TWAS
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Usage
Models
Genes
Traits
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Medication: Allopurinol
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chr12:121,820,692-123,326,374
Best TWAS P=3.04e-09 · Best GWAS P=9.72e-10 conditioned to 0.0918
121.8M
122M
122.2M
122.4M
122.6M
122.8M
123M
123.2M
123.4M
0
2
4
6
8
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
1
GTEx
Colon Transverse
MLXIP
0.20
0.18
enet
23
0.14
5.8e-07
-6.0
-5.9
3.0e-09
0.92
0.01
0.99
TRUE
2
The Cancer Genome Atlas
Colon Adenocarcinoma
MLXIP
0.06
0.04
lasso
7
0.02
2.7e-02
-6.1
-5.9
3.1e-09
0.99
0.02
0.94
FALSE
3
The Cancer Genome Atlas
Rectum Adenocarcinoma
MLXIP
0.18
0.14
lasso
4
0.13
5.1e-04
-5.1
-5.4
8.5e-08
0.92
0.02
0.88
FALSE
4
The Cancer Genome Atlas
Stomach Adenocarcinoma
MLXIP
0.06
0.02
blup
68
0.04
1.2e-03
-6.1
-5.2
1.8e-07
0.89
0.02
0.89
FALSE