Hub : Genes

TESC

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.1110 0.0270 3.2e-08 0.085 0.072 0.073 0.086 0.083 1.6e-10 4.0e-09 3.0e-09 1.3e-10 2.6e-10
2 GTEx Adipose Subcutaneous 0.0950 0.0340 1.5e-03 0.035 NA 0.000 NA 0.015 6.6e-04 NA 3.1e-01 NA 2.1e-02
3 GTEx Artery Aorta 0.2230 0.0820 5.7e-03 0.023 NA -0.003 NA 0.004 2.0e-02 NA 5.2e-01 NA 1.8e-01
4 GTEx Brain Frontal Cortex BA9 0.2976 0.0862 9.3e-04 0.066 NA 0.040 NA 0.050 7.9e-03 NA 3.2e-02 NA 1.9e-02
5 GTEx Brain Putamen basal ganglia 0.4310 0.1370 3.2e-03 -0.012 NA -0.001 NA 0.011 7.7e-01 NA 3.4e-01 NA 1.8e-01
6 METSIM Adipose 0.0613 0.0238 2.9e-03 -0.001 0.018 0.010 0.017 0.001 5.1e-01 8.4e-04 1.0e-02 1.2e-03 2.5e-01
7 YFS Blood 0.0769 0.0143 0.0e+00 0.099 0.108 0.131 0.128 0.133 1.3e-30 1.6e-33 1.2e-40 1.7e-39 3.9e-41
8 TCGA Kidney Renal Clear Cell Carcinoma 0.0337 0.0186 5.1e-03 0.011 0.024 0.011 NA 0.015 2.0e-02 8.3e-04 1.7e-02 NA 7.5e-03
9 TCGA Thyroid Carcinoma 0.0630 0.0280 5.0e-04 0.053 0.032 0.031 NA 0.039 7.2e-06 3.9e-04 4.4e-04 NA 1.0e-04

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9
Bipolar Disorder (2018) 0.5 0.8 1.8 1.2 -0.9 -0.0 1.3 0.9 -1.1 0.0 -0.9 -0.7
Bipolar Disorder or Schizophrenia 0.4 1.0 3.2 1.4 -0.1 1.8 1.2 1.3 -0.2 0.0 -0.4 0.3
Depressed Affect (Nagel 2018) 0.7 1.4 7.4 0.4 -0.7 -2.7 1.1 0.4 0.0 0.0 1.4 1.2
Depression (Nagel 2018) 0.9 1.3 4.2 1.1 -0.2 -1.7 2.0 -0.8 -0.0 0.0 1.5 0.8
Intelligence (Savage-Jansen 2018) 0.1 0.4 1.2 -0.5 0.4 0.7 -0.4 -0.5 -1.1 0.0 0.9 -0.1
Neuroticism (Nagel 2018) 0.7 1.6 5.0 1.3 -1.2 -2.2 1.9 1.4 -0.1 0.0 0.8 0.4
Schizophrenia (2018) 0.5 1.0 5.6 0.9 0.6 2.4 0.5 0.9 0.6 0.0 0.1 0.9
Schizophrenia vs Biploar Disorder 0.2 0.3 1.4 0.5 -0.6 -0.2 0.1 -1.2 -0.2 0.0 -0.4 -0.3
Worry (Nagel 2018) 0.3 0.7 2.1 1.4 -1.0 -0.8 1.5 0.6 0.2 0.0 -0.2 -0.1
Alzheimer’s Disease (in mother) 1.0 1.2 3.2 -1.5 1.5 0.5 -0.8 0.9 0.5 0.0 1.8 1.0
Alzheimer’s Disease (in father) 1.2 1.3 6.5 -1.1 1.3 0.6 0.1 2.6 0.1 0.0 -0.8 -1.0
Alzheimer’s Disease (including proxy) 0.7 1.0 3.1 -1.8 1.7 0.7 -0.8 1.4 0.0 0.0 0.4 -0.3
Crohns Disease (2017) 0.2 0.5 1.0 0.8 -1.0 -0.8 1.0 0.8 -0.2 0.0 0.4 0.2
