Hub : Traits :

Migraine (self-reported)

22 significantly associated models · 11 unique genes.

Significant Loci

#	chr	p0	p1	# assoc genes	# joint genes	best TWAS P	best SNP P	cond SNP P	% var exp	joint genes
1	6	12020241	13990267	2	1	1.5e-14	3.8e-14	1.0000	100	RP1-257A7.5
2	6	96275538	97756290	3	1	1.8e-14	5.1e-16	0.0050	88	KIAA0776
3	10	29001607	30472392	1	1	8.2e-08	8.6e-06	0.0054	61	PTCHD3P1
4	12	56805309	58303535	4	1	7.3e-23	7.9e-23	1.0000	100	LRP1
5	14	55781054	56293564	1	1	1.2e-07	3.8e-05	0.4700	97	C14orf33

Pleiotropic Associations

Trait	chisq ratio	# genes⁺	# genes⁺⁺	% genes⁺⁺	corr	corr P	genes
Headache pain in last month	41.83	4	3	6.7	0.95	0.048	C14orf33 KIAA0776 LRP1 RP1-257A7.5
Medication: Paracetamol	18.00	3	3	6.7	0.00	1.000	KIAA0776 LRP1 RP1-257A7.5
Medication: Ibuprofen (e.g. Nurofen)	17.65	3	2	4.4	0.00	1.000	KIAA0776 LRP1 RP1-257A7.5
Medication for pain relief, constipation, heartburn	14.91	3	2	4.4	0.00	1.000	KIAA0776 LRP1 RP1-257A7.5
Medication: Paracetamol	14.82	3	2	4.4	0.00	1.000	KIAA0776 LRP1 RP1-257A7.5
Medication: Ibuprofen	13.56	2	2	4.4	0.00	1.000	LRP1 RP1-257A7.5
Heart attack/myocardial infarction (self-reported)	10.71	1	1	2.2	0.00	1.000	RP1-257A7.5
Heart attack	10.41	1	1	2.2	0.00	1.000	RP1-257A7.5
Pain experienced in last month	8.39	3	1	2.2	0.00	1.000	KIAA0776 LRP1 RP1-257A7.5
Coronary Artery Disease (CAD)	8.36	1	1	2.2	0.00	1.000	RP1-257A7.5
Illnesses of father: Heart disease	6.81	1	1	2.2	0.00	1.000	RP1-257A7.5
Lung FEV1/FVC ratio	5.74	1	1	2.2	0.00	1.000	LRP1
Angina (self-reported)	5.67	1	1	2.2	0.00	1.000	RP1-257A7.5
Angina	5.66	1	1	2.2	0.00	1.000	RP1-257A7.5
Vitamin and mineral supplements	5.00	1	1	2.2	0.00	1.000	LRP1
Alcohol intake frequency.	4.97	2	0	0.0	0.00	1.000	LRP1 RP1-257A7.5
Heart disease (siblings)	4.83	1	1	2.2	0.00	1.000	RP1-257A7.5
Number of treatments/medications taken	4.66	2	0	0.0	0.00	1.000	KIAA0776 LRP1
Pulse wave Arterial Stiffness index	4.48	1	0	0.0	0.00	1.000	RP1-257A7.5
Pulse wave peak to peak time	4.25	1	0	0.0	0.00	1.000	RP1-257A7.5
Pulse wave reflection index	4.22	1	0	0.0	0.00	1.000	PTCHD3P1
Pulse rate, automated reading	4.18	3	1	2.2	0.00	1.000	C14orf33 PTCHD3P1 RP1-257A7.5
Heart disease (mother)	4.05	1	0	0.0	0.00	1.000	RP1-257A7.5
Mineral and other dietary supplements	4.02	1	0	0.0	0.00	1.000	LRP1
Birth weight	3.71	2	0	0.0	0.00	1.000	LRP1 PTCHD3P1
Respiratory disease	3.68	1	1	2.2	0.00	1.000	LRP1
Systolic blood pressure, automated reading	3.56	2	0	0.0	0.00	1.000	KIAA0776 RP1-257A7.5
Supplements: Fish oil (including cod liver oil)	3.36	1	0	0.0	0.00	1.000	LRP1
Birth weight of first child	3.34	1	0	0.0	0.00	1.000	PTCHD3P1
High blood pressure (mother)	3.30	1	0	0.0	0.00	1.000	RP1-257A7.5
Had major operations	3.22	1	0	0.0	0.00	1.000	RP1-257A7.5
Asthma (self-reported)	3.09	1	0	0.0	0.00	1.000	LRP1
Myopia	3.08	1	0	0.0	0.00	1.000	LRP1
Hayfever/allergic rhinitis (self-reported)	3.07	1	0	0.0	0.00	1.000	LRP1
Primary Biliary Cirrhosis	3.00	1	0	0.0	0.00	1.000	LRP1
