TWAS hub - CBX5

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	YFS	Blood	0.0191	0.0071	0.00056	0.013	0.007	0.018	0.012	0.020	2.1e-05	0.0017	1.4e-06	6.6e-05	2.0e-07
2	TCGA	Rectum Adenocarcinoma	0.1610	0.0950	0.00900	0.096	0.101	0.072	NA	0.111	3.0e-03	0.0023	9.1e-03	NA	1.5e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Alcohol intake frequency.	24.3	56.4	62.1	-7.1	-7.9
Blood Platelet Count	23.0	266.8	320.4	14.6	17.9
Average weekly champagne plus white wine intake	17.4	23.9	25.2	4.8	5.0
Alcohol intake versus 10 years previously	16.8	25.2	25.3	-5.0	-5.0
Exposure to tobacco smoke at home	10.4	11.7	14.1	-3.0	-3.8
Hair/balding pattern: Pattern 4	9.8	23.7	25.5	4.7	5.1
Qualifications: nursing, teaching	9.8	15.3	16.9	3.7	4.1
Chronotype (morning person)	8.5	19.7	20.4	-4.5	-4.4
Mouth/teeth dental problems: Dentures	8.3	14.0	17.8	-4.2	-3.2
Townsend deprivation index at recruitment	7.8	10.9	12.3	-3.5	-3.1
Mouth/teeth dental problems	7.6	11.6	13.5	3.7	3.1
Qualifications: College or University degree	7.5	23.5	25.4	4.7	5.0
Commuting to job workplace: Walk	7.5	8.1	8.3	-2.9	-2.8
BMI	7.3	42.4	43.3	-6.5	-6.6
Birth weight of first child	7.3	13.2	15.5	-3.3	-3.9
Hair/balding pattern: Pattern 2	7.0	8.9	9.3	-3.1	-2.9
Qualifications: NVQ or HND or HNC or equivalent	7.0	8.5	11.1	-2.4	-3.3
Impedance of arm (left)	6.7	31.1	34.2	5.9	5.3
Alcohol drinker status: Previous	6.7	7.6	9.6	-2.4	-3.1
Impedance of arm (right)	6.2	28.8	34.1	5.8	4.8
Age at First Birth	6.1	8.9	12.6	3.6	2.3
Fluid intelligence score	6.1	12.7	12.7	3.6	3.6
Qualifications: A levels/AS levels or equivalent	5.8	12.7	16.2	3.0	4.0
Average weekly red wine intake	5.8	8.5	9.3	2.8	3.0
Impedance of whole body	5.8	29.5	31.1	5.6	5.3
Arm fat-free mass (right)	5.3	27.4	29.7	-5.0	-5.5
Arm fat-free mass (left)	5.2	26.2	30.1	-4.7	-5.5
Number of full brothers	5.1	6.4	7.6	-2.8	-2.3
Medication: Paracetamol	5.1	7.9	9.2	-2.6	-3.0
Coronary Artery Disease (CAD)	5.0	6.0	9.1	-1.7	-3.0
Body mass index (BMI)	5.0	21.5	22.3	-4.5	-4.7
Ever highly irritable/argumentative for 2 days	5.0	6.0	8.1	-2.0	-2.8
Age at first live birth	5.0	8.9	10.7	3.3	2.7
Arm predicted mass (left)	5.0	25.3	29.0	-4.6	-5.4
Pain type(s) experienced in last month: Hip pain	4.9	6.2	6.5	-2.5	-2.4
Arm predicted mass (right)	4.7	24.1	27.3	-4.6	-5.2
Tinnitus: Yes, now most or all of the time	4.7	5.4	6.2	-2.5	-2.2
Maternal smoking around birth	4.5	6.5	10.5	-1.6	-3.2
Qualifications: None of the above	4.4	9.5	11.0	-3.3	-2.8
Had major operations	4.4	5.1	6.3	-2.5	-2.0
Waist circumference	4.3	15.6	19.0	-3.5	-4.4
