Best TWAS P=1.44e-14 · Best GWAS P=4.52e-20 conditioned to 8.58e-10
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Aorta | PLEKHH2 | 0.50 | 0.18 | lasso | 9 | 0.31 | 9.4e-18 | -2.36 | 6.0 | 2.3e-09 | 0.06 | 1.00 | 0.00 | FALSE |
| 2 | GTEx | Artery Tibial | PLEKHH2 | 0.49 | 0.17 | enet | 48 | 0.29 | 2.6e-23 | -2.36 | 7.7 | 1.4e-14 | 0.08 | 1.00 | 0.00 | TRUE |
| 3 | GTEx | Nerve Tibial | ZFP36L2 | 0.06 | 0.00 | lasso | 8 | 0.01 | 3.5e-02 | 7.67 | -7.1 | 1.5e-12 | -0.06 | 0.07 | 0.75 | FALSE |
| 4 | GTEx | Stomach | AC010883.5 | 0.16 | 0.07 | lasso | 6 | 0.07 | 2.4e-04 | -6.28 | 5.6 | 2.3e-08 | -0.03 | 0.31 | 0.09 | TRUE |
| 5 | GTEx | Thyroid | AC010883.5 | 0.11 | 0.09 | lasso | 2 | 0.08 | 1.5e-06 | 5.74 | 5.8 | 5.2e-09 | 0.09 | 0.97 | 0.01 | FALSE |
| 6 | GTEx | Vagina | ZFP36L2 | 0.32 | 0.08 | enet | 27 | 0.14 | 4.7e-04 | 7.83 | -6.0 | 1.9e-09 | -0.09 | 0.04 | 0.54 | FALSE |
| 7 | METSIM | Adipose | AC016735.2 | 0.05 | 0.00 | bslmm | 466 | 0.01 | 3.0e-03 | -0.49 | 5.8 | 9.1e-09 | 0.06 | 0.06 | 0.08 | FALSE |
| 8 | The Cancer Genome Atlas | Glioblastoma Multiforme | PPM1B | 0.14 | 0.04 | blup | 65 | 0.04 | 2.4e-02 | -0.24 | 5.9 | 2.9e-09 | 0.65 | 0.02 | 0.35 | TRUE |
| 9 | The Cancer Genome Atlas | Lung Adenocarcinoma | ZFP36L2 | 0.03 | 0.01 | blup | 38 | 0.01 | 1.1e-02 | 2.35 | -5.5 | 3.8e-08 | -0.05 | 0.01 | 0.80 | TRUE |