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chr12:116,650,803-118,234,710

Best TWAS P=1.14e-11 · Best GWAS P=1.01e-10 conditioned to 0.493

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	TESC	0.11	0.08	bslmm	556	0.09	1.3e-10	-5.3	5.5	2.9e-08	-0.86	0.36	0.64	FALSE
2	GTEx	Adipose Subcutaneous	TESC	0.09	0.04	lasso	2	0.01	2.1e-02	-5.4	-5.7	1.2e-08	0.87	0.10	0.78	FALSE
3	GTEx	Cells Transformed fibroblasts	FBXW8	0.25	0.24	lasso	4	0.25	5.0e-19	-5.9	5.8	5.6e-09	-0.88	0.17	0.83	FALSE
4	GTEx	Cells Transformed fibroblasts	RP11-231I16.1	0.16	0.18	lasso	2	0.16	2.5e-12	-5.9	6.1	9.2e-10	-0.94	0.09	0.91	FALSE
5	GTEx	Lung	FBXW8	0.15	0.05	lasso	5	0.03	2.5e-03	-5.3	-5.3	9.3e-08	0.84	0.36	0.62	FALSE
6	GTEx	Skin Not Sun Exposed Suprapubic	FBXW8	0.29	0.10	lasso	4	0.17	1.4e-09	-6.0	-5.2	1.5e-07	0.80	0.15	0.84	FALSE
7	GTEx	Skin Sun Exposed Lower leg	FBXW8	0.19	0.10	enet	23	0.13	4.2e-11	-6.0	-5.2	2.3e-07	0.87	0.13	0.86	FALSE
8	GTEx	Spleen	FBXW8	0.36	0.16	lasso	2	0.12	5.8e-04	-5.9	-5.7	9.6e-09	0.90	0.05	0.77	FALSE
9	GTEx	Testis	FBXW8	0.27	0.10	lasso	4	0.06	1.9e-03	-5.9	-5.7	1.4e-08	0.83	0.12	0.78	FALSE
10	GTEx	Thyroid	FBXW8	0.14	0.08	lasso	3	0.07	2.3e-06	-5.5	-5.8	6.0e-09	0.93	0.18	0.82	FALSE
11	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	FBXW8	0.14	0.09	lasso	8	0.08	1.8e-07	-5.9	5.8	8.0e-09	-0.90	0.05	0.95	FALSE
12	The Cancer Genome Atlas	Breast Invasive Carcinoma	FBXW8	0.16	0.17	blup	83	0.17	3.9e-34	-6.0	5.7	1.2e-08	-0.88	0.14	0.86	FALSE
13	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	FBXW8	0.09	0.04	blup	81	0.04	3.0e-03	-5.3	6.8	1.1e-11	-0.91	0.02	0.87	TRUE
14	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	FBXW8	0.20	0.22	enet	18	0.24	4.5e-26	-6.0	5.5	5.0e-08	-0.81	0.11	0.89	FALSE
15	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	FBXW8	0.12	0.17	enet	12	0.20	1.2e-21	-6.0	5.9	4.0e-09	-0.90	0.24	0.76	FALSE
16	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	FBXW8	0.10	0.10	lasso	7	0.09	7.5e-06	-6.4	6.5	1.1e-10	-0.99	0.02	0.98	FALSE
17	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	FBXW8	0.11	0.15	blup	75	0.12	2.4e-06	-5.3	6.4	1.2e-10	-0.94	0.06	0.94	FALSE
18	The Cancer Genome Atlas	Lung Adenocarcinoma	FBXW8	0.10	0.08	enet	15	0.08	1.2e-09	-5.9	5.7	1.1e-08	-0.89	0.08	0.92	FALSE
19	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	FBXW8	0.11	0.12	lasso	6	0.12	3.1e-13	-5.3	5.8	6.3e-09	-0.91	0.11	0.89	FALSE
20	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	FBXW8	0.15	0.11	blup	79	0.13	7.7e-09	-5.3	5.3	1.1e-07	-0.89	0.21	0.79	FALSE
21	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	FBXW8	0.14	0.16	lasso	3	0.17	1.3e-07	-5.7	5.5	3.6e-08	-0.79	0.27	0.61	FALSE
22	The Cancer Genome Atlas	Prostate Adenocarcinoma	FBXW8	0.20	0.29	lasso	9	0.29	1.2e-30	-5.9	5.8	5.3e-09	-0.91	0.17	0.83	FALSE
23	The Cancer Genome Atlas	Rectum Adenocarcinoma	FBXW8	0.13	0.17	lasso	7	0.10	2.0e-03	-6.0	6.0	2.1e-09	-0.91	0.03	0.68	FALSE
24	The Cancer Genome Atlas	Stomach Adenocarcinoma	FBXW8	0.09	0.12	lasso	3	0.12	9.1e-09	-5.7	5.9	3.6e-09	-0.88	0.14	0.86	FALSE
25	The Cancer Genome Atlas	Thyroid Carcinoma	FBXW8	0.22	0.16	blup	83	0.17	2.1e-16	-5.9	5.4	5.9e-08	-0.82	0.17	0.83	FALSE