3	-0.9	1.0	0.1	0.4	-0.4	0.2	-0.4	0.3	1.1	0.1	-0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.7	2.4	0.3	0.5	-0.0	-0.4	-0.7	-0.5	-0.6	-0.9	-0.5	-1.3	-0.3	-1.2	-0.9	-1.6	-0.4	-0.2	-0.8	-1.4
Miserableness	0.3	0.6	2.8	0.3	0.8	0.2	0.3	1.3	-1.0	0.4	-0.3	-1.6	0.0	0.1	-0.5	-0.3	-1.7	0.1	0.1	-0.5	-0.5
Tinnitus: Yes, now most or all of the time	0.3	0.3	1.7	0.7	0.9	0.6	0.3	-0.1	0.1	0.0	-1.3	-0.0	-0.5	0.3	-0.5	-0.2	-1.1	-0.2	0.2	-0.5	-0.9
Commuting to job workplace: Public transport	0.3	0.4	2.5	-0.4	-0.0	-0.1	-0.6	-1.6	-0.4	-0.3	0.5	0.3	-1.1	-0.6	-0.5	-0.7	-0.6	-0.6	0.2	0.0	-0.8
Irritability	0.3	0.6	3.8	0.8	1.0	0.9	0.5	1.9	0.6	0.9	0.7	-0.2	-0.0	0.9	0.4	0.6	-0.3	0.3	-0.5	-0.0	0.2
Bipolar Disorder or Schizophrenia	0.2	0.4	3.2	0.0	0.0	-0.7	0.0	0.0	-1.4	0.0	0.0	0.0	0.0	0.0	0.0	-1.1	-1.8	0.0	0.0	0.0	0.0
Major Depression (MDD)	0.2	0.3	1.9	0.0	0.4	-0.2	-0.2	0.0	-1.3	0.0	0.0	0.0	0.0	-0.2	-0.8	-0.1	-1.4	0.1	0.0	0.0	-0.8
Blood Eosinophil Count	0.2	1.9	5.5	0.7	-0.1	0.7	1.2	1.9	0.9	1.2	1.0	0.3	2.1	1.0	2.3	1.8	1.6	1.1	0.6	0.7	2.4
Average weekly spirits intake	0.2	0.2	1.0	0.6	0.2	0.0	0.4	-0.7	0.2	0.1	-0.2	0.3	0.4	0.1	0.3	0.3	0.2	0.8	1.0	-0.2	0.4
Frequency of depressed mood in last 2 weeks	0.2	0.3	1.4	0.3	0.6	0.1	0.3	0.0	-0.2	0.3	-0.9	-0.6	-0.0	0.1	0.0	0.2	-0.7	0.8	1.2	-0.4	0.0
Medication: Co-codamol	0.2	0.2	1.3	1.1	0.5	0.4	0.4	-0.8	0.3	-0.0	-1.0	0.1	0.1	0.3	0.2	0.3	-0.3	0.3	0.5	-0.3	0.0
Current tobacco smoking	0.2	0.4	1.9	0.9	0.5	0.1	0.2	-1.4	-0.3	-0.1	-1.0	0.9	-0.0	0.2	-0.5	0.0	-0.5	0.2	0.9	-0.2	-0.5
Forced vital capacity (FVC)	0.2	0.9	2.4	0.8	1.2	0.9	0.9	1.6	0.5	1.4	0.7	-0.6	0.9	1.3	1.0	1.1	0.4	1.2	0.4	-0.0	1.1
Financial difficulties in last 2 years	0.2	0.2	1.1	0.8	0.2	0.0	0.4	-1.0	-0.4	-0.0	-0.3	0.5	0.3	-0.1	-0.4	-0.1	-0.8	0.0	0.9	0.4	-0.4
Pulse rate	0.2	0.4	1.8	-0.7	0.0	-0.5	-0.1	0.1	-1.4	-0.2	-0.6	-1.3	0.1	-0.1	-0.7	0.1	-0.6	0.2	-0.0	-1.4	-0.3
Length of working week for main job	0.2	0.2	0.8	0.9	0.8	0.7	0.2	0.6	0.4	0.3	0.5	0.0	-0.4	0.3	-0.3	0.2	-0.3	-0.0	-0.3	-0.2	-0.6