Exposure to tobacco smoke outside home	4.1	5.4	5.5	-2.4	-2.3
Number of children fathered	4.1	4.6	5.2	-2.3	-2.0
Leg fat mass (right)	4.1	15.8	17.8	-3.7	-4.2
Leg fat mass (left)	4.1	15.9	18.1	-3.7	-4.3
Alcohol usually taken with meals	4.0	6.5	7.0	2.5	2.6
Weight	4.0	19.7	24.1	-3.9	-4.9
Neuroticism (2016)	3.9	5.6	7.8	-1.9	-2.8
Impedance of leg (right)	3.9	19.0	20.0	4.2	4.5
Long-standing illness, disability or infirmity	3.9	6.0	6.2	-2.4	-2.5
Headache pain in last month	3.8	6.5	11.4	-1.2	-3.4
Whole body fat-free mass	3.8	21.9	26.4	-4.2	-5.1
Whole body water mass	3.8	21.5	26.0	-4.1	-5.1
Supplements: Fish oil (including cod liver oil)	3.8	4.9	6.6	-2.6	-1.8
Basal metabolic rate	3.8	21.2	25.9	-4.1	-5.1
Number of incorrect matches in round	3.6	6.0	6.4	-2.5	-2.4
Medication: Paracetamol	3.6	5.9	7.6	-2.1	-2.8
Leg predicted mass (right)	3.6	19.1	24.8	-3.7	-5.0
Smoking Status	3.5	8.4	9.8	-2.6	-3.1
Leg fat-free mass (left)	3.5	18.5	23.1	-3.7	-4.8
Noisy workplace	3.5	4.3	4.9	-2.2	-1.9
Leg fat-free mass (right)	3.5	18.8	24.3	-3.6	-4.9
Hand grip strength (left)	3.4	8.9	9.6	-2.8	-3.1
Leg predicted mass (left)	3.4	18.1	22.6	-3.7	-4.8
Leg pain on walking	3.4	4.3	5.9	-1.6	-2.4
Medication for hormone replacement therapy	3.3	3.7	4.8	1.6	2.2
Impedance of leg (left)	3.3	16.0	16.6	4.1	3.9
Hip circumference	3.3	14.1	17.0	-3.4	-4.1
Stomach or abdominal pain in last month	3.2	4.0	4.0	-2.0	-2.0
Trunk fat-free mass	3.2	18.2	21.3	-3.9	-4.6
Arm fat mass (right)	3.2	13.3	15.3	-3.4	-3.9
Trunk predicted mass	3.2	18.2	21.3	-3.9	-4.6
Heart disease (mother)	3.2	3.9	6.7	-1.0	-2.6
Leg fat percentage (left)	3.2	11.7	13.3	-3.2	-3.6
Arm fat mass (left)	3.1	12.7	14.6	-3.3	-3.8
Body Mass Index (BMI) (2010)	3.0	4.1	5.0	-1.8	-2.2
Relative age of first facial hair	3.0	6.2	7.9	-2.1	-2.8
Frequency of unenthusiasm / disinterest in last 2 weeks	3.0	4.0	4.9	-2.2	-1.8
Happiness	3.0	3.6	4.6	2.1	1.6
Verbal and Numeric Reasoning (VNR)	2.9	6.9	7.2	2.6	2.7
HDL Cholesterol	2.9	4.8	7.7	2.8	1.4
Qualifications: CSEs or equivalent	2.9	3.9	4.6	-1.8	-2.1
Whole body fat mass	2.9	12.2	14.2	-3.2	-3.8
Number of self-reported non-cancer illnesses	2.9	5.1	7.2	-2.7	-1.7
Lung FEV1/FVC ratio	2.7	13.6	16.9	-4.1	-3.2
Leg fat percentage (right)	2.6	9.6	10.2	-3.0	-3.2
Friendships satisfaction	2.6	3.3	4.5	2.1	1.4
Smoking status: Current	2.6	4.2	4.8	-2.2	-1.9
Trunk fat mass	2.4	10.4	12.1	-2.9	-3.5
Illnesses of mother	2.4	3.0	3.2	1.7	1.8
Alzheimer’s Disease (in mother)	2.2	2.6	3.8	1.1	1.9
Fed-up feelings	2.2	4.0	5.7	-1.5	-2.4
Arm fat percentage (right)	2.2	8.6	10.4	-2.6	-3.2
Loneliness, isolation	2.2	3.0	4.5	-1.2	-2.1
