Best TWAS P=5.9e-10 · Best GWAS P=1.35e-13 conditioned to 1.11e-08
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Subcutaneous | C7orf73 | 0.23 | 0.14 | lasso | 7 | 0.18 | 9.5e-15 | 5.0 | -5.7 | 1.6e-08 | 0.36 | 1.00 | 0.00 | FALSE |
2 | GTEx | Adipose Visceral Omentum | C7orf73 | 0.18 | 0.11 | lasso | 4 | 0.09 | 2.8e-05 | 5.0 | -5.2 | 1.6e-07 | 0.40 | 0.94 | 0.01 | FALSE |
3 | GTEx | Adrenal Gland | C7orf73 | 0.24 | 0.23 | lasso | 1 | 0.21 | 3.8e-08 | 6.0 | -6.0 | 2.5e-09 | 0.34 | 0.74 | 0.08 | FALSE |
4 | GTEx | Artery Aorta | C7orf73 | 0.27 | 0.23 | lasso | 4 | 0.21 | 1.5e-11 | 6.0 | -5.9 | 4.6e-09 | 0.33 | 0.96 | 0.04 | FALSE |
5 | GTEx | Artery Coronary | C7orf73 | 0.40 | 0.29 | enet | 18 | 0.30 | 1.3e-10 | 5.0 | -5.6 | 2.5e-08 | 0.42 | 0.99 | 0.01 | FALSE |
6 | GTEx | Artery Tibial | C7orf73 | 0.18 | 0.18 | lasso | 5 | 0.18 | 2.5e-14 | 5.0 | -5.5 | 3.2e-08 | 0.34 | 0.99 | 0.01 | FALSE |
7 | GTEx | Breast Mammary Tissue | C7orf73 | 0.15 | 0.11 | lasso | 6 | 0.15 | 4.3e-08 | 5.0 | -5.8 | 6.8e-09 | 0.35 | 0.96 | 0.01 | FALSE |
8 | GTEx | Breast Mammary Tissue (Female) | C7orf73 | 0.20 | 0.17 | lasso | 4 | 0.12 | 1.5e-04 | 6.0 | -6.0 | 1.6e-09 | 0.37 | 0.30 | 0.06 | FALSE |
9 | GTEx | Cells EBV-transformed lymphocytes | C7orf73 | 0.49 | 0.28 | enet | 33 | 0.44 | 7.4e-16 | 5.0 | -5.1 | 2.8e-07 | 0.26 | 1.00 | 0.00 | FALSE |
10 | GTEx | Cells Transformed fibroblasts | C7orf73 | 0.44 | 0.49 | lasso | 8 | 0.53 | 5.3e-46 | 5.0 | -5.5 | 4.5e-08 | 0.36 | 1.00 | 0.00 | FALSE |
11 | GTEx | Colon Sigmoid | C7orf73 | 0.25 | 0.22 | lasso | 2 | 0.21 | 6.1e-08 | 6.0 | -6.2 | 5.9e-10 | 0.32 | 0.60 | 0.05 | TRUE |
12 | GTEx | Colon Transverse | C7orf73 | 0.25 | 0.29 | lasso | 5 | 0.24 | 1.1e-11 | 6.0 | -5.8 | 8.0e-09 | 0.33 | 0.95 | 0.05 | FALSE |
13 | GTEx | Esophagus Gastroesophageal Junction | C7orf73 | 0.25 | 0.19 | lasso | 3 | 0.14 | 8.6e-06 | 5.0 | -5.3 | 9.2e-08 | 0.32 | 0.53 | 0.04 | FALSE |
14 | GTEx | Esophagus Mucosa | C7orf73 | 0.42 | 0.31 | lasso | 6 | 0.38 | 1.3e-26 | 6.0 | -6.1 | 1.1e-09 | 0.35 | 0.95 | 0.05 | FALSE |
15 | GTEx | Esophagus Muscularis | C7orf73 | 0.22 | 0.31 | lasso | 2 | 0.29 | 8.8e-18 | 6.0 | -6.0 | 2.2e-09 | 0.35 | 0.95 | 0.05 | FALSE |
16 | GTEx | Heart Left Ventricle | C7orf73 | 0.14 | 0.09 | lasso | 12 | 0.07 | 2.1e-04 | 5.5 | -5.9 | 4.3e-09 | 0.42 | 0.89 | 0.02 | FALSE |
17 | GTEx | Lung | C7orf73 | 0.26 | 0.21 | lasso | 10 | 0.22 | 1.5e-16 | 6.0 | -6.0 | 2.5e-09 | 0.35 | 0.96 | 0.04 | FALSE |
18 | GTEx | Nerve Tibial | C7orf73 | 0.19 | 0.10 | lasso | 9 | 0.18 | 9.5e-13 | 5.0 | -5.5 | 4.4e-08 | 0.27 | 0.99 | 0.01 | FALSE |