Breastfed as a baby	0.2	0.2	0.8	-0.5	-0.3	-0.2	-0.2	-0.6	0.2	0.2	0.4	0.3	-0.0	-0.0	-0.8	-0.3	0.3	-0.9	-0.8	-0.4	-0.7
Pulse wave reflection index	0.2	0.2	0.8	-0.6	-0.9	-0.6	-0.5	0.4	0.3	0.5	0.9	-0.0	-0.0	-0.5	0.1	-0.6	0.6	-0.2	-0.4	0.3	0.3
Number of full brothers	0.2	0.2	0.7	0.6	-0.3	-0.5	-0.1	0.7	-0.3	0.4	-0.8	-0.1	0.0	-0.4	0.1	0.2	0.7	0.5	0.8	-0.5	0.2
Mouth/teeth dental problems: Loose teeth	0.2	0.2	0.9	-0.1	-0.3	-0.4	-0.7	0.1	-0.3	0.0	0.1	-0.9	-0.9	-0.6	-0.5	-0.6	-0.2	-0.0	-0.6	-0.1	-0.4
Neck or shoulder pain in last month	0.2	0.3	1.2	0.2	-0.1	-0.3	0.1	0.6	-0.4	-0.1	-0.5	-1.1	0.1	-0.3	0.4	0.2	-0.1	0.8	0.4	-1.0	0.5
Medication: Ibuprofen	0.2	0.3	1.6	0.3	-0.2	-0.2	-0.3	0.3	-0.6	0.4	-0.3	-1.3	-0.3	-0.2	0.3	0.1	-0.6	0.3	-0.2	-1.2	0.4
Medication: Allopurinol	0.2	0.3	0.9	0.8	0.6	0.4	0.7	0.1	0.4	0.1	-0.3	0.5	0.5	0.5	0.4	0.6	0.2	0.8	0.9	-0.3	0.4
Had major operations	0.2	0.2	1.1	-0.4	-0.3	-0.2	-0.3	-0.5	-0.3	-1.0	-0.9	0.6	-0.4	-0.3	-0.3	-0.0	0.3	-0.5	-0.1	0.2	-0.4
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	2.0	0.5	0.3	0.4	0.2	0.0	0.0	1.4	1.4	0.2	0.1	0.3	0.3	0.4	-0.0	0.3	0.4	0.3	0.2
Blood White Count	0.1	0.9	3.2	-1.3	-1.8	-1.7	-1.0	-0.8	-1.0	0.1	-1.6	-0.7	-0.0	-1.2	-0.0	-0.6	0.1	0.0	0.1	-1.1	0.6
Hair Pigment	0.1	2.5	8.6	2.4	2.9	2.7	2.1	0.2	0.9	0.9	0.6	0.8	1.1	2.7	0.5	2.2	0.2	0.7	0.9	1.2	-0.0
Hearing difficulty/problems: Yes	0.1	0.1	0.9	-0.1	-0.1	-0.2	-0.3	-0.2	-0.5	-0.5	-0.9	0.2	-0.4	-0.1	-0.4	0.0	0.3	-0.1	-0.1	-0.4	-0.3
Vitamin and mineral supplements	0.1	0.1	0.6	0.1	0.0	0.2	0.0	-0.2	-0.4	-0.2	0.8	0.0	0.1	0.2	-0.5	0.1	-0.1	-0.5	-0.7	0.5	-0.5
Hand grip strength (right)	0.1	0.3	1.3	1.0	1.1	0.9	0.7	0.0	0.2	-0.3	0.0	0.1	0.2	0.9	0.1	0.6	0.1	0.5	-0.0	0.2	-0.0
Past tobacco smoking	0.1	0.2	0.7	0.0	0.3	0.1	0.4	0.4	0.1	-0.3	0.5	0.2	0.7	0.2	0.5	0.2	0.5	0.8	0.6	0.8	0.6
Hearing difficulty/problems with background noise	0.1	0.2	0.5	-0.5	0.0	-0.0	-0.4	-0.5	-0.3	-0.1	-0.0	0.2	-0.6	0.0	-0.7	-0.2	0.0	-0.7	-0.6	0.1	-0.7