Ever smoked	2.2	3.8	4.2	-2.0	-1.8
Ever had hysterectomy (womb removed)	2.1	2.4	2.7	-1.4	-1.6
Current tobacco smoking	2.1	3.4	4.0	-2.0	-1.7
High blood pressure (mother)	2.1	3.0	4.5	-2.1	-1.2
Age started oral contraceptive pill	2.1	2.7	3.0	1.6	1.7
Bipolar Disorder (2018)	2.0	3.1	4.4	-1.4	-2.1
Illness, injury, bereavement, stress in last 2 years	2.0	2.4	3.4	1.2	1.9
Arm fat percentage (left)	2.0	8.1	9.2	-2.6	-3.0
Commuting to job workplace: Cycle	2.0	2.5	3.8	1.9	1.1
Intelligence (Savage-Jansen 2018)	1.9	5.8	6.3	2.3	2.5
Depressed Affect (Nagel 2018)	1.8	3.7	4.8	-1.6	-2.2
Neuroticism	1.8	4.3	6.2	-1.6	-2.5
Emphysema/chronic bronchitis	1.8	2.1	3.4	-1.8	-0.9
Overall health rating	1.8	4.0	5.5	-1.6	-2.3
Commuting to job workplace: Car/motor vehicle	1.8	2.1	3.0	1.7	1.1
Number of operations (self-reported)	1.8	2.7	4.0	-2.0	-1.2
Type 2 Diabetes (T2D) (2012)	1.7	2.0	3.5	-1.9	-0.7
Past tobacco smoking	1.7	3.1	3.4	1.7	1.8
Frequency of tiredness / lethargy in last 2 weeks	1.7	2.8	3.8	-1.3	-1.9
Body fat percentage	1.7	6.7	7.8	-2.4	-2.8
Mood swings	1.7	3.1	5.2	-1.1	-2.3
Relative age voice broke	1.6	2.4	2.8	-1.7	-1.4
Seen a psychiatrist for nerves, anxiety, tension or depression	1.6	2.1	3.6	-0.8	-1.9
Age at last live birth	1.6	2.3	2.6	1.6	1.4
Fractured/broken bones in last 5 years	1.6	2.0	2.4	-1.5	-1.3
Crohns Disease (2012)	1.5	2.5	3.0	-1.4	-1.7
Medication: Blood pressure	1.5	2.6	4.2	-2.0	-1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.5	1.8	2.9	1.7	0.8
Pain experienced in last month	1.5	2.5	3.0	1.4	1.7
Hand grip strength (right)	1.4	3.8	4.6	-1.8	-2.1
Length of working week for main job	1.4	1.5	2.5	-0.7	-1.6
Alzheimer’s Disease (in father)	1.3	1.4	2.5	1.6	0.6
Reason for reducing amount of alcohol drunk: Health precaution	1.3	1.6	2.4	1.5	0.9
Eye problems/disorders: Cataract	1.3	1.5	2.5	0.8	1.6
Medication for cholesterol	1.3	1.9	3.7	0.4	-1.9
Guilty feelings	1.3	1.9	2.2	-1.5	-1.3
Ever taken oral contraceptive pill	1.3	1.5	2.1	1.4	0.9
High cholesterol (Self-reported)	1.3	2.2	4.3	-0.4	2.1
Myopia	1.3	1.9	3.3	-1.8	-0.6
Trunk fat percentage	1.2	4.7	5.5	-2.0	-2.4
Nervous feelings	1.2	2.3	2.5	-1.5	-1.6
Heel bone mineral density (BMD) T-score, automated (right)	1.2	2.8	3.5	1.9	1.5
Prospective memory result	1.2	1.5	1.7	-1.1	-1.3
High blood pressure (siblings)	1.2	1.7	2.0	1.2	1.4
Neck or shoulder pain in last month	1.2	1.7	2.9	1.7	0.7
Vascular/heart problems diagnosed by doctor	1.2	3.4	6.1	2.5	0.8
Pack years of smoking	1.2	1.7	2.5	-1.6	-1.0
Crohns Disease (2017)	1.1	2.4	3.8	-2.0	-1.0
