[Hub]/) : Traits : Hypothyroidism/myxoedema (self-reported) : ← →

chr15:38,088,200-39,556,796

Best TWAS P=7.37e-11 · Best GWAS P=4.45e-12 conditioned to 0.0149

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Esophagus Mucosa RASGRP1 0.31 0.34 lasso 5 0.33 6.6e-23 6.1 6.2 6.2e-10 0.76 0.31 0.69 FALSE
2 GTEx Skin Not Sun Exposed Suprapubic RASGRP1 0.37 0.44 lasso 5 0.42 3.6e-25 6.1 6.2 6.1e-10 0.75 0.31 0.69 FALSE
3 GTEx Skin Sun Exposed Lower leg RASGRP1 0.37 0.33 lasso 6 0.38 1.2e-32 6.1 5.9 4.8e-09 0.73 0.33 0.67 FALSE
4 The Cancer Genome Atlas Colon Adenocarcinoma RASGRP1 0.10 0.01 blup 67 0.02 1.9e-02 3.9 5.2 2.6e-07 0.64 0.03 0.30 FALSE
5 The Cancer Genome Atlas Prostate Adenocarcinoma RASGRP1 0.05 0.03 lasso 2 0.02 1.9e-03 6.8 6.5 7.4e-11 0.90 0.01 0.97 TRUE
6 The Cancer Genome Atlas Skin Cutaneous Melanoma RASGRP1 0.17 -0.01 blup 72 0.03 5.8e-02 3.6 5.4 6.7e-08 0.79 0.01 0.45 FALSE