[Hub]/) : Traits : Hypothyroidism/myxoedema (self-reported) : ← →

chr12:109,641,978-113,517,494

Best TWAS P=8.48e-48 · Best GWAS P=1.11e-81 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	ALDH2	0.05	0.11	blup	223	0.10	1.8e-12	-7.19	7.7	1.2e-14	0.42	1.00	0.00	TRUE
2	CommonMind	Brain Pre-frontal Cortex	ATXN2	0.02	0.03	enet	8	0.02	4.8e-04	-7.95	10.4	1.8e-25	0.56	0.28	0.61	FALSE
3	CommonMind	Brain Pre-frontal Cortex	NAA25	0.03	0.02	blup	213	0.03	1.1e-04	-4.28	-5.4	7.7e-08	-0.33	0.74	0.02	FALSE
4	GTEx	Adipose Subcutaneous	HECTD4	0.06	0.00	enet	15	0.02	1.0e-02	-7.20	13.0	9.7e-39	0.65	0.06	0.84	TRUE
5	GTEx	Adipose Subcutaneous	MAPKAPK5-AS1	0.08	0.01	enet	26	0.03	2.1e-03	-8.30	-8.2	2.9e-16	-0.44	0.98	0.01	FALSE
6	GTEx	Adipose Subcutaneous	AC003029.1	0.08	0.07	enet	30	0.05	1.2e-04	-7.20	-8.7	3.5e-18	-0.47	1.00	0.00	FALSE
7	GTEx	Adrenal Gland	MAPKAPK5-AS1	0.10	0.08	lasso	12	0.03	3.0e-02	-7.10	-7.1	1.5e-12	-0.39	0.56	0.06	FALSE
8	GTEx	Adrenal Gland	AC003029.1	0.12	0.10	lasso	13	0.07	2.0e-03	-7.10	-7.2	6.1e-13	-0.39	0.80	0.04	FALSE
9	GTEx	Artery Aorta	ALDH2	0.05	0.04	enet	33	0.05	1.3e-03	-5.81	7.3	2.2e-13	0.38	0.59	0.10	FALSE
10	GTEx	Artery Aorta	AC003029.1	0.07	0.01	lasso	7	0.01	5.4e-02	-8.21	-8.2	3.5e-16	-0.43	0.20	0.27	FALSE
11	GTEx	Artery Coronary	MAPKAPK5-AS1	0.16	0.10	lasso	13	0.06	5.7e-03	-7.12	-7.3	3.6e-13	-0.38	0.39	0.07	FALSE
12	GTEx	Artery Coronary	AC003029.1	0.14	0.12	enet	39	0.07	1.8e-03	-7.12	-6.9	6.2e-12	-0.34	0.61	0.04	FALSE
13	GTEx	Artery Tibial	ALDH2	0.08	0.09	lasso	2	0.07	2.7e-06	-7.20	7.8	8.5e-15	0.41	0.95	0.02	FALSE
14	GTEx	Artery Tibial	HECTD4	0.05	0.02	lasso	3	0.01	3.1e-02	15.33	14.5	8.5e-48	0.78	0.02	0.92	TRUE
15	GTEx	Artery Tibial	MAPKAPK5-AS1	0.07	0.05	lasso	11	0.05	9.7e-05	-4.28	-5.6	2.1e-08	-0.33	0.76	0.02	FALSE
16	GTEx	Artery Tibial	AC003029.1	0.05	0.04	lasso	12	0.03	3.6e-03	-7.15	-6.9	6.4e-12	-0.38	0.58	0.04	FALSE
17	GTEx	Brain Cerebellar Hemisphere	NAA25	0.11	0.02	enet	10	0.00	2.5e-01	-3.80	-5.5	4.4e-08	-0.33	0.14	0.06	FALSE
18	GTEx	Brain Cerebellar Hemisphere	ADAM1A	0.21	0.01	enet	29	0.03	6.8e-02	-3.79	7.3	3.2e-13	0.39	0.04	0.16	TRUE
19	GTEx	Brain Cerebellum	NAA25	0.12	-0.01	lasso	12	0.00	3.0e-01	-3.87	-6.0	2.3e-09	-0.34	0.12	0.07	FALSE