Irritable Bowel Disease (IBD)	1.1	2.6	3.5	-1.9	-1.3
Blood Eosinophil Count	1.1	8.8	11.4	2.5	3.4
Cardiovascular Disease	1.1	3.6	7.1	-2.7	-0.3
Pack years adult smoking proportion	1.1	1.6	2.5	-1.6	-0.9
Financial difficulties in last 2 years	1.1	1.5	1.6	-1.2	-1.3
Medication: Ramipril	1.1	1.4	2.8	-1.7	-0.3
Pulse rate, automated reading	1.1	3.5	3.5	-1.9	-1.9
Medication: Lisinopril	1.1	1.4	2.1	-1.4	-0.9
Ovarian Cancer	1.0	1.3	2.5	-0.1	-1.6
Blood Red Count	1.0	9.4	14.6	2.0	3.8
Other serious medical condition/disability diagnosed by doctor	1.0	1.3	1.6	-1.0	-1.3
Taking other prescription medications	1.0	1.5	1.8	1.1	1.4
Tinnitus: Yes, but not now, but have in the past	1.0	1.0	1.1	-1.0	-1.0
Frequency of tenseness / restlessness in last 2 weeks	1.0	1.6	2.3	-0.9	-1.5
Neuroticism score	1.0	2.1	3.7	-0.7	-1.9
Glaucoma (self-reported)	1.0	1.1	1.5	-0.9	-1.2
Supplements: Vitamin C	1.0	1.2	1.2	-1.1	-1.1
Mother’s age at death	1.0	1.2	2.0	0.7	1.4
Illnesses of father: High blood pressure	1.0	1.2	1.6	-0.9	1.3
Birth weight	0.9	1.9	2.9	-1.0	-1.7
Chronic bronchitis/emphysema (mother)	0.9	1.0	1.1	-1.0	-1.0
Smoking status: Previous	0.9	1.3	1.8	-0.9	-1.3
Heart attack/myocardial infarction (self-reported)	0.9	1.1	1.6	-0.8	-1.3
Neuroticism (Nagel 2018)	0.8	1.8	2.2	-1.2	-1.5
Fasting Glucose	0.8	0.9	1.1	-1.1	-0.9
Heel T-Score	0.8	6.2	7.5	2.2	2.7
Waist Hip Ratio (WHR)	0.8	3.5	5.1	2.3	1.4
Bilateral oophorectomy (both ovaries removed)	0.8	0.9	1.0	-0.9	-1.0
High blood pressure	0.8	2.3	4.7	-2.2	-0.1
Forced vital capacity (FVC)	0.8	2.9	5.8	2.4	0.2
Number of live births	0.8	1.1	1.3	-1.0	-1.1
Worry too long after embarrassment	0.8	1.4	2.7	1.6	-0.3
Medication for pain relief, constipation, heartburn	0.8	1.3	1.4	1.2	1.1
Family relationship satisfaction	0.8	0.9	1.3	1.1	0.7
Hypertension (Self-reported)	0.8	2.2	4.4	-2.1	-0.1
Mouth/teeth dental problems: Mouth ulcers	0.8	1.2	1.8	-0.8	-1.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.8	1.0	1.6	-1.3	-0.5
Bipolar Disorder or Schizophrenia	0.7	1.8	2.6	-1.0	-1.6
Ulcerative Colitis (UC)	0.7	1.3	1.5	-1.2	-1.1
Blood White Count	0.7	5.3	6.0	-2.5	-2.1
Type 2 Diabetes (T2D) (2018)	0.7	1.4	2.3	-1.5	-0.7
Sensitivity / hurt feelings	0.7	1.2	2.3	-0.2	-1.5
Hair/balding pattern: Pattern 3	0.7	1.1	1.3	0.9	1.2
Pulse wave reflection index	0.7	0.8	1.1	1.1	0.7
Hypothyroidism/myxoedema (self-reported)	0.7	1.3	1.7	1.0	1.3
Medication: Ventolin 100micrograms inhaler	0.7	0.9	1.2	0.8	1.1
Suffer from ‘nerves’	0.7	1.1	2.2	-0.2	-1.5
Knee pain experienced in last month	0.7	1.2	1.3	-1.0	-1.1
Financial situation satisfaction	0.7	0.9	1.3	1.1	0.7