Forced expiratory volume in 1-second (FEV1)	0.1	0.2	1.1	0.2	0.3	0.1	0.0	0.9	0.1	0.5	-0.0	-1.1	0.1	0.3	0.4	0.1	-0.2	0.5	-0.4	-0.6	0.6
Hair/balding pattern: Pattern 4	0.1	0.2	1.1	-0.1	0.3	0.1	0.2	-0.8	-0.4	-0.3	-0.3	-0.5	0.5	0.5	-0.2	0.3	-0.0	-0.1	-0.4	-1.1	0.1
Gout (self-reported)	0.1	0.1	0.5	-0.2	-0.2	-0.1	-0.0	0.1	0.5	-0.2	0.5	0.7	0.0	-0.0	0.3	0.1	0.7	0.1	0.4	-0.0	0.3
Forced vital capacity (FVC), Best measure	0.1	0.4	0.8	0.8	0.9	0.7	0.4	0.8	0.3	0.7	0.6	-0.3	0.2	0.8	0.5	0.7	0.3	0.8	0.3	-0.0	0.6
Illnesses of father: Heart disease	0.1	0.2	1.0	-0.1	-0.1	-0.4	-0.2	0.4	-0.3	1.0	-0.4	-0.2	0.2	0.1	0.2	-0.0	0.0	0.6	0.2	-0.3	0.7
Smoking status: Previous	0.1	0.1	0.5	0.1	-0.3	0.1	0.0	0.7	0.5	0.7	0.2	0.1	0.2	0.2	0.2	0.3	0.4	-0.3	-0.4	-0.0	0.2
Ever had bowel cancer screening	0.1	0.1	1.1	-0.2	-0.3	-0.1	-0.1	-1.1	-0.1	-0.5	-0.4	-0.1	0.0	-0.2	0.1	-0.1	-0.2	-0.4	-0.8	-0.3	-0.0
Eye problems/disorders: Cataract	0.1	0.1	0.5	-0.0	0.3	0.1	-0.0	0.7	-0.1	0.7	0.4	-0.5	0.0	0.4	0.3	0.1	-0.2	0.3	-0.0	-0.2	0.5
Pain type(s) experienced in last month: Hip pain	0.1	0.2	0.6	0.8	0.7	0.6	0.3	0.3	0.3	-0.0	-0.3	-0.3	-0.1	0.6	-0.1	0.2	-0.1	-0.2	-0.5	0.2	-0.3
Bipolar Disorder (2018)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Schizophrenia vs Biploar Disorder	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Crohns Disease (2012)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
LDL Cholesterol	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Triglycerides	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Ulcerative Colitis	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Blood Platelet Count	0.0	0.4	2.2	-0.5	-0.5	-0.7	-0.4	-1.5	-0.9	-0.5	-0.3	0.1	-0.5	-0.8	-0.7	-0.4	-0.6	0.0	0.8	0.1	-0.6
Tanning	0.0	0.4	2.8	0.7	-0.8	-0.6	0.0	1.7	0.7	0.5	0.1	0.3	0.4	-0.5	0.5	-0.1	0.9	0.7	0.4	-0.2	0.7
Forced expiratory volume in 1-second (FEV1), Best measure	0.0	0.1	0.3	0.4	0.3	0.1	-0.2	0.3	-0.2	-0.0	-0.0	-0.6	-0.5	0.0	-0.1	-0.1	-0.4	0.2	-0.2	-0.5	-0.0

Hub : Genes

PMS2P5

Models

Trait associations