20	GTEx	Brain Cerebellum	HECTD4	0.25	-0.01	enet	24	0.06	7.7e-03	-2.08	7.4	1.9e-13	0.42	0.06	0.72	FALSE
21	GTEx	Brain Frontal Cortex BA9	ALDH2	0.33	0.04	enet	24	0.09	2.0e-03	-7.00	6.9	4.9e-12	0.33	0.09	0.08	FALSE
22	GTEx	Brain Frontal Cortex BA9	TMEM116	0.10	0.09	lasso	7	0.18	1.9e-05	-7.03	-6.0	1.6e-09	-0.36	0.38	0.04	FALSE
23	GTEx	Brain Putamen basal ganglia	ALDH2	0.12	0.00	lasso	14	0.02	1.3e-01	-6.64	6.8	9.0e-12	0.39	0.17	0.13	FALSE
24	GTEx	Breast Mammary Tissue	VPS29	0.20	0.03	enet	33	0.08	5.2e-05	8.56	-5.8	6.2e-09	-0.25	0.05	0.76	FALSE
25	GTEx	Breast Mammary Tissue	HECTD4	0.06	0.08	lasso	1	0.07	1.6e-04	-7.12	7.1	1.1e-12	0.38	0.32	0.19	FALSE
26	GTEx	Breast Mammary Tissue (Male)	RP3-462E2.3	0.12	0.03	lasso	7	0.04	4.0e-02	-4.03	-7.2	8.6e-13	-0.39	0.02	0.06	TRUE
27	GTEx	Breast Mammary Tissue (Female)	VPS29	0.10	-0.01	lasso	2	0.02	1.0e-01	8.56	-7.1	1.0e-12	-0.34	0.03	0.21	TRUE
28	GTEx	Breast Mammary Tissue (Female)	RP3-462E2.3	0.13	0.00	lasso	5	-0.01	7.8e-01	-5.32	-5.4	5.6e-08	-0.24	0.04	0.05	FALSE
29	GTEx	Cells Transformed fibroblasts	HECTD4	0.04	0.01	lasso	5	0.00	4.5e-01	-3.81	6.0	2.2e-09	0.35	0.22	0.04	FALSE
30	GTEx	Cells Transformed fibroblasts	MAPKAPK5-AS1	0.06	0.04	lasso	12	0.02	9.5e-03	-7.12	-7.0	1.8e-12	-0.38	0.53	0.04	FALSE
31	GTEx	Cells Transformed fibroblasts	AC003029.1	0.06	0.05	lasso	1	0.03	2.1e-03	-7.12	-7.1	1.1e-12	-0.38	0.66	0.02	FALSE
32	GTEx	Colon Sigmoid	MAPKAPK5-AS1	0.17	0.05	lasso	15	0.07	1.5e-03	-7.12	-6.6	4.7e-11	-0.37	0.51	0.06	FALSE
33	GTEx	Colon Sigmoid	AC003029.1	0.17	0.08	lasso	14	0.09	3.8e-04	-7.12	-6.1	9.6e-10	-0.35	0.60	0.07	FALSE
34	GTEx	Colon Transverse	VPS29	0.13	0.01	enet	41	0.10	2.0e-05	-1.16	-5.6	2.4e-08	-0.12	0.08	0.20	FALSE
35	GTEx	Colon Transverse	FAM109A	0.21	0.00	lasso	4	0.01	1.3e-01	-8.27	7.4	1.5e-13	0.41	0.06	0.06	FALSE
36	GTEx	Colon Transverse	MAPKAPK5-AS1	0.16	0.09	lasso	13	0.06	7.1e-04	-7.12	-7.1	1.4e-12	-0.39	0.82	0.02	FALSE
37	GTEx	Colon Transverse	AC003029.1	0.15	0.09	lasso	12	0.07	2.1e-04	-7.15	-7.1	1.0e-12	-0.39	0.81	0.02	FALSE
38	GTEx	Esophagus Gastroesophageal Junction	AC003029.1	0.06	0.03	lasso	3	0.04	1.9e-02	-6.65	-7.1	1.2e-12	-0.38	0.15	0.09	FALSE
39	GTEx	Esophagus Mucosa	ALDH2	0.05	0.06	lasso	6	0.07	1.7e-05	-7.10	7.9	1.9e-15	0.43	0.92	0.04	FALSE