Schizophrenia vs Biploar Disorder	0.6	0.7	0.9	-0.7	1.0
Average weekly spirits intake	0.6	0.7	0.9	0.7	0.9
Diabetes (mother)	0.6	0.8	1.4	1.2	0.4
Age when periods started (menarche)	0.6	1.5	2.3	0.9	1.5
Serious illness, injury or assault to yourself	0.6	0.7	0.8	-0.7	-0.9
Hayfever, allergic rhinitis or eczema	0.6	1.3	2.2	1.5	0.6
Hayfever/allergic rhinitis (self-reported)	0.6	0.8	1.7	0.1	-1.3
Illnesses of siblings	0.6	0.8	1.0	-1.0	-0.7
Qualifications: O levels/GCSEs or equivalent	0.6	0.9	1.7	0.3	1.3
Medication: Allopurinol	0.6	0.8	1.4	-0.4	-1.2
Ever had bowel cancer screening	0.6	0.7	0.9	-0.8	-0.9
Mineral and other dietary supplements	0.6	0.8	1.1	1.1	0.7
Medication: Gliclazide	0.6	0.7	0.8	-0.9	-0.7
Miserableness	0.6	1.0	1.4	-0.8	-1.2
Supplements: Calcium	0.6	0.7	1.1	-0.5	-1.0
Frequency of depressed mood in last 2 weeks	0.5	0.7	0.8	-0.9	-0.8
Angina	0.5	0.7	1.2	-1.1	-0.4
Heart attack	0.5	0.6	1.0	-0.6	-1.0
Mouth/teeth dental problems: Bleeding gums	0.5	0.6	0.9	-1.0	-0.6
Blood clot in the leg (DVT)	0.5	0.7	1.3	-1.2	0.0
Medication: Omeprazole	0.5	0.6	0.7	0.7	0.8
Schizophrenia (2014)	0.4	0.9	1.2	0.8	1.1
Number of treatments/medications taken	0.4	0.7	1.2	-1.1	-0.5
Severe depression (siblings)	0.4	0.5	0.9	0.3	-0.9
Supplements: Glucosamine	0.4	0.5	1.0	-1.0	0.2
Medication: Atenolol	0.4	0.5	0.8	0.5	0.9
Had menopause	0.4	0.5	0.6	-0.8	-0.6
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.4	0.4	0.6	0.7
Tense / ‘highly strung’	0.4	0.6	1.2	1.1	0.3
Medication for cholesterol, blood pressure or diabetes	0.4	0.7	0.8	0.8	-0.9
Forced vital capacity (FVC), Best measure	0.4	1.6	3.1	1.8	-0.2
Chest pain or discomfort	0.4	0.6	1.1	-0.4	-1.1
Back pain experienced in last month	0.4	0.5	1.1	-0.1	-1.0
Breast cancer (self-reported)	0.4	0.5	1.0	0.2	1.0
Medication: Bendroflumethiazide	0.4	0.7	1.3	-0.1	1.1
Alcohol drinker status: Never	0.4	0.5	0.8	-0.9	-0.4
Ever depressed for a whole week	0.4	0.5	1.1	1.0	-0.0
Cholesterol lowering medication	0.4	0.6	1.2	-1.1	0.3
Depression (Nagel 2018)	0.3	0.4	0.8	-0.9	-0.3
Reaction Time	0.3	0.6	1.0	-1.0	-0.4
Triglycerides	0.3	0.5	1.0	-1.0	0.2
Lung FVC	0.3	1.4	2.8	1.7	0.3
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	0.3	-0.5	-0.6
Vitamin and mineral supplements	0.3	0.4	0.6	0.8	0.4
Supplements: Zinc	0.3	0.3	0.5	0.3	-0.7
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.7	0.8	0.9	0.8
Chronic bronchitis/emphysema (father)	0.3	0.4	0.4	0.6	0.6
Diabetes (self-reported)	0.3	0.4	0.4	-0.6	-0.6
Medication: Simvastatin	0.3	0.4	0.7	-0.9	-0.2
Forced expiratory volume in 1-second (FEV1)	0.3	0.9	1.6	1.3	-0.5
