Best TWAS P=1.76e-14 · Best GWAS P=5.1e-16 conditioned to 0.00497
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Subcutaneous | UFL1 | 0.06 | 0.01 | enet | 17 | 0.01 | 2.5e-02 | 7.6 | 5.7 | 1.0e-08 | 0.68 | 0.04 | 0.72 | FALSE |
2 | GTEx | Artery Tibial | UFL1 | 0.08 | 0.05 | lasso | 4 | 0.04 | 7.9e-04 | 5.2 | 5.3 | 1.3e-07 | 0.71 | 0.17 | 0.75 | FALSE |
3 | GTEx | Pancreas | UFL1 | 0.08 | 0.11 | enet | 7 | 0.09 | 1.1e-04 | 5.3 | 5.9 | 4.2e-09 | 0.70 | 0.20 | 0.56 | FALSE |
4 | GTEx | Testis | FHL5 | 0.11 | 0.11 | lasso | 5 | 0.10 | 3.5e-05 | 4.2 | -5.6 | 2.6e-08 | -0.76 | 0.16 | 0.56 | FALSE |
5 | GTEx | Thyroid | UFL1 | 0.06 | 0.00 | lasso | 2 | 0.00 | 6.6e-01 | 5.5 | 5.4 | 6.4e-08 | 0.68 | 0.10 | 0.52 | FALSE |
6 | NTR | Blood | KIAA0776 | 0.02 | 0.02 | lasso | 1 | 0.02 | 1.1e-07 | 7.7 | 7.7 | 1.8e-14 | 0.89 | 0.05 | 0.95 | TRUE |
7 | The Cancer Genome Atlas | Lung Adenocarcinoma | FHL5 | 0.03 | 0.02 | blup | 55 | 0.01 | 7.1e-03 | 5.2 | -5.6 | 1.8e-08 | -0.73 | 0.02 | 0.69 | FALSE |
8 | The Cancer Genome Atlas | Thyroid Carcinoma | KIAA0776 | 0.05 | 0.07 | lasso | 2 | 0.06 | 1.8e-06 | 5.2 | 5.5 | 2.9e-08 | 0.74 | 0.35 | 0.62 | FALSE |