19 | GTEx | Pancreas | C7orf73 | 0.22 | 0.28 | lasso | 8 | 0.28 | 4.5e-12 | 5.0 | -5.5 | 3.9e-08 | 0.33 | 0.99 | 0.01 | FALSE |
20 | GTEx | Skin Not Sun Exposed Suprapubic | C7orf73 | 0.38 | 0.33 | lasso | 5 | 0.37 | 2.3e-21 | 5.0 | -5.7 | 1.5e-08 | 0.36 | 1.00 | 0.00 | FALSE |
21 | GTEx | Skin Sun Exposed Lower leg | C7orf73 | 0.29 | 0.28 | enet | 21 | 0.32 | 3.2e-27 | 5.0 | -5.8 | 8.5e-09 | 0.35 | 1.00 | 0.00 | FALSE |
22 | GTEx | Stomach | C7orf73 | 0.29 | 0.17 | lasso | 6 | 0.13 | 6.3e-07 | 6.0 | -5.8 | 5.3e-09 | 0.33 | 0.96 | 0.04 | FALSE |
23 | GTEx | Testis | C7orf73 | 0.38 | 0.27 | lasso | 4 | 0.30 | 1.1e-13 | 5.0 | -5.3 | 1.0e-07 | 0.32 | 0.97 | 0.03 | FALSE |
24 | GTEx | Thyroid | C7orf73 | 0.18 | 0.11 | lasso | 7 | 0.16 | 2.1e-12 | 5.0 | -5.7 | 1.2e-08 | 0.38 | 1.00 | 0.00 | FALSE |
25 | GTEx | Vagina | C7orf73 | 0.27 | 0.19 | lasso | 3 | 0.17 | 9.3e-05 | 5.0 | -5.8 | 6.2e-09 | 0.39 | 0.23 | 0.12 | FALSE |
26 | The Cancer Genome Atlas | Breast Invasive Carcinoma | PL-5283 | 0.33 | 0.24 | enet | 14 | 0.24 | 1.5e-48 | 5.0 | -5.7 | 9.9e-09 | 0.39 | 0.00 | 1.00 | FALSE |
27 | The Cancer Genome Atlas | Colon Adenocarcinoma | PL-5283 | 0.52 | 0.40 | lasso | 4 | 0.42 | 6.8e-26 | 5.0 | -5.2 | 2.1e-07 | 0.33 | 0.00 | 1.00 | FALSE |
28 | The Cancer Genome Atlas | Colon Adenocarcinoma | SLC13A4 | 0.46 | 0.24 | lasso | 3 | 0.24 | 2.4e-14 | 5.0 | 5.2 | 1.9e-07 | -0.33 | 0.00 | 1.00 | FALSE |
29 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | SLC13A4 | 0.27 | 0.04 | enet | 10 | 0.15 | 4.8e-09 | 5.0 | 5.2 | 2.3e-07 | -0.29 | 0.00 | 0.99 | FALSE |
30 | The Cancer Genome Atlas | Lung Adenocarcinoma | PL-5283 | 0.40 | 0.24 | lasso | 5 | 0.26 | 4.2e-30 | 5.0 | -5.4 | 8.5e-08 | 0.33 | 0.00 | 1.00 | FALSE |
31 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | SLC13A4 | 0.33 | 0.16 | lasso | 3 | 0.16 | 5.5e-07 | 5.0 | 5.4 | 7.3e-08 | -0.35 | 0.00 | 0.99 | FALSE |
32 | The Cancer Genome Atlas | Soft Tissue Sarcoma | NUP205 | 0.07 | 0.05 | lasso | 4 | 0.04 | 2.7e-03 | 5.5 | -5.2 | 1.6e-07 | 0.29 | 0.01 | 0.61 | FALSE |
33 | The Cancer Genome Atlas | Soft Tissue Sarcoma | PL-5283 | 0.20 | 0.12 | lasso | 2 | 0.11 | 5.1e-07 | 5.0 | -5.3 | 1.1e-07 | 0.31 | 0.00 | 1.00 | FALSE |
34 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | PL-5283 | 0.40 | 0.26 | enet | 9 | 0.23 | 1.5e-08 | 5.0 | -5.2 | 2.0e-07 | 0.34 | 0.00 | 1.00 | FALSE |
35 | The Cancer Genome Atlas | Thyroid Carcinoma | PL-5283 | 0.59 | 0.38 | lasso | 6 | 0.42 | 1.5e-44 | 5.0 | -5.4 | 5.7e-08 | 0.36 | 0.00 | 1.00 | FALSE |
36 | The Cancer Genome Atlas | Thyroid Carcinoma | SLC13A4 | 0.44 | 0.18 | blup | 56 | 0.24 | 2.0e-23 | 5.0 | 5.4 | 7.5e-08 | -0.34 | 0.00 | 1.00 | FALSE |