40	GTEx	Esophagus Muscularis	HECTD4	0.06	0.03	lasso	4	0.02	1.8e-02	-7.10	7.7	1.5e-14	0.41	0.57	0.07	FALSE
41	GTEx	Esophagus Muscularis	MAPKAPK5-AS1	0.04	0.02	enet	7	0.02	2.7e-02	-7.10	-7.2	5.2e-13	-0.39	0.35	0.03	FALSE
42	GTEx	Esophagus Muscularis	RP3-462E2.5	0.06	0.04	lasso	14	0.03	4.6e-03	-4.28	5.2	2.5e-07	0.32	0.75	0.02	FALSE
43	GTEx	Heart Atrial Appendage	ALDH2	0.16	0.14	lasso	3	0.10	2.4e-05	-5.65	6.2	6.8e-10	0.28	0.52	0.04	FALSE
44	GTEx	Heart Left Ventricle	ADAM1A	0.20	0.07	enet	22	0.10	4.3e-06	-3.81	-7.7	1.0e-14	-0.34	0.35	0.15	TRUE
45	GTEx	Lung	ALDH2	0.07	0.01	lasso	10	0.02	5.9e-03	-7.03	7.4	1.3e-13	0.39	0.38	0.04	FALSE
46	GTEx	Lung	RP3-462E2.3	0.11	0.10	lasso	6	0.09	2.2e-07	-5.81	-6.2	7.3e-10	-0.29	1.00	0.00	FALSE
47	GTEx	Muscle Skeletal	MAPKAPK5	0.08	0.04	lasso	7	0.02	3.6e-03	-5.32	6.0	2.2e-09	0.28	0.79	0.01	FALSE
48	GTEx	Nerve Tibial	ALDH2	0.05	0.04	lasso	3	0.05	2.4e-04	-7.10	7.2	4.8e-13	0.39	0.76	0.02	FALSE
49	GTEx	Nerve Tibial	HECTD4	0.05	0.01	enet	6	0.01	3.6e-02	-8.18	8.2	3.3e-16	0.41	0.22	0.46	FALSE
50	GTEx	Nerve Tibial	AC003029.1	0.04	0.00	lasso	23	0.00	4.2e-01	-4.28	-6.8	9.4e-12	-0.38	0.18	0.05	FALSE
51	GTEx	Nerve Tibial	RP3-462E2.3	0.12	0.03	lasso	7	0.03	2.7e-03	-5.32	-6.6	4.8e-11	-0.32	0.93	0.00	FALSE
52	GTEx	Pituitary	ADAM1A	0.18	0.22	enet	42	0.20	9.6e-06	-3.77	6.0	2.7e-09	0.35	0.80	0.03	FALSE
53	GTEx	Pituitary	RP3-462E2.5	0.15	0.12	lasso	3	0.14	2.3e-04	-7.20	8.1	5.4e-16	0.43	0.23	0.05	FALSE
54	GTEx	Prostate	ADAM1A	0.30	0.11	lasso	16	0.12	5.4e-04	-4.25	5.3	9.5e-08	0.34	0.49	0.22	FALSE
55	GTEx	Skin Not Sun Exposed Suprapubic	ALDH2	0.13	0.18	lasso	9	0.16	5.0e-09	-7.12	7.5	8.4e-14	0.40	1.00	0.00	FALSE
56	GTEx	Skin Not Sun Exposed Suprapubic	MAPKAPK5-AS1	0.04	0.00	enet	30	0.00	7.0e-01	-7.15	-9.8	8.9e-23	-0.53	0.21	0.17	FALSE
57	GTEx	Skin Sun Exposed Lower leg	ALDH2	0.10	0.09	enet	13	0.13	6.7e-11	-7.19	11.8	5.7e-32	0.62	0.98	0.02	FALSE
58	GTEx	Skin Sun Exposed Lower leg	MAPKAPK5-AS1	0.09	0.10	lasso	4	0.10	1.1e-08	-7.20	-7.2	6.4e-13	-0.39	1.00	0.00	FALSE
59	GTEx	Skin Sun Exposed Lower leg	AC003029.1	0.09	0.10	lasso	2	0.10	8.8e-09	-7.22	-7.3	2.8e-13	-0.39	1.00	0.00	FALSE
60	GTEx	Skin Sun Exposed Lower leg	RP3-462E2.3	0.06	0.05	lasso	6	0.05	1.0e-04	-5.81	-5.8	6.4e-09	-0.27	0.41	0.02	FALSE
