Best TWAS P=1.97e-10 · Best GWAS P=1.1e-09 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2 | GTEx | Artery Aorta | RP11-268J15.5 | 0.20 | 0.14 | lasso | 4 | 0.13 | 1.2e-07 | -6.1 | -6.4 | 2.0e-10 | 1.00 | 0 | 1 | TRUE |
| 5 | GTEx | Lung | SH3D21 | 0.12 | 0.02 | lasso | 1 | 0.03 | 2.1e-03 | -6.1 | 6.1 | 1.1e-09 | -1.00 | 0 | 1 | FALSE |
| 4 | GTEx | Lung | RP11-268J15.5 | 0.27 | 0.16 | lasso | 4 | 0.15 | 1.6e-11 | -6.1 | -6.0 | 1.5e-09 | 0.98 | 0 | 1 | FALSE |
| 8 | GTEx | Thyroid | RP11-268J15.5 | 0.13 | 0.12 | lasso | 4 | 0.10 | 2.7e-08 | -6.1 | -6.0 | 1.8e-09 | 1.00 | 0 | 1 | FALSE |
| 13 | ROSMAP | Brain Pre-frontal Cortex | SH3D21 | 0.28 | 0.18 | lasso | 5 | 0.19 | 4.1e-24 | -6.1 | 6.0 | 2.4e-09 | -0.99 | 0 | 1 | FALSE |
| 11 | METSIM | Adipose | SH3D21 | 0.05 | 0.05 | lasso | 3 | 0.04 | 5.1e-07 | -6.1 | 5.9 | 3.2e-09 | -0.99 | 0 | 1 | FALSE |
| 1 | GTEx | Adipose Visceral Omentum | RP11-268J15.5 | 0.17 | 0.14 | lasso | 2 | 0.11 | 2.8e-06 | -6.1 | -5.9 | 3.7e-09 | 0.99 | 0 | 1 | FALSE |
| 3 | GTEx | Artery Tibial | RP11-268J15.5 | 0.11 | 0.10 | lasso | 3 | 0.08 | 4.1e-07 | -6.1 | -5.8 | 5.5e-09 | 0.99 | 0 | 1 | FALSE |
| 10 | METSIM | Adipose | RP11-268J15.5 | 0.05 | 0.06 | lasso | 3 | 0.05 | 4.0e-08 | -6.1 | -5.8 | 6.5e-09 | 0.99 | 0 | 1 | FALSE |
| 9 | GTEx | Thyroid | SH3D21 | 0.14 | 0.03 | lasso | 4 | 0.05 | 6.6e-05 | -6.1 | 5.8 | 7.7e-09 | -0.93 | 0 | 1 | FALSE |
| 12 | ROSMAP | Brain Pre-frontal Cortex | RP11-268J15.5 | 0.21 | 0.16 | lasso | 5 | 0.17 | 4.3e-21 | -6.1 | -5.8 | 8.1e-09 | 0.96 | 0 | 1 | FALSE |
| 6 | GTEx | Nerve Tibial | RP11-268J15.5 | 0.18 | 0.09 | lasso | 5 | 0.08 | 1.5e-06 | -6.1 | -5.7 | 1.2e-08 | 0.96 | 0 | 1 | FALSE |
| 7 | GTEx | Skin Sun Exposed Lower leg | SH3D21 | 0.15 | 0.07 | lasso | 5 | 0.08 | 4.7e-07 | 5.3 | 5.4 | 8.4e-08 | -0.88 | 0 | 1 | FALSE |