Best TWAS P=1.11e-08 · Best GWAS P=7.01e-08 conditioned to 0.648
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Brain Cerebellar Hemisphere | GCDH | 0.62 | 0.43 | lasso | 5 | 0.49 | 1.7e-14 | 4.0 | -5.2 | 2.4e-07 | 0.86 | 0.02 | 0.97 | FALSE |
| 2 | GTEx | Brain Cortex | GCDH | 0.33 | 0.23 | lasso | 4 | 0.26 | 7.7e-08 | -4.9 | -5.2 | 2.3e-07 | 0.93 | 0.01 | 0.98 | FALSE |
| 3 | GTEx | Muscle Skeletal | FARSA | 0.05 | 0.05 | lasso | 3 | 0.05 | 1.3e-05 | -5.2 | -5.3 | 1.5e-07 | 0.98 | 0.01 | 0.99 | FALSE |
| 4 | NTR | Blood | CALR | 0.04 | 0.03 | lasso | 8 | 0.02 | 4.2e-08 | -5.3 | 5.5 | 3.7e-08 | -0.86 | 0.01 | 0.99 | FALSE |
| 5 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | DAND5 | 0.03 | 0.02 | blup | 31 | 0.03 | 3.0e-04 | -5.0 | 5.7 | 1.1e-08 | -0.91 | 0.01 | 0.94 | TRUE |
| 6 | The Cancer Genome Atlas | Brain Lower Grade Glioma | FARSA | 0.05 | 0.04 | blup | 33 | 0.05 | 1.8e-06 | 4.5 | -5.4 | 8.4e-08 | 0.84 | 0.02 | 0.98 | FALSE |