Irritable Bowel Disease (IBD) 0.8 1.8 4.5 2.0 -1.8 -1.6 2.1 1.1 -0.6 0.0 -0.3 -0.8
Ulcerative Colitis (UC) 1.1 2.0 4.7 1.9 -1.5 -2.2 1.9 1.0 -0.7 0.0 -0.8 -1.3
Major Depression (MDD) 0.2 0.3 0.6 0.6 0.3 -0.3 0.7 -0.7 0.5 0.0 0.8 0.2
Reaction Time 0.2 0.3 1.5 0.6 -1.2 -0.6 0.3 0.1 -0.1 0.0 -0.5 -0.6
Verbal and Numeric Reasoning (VNR) 0.2 0.5 1.6 0.1 -0.8 0.3 0.5 -1.0 -1.3 0.0 0.7 -0.6
Breast Cancer 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Ovarian Cancer 0.3 0.4 1.5 -0.6 0.8 -1.2 -0.8 -0.2 -0.3 0.0 -0.0 0.3
Prostate Cancer 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Age at First Birth 0.3 0.4 1.3 -0.4 1.1 0.3 -0.0 -0.1 0.6 0.0 0.4 1.2
Bipolar Disorder (2011) 0.4 0.4 1.4 -0.2 1.1 0.3 0.5 0.3 0.1 0.0 0.7 1.2
Body Mass Index (BMI) (2010) 0.3 0.4 2.3 -0.4 0.0 0.8 -0.4 1.5 -0.7 0.0 -0.2 0.3
Coronary Artery Disease (CAD) 0.9 1.0 3.3 1.2 -1.0 1.8 1.0 0.8 -1.3 0.0 -0.5 -0.4
Crohns Disease (2012) 1.0 1.6 4.9 2.0 -2.1 0.4 2.2 0.2 0.4 0.0 0.3 0.0
Mean Putamen Volume 0.9 1.1 5.6 -0.1 -0.4 2.4 -0.8 -0.8 -1.5 0.0 -0.4 0.3
Fasting Glucose 0.6 0.7 1.9 -0.8 1.4 0.1 -0.6 -0.9 1.0 0.0 0.9 1.0
HbA1C 0.5 0.5 2.1 -0.8 1.4 -0.0 -0.2 0.7 0.3 0.0 0.8 0.8
HDL Cholesterol 0.2 0.4 2.0 0.1 0.4 -0.7 -0.2 0.7 1.4 0.0 -0.1 -0.4
LDL Cholesterol 0.5 0.7 2.2 -1.3 1.5 0.0 -0.8 -1.0 -1.0 0.0 0.3 0.2
Lupus 1.3 2.0 4.0 2.0 -1.9 0.2 1.7 1.4 0.8 0.0 -1.2 -1.9
Neuroticism (2016) 0.9 1.2 2.9 1.1 -1.6 -1.7 1.0 1.1 0.6 0.0 -0.5 -1.2
Primary Biliary Cirrhosis 0.7 1.0 3.4 -1.0 1.9 1.6 -0.6 0.9 0.2 0.0 0.6 0.8
Rheumatoid Arthritis 2.0 2.8 9.0 3.0 -2.3 -0.9 2.4 -1.0 1.4 0.0 -1.0 -0.5
Schizophrenia (2014) 0.5 1.1 3.7 1.1 0.3 1.9 1.1 1.8 0.5 0.0 -0.2 -0.2
Triglycerides 0.8 1.4 3.8 -1.3 1.1 -1.4 -0.8 0.4 -0.1 0.0 2.0 1.7
Type 2 Diabetes (T2D) (2012) 0.6 0.7 4.3 0.1 0.0 -2.1 -0.3 -1.1 0.4 0.0 0.7 0.4
Ulcerative Colitis 0.8 1.2 3.5 1.7 -1.9 0.0 1.7 0.5 -1.0 0.0 -0.5 -0.6
Blood Eosinophil Count 0.2 1.9 3.8 1.7 -1.8 0.3 1.0 -1.9 0.8 0.0 1.3 1.9
Blood Platelet Count 0.2 2.1 5.6 -1.8 0.9 1.6 -1.9 -0.2 0.8 0.0 1.6 2.4
Blood Red Count 0.2 1.5 8.2 -0.8 -0.6 0.2 -0.9 1.2 0.5 0.0 -2.9 -1.3
Blood White Count 0.1 0.6 2.4 0.6 -0.6 0.2 0.1 -0.4 1.5 0.0 0.5 1.3
