Best TWAS P=1.9e-14 · Best GWAS P=7.5e-18 conditioned to 1.38e-11
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | CRIPT | 0.12 | 0.10 | lasso | 3 | 0.09 | 7.1e-08 | 4.7 | 5.4 | 5.7e-08 | -0.05 | 0.99 | 0.00 | FALSE |
| 2 | GTEx | Adrenal Gland | CRIPT | 0.16 | 0.10 | enet | 11 | 0.13 | 2.3e-05 | 4.9 | 5.3 | 1.4e-07 | -0.08 | 0.69 | 0.02 | FALSE |
| 3 | GTEx | Brain Frontal Cortex BA9 | ATP6V1E2 | 0.40 | -0.01 | enet | 35 | 0.06 | 1.4e-02 | 3.6 | -5.5 | 5.2e-08 | -0.06 | 0.11 | 0.06 | FALSE |
| 4 | GTEx | Brain Nucleus accumbens basal ganglia | CRIPT | 0.27 | -0.01 | enet | 8 | 0.02 | 1.2e-01 | 5.1 | 5.6 | 2.2e-08 | -0.09 | 0.12 | 0.06 | FALSE |
| 5 | GTEx | Brain Nucleus accumbens basal ganglia | ATP6V1E2 | 0.31 | -0.01 | enet | 28 | 0.05 | 2.1e-02 | 3.5 | -5.5 | 5.1e-08 | -0.05 | 0.12 | 0.05 | FALSE |
| 6 | GTEx | Breast Mammary Tissue (Female) | AC016722.4 | 0.20 | 0.05 | lasso | 3 | 0.05 | 1.3e-02 | -4.1 | -5.7 | 1.5e-08 | 0.51 | 0.06 | 0.36 | FALSE |
| 7 | GTEx | Colon Sigmoid | ATP6V1E2 | 0.25 | 0.08 | enet | 17 | 0.13 | 3.3e-05 | 4.6 | -6.5 | 9.2e-11 | 0.14 | 0.56 | 0.19 | FALSE |
| 8 | GTEx | Esophagus Gastroesophageal Junction | CRIPT | 0.21 | 0.14 | enet | 9 | 0.18 | 6.4e-07 | 4.4 | 5.7 | 1.5e-08 | -0.13 | 0.77 | 0.02 | FALSE |
| 9 | GTEx | Esophagus Gastroesophageal Junction | AC016722.2 | 0.30 | 0.07 | lasso | 4 | 0.11 | 7.7e-05 | 5.2 | -6.5 | 8.0e-11 | 0.07 | 0.25 | 0.04 | FALSE |
| 10 | GTEx | Heart Left Ventricle | ATP6V1E2 | 0.38 | 0.05 | enet | 32 | 0.20 | 1.1e-10 | 3.6 | -6.4 | 1.5e-10 | 0.11 | 0.94 | 0.00 | FALSE |
| 11 | GTEx | Pituitary | ATP6V1E2 | 0.33 | 0.05 | enet | 19 | 0.14 | 2.6e-04 | 5.8 | -5.7 | 1.4e-08 | 0.06 | 0.20 | 0.12 | FALSE |
| 12 | GTEx | Skin Not Sun Exposed Suprapubic | PIGF | 0.14 | 0.08 | lasso | 4 | 0.07 | 1.7e-04 | 7.3 | -7.7 | 1.9e-14 | 0.28 | 0.53 | 0.04 | TRUE |
| 13 | GTEx | Vagina | ATP6V1E2 | 0.31 | 0.00 | lasso | 7 | -0.01 | 6.5e-01 | 3.6 | -5.4 | 5.4e-08 | 0.29 | 0.10 | 0.06 | FALSE |
| 14 | GTEx | Whole Blood | CRIPT | 0.11 | 0.04 | enet | 18 | 0.05 | 1.2e-05 | 4.5 | 5.1 | 2.8e-07 | -0.09 | 0.91 | 0.00 | FALSE |
| 15 | The Cancer Genome Atlas | Colon Adenocarcinoma | ATP6V1E2 | 0.11 | 0.04 | blup | 75 | 0.06 | 2.0e-04 | 3.7 | -5.3 | 9.2e-08 | 0.11 | 0.19 | 0.72 | FALSE |
| 16 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | CRIPT | 0.11 | 0.11 | lasso | 3 | 0.10 | 1.7e-06 | 4.9 | 5.2 | 2.6e-07 | -0.09 | 0.46 | 0.52 | FALSE |
| 17 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | CRIPT | 0.13 | 0.07 | enet | 13 | 0.10 | 7.9e-05 | 4.5 | 5.4 | 5.7e-08 | 0.00 | 0.09 | 0.38 | FALSE |
| 18 | The Cancer Genome Atlas | Prostate Adenocarcinoma | ATP6V1E2 | 0.04 | 0.02 | lasso | 3 | 0.02 | 4.6e-03 | 6.5 | -6.3 | 3.5e-10 | 0.16 | 0.02 | 0.97 | FALSE |