Best TWAS P=9.2e-09 · Best GWAS P=1.73e-08 conditioned to 0.486
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Subcutaneous | RP11-165J3.6 | 0.22 | 0.13 | enet | 18 | 0.16 | 2.5e-13 | 4.8 | 5.1 | 3.0e-07 | 0.89 | 0.04 | 0.96 | FALSE |
2 | GTEx | Artery Aorta | RP11-165J3.6 | 0.23 | 0.22 | enet | 10 | 0.22 | 2.3e-12 | 4.8 | 5.1 | 2.8e-07 | 0.86 | 0.04 | 0.96 | FALSE |
3 | GTEx | Breast Mammary Tissue | RP11-165J3.6 | 0.28 | 0.11 | enet | 24 | 0.13 | 2.7e-07 | 5.1 | 5.5 | 4.8e-08 | 0.85 | 0.02 | 0.97 | FALSE |
4 | GTEx | Breast Mammary Tissue (Female) | RP11-165J3.6 | 0.21 | 0.02 | lasso | 3 | 0.00 | 2.3e-01 | 5.1 | 5.2 | 2.3e-07 | 0.88 | 0.03 | 0.66 | FALSE |
5 | GTEx | Colon Sigmoid | RP11-165J3.6 | 0.31 | 0.12 | enet | 17 | 0.16 | 1.8e-06 | 5.0 | 5.4 | 5.2e-08 | 0.83 | 0.02 | 0.98 | FALSE |
6 | GTEx | Esophagus Mucosa | RP11-165J3.6 | 0.24 | 0.15 | enet | 13 | 0.16 | 4.5e-11 | 5.1 | 5.2 | 2.3e-07 | 0.84 | 0.05 | 0.95 | FALSE |
7 | GTEx | Heart Atrial Appendage | RP11-165J3.6 | 0.38 | 0.21 | lasso | 7 | 0.25 | 8.7e-12 | 5.3 | 5.7 | 9.2e-09 | 0.94 | 0.00 | 1.00 | TRUE |
8 | GTEx | Heart Left Ventricle | RP11-165J3.6 | 0.13 | 0.06 | lasso | 5 | 0.05 | 1.9e-03 | 4.8 | 5.2 | 2.3e-07 | 0.82 | 0.02 | 0.96 | FALSE |
9 | GTEx | Lung | RP11-165J3.6 | 0.25 | 0.16 | lasso | 7 | 0.17 | 4.1e-13 | 4.8 | 5.3 | 1.2e-07 | 0.89 | 0.04 | 0.95 | FALSE |
10 | GTEx | Pituitary | RP11-165J3.6 | 0.49 | 0.22 | lasso | 8 | 0.29 | 6.9e-08 | 5.1 | 5.6 | 2.9e-08 | 0.94 | 0.01 | 0.99 | FALSE |
11 | GTEx | Skin Not Sun Exposed Suprapubic | RP11-165J3.6 | 0.27 | 0.14 | lasso | 7 | 0.19 | 1.4e-10 | 5.5 | 5.3 | 9.5e-08 | 0.94 | 0.01 | 0.99 | FALSE |
12 | GTEx | Skin Sun Exposed Lower leg | RP11-165J3.6 | 0.32 | 0.27 | lasso | 5 | 0.35 | 6.8e-30 | 5.1 | 5.6 | 2.4e-08 | 0.96 | 0.01 | 0.99 | FALSE |
13 | GTEx | Thyroid | RP11-165J3.6 | 0.35 | 0.27 | lasso | 3 | 0.29 | 1.2e-22 | 4.8 | 5.3 | 1.3e-07 | 0.86 | 0.04 | 0.96 | FALSE |