Best TWAS P=8.44e-17 · Best GWAS P=1.08e-15 conditioned to 0.00946
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Cells Transformed fibroblasts | KPNA6 | 0.13 | 0.10 | lasso | 5 | 0.11 | 1.3e-08 | 5.4 | 5.4 | 7.1e-08 | 0.39 | 1.00 | 0.00 | FALSE |
| 2 | GTEx | Skin Not Sun Exposed Suprapubic | EIF3I | 0.12 | 0.06 | lasso | 1 | 0.03 | 7.2e-03 | 5.3 | -5.3 | 1.1e-07 | -0.39 | 0.09 | 0.04 | FALSE |
| 3 | GTEx | Testis | RP4-622L5.7 | 0.12 | 0.11 | lasso | 5 | 0.08 | 2.3e-04 | 5.5 | 5.5 | 3.3e-08 | 0.40 | 0.35 | 0.12 | FALSE |
| 4 | METSIM | Adipose | KPNA6 | 0.07 | 0.06 | lasso | 10 | 0.06 | 1.8e-09 | 5.5 | 5.8 | 6.0e-09 | 0.42 | 1.00 | 0.00 | FALSE |
| 5 | ROSMAP | Brain Pre-frontal Cortex | KPNA6 | 0.03 | 0.04 | lasso | 4 | 0.02 | 8.1e-04 | 5.3 | 5.2 | 2.4e-07 | 0.44 | 0.60 | 0.21 | FALSE |
| 6 | YFS | Blood | KPNA6 | 0.03 | 0.03 | bslmm | 236 | 0.04 | 1.1e-11 | 5.5 | 6.2 | 6.0e-10 | 0.42 | 1.00 | 0.00 | FALSE |
| 7 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | PTP4A2 | 0.09 | -0.01 | blup | 26 | 0.00 | 4.1e-01 | 6.8 | 8.3 | 8.4e-17 | 0.76 | 0.01 | 0.52 | TRUE |
| 8 | The Cancer Genome Atlas | Thyroid Carcinoma | SPOCD1 | 0.04 | 0.02 | blup | 38 | 0.02 | 3.0e-03 | -4.7 | 5.2 | 2.3e-07 | 0.35 | 0.02 | 0.45 | FALSE |