Medication: Cholesterol lowering	0.3	0.5	0.9	-0.0	1.0
Gout (self-reported)	0.3	0.4	0.6	-0.4	-0.7
Wheeze or whistling in the chest in last year	0.3	0.5	0.8	-0.3	-0.9
Angina (self-reported)	0.3	0.4	0.8	-0.9	-0.2
Illnesses of siblings: Diabetes	0.3	0.4	0.8	0.1	-0.9
Handedness (chirality/laterality): Left-handed	0.3	0.3	0.3	0.6	-0.6
Commuting to job workplace: Public transport	0.3	0.3	0.6	-0.2	0.8
Irritability	0.3	0.6	0.6	-0.7	-0.8
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	0.8	-0.9	-0.1
Major Depression (MDD)	0.2	0.2	0.4	-0.6	-0.3
HbA1C	0.2	0.2	0.3	0.5	0.3
LDL Cholesterol	0.2	0.3	0.4	0.4	0.6
Primary Biliary Cirrhosis	0.2	0.3	0.3	-0.6	-0.6
Systolic Blood Pressure	0.2	1.1	2.0	0.3	1.4
Hearing difficulty/problems: Yes	0.2	0.3	0.5	-0.1	-0.7
Ever used hormone-replacement therapy (HRT)	0.2	0.3	0.5	-0.0	0.7
Diabetes (father)	0.2	0.2	0.4	0.2	0.6
Ever unenthusiastic/disinterested for a whole week	0.2	0.2	0.2	0.5	-0.5
Pulse rate	0.2	0.4	0.7	-0.1	0.8
Depression (self-reported)	0.2	0.2	0.4	-0.1	-0.6
Medication: Lansoprazole	0.2	0.2	0.2	0.4	-0.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.7	0.9	0.9	-0.7
Breastfed as a baby	0.2	0.3	0.4	0.4	0.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	0.6	0.7	-0.3
Comparative body size at age 10	0.2	0.5	0.5	-0.6	-0.7
Shortness of breath walking on level ground	0.2	0.2	0.3	-0.2	0.6
Mean time to correctly identify matches	0.2	0.5	0.9	0.1	1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.2	0.2	0.4	0.5
Number of full sisters	0.2	0.3	0.4	0.3	-0.7
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.3	0.6	0.8	-0.1
Diabetes diagnosed by doctor	0.2	0.3	0.6	-0.8	-0.2
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.3	0.6	0.4
Osteoarthritis (self-reported)	0.2	0.2	0.4	-0.6	-0.3
Medication: Blood pressure	0.2	0.4	0.8	-0.2	0.9
Medication: Atorvastatin	0.2	0.2	0.4	0.1	0.7
Unable to work because of sickness or disability	0.2	0.3	0.5	-0.7	-0.4
Heart disease (siblings)	0.2	0.2	0.4	0.2	-0.6
Schizophrenia (2018)	0.1	0.2	0.4	-0.2	-0.6
Alzheimer’s Disease (including proxy)	0.1	0.2	0.2	0.5	0.3
Mean Putamen Volume	0.1	0.1	0.1	0.3	0.3
Lupus	0.1	0.2	0.4	0.0	0.6
Hypothyroidism (self reported)	0.1	0.1	0.1	0.4	0.4
Respiratory disease	0.1	0.2	0.3	-0.6	0.1
Systolic blood pressure, automated reading	0.1	0.2	0.2	-0.4	0.5
Medication: Co-codamol	0.1	0.1	0.3	0.5	-0.1
Medication: Metformin	0.1	0.1	0.2	-0.5	-0.1
Average weekly fortified wine intake	0.1	0.2	0.3	0.1	0.6
Multivitamins +/- minerals	0.1	0.1	0.2	-0.4	0.0
Sitting height	0.1	0.4	0.7	0.9	-0.4
Hearing difficulty/problems with background noise	0.1	0.2	0.2	-0.2	-0.5