Asthma	2.97	1	0	0.0	0.00	1.000	LRP1
Systolic Blood Pressure	2.85	2	2	4.4	0.00	1.000	KIAA0776 RP1-257A7.5
Diastolic blood pressure, automated reading	2.85	2	0	0.0	0.00	1.000	C14orf33 PTCHD3P1
Multivitamins +/- minerals	2.79	1	0	0.0	0.00	1.000	LRP1
Leg fat percentage (right)	2.57	1	0	0.0	0.00	1.000	LRP1
Leg fat percentage (left)	2.52	1	0	0.0	0.00	1.000	LRP1
Allergy	2.46	1	0	0.0	0.00	1.000	LRP1
Hand grip strength (left)	2.40	1	1	2.2	0.00	1.000	RP1-257A7.5
Medication: Bendroflumethiazide	2.34	1	0	0.0	0.00	1.000	RP1-257A7.5
Hand grip strength (right)	2.32	2	0	0.0	0.00	1.000	LRP1 RP1-257A7.5
Sensitivity / hurt feelings	2.31	1	0	0.0	0.00	1.000	LRP1
Number of operations (self-reported)	2.23	1	0	0.0	0.00	1.000	LRP1
Mouth/teeth dental problems: Loose teeth	2.22	1	0	0.0	0.00	1.000	PTCHD3P1
Hayfever, allergic rhinitis or eczema	2.15	1	0	0.0	0.00	1.000	LRP1
Pulse rate	2.12	1	0	0.0	0.00	1.000	PTCHD3P1
Mood swings	2.10	1	0	0.0	0.00	1.000	LRP1
Allergy or Eczema	1.97	1	0	0.0	0.00	1.000	LRP1
High blood pressure (siblings)	1.97	1	0	0.0	0.00	1.000	LRP1
Body fat percentage	1.69	1	0	0.0	0.00	1.000	LRP1
Arm fat percentage (left)	1.59	1	0	0.0	0.00	1.000	LRP1
BMI	1.53	2	0	0.0	0.00	1.000	C14orf33 LRP1
Arm fat percentage (right)	1.52	1	0	0.0	0.00	1.000	LRP1
Body mass index (BMI)	1.49	2	0	0.0	0.00	1.000	C14orf33 LRP1
Sitting height	1.48	1	1	2.2	0.00	1.000	LRP1
Neuroticism	1.47	1	0	0.0	0.00	1.000	LRP1
Depressed Affect (Nagel 2018)	1.44	1	0	0.0	0.00	1.000	LRP1
Miserableness	1.42	1	0	0.0	0.00	1.000	LRP1
Impedance of arm (left)	1.34	1	0	0.0	0.00	1.000	C14orf33
Leg fat mass (right)	1.33	1	0	0.0	0.00	1.000	LRP1
Leg fat mass (left)	1.33	1	0	0.0	0.00	1.000	LRP1
Trunk fat percentage	1.27	1	0	0.0	0.00	1.000	LRP1
Schizophrenia (2018)	1.23	1	0	0.0	0.00	1.000	LRP1
Hypertension (Self-reported)	1.20	1	0	0.0	0.00	1.000	RP1-257A7.5
Impedance of whole body	1.20	1	0	0.0	0.00	1.000	C14orf33
Blood Eosinophil Count	1.10	1	1	2.2	0.00	1.000	LRP1
Blood Platelet Count	0.98	2	0	0.0	0.00	1.000	KIAA0776 PTCHD3P1
Standing height	0.95	1	1	2.2	0.00	1.000	LRP1
Blood White Count	0.94	1	0	0.0	0.00	1.000	PTCHD3P1
Heel bone mineral density (BMD) T-score, automated (right)	0.94	1	0	0.0	0.00	1.000	PTCHD3P1
Impedance of arm (right)	0.93	1	0	0.0	0.00	1.000	C14orf33
Height	0.91	3	2	4.4	0.00	1.000	C14orf33 LRP1 PTCHD3P1
Impedance of leg (right)	0.85	1	0	0.0	0.00	1.000	C14orf33
Bipolar Disorder or Schizophrenia	0.84	1	0	0.0	0.00	1.000	LRP1
Impedance of leg (left)	0.74	1	0	0.0	0.00	1.000	C14orf33
Trunk fat-free mass	0.74	1	0	0.0	0.00	1.000	LRP1
Trunk predicted mass	0.74	1	0	0.0	0.00	1.000	LRP1
Lung FVC	0.59	1	0	0.0	0.00	1.000	PTCHD3P1
Whole body fat-free mass	0.59	1	0	0.0	0.00	1.000	LRP1
Whole body water mass	0.57	1	0	0.0	0.00	1.000	LRP1
Blood Red Count	0.56	1	0	0.0	0.00	1.000	RP1-257A7.5
Heel T-Score	0.53	1	0	0.0	0.00	1.000	PTCHD3P1
Tanning	0.21	1	0	0.0	0.00	1.000	C14orf33
Hair Pigment	0.15	1	0	0.0	0.00	1.000	LRP1

