Best TWAS P=8.25e-12 · Best GWAS P=5.06e-16 conditioned to 0.975
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Brain Cerebellum | KCNH2 | 0.35 | 0.20 | enet | 24 | 0.28 | 4.8e-09 | -8.0 | -6.8 | 8.3e-12 | 0.83 | 0.00 | 1.00 | TRUE |
| 7 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | ATG9B | 0.08 | 0.03 | lasso | 3 | 0.03 | 2.5e-03 | -2.2 | -6.5 | 7.4e-11 | 0.49 | 0.01 | 0.84 | TRUE |
| 2 | GTEx | Skin Sun Exposed Lower leg | NUB1 | 0.20 | 0.12 | enet | 26 | 0.13 | 5.9e-11 | -4.2 | 6.5 | 1.1e-10 | -0.07 | 1.00 | 0.00 | TRUE |
| 4 | METSIM | Adipose | AOC1 | 0.17 | 0.08 | enet | 26 | 0.11 | 3.2e-16 | 3.9 | 5.4 | 6.1e-08 | -0.30 | 1.00 | 0.00 | TRUE |
| 3 | GTEx | Uterus | GIMAP4 | 0.32 | -0.01 | enet | 42 | 0.02 | 1.4e-01 | 1.9 | -6.0 | 2.1e-09 | 0.48 | 0.05 | 0.20 | FALSE |
| 5 | YFS | Blood | FASTK | 0.04 | 0.01 | blup | 515 | 0.02 | 1.9e-07 | 2.9 | 5.7 | 1.2e-08 | -0.49 | 1.00 | 0.00 | FALSE |
| 6 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | TMEM176B | 0.21 | 0.11 | blup | 72 | 0.15 | 2.4e-16 | 2.8 | 5.4 | 7.3e-08 | -0.32 | 1.00 | 0.00 | FALSE |
| 8 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | TMEM176A | 0.15 | 0.00 | lasso | 10 | 0.02 | 5.7e-02 | 5.8 | 5.2 | 1.6e-07 | -0.24 | 0.01 | 0.31 | FALSE |