61	GTEx	Stomach	TMEM116	0.13	0.03	lasso	7	0.03	1.6e-02	-3.87	-8.1	4.0e-16	-0.46	0.07	0.15	FALSE
62	GTEx	Stomach	AC003029.1	0.10	0.03	enet	32	0.02	2.6e-02	-7.12	-6.4	1.5e-10	-0.34	0.47	0.08	FALSE
63	GTEx	Testis	MAPKAPK5	0.23	0.12	lasso	5	0.15	3.1e-07	-5.81	8.1	4.7e-16	0.41	0.72	0.22	FALSE
64	GTEx	Testis	BRAP	0.06	0.03	enet	13	0.01	8.7e-02	-7.10	-7.5	6.5e-14	-0.41	0.43	0.08	FALSE
65	GTEx	Testis	MAPKAPK5-AS1	0.07	0.04	lasso	1	0.03	1.3e-02	-7.15	-7.2	8.8e-13	-0.38	0.19	0.13	FALSE
66	GTEx	Testis	AC003029.1	0.10	0.10	lasso	14	0.09	5.8e-05	-7.15	-6.9	4.3e-12	-0.38	0.64	0.12	FALSE
67	GTEx	Thyroid	BRAP	0.07	0.02	lasso	7	0.03	1.1e-03	-8.26	-10.5	7.7e-26	-0.54	0.40	0.36	FALSE
68	GTEx	Thyroid	ALDH2	0.06	0.04	lasso	4	0.05	9.7e-05	-8.21	8.5	1.5e-17	0.47	0.87	0.07	FALSE
69	GTEx	Thyroid	MAPKAPK5-AS1	0.04	0.04	lasso	2	0.03	1.5e-03	-7.12	-7.2	8.9e-13	-0.38	0.62	0.02	FALSE
70	GTEx	Thyroid	AC003029.1	0.04	0.05	lasso	3	0.04	8.3e-04	-7.12	-7.2	4.2e-13	-0.39	0.81	0.04	FALSE
71	GTEx	Whole Blood	RP3-462E2.3	0.07	0.05	lasso	4	0.03	1.7e-03	-5.32	-5.3	1.0e-07	-0.24	0.65	0.01	FALSE
72	METSIM	Adipose	ALDH2	0.07	0.00	bslmm	220	0.02	2.5e-04	-5.81	7.1	1.1e-12	0.32	0.16	0.04	FALSE
73	NTR	Blood	ALDH2	0.06	0.01	blup	222	0.02	4.3e-08	-3.33	-7.8	8.8e-15	-0.43	0.99	0.00	FALSE
74	NTR	Blood	TCHP	0.01	0.00	lasso	2	0.00	2.6e-02	-4.97	-5.5	3.0e-08	-0.13	0.02	0.65	FALSE
75	YFS	Blood	ACAD10	0.07	0.01	bslmm	241	0.02	4.3e-08	-8.18	-8.3	8.4e-17	-0.41	0.09	0.40	FALSE
76	YFS	Blood	SH2B3	0.05	0.01	enet	22	0.02	3.3e-07	-8.26	13.5	2.1e-41	0.64	0.77	0.23	FALSE
77	YFS	Blood	TCTN1	0.05	0.00	bslmm	204	0.02	3.1e-06	0.92	-6.4	1.3e-10	-0.21	0.25	0.64	FALSE
78	YFS	Blood	TRAFD1	0.04	0.02	lasso	2	0.01	2.9e-05	8.98	11.0	4.6e-28	0.55	0.09	0.85	FALSE
79	The Cancer Genome Atlas	Breast Invasive Carcinoma	C12orf47	0.01	0.01	blup	31	0.01	7.3e-03	-7.14	-6.9	4.3e-12	-0.38	0.08	0.04	FALSE
80	The Cancer Genome Atlas	Breast Invasive Carcinoma	MAPKAPK5	0.04	0.02	lasso	4	0.02	5.4e-05	-5.81	6.1	1.0e-09	0.28	0.54	0.26	FALSE
81	The Cancer Genome Atlas	Colon Adenocarcinoma	ALDH2	0.07	0.03	lasso	4	0.06	3.9e-04	-5.32	8.9	3.4e-19	0.44	0.01	0.91	TRUE
82	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	C12orf47	0.03	0.03	lasso	3	0.03	6.3e-04	-5.32	-6.1	9.0e-10	-0.29	0.16	0.10	FALSE
