Best TWAS P=8.69e-08 · Best GWAS P=1.36e-07 conditioned to 0.427
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Muscle Skeletal | FADS2 | 0.08 | 0.04 | lasso | 2 | 0.03 | 5.9e-04 | -5.1 | -5.4 | 8.7e-08 | 0.93 | 0.02 | 0.98 | TRUE |
| 2 | ROSMAP | Brain Pre-frontal Cortex | TMEM258 | 0.14 | 0.16 | lasso | 4 | 0.15 | 4.7e-19 | -5.0 | -5.3 | 1.1e-07 | 0.92 | 0.02 | 0.98 | FALSE |
| 3 | The Cancer Genome Atlas | Brain Lower Grade Glioma | FADS1 | 0.05 | 0.05 | blup | 53 | 0.04 | 6.8e-05 | -4.2 | 5.3 | 1.4e-07 | -0.87 | 0.03 | 0.96 | FALSE |