Heel T-Score 0.4 3.4 11.7 -1.6 0.7 0.7 -1.1 -0.9 1.4 0.0 3.4 3.4
BMI 0.8 4.4 12.2 -2.4 1.3 2.4 -2.0 1.5 -1.4 0.0 -3.5 -2.5
Height 1.9 35.8 99.9 10.0 -9.4 -5.2 8.6 2.8 1.8 0.0 -2.8 -3.6
Waist Hip Ratio (WHR) 0.1 0.4 1.3 -0.3 0.4 -0.0 -0.0 0.7 -0.5 0.0 1.0 1.1
Systolic Blood Pressure 0.5 2.3 6.8 -2.1 2.6 1.0 -1.6 -0.2 2.0 0.0 0.9 1.0
Smoking Status 0.4 1.0 3.4 1.8 -0.4 -1.5 1.4 -0.5 -0.5 0.0 0.8 0.3
Allergy or Eczema 0.2 0.6 2.2 -0.0 0.5 0.4 -1.5 -0.6 -0.3 0.0 -0.6 1.2
Cardiovascular Disease 1.1 3.8 11.0 -3.3 3.0 0.8 -3.2 -1.6 0.2 0.0 0.5 -0.5
Hypothyroidism (self reported) 0.1 0.3 1.3 -1.0 1.1 -0.4 -0.2 -0.2 -0.6 0.0 -0.0 -0.2
Respiratory disease 1.3 2.9 12.6 0.8 -0.9 -0.9 0.2 -3.6 2.1 0.0 1.9 1.6
Type 2 Diabetes (T2D) (2018) 0.3 0.5 1.2 -0.6 0.9 0.9 -0.5 -0.8 1.1 0.0 0.4 0.5
Lung FEV1/FVC ratio 0.4 1.9 8.2 -2.0 2.9 -0.4 -2.0 -0.2 0.2 0.0 0.1 0.6
Lung FVC 1.4 7.0 12.2 -3.5 3.0 1.2 -2.5 1.9 -3.0 0.0 -3.5 -3.0
Neuroticism 0.3 0.8 2.7 0.5 -0.2 -1.6 1.2 0.3 -0.6 0.0 1.2 0.6
Chronotype (morning person) 0.8 1.9 10.7 0.8 -0.8 0.7 0.7 -0.0 -3.3 0.0 -1.3 -1.6
Hair Pigment 0.1 1.6 4.6 2.1 -1.5 -0.9 2.1 0.8 -0.1 0.0 -1.0 -0.6
Tanning 0.1 0.9 4.4 0.4 0.0 -0.5 0.4 2.1 0.7 0.0 -1.1 -1.0
Hand grip strength (left) 1.2 3.3 8.8 2.5 -2.0 0.1 1.9 1.1 -0.2 0.0 -3.0 -2.4
Number of treatments/medications taken 2.2 4.0 7.9 -2.0 2.0 1.2 -1.8 -0.9 2.8 0.0 2.6 2.8
Average weekly spirits intake 0.8 1.1 2.8 -1.7 1.4 -0.5 -0.3 1.4 0.4 0.0 1.4 0.4
Sensitivity / hurt feelings 0.3 0.5 1.3 0.3 0.2 -0.8 1.1 0.4 0.9 0.0 0.8 1.1
Frequency of depressed mood in last 2 weeks 0.6 0.8 2.8 0.8 0.2 -1.7 1.2 -0.4 -0.4 0.0 1.4 0.7
Hearing difficulty/problems: Yes 1.0 1.5 4.0 -1.8 2.0 -0.4 -1.5 -0.3 2.0 0.0 -0.1 0.1
Relative age of first facial hair 0.4 0.8 2.9 -0.5 1.7 0.1 -1.4 -0.5 -1.4 0.0 -0.3 -0.5
Other serious medical condition/disability diagnosed by doctor 3.8 5.0 15.1 -3.6 3.9 0.5 -3.2 0.3 1.8 0.0 1.5 1.0
Ever used hormone-replacement therapy (HRT) 1.0 1.3 4.1 -0.6 0.5 0.9 -0.7 -2.0 1.7 0.0 1.5 0.2
Ever had hysterectomy (womb removed) 0.3 0.3 1.5 0.0 0.4 1.2 -0.2 -1.0 0.0 0.0 0.2 0.2
Systolic blood pressure, automated reading 0.5 1.4 4.0 -2.0 2.0 0.2 -1.5 0.3 1.1 0.0 0.2 0.7
