Best TWAS P=4.4e-09 · Best GWAS P=8.52e-21 conditioned to 7.62e-13
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Stomach | RP4-635E18.7 | 0.13 | 0.06 | enet | 25 | 0.03 | 8.8e-03 | -0.85 | -5.5 | 3.8e-08 | -0.44 | 0.12 | 0.58 | TRUE |
| 2 | The Cancer Genome Atlas | Breast Invasive Carcinoma | CLCN6 | 0.06 | 0.06 | blup | 104 | 0.06 | 5.0e-12 | -4.86 | -5.9 | 4.4e-09 | -0.09 | 0.13 | 0.87 | TRUE |
| 3 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | CLCN6 | 0.04 | 0.06 | lasso | 2 | 0.05 | 1.1e-06 | -4.86 | -5.2 | 2.3e-07 | -0.08 | 0.11 | 0.87 | FALSE |
| 4 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | CLCN6 | 0.05 | 0.05 | lasso | 6 | 0.05 | 9.2e-07 | -4.29 | -5.4 | 6.7e-08 | -0.07 | 0.05 | 0.95 | FALSE |
| 5 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | CLCN6 | 0.07 | 0.00 | blup | 104 | 0.03 | 7.9e-03 | 2.86 | -5.6 | 2.3e-08 | -0.09 | 0.03 | 0.65 | FALSE |
| 6 | The Cancer Genome Atlas | Lung Adenocarcinoma | CLCN6 | 0.06 | 0.04 | blup | 104 | 0.04 | 5.2e-06 | -5.04 | -5.3 | 1.2e-07 | -0.07 | 0.13 | 0.85 | FALSE |