Had other major operations	0.1	0.1	0.1	0.4	-0.1
Allergy	0.1	0.3	0.5	-0.7	-0.2
Pain all over the body in last month	0.1	0.1	0.2	-0.4	0.2
Time employed in main current job	0.1	0.1	0.3	0.0	-0.5
Father’s age at death	0.1	0.2	0.3	-0.2	0.5
Worrier / anxious feelings	0.1	0.1	0.2	-0.3	-0.5
Asthma	0.1	0.1	0.2	0.4	0.1
Standing height	0.1	0.7	0.8	0.9	-0.8
Peak expiratory flow (PEF)	0.1	0.1	0.3	0.5	-0.1
Loud music exposure frequency	0.1	0.1	0.2	-0.4	0.0
Medication: Amlodipine	0.1	0.1	0.1	-0.4	0.3
Pulse wave peak to peak time	0.1	0.1	0.1	0.3	0.1
Eye problems/disorders: None of the above	0.1	0.1	0.1	-0.3	-0.3
Medication: Ibuprofen	0.1	0.1	0.1	0.2	0.4
Medication: Seretide 50 evohaler	0.1	0.1	0.2	-0.2	-0.4
Medication: Aspirin	0.1	0.1	0.2	-0.4	0.2
Asthma (self-reported)	0.1	0.1	0.1	0.4	0.2
Osteoporosis (self-reported)	0.1	0.1	0.2	0.4	0.0
Medication: Aspirin	0.1	0.2	0.4	-0.6	0.1
Illnesses of father: None of the above (group 1)	0.1	0.2	0.3	-0.0	-0.6
Hearing aid user	0.1	0.2	0.3	-0.5	-0.2
Ever had prostate specific antigen (PSA) test	0.1	0.1	0.1	-0.4	-0.1
Diastolic blood pressure, automated reading	0.1	0.4	0.7	-0.9	-0.2
Basal cell carcinoma (self-reported)	0.1	0.2	0.3	-0.5	0.2
Worry (Nagel 2018)	0.0	0.1	0.1	-0.1	-0.4
Breast Cancer	0.0	0.0	0.0	0.0	0.0
Prostate Cancer	0.0	0.0	0.0	0.0	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0
Rheumatoid Arthritis	0.0	0.1	0.1	-0.0	-0.3
Ulcerative Colitis	0.0	0.0	0.0	-0.2	-0.1
Height	0.0	0.3	0.4	0.6	-0.4
Allergy or Eczema	0.0	0.0	0.0	-0.1	-0.1
Hair Pigment	0.0	0.5	0.7	-0.5	-0.9
Tanning	0.0	0.3	0.6	-0.2	0.8
Diverticular disease/diverticulitis (self-reported)	0.0	0.1	0.1	0.3	-0.1
Medication: Levothyroxine sodium	0.0	0.1	0.1	0.4	0.1
Falls in the last year	0.0	0.1	0.1	0.3	-0.2
Medication: Ibuprofen (e.g. Nurofen)	0.0	0.0	0.0	-0.1	0.1
Lung cancer (father)	0.0	0.0	0.0	0.0	0.1
Pulse wave Arterial Stiffness index	0.0	0.0	0.1	0.1	0.3
Health satisfaction	0.0	0.1	0.1	-0.1	0.3
Mouth/teeth dental problems: Loose teeth	0.0	0.0	0.1	-0.1	-0.3
Migraine (self-reported)	0.0	0.0	0.1	-0.0	-0.3
Comparative height size at age 10	0.0	0.2	0.3	-0.1	-0.6
Illnesses of father: Heart disease	0.0	0.0	0.0	0.1	-0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.0	0.1	0.2	0.5	0.0
Wears glasses or contact lenses	0.0	0.0	0.0	0.1	-0.2
Eye problems/disorders: Glaucoma	0.0	0.0	0.1	-0.0	-0.3
Average weekly beer plus cider intake	0.0	0.1	0.1	-0.2	0.3
Risk taking	0.0	0.0	0.0	-0.1	-0.2
Medication: Omeprazole (e.g. Zanprol)	0.0	0.0	0.1	0.2	0.1

Hub : Genes

CBX5

Models

Trait associations