Eye problems/disorders: Diabetes related eye disease 1.2 1.3 3.1 -1.5 1.7 -0.8 -0.7 1.4 1.8 0.0 0.1 0.7
Angina 1.1 1.4 6.1 -2.5 1.8 0.5 -1.0 -1.0 -1.0 0.0 -0.0 -0.4
Medication for hormone replacement therapy 1.5 1.7 7.1 -1.0 1.0 2.7 -0.9 0.5 -2.1 0.0 -0.1 -0.7
Vitamin and mineral supplements 0.5 0.7 2.5 0.1 0.2 1.6 -0.4 -0.7 -1.2 0.0 -1.2 -0.4
Supplements: Zinc 0.4 0.4 1.7 0.3 -0.3 0.8 0.2 0.5 1.3 0.0 -0.7 -0.4
Medication: Co-codamol 0.5 0.5 1.5 -0.9 0.1 -1.2 -1.0 -1.0 0.5 0.0 0.5 0.2
Medication: Metformin 0.3 0.4 2.0 -0.5 0.9 0.4 0.0 0.3 1.4 0.0 0.5 0.1
Diabetes (father) 0.4 0.5 2.2 1.0 -1.5 -0.6 0.4 -0.3 0.0 0.0 -0.1 -0.7
Diabetes (mother) 0.2 0.3 2.1 -0.4 0.3 0.2 -0.2 -1.5 0.1 0.0 0.5 -0.3
Severe depression (siblings) 0.4 0.5 3.4 0.6 0.6 0.3 0.4 -1.8 -0.2 0.0 0.0 0.1
Pack years adult smoking proportion 1.3 2.0 4.8 0.1 -0.3 2.1 -0.3 -0.6 -2.0 0.0 -2.0 -2.2
Impedance of leg (right) 0.3 1.3 5.3 -1.1 1.2 0.1 -0.5 0.0 0.1 0.0 2.3 2.0
Leg fat-free mass (left) 1.0 5.5 11.7 3.1 -3.4 -0.9 2.1 0.9 -1.0 0.0 -3.2 -3.4
Trunk fat percentage 0.6 2.6 9.2 -3.0 2.0 1.1 -2.8 -0.9 -0.1 0.0 -0.1 0.0
Hand grip strength (right) 1.9 5.1 12.1 2.6 -2.6 -1.0 2.1 2.0 0.6 0.0 -3.5 -3.1
Townsend deprivation index at recruitment 0.4 0.6 2.5 0.5 -0.2 0.8 -0.4 -0.5 -1.6 0.0 -0.7 -1.1
Current tobacco smoking 0.8 1.3 4.9 2.2 -0.8 -0.5 0.9 -1.5 -0.5 0.0 0.8 1.5
Average weekly fortified wine intake 0.2 0.2 0.9 -0.4 0.3 -0.1 -0.1 0.6 0.3 0.0 0.9 0.8
Maternal smoking around birth 3.1 4.5 12.2 3.5 -3.3 -1.6 3.4 -1.0 1.2 0.0 0.3 0.7
Fed-up feelings 0.4 0.8 1.9 1.0 -0.9 -1.4 1.3 1.3 -0.2 0.0 -0.4 -0.4
Frequency of unenthusiasm / disinterest in last 2 weeks 1.1 1.4 4.7 2.2 -1.1 -1.2 2.1 -0.2 -0.7 0.0 -0.4 -0.5
Relative age voice broke 0.7 1.1 3.2 -1.1 1.8 -1.0 -1.4 -0.3 -1.2 0.0 -0.5 -0.9
Taking other prescription medications 1.6 2.4 5.6 -0.9 1.4 1.2 -0.6 -1.8 2.1 0.0 1.9 2.4
Age when periods started (menarche) 0.3 0.7 1.8 1.4 -1.4 -1.2 0.5 -0.4 0.0 0.0 -0.5 -0.8
Bilateral oophorectomy (both ovaries removed) 0.7 0.8 4.7 -0.6 0.8 -0.3 -0.8 -2.2 1.0 0.0 -0.3 -0.3
Heel bone mineral density (BMD) T-score, automated (left) 0.5 1.1 5.8 -0.0 0.1 0.2 0.2 -0.7 0.7 0.0 1.8 2.4
