TWAS
hub
About
Usage
Models
Genes
Traits
[Hub]/) :
Traits
:
Alcohol intake frequency.
:
←
→
chr12:53,926,889-55,370,164
Best TWAS P=3.27e-15 · Best GWAS P=1.07e-16 conditioned to 0.00784
54M
54.2M
54.4M
54.6M
54.8M
55M
55.2M
55.4M
0
5
10
15
physical position
-log10 P
Conditional
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
4
The Cancer Genome Atlas
Rectum Adenocarcinoma
CBX5
0.16
0.10
lasso
4
0.11
1.5e-03
-8.3
-7.9
3.3e-15
0.92
0.01
0.71
TRUE
1
YFS
Blood
CBX5
0.02
0.01
lasso
3
0.02
2.0e-07
-8.3
-7.1
1.0e-12
0.82
0.01
0.99
FALSE
2
The Cancer Genome Atlas
Brain Lower Grade Glioma
SMUG1
0.08
0.05
enet
13
0.06
3.8e-07
3.5
5.8
7.2e-09
-0.54
0.67
0.13
FALSE
5
The Cancer Genome Atlas
Skin Cutaneous Melanoma
SMUG1
0.28
0.12
enet
15
0.18
1.9e-05
-2.8
5.4
6.2e-08
-0.42
0.07
0.46
FALSE
3
The Cancer Genome Atlas
Pancreatic Adenocarcinoma
SMUG1
0.18
0.02
blup
42
0.06
2.1e-03
3.7
5.4
7.7e-08
-0.46
0.02
0.75
FALSE