Associations by panel

study	tissue	# hits	% hits/tests	avg chisq
GTEx	Artery Coronary	1	0.085	1.4
GTEx	Artery Tibial	5	0.133	1.4
GTEx	Brain Caudate basal ganglia	0	0.000	1.4
The Cancer Genome Atlas	Esophageal Carcinoma	0	0.000	1.4
GTEx	Adipose Visceral Omentum	0	0.000	1.3
GTEx	Artery Aorta	4	0.134	1.3
GTEx	Brain Cerebellar Hemisphere	0	0.000	1.3
GTEx	Brain Frontal Cortex BA9	0	0.000	1.3
GTEx	Brain Hippocampus	0	0.000	1.3
GTEx	Brain Putamen basal ganglia	0	0.000	1.3
GTEx	Breast Mammary Tissue (Male)	0	0.000	1.3
GTEx	Cells EBV-transformed lymphocytes	0	0.000	1.3
GTEx	Cells Transformed fibroblasts	0	0.000	1.3
GTEx	Colon Sigmoid	0	0.000	1.3
GTEx	Esophagus Mucosa	0	0.000	1.3
GTEx	Esophagus Muscularis	0	0.000	1.3
GTEx	Heart Left Ventricle	0	0.000	1.3
GTEx	Liver	0	0.000	1.3
GTEx	Lung	0	0.000	1.3
GTEx	Pancreas	1	0.061	1.3
GTEx	Prostate	0	0.000	1.3
GTEx	Skin Not Sun Exposed Suprapubic	0	0.000	1.3
GTEx	Spleen	0	0.000	1.3
GTEx	Stomach	0	0.000	1.3
GTEx	Testis	1	0.032	1.3
GTEx	Thyroid	1	0.025	1.3
GTEx	Whole Blood	0	0.000	1.3
ROSMAP	Brain Pre-frontal Cortex	0	0.000	1.3
CommonMind	Brain Pre-frontal Cortex	1	0.019	1.3
The Cancer Genome Atlas	Bladder Urothelial Carcinoma	0	0.000	1.3
The Cancer Genome Atlas	Colon Adenocarcinoma	0	0.000	1.3
The Cancer Genome Atlas	Glioblastoma Multiforme	0	0.000	1.3
The Cancer Genome Atlas	Lung Adenocarcinoma	1	0.034	1.3
GTEx	Adipose Subcutaneous	1	0.029	1.2
GTEx	Adrenal Gland	0	0.000	1.2
GTEx	Brain Cerebellum	0	0.000	1.2
GTEx	Brain Cortex	0	0.000	1.2
GTEx	Brain Hypothalamus	0	0.000	1.2
GTEx	Brain Nucleus accumbens basal ganglia	0	0.000	1.2
GTEx	Breast Mammary Tissue	0	0.000	1.2
GTEx	Colon Transverse	0	0.000	1.2
GTEx	Esophagus Gastroesophageal Junction	0	0.000	1.2
GTEx	Heart Atrial Appendage	0	0.000	1.2
GTEx	Muscle Skeletal	0	0.000	1.2
GTEx	Nerve Tibial	0	0.000	1.2
GTEx	Ovary	0	0.000	1.2
GTEx	Pituitary	0	0.000	1.2
GTEx	Skin Sun Exposed Lower leg	0	0.000	1.2
GTEx	Small Intestine Terminal Ileum	0	0.000	1.2
GTEx	Uterus	0	0.000	1.2
GTEx	Vagina	0	0.000	1.2
METSIM	Adipose	1	0.022	1.2
NTR	Blood	1	0.042	1.2
YFS	Blood	0	0.000	1.2
The Cancer Genome Atlas	Breast Invasive Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Brain Lower Grade Glioma	0	0.000	1.2
The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	0	0.000	1.2
The Cancer Genome Atlas	Pancreatic Adenocarcinoma	0	0.000	1.2
The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	0	0.000	1.2
The Cancer Genome Atlas	Prostate Adenocarcinoma	0	0.000	1.2
The Cancer Genome Atlas	Rectum Adenocarcinoma	0	0.000	1.2
The Cancer Genome Atlas	Soft Tissue Sarcoma	0	0.000	1.2
The Cancer Genome Atlas	Skin Cutaneous Melanoma	0	0.000	1.2
The Cancer Genome Atlas	Stomach Adenocarcinoma	0	0.000	1.2
The Cancer Genome Atlas	Testicular Germ Cell Tumors	0	0.000	1.2
The Cancer Genome Atlas	Thyroid Carcinoma	4	0.078	1.2
The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	0	0.000	1.2
GTEx	Breast Mammary Tissue (Female)	0	0.000	1.1