Tinnitus: Yes, but not now, but have in the past 1.9 2.0 5.3 2.3 -1.6 -1.2 2.2 0.5 1.5 0.0 -0.6 -1.0
Qualifications: CSEs or equivalent 0.4 0.5 1.6 1.3 -0.5 -0.0 -0.2 -1.0 -1.0 0.0 0.1 1.0
Serious illness, injury or assault to yourself 0.5 0.6 1.6 0.7 -0.3 -0.8 0.1 -1.3 0.6 0.0 -1.0 -1.1
High blood pressure 1.0 2.8 9.7 -2.3 2.5 -0.3 -3.1 -1.9 0.4 0.0 0.2 0.2
Hayfever, allergic rhinitis or eczema 0.4 0.8 2.5 0.4 0.5 1.1 -1.2 -1.6 -0.8 0.0 -0.0 1.0
Multivitamins +/- minerals 0.3 0.4 1.6 -0.7 0.3 -1.3 -0.3 0.8 1.0 0.0 -0.2 -0.1
Stomach or abdominal pain in last month 1.5 1.8 5.6 2.4 -2.3 0.1 2.1 1.0 0.0 0.0 -0.1 -0.0
Supplements: Glucosamine 0.5 0.7 1.6 -1.2 0.6 -0.1 -1.0 0.4 1.2 0.0 1.0 0.9
Diverticular disease/diverticulitis (self-reported) 0.2 0.3 0.9 -0.2 -0.1 -0.6 -0.1 -0.4 -0.6 0.0 -1.0 -0.9
Medication: Atenolol 0.9 1.1 7.1 -0.2 -0.2 -0.9 0.6 -2.7 0.7 0.0 0.7 0.8
Medication: Levothyroxine sodium 0.2 0.3 1.2 0.5 -0.4 -0.2 0.4 -0.7 0.0 0.0 1.1 0.5
Sitting height 1.4 10.2 32.5 5.5 -5.7 -1.7 4.7 0.7 1.1 0.0 -0.6 -1.2
Chronic bronchitis/emphysema (father) 0.7 0.8 4.0 1.1 -2.0 0.9 0.2 -0.9 -0.3 0.0 -0.1 0.3
High blood pressure (mother) 0.4 0.6 3.3 -0.4 1.4 1.8 -0.1 -0.1 -0.1 0.0 -0.1 -0.5
Body mass index (BMI) 0.4 1.8 7.7 -1.1 -0.1 0.5 -1.3 0.0 -1.3 0.0 -2.8 -2.0
Impedance of leg (left) 0.4 1.9 6.1 -1.4 1.4 0.9 -0.9 -0.3 0.6 0.0 2.5 2.3
Leg predicted mass (left) 1.0 5.4 11.5 3.0 -3.4 -0.8 2.0 0.9 -0.9 0.0 -3.2 -3.4
Trunk fat mass 0.2 0.8 2.0 -1.2 0.3 0.5 -1.4 -0.3 -0.2 0.0 -1.3 -1.1
Waist circumference 0.2 0.8 3.7 -0.7 -0.1 -0.3 -0.8 0.6 -0.8 0.0 -1.9 -1.0
Number of incorrect matches in round 1.2 1.9 7.1 -1.6 1.2 0.8 -1.8 -2.7 -0.6 0.0 0.4 1.5
Past tobacco smoking 0.2 0.4 2.0 -0.2 -0.3 1.4 -0.1 0.5 -0.4 0.0 -0.8 0.6
Alcohol usually taken with meals 1.3 2.0 6.9 -2.6 2.0 0.5 -2.0 0.2 1.6 0.0 -0.8 -0.0
Nervous feelings 0.4 0.8 2.2 1.3 0.1 -0.6 1.5 1.0 0.7 0.0 -1.0 -0.9
Frequency of tenseness / restlessness in last 2 weeks 0.6 0.9 2.8 1.7 -0.8 -0.1 1.6 0.5 -1.3 0.0 0.7 -0.2
Hearing difficulty/problems with background noise 0.2 0.4 2.0 0.0 0.2 -0.1 -0.5 -0.1 0.1 0.0 -1.0 -1.4
Hair/balding pattern: Pattern 2 0.4 