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chr10:130,566,749-132,263,732

Best TWAS P=7.04e-12 · Best GWAS P=2.14e-12 conditioned to 7.43e-05

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
36	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	MGMT	0.25	0.05	blup	234	0.12	1.9e-06	-4.7	6.9	7.0e-12	-0.54	0.05	0.91	TRUE
14	GTEx	Heart Atrial Appendage	MGMT	0.41	0.17	enet	33	0.22	4.6e-10	-4.7	6.8	1.5e-11	-0.77	0.07	0.93	FALSE
11	GTEx	Esophagus Gastroesophageal Junction	MGMT	0.34	0.31	lasso	6	0.28	9.8e-11	-6.8	6.4	1.4e-10	-0.87	0.01	0.99	FALSE
26	GTEx	Vagina	MGMT	0.33	0.23	lasso	4	0.24	3.3e-06	-5.7	6.3	3.4e-10	-0.87	0.03	0.90	FALSE
21	GTEx	Prostate	MGMT	0.25	0.13	lasso	4	0.20	9.4e-06	-5.5	6.2	4.0e-10	-0.83	0.03	0.92	FALSE
24	GTEx	Stomach	MGMT	0.33	0.20	enet	9	0.25	2.3e-12	-6.1	6.2	4.0e-10	-0.81	0.32	0.68	FALSE
23	GTEx	Small Intestine Terminal Ileum	MGMT	0.31	0.14	enet	11	0.21	1.6e-05	-6.8	6.2	4.6e-10	-0.82	0.04	0.89	FALSE
34	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	MGMT	0.26	0.32	lasso	10	0.37	2.9e-43	-5.5	6.2	5.2e-10	-0.81	0.97	0.03	FALSE
5	GTEx	Brain Cerebellar Hemisphere	MGMT	0.53	0.15	lasso	8	0.19	1.3e-05	-5.5	6.0	1.4e-09	-0.74	0.10	0.76	FALSE
22	GTEx	Skin Sun Exposed Lower leg	MGMT	0.45	0.30	enet	42	0.46	1.6e-41	-6.8	6.0	1.6e-09	-0.73	0.01	0.99	FALSE
20	GTEx	Pancreas	MGMT	0.32	0.03	lasso	7	0.17	8.0e-08	-4.7	6.0	1.8e-09	-0.57	0.19	0.73	FALSE
10	GTEx	Colon Sigmoid	MGMT	0.55	0.21	enet	29	0.29	9.1e-11	-4.7	6.0	2.1e-09	-0.63	0.03	0.97	FALSE
3	GTEx	Adrenal Gland	MGMT	0.39	0.25	lasso	6	0.30	1.5e-11	-5.5	5.9	3.9e-09	-0.77	0.11	0.88	FALSE
9	GTEx	Cells Transformed fibroblasts	MGMT	0.45	0.30	enet	31	0.42	4.8e-34	-5.7	5.8	6.6e-09	-0.78	0.78	0.22	FALSE
7	GTEx	Breast Mammary Tissue	MGMT	0.60	0.21	enet	13	0.33	1.6e-17	-4.7	5.7	1.0e-08	-0.75	0.25	0.75	FALSE
25	GTEx	Thyroid	MGMT	0.44	0.35	lasso	11	0.43	1.9e-35	-5.5	5.7	1.1e-08	-0.76	0.93	0.07	FALSE
35	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	MGMT	0.40	0.24	enet	29	0.37	1.9e-22	-5.5	5.7	1.1e-08	-0.67	0.52	0.48	FALSE
6	GTEx	Brain Nucleus accumbens basal ganglia	MGMT	0.32	0.29	lasso	1	0.21	2.4e-06	-5.7	5.7	1.2e-08	-0.77	0.21	0.62	FALSE
29	ROSMAP	Brain Pre-frontal Cortex	MGMT	0.41	0.38	enet	46	0.48	3.6e-69	-4.7	5.7	1.4e-08	-0.74	0.99	0.01	FALSE
4	GTEx	Artery Tibial	MGMT	0.42	0.30	enet	22	0.46	1.9e-40	-6.8	5.6	1.7e-08	-0.80	0.01	0.99	FALSE
