Best TWAS P=1.82e-12 · Best GWAS P=7.61e-13 conditioned to 1.28e-12
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | MPHOSPH6 | 0.30 | 0.24 | lasso | 8 | 0.23 | 2.1e-27 | 6.1 | -5.4 | 5.6e-08 | -0.04 | 0.04 | 0.96 | FALSE |
2 | GTEx | Adipose Subcutaneous | MPHOSPH6 | 0.15 | 0.08 | enet | 8 | 0.09 | 5.1e-08 | 6.3 | 5.9 | 2.9e-09 | 0.00 | 0.01 | 0.99 | FALSE |
3 | GTEx | Adipose Visceral Omentum | MPHOSPH6 | 0.32 | 0.14 | lasso | 4 | 0.17 | 3.5e-09 | 6.1 | 6.4 | 2.1e-10 | 0.02 | 0.01 | 0.99 | FALSE |
4 | GTEx | Adrenal Gland | MPHOSPH6 | 0.34 | 0.25 | lasso | 3 | 0.26 | 8.4e-10 | 6.5 | 6.0 | 1.5e-09 | 0.02 | 0.00 | 1.00 | FALSE |
5 | GTEx | Artery Aorta | MPHOSPH6 | 0.32 | 0.15 | lasso | 6 | 0.17 | 7.8e-10 | 6.3 | 6.2 | 7.8e-10 | 0.03 | 0.01 | 0.99 | FALSE |
6 | GTEx | Artery Tibial | MPHOSPH6 | 0.36 | 0.24 | enet | 9 | 0.27 | 1.9e-21 | 6.3 | 6.4 | 1.4e-10 | 0.01 | 0.01 | 0.99 | FALSE |
7 | GTEx | Brain Cerebellar Hemisphere | MPHOSPH6 | 0.49 | 0.30 | enet | 12 | 0.31 | 8.5e-09 | 6.5 | 6.3 | 2.7e-10 | 0.01 | 0.00 | 0.99 | FALSE |
8 | GTEx | Brain Cerebellum | MPHOSPH6 | 0.40 | 0.36 | enet | 10 | 0.39 | 1.8e-12 | 5.1 | 6.0 | 1.8e-09 | 0.00 | 0.01 | 0.99 | FALSE |
9 | GTEx | Cells Transformed fibroblasts | CMIP | 0.20 | 0.05 | lasso | 6 | 0.07 | 1.0e-05 | -3.4 | -5.4 | 5.4e-08 | -0.04 | 0.98 | 0.00 | FALSE |
10 | GTEx | Colon Transverse | MPHOSPH6 | 0.21 | 0.16 | lasso | 3 | 0.17 | 1.4e-08 | 6.3 | 6.4 | 1.4e-10 | 0.02 | 0.01 | 0.99 | FALSE |
11 | GTEx | Esophagus Muscularis | MPHOSPH6 | 0.36 | 0.23 | lasso | 7 | 0.20 | 1.7e-12 | 6.3 | 6.4 | 1.8e-10 | 0.01 | 0.01 | 0.99 | FALSE |
12 | GTEx | Heart Atrial Appendage | MPHOSPH6 | 0.33 | 0.19 | enet | 27 | 0.21 | 5.4e-10 | 6.3 | 5.9 | 3.7e-09 | 0.01 | 0.01 | 0.99 | FALSE |
13 | GTEx | Heart Left Ventricle | MPHOSPH6 | 0.28 | 0.24 | lasso | 3 | 0.24 | 8.9e-13 | 6.3 | 6.4 | 1.2e-10 | 0.01 | 0.00 | 1.00 | FALSE |
14 | GTEx | Lung | MPHOSPH6 | 0.16 | 0.10 | lasso | 4 | 0.11 | 8.3e-09 | 6.5 | 6.4 | 1.5e-10 | 0.02 | 0.00 | 1.00 | FALSE |
15 | GTEx | Muscle Skeletal | MPHOSPH6 | 0.27 | 0.19 | lasso | 7 | 0.23 | 1.4e-22 | 6.5 | 6.4 | 1.6e-10 | 0.02 | 0.00 | 1.00 | FALSE |
16 | GTEx | Nerve Tibial | MPHOSPH6 | 0.40 | 0.22 | lasso | 7 | 0.28 | 1.0e-19 | 6.3 | 6.2 | 6.8e-10 | 0.01 | 0.01 | 0.99 | FALSE |
17 | GTEx | Pancreas | MPHOSPH6 | 0.25 | 0.14 | enet | 15 | 0.15 | 9.2e-07 | 6.3 | 7.0 | 1.8e-12 | 0.01 | 0.01 | 0.99 | TRUE |
18 | GTEx | Stomach | MPHOSPH6 | 0.41 | 0.10 | lasso | 7 | 0.09 | 3.5e-05 | 5.8 | 6.3 | 3.6e-10 | 0.02 | 0.01 | 0.99 | FALSE |
19 | GTEx | Testis | MPHOSPH6 | 0.52 | 0.32 | lasso | 11 | 0.35 | 2.0e-16 | 6.3 | 6.0 | 2.3e-09 | 0.01 | 0.01 | 0.99 | FALSE |
20 | GTEx | Thyroid | MPHOSPH6 | 0.31 | 0.21 | lasso | 4 | 0.26 | 4.7e-20 | 6.1 | 6.4 | 1.2e-10 | 0.02 | 0.01 | 0.99 | FALSE |
21 | METSIM | Adipose | MPHOSPH6 | 0.12 | 0.07 | bslmm | 741 | 0.08 | 2.0e-11 | 6.4 | 5.4 | 7.7e-08 | 0.00 | 0.00 | 1.00 | FALSE |
22 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | MPHOSPH6 | 0.14 | 0.15 | lasso | 6 | 0.15 | 7.0e-17 | 6.1 | 5.9 | 3.0e-09 | 0.03 | 0.03 | 0.97 | FALSE |
23 | The Cancer Genome Atlas | Lung Adenocarcinoma | MPHOSPH6 | 0.04 | 0.01 | blup | 90 | 0.02 | 2.2e-03 | 4.9 | 5.1 | 2.8e-07 | 0.04 | 0.04 | 0.51 | FALSE |
24 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | MPHOSPH6 | 0.13 | 0.09 | lasso | 2 | 0.12 | 2.4e-05 | 4.9 | 5.8 | 6.3e-09 | 0.02 | 0.02 | 0.92 | FALSE |
25 | The Cancer Genome Atlas | Prostate Adenocarcinoma | MPHOSPH6 | 0.07 | 0.03 | lasso | 4 | 0.06 | 8.0e-07 | 6.5 | 5.2 | 1.9e-07 | -0.03 | 0.01 | 0.98 | FALSE |
26 | The Cancer Genome Atlas | Thyroid Carcinoma | MPHOSPH6 | 0.18 | 0.16 | lasso | 3 | 0.16 | 5.1e-15 | 6.5 | 6.5 | 6.3e-11 | 0.01 | 0.00 | 1.00 | FALSE |