83	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	C12orf47	0.07	0.04	lasso	2	0.03	1.0e-04	-7.18	-6.7	2.2e-11	-0.36	0.18	0.77	FALSE
84	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	MAPKAPK5	0.06	0.03	lasso	3	0.03	6.5e-04	-5.81	5.8	7.7e-09	0.26	0.24	0.08	FALSE
85	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	ALDH2	0.10	0.08	blup	30	0.09	4.5e-06	-7.25	6.3	3.2e-10	0.36	0.72	0.09	FALSE
86	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	TMEM116	0.04	0.04	enet	13	0.04	2.7e-03	-3.87	-5.3	1.2e-07	-0.31	0.05	0.12	FALSE
87	The Cancer Genome Atlas	Brain Lower Grade Glioma	ACAD10	0.02	0.02	lasso	3	0.01	7.0e-03	-9.82	-9.8	7.4e-23	-0.50	0.00	0.92	FALSE
88	The Cancer Genome Atlas	Brain Lower Grade Glioma	ALDH2	0.03	0.03	lasso	1	0.03	3.1e-04	-7.19	7.2	6.3e-13	0.38	0.04	0.50	FALSE
89	The Cancer Genome Atlas	Brain Lower Grade Glioma	MAPKAPK5	0.03	0.01	blup	42	0.01	2.5e-02	-5.81	7.5	8.7e-14	0.37	0.05	0.48	FALSE
90	The Cancer Genome Atlas	Brain Lower Grade Glioma	TMEM116	0.03	0.03	blup	43	0.03	8.0e-05	-4.22	-7.4	1.3e-13	-0.43	0.52	0.21	FALSE
91	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	TMEM116	0.04	0.02	blup	43	0.02	3.5e-02	-4.28	-6.8	1.3e-11	-0.39	0.03	0.12	FALSE
92	The Cancer Genome Atlas	Lung Adenocarcinoma	C12orf47	0.02	0.01	blup	31	0.02	1.7e-03	-7.12	-6.7	2.4e-11	-0.36	0.14	0.08	FALSE
93	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	TMEM116	0.12	0.07	blup	43	0.10	7.6e-05	-4.28	-6.1	1.2e-09	-0.37	0.36	0.21	FALSE
94	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	ALDH2	0.08	0.08	blup	32	0.09	2.3e-04	-7.12	7.0	2.7e-12	0.37	0.18	0.40	FALSE
95	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	ERP29	0.11	0.03	blup	25	0.05	5.0e-03	-7.16	-11.0	3.7e-28	-0.60	0.01	0.75	FALSE
96	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	TMEM116	0.17	0.06	blup	43	0.05	5.6e-03	-4.28	-5.3	1.4e-07	-0.34	0.09	0.20	FALSE
97	The Cancer Genome Atlas	Prostate Adenocarcinoma	ALDH2	0.02	0.02	blup	31	0.01	1.2e-02	-7.06	6.3	2.3e-10	0.35	0.06	0.05	FALSE
98	The Cancer Genome Atlas	Prostate Adenocarcinoma	C12orf47	0.04	0.03	blup	31	0.02	2.8e-03	-7.06	-5.2	1.8e-07	-0.30	0.13	0.06	FALSE
99	The Cancer Genome Atlas	Thyroid Carcinoma	ALDH2	0.03	0.02	blup	31	0.02	6.4e-03	-7.12	6.0	1.7e-09	0.32	0.08	0.12	FALSE