28	NTR	Blood	MGMT	0.08	0.07	lasso	8	0.08	3.7e-24	-4.7	5.6	2.4e-08	-0.76	0.98	0.02	FALSE
40	The Cancer Genome Atlas	Soft Tissue Sarcoma	MGMT	0.14	0.05	blup	235	0.11	5.4e-07	-6.9	5.6	2.7e-08	-0.75	0.02	0.98	FALSE
31	The Cancer Genome Atlas	Breast Invasive Carcinoma	MGMT	0.16	0.17	enet	22	0.21	2.4e-41	-4.7	5.5	3.0e-08	-0.73	1.00	0.00	FALSE
16	GTEx	Liver	MGMT	0.46	0.39	lasso	4	0.42	8.2e-13	-4.7	5.5	3.2e-08	-0.73	0.38	0.62	FALSE
39	The Cancer Genome Atlas	Prostate Adenocarcinoma	MGMT	0.39	0.31	enet	60	0.35	1.8e-37	-4.7	5.5	3.8e-08	-0.57	1.00	0.00	FALSE
27	METSIM	Adipose	MGMT	0.18	0.11	lasso	9	0.18	1.5e-25	-4.8	5.5	4.3e-08	-0.81	0.26	0.74	FALSE
8	GTEx	Breast Mammary Tissue (Female)	MGMT	0.46	0.31	lasso	4	0.33	1.1e-10	-4.7	5.4	5.5e-08	-0.68	0.20	0.77	FALSE
33	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	MGMT	0.10	0.09	enet	23	0.10	1.9e-11	-5.7	5.4	5.6e-08	-0.73	0.67	0.33	FALSE
1	CommonMind	Brain Pre-frontal Cortex	MGMT	0.29	0.27	lasso	14	0.31	6.0e-38	-5.5	5.4	6.1e-08	-0.77	0.10	0.90	FALSE
30	YFS	Blood	MGMT	0.50	0.40	enet	94	0.55	1.6e-218	-4.7	5.4	6.4e-08	-0.63	1.00	0.00	FALSE
32	The Cancer Genome Atlas	Colon Adenocarcinoma	MGMT	0.24	0.09	blup	238	0.14	2.3e-08	-6.8	5.3	1.1e-07	-0.67	0.03	0.97	FALSE
17	GTEx	Lung	MGMT	0.39	0.24	enet	28	0.33	5.5e-26	-4.7	5.3	1.3e-07	-0.70	0.13	0.87	FALSE
2	GTEx	Adipose Subcutaneous	MGMT	0.39	0.27	enet	30	0.48	1.2e-44	-5.7	5.2	1.5e-07	-0.69	0.60	0.40	FALSE
38	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	MGMT	0.27	0.24	lasso	7	0.19	3.3e-08	-5.4	5.2	1.7e-07	-0.69	0.10	0.89	FALSE
41	The Cancer Genome Atlas	Stomach Adenocarcinoma	MGMT	0.15	0.08	lasso	4	0.10	7.5e-08	-4.7	5.2	1.7e-07	-0.70	0.77	0.22	FALSE
37	The Cancer Genome Atlas	Lung Adenocarcinoma	MGMT	0.11	0.07	enet	16	0.14	2.8e-16	-4.7	5.2	1.9e-07	-0.78	0.46	0.54	FALSE
19	GTEx	Ovary	MGMT	0.52	0.09	enet	59	0.12	8.6e-04	-5.7	5.2	2.0e-07	-0.58	0.04	0.93	FALSE
18	GTEx	Nerve Tibial	MGMT	0.50	0.23	enet	46	0.42	6.9e-32	-5.7	5.2	2.1e-07	-0.70	0.01	0.99	FALSE
15	GTEx	Heart Left Ventricle	MGMT	0.27	0.20	lasso	7	0.22	6.3e-12	-4.7	5.2	2.3e-07	-0.66	0.86	0.14	FALSE
13	GTEx	Esophagus Muscularis	MGMT	0.50	0.29	enet	40	0.34	3.4e-21	-4.7	5.2	2.4e-07	-0.64	0.54	0.46	FALSE
12	GTEx	Esophagus Mucosa	MGMT	0.41	0.33	enet	37	0.38	2.3e-26	-4.7	5.2	2.6e-07	-0.65	0.94	0.06	FALSE