Best TWAS P=2.78e-08 · Best GWAS P=8.94e-08 conditioned to 0.113
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Subcutaneous | RP11-477D19.2 | 0.10 | 0.07 | lasso | 2 | 0.05 | 3.0e-05 | -5.1 | -5.1 | 3.1e-07 | 0.91 | 0.02 | 0.98 | FALSE |
2 | GTEx | Adrenal Gland | RP11-477D19.2 | 0.36 | 0.34 | lasso | 6 | 0.35 | 2.5e-13 | -5.1 | -5.3 | 1.2e-07 | 0.84 | 0.02 | 0.98 | FALSE |
3 | GTEx | Brain Cerebellar Hemisphere | RP11-477D19.2 | 0.56 | 0.48 | lasso | 7 | 0.50 | 8.6e-15 | -5.3 | -5.4 | 6.4e-08 | 0.96 | 0.01 | 0.99 | FALSE |
4 | GTEx | Brain Cerebellum | RP11-477D19.2 | 0.60 | 0.52 | lasso | 5 | 0.53 | 3.0e-18 | -5.1 | -5.1 | 3.1e-07 | 0.91 | 0.01 | 0.98 | FALSE |
5 | GTEx | Brain Hypothalamus | RP11-477D19.2 | 0.52 | 0.26 | lasso | 6 | 0.31 | 6.0e-08 | -5.1 | -5.2 | 2.0e-07 | 0.88 | 0.02 | 0.98 | FALSE |
6 | GTEx | Cells Transformed fibroblasts | RP11-477D19.2 | 0.13 | 0.07 | lasso | 2 | 0.07 | 1.2e-05 | -5.1 | -5.2 | 2.1e-07 | 0.90 | 0.02 | 0.98 | FALSE |
7 | GTEx | Colon Transverse | RP11-477D19.2 | 0.21 | 0.24 | lasso | 11 | 0.21 | 2.3e-10 | -5.1 | -5.4 | 6.5e-08 | 0.84 | 0.02 | 0.98 | FALSE |
8 | GTEx | Esophagus Mucosa | RP11-477D19.2 | 0.15 | 0.11 | enet | 10 | 0.09 | 6.9e-07 | -5.1 | -5.1 | 2.9e-07 | 0.88 | 0.02 | 0.98 | FALSE |
9 | GTEx | Heart Left Ventricle | RP11-477D19.2 | 0.19 | 0.13 | lasso | 2 | 0.12 | 1.0e-06 | -5.3 | -5.4 | 8.5e-08 | 1.00 | 0.01 | 0.99 | FALSE |
10 | GTEx | Pituitary | RP11-477D19.2 | 0.45 | 0.29 | lasso | 8 | 0.20 | 8.4e-06 | -5.1 | -5.2 | 1.8e-07 | 0.91 | 0.01 | 0.98 | FALSE |
11 | GTEx | Stomach | RP11-477D19.2 | 0.21 | 0.17 | lasso | 5 | 0.16 | 7.2e-08 | -5.2 | -5.3 | 1.1e-07 | 0.89 | 0.02 | 0.98 | FALSE |
12 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | TFB1M | 0.05 | 0.03 | blup | 96 | 0.02 | 7.9e-04 | -4.7 | -5.5 | 2.8e-08 | 0.79 | 0.03 | 0.96 | TRUE |