Best TWAS P=1.87e-09 · Best GWAS P=1.09e-08 conditioned to 0.574
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | C1orf123 | 0.21 | 0.27 | bslmm | 483 | 0.28 | 6.4e-34 | -5.6 | 5.4 | 6.4e-08 | -0.83 | 0.02 | 0.98 | FALSE |
2 | GTEx | Muscle Skeletal | C1orf123 | 0.07 | 0.06 | lasso | 5 | 0.06 | 8.9e-07 | -5.6 | 5.6 | 1.9e-08 | -0.82 | 0.02 | 0.98 | FALSE |
3 | ROSMAP | Brain Pre-frontal Cortex | LRP8 | 0.07 | 0.04 | lasso | 3 | 0.04 | 3.0e-06 | -5.5 | 5.9 | 4.2e-09 | -0.94 | 0.01 | 0.98 | FALSE |
4 | ROSMAP | Brain Pre-frontal Cortex | C1orf123 | 0.31 | 0.28 | enet | 14 | 0.34 | 3.2e-45 | -5.1 | 5.4 | 5.8e-08 | -0.81 | 0.02 | 0.98 | FALSE |
5 | The Cancer Genome Atlas | Breast Invasive Carcinoma | C1orf123 | 0.03 | 0.03 | blup | 43 | 0.04 | 2.9e-08 | -5.6 | 6.0 | 1.9e-09 | -0.91 | 0.01 | 0.99 | TRUE |
6 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | C1orf123 | 0.05 | 0.05 | blup | 42 | 0.04 | 8.2e-06 | -5.6 | 5.8 | 8.1e-09 | -0.87 | 0.02 | 0.98 | FALSE |
7 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | C1orf123 | 0.10 | 0.08 | lasso | 2 | 0.08 | 3.5e-05 | -5.7 | 5.7 | 1.1e-08 | -0.96 | 0.02 | 0.98 | FALSE |
8 | The Cancer Genome Atlas | Lung Adenocarcinoma | C1orf123 | 0.03 | 0.03 | lasso | 4 | 0.03 | 5.4e-04 | -5.1 | 5.2 | 1.5e-07 | -0.87 | 0.02 | 0.93 | FALSE |
9 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | C1orf123 | 0.04 | 0.06 | blup | 43 | 0.06 | 2.2e-07 | -5.1 | 5.5 | 3.3e-08 | -0.91 | 0.03 | 0.97 | FALSE |
10 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | C1orf123 | 0.07 | 0.06 | lasso | 4 | 0.02 | 4.0e-02 | -5.6 | 5.6 | 1.9e-08 | -0.82 | 0.01 | 0.69 | FALSE |
11 | The Cancer Genome Atlas | Prostate Adenocarcinoma | C1orf123 | 0.11 | 0.07 | lasso | 4 | 0.06 | 2.8e-07 | -5.6 | 5.5 | 3.6e-08 | -0.87 | 0.02 | 0.98 | FALSE |
12 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | C1orf123 | 0.08 | 0.06 | blup | 43 | 0.05 | 8.3e-03 | -5.7 | 5.3 | 1.2e-07 | -0.92 | 0.01 | 0.70 | FALSE |
13 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | CPT2 | 0.10 | 0.05 | blup | 53 | 0.02 | 5.2e-02 | -5.7 | 5.3 | 9.9e-08 | -0.93 | 0.01 | 0.86 | FALSE |
14 | The Cancer Genome Atlas | Thyroid Carcinoma | C1orf123 | 0.09 | 0.14 | lasso | 4 | 0.15 | 3.7e-14 | -5.6 | 5.6 | 1.9e-08 | -0.88 | 0.02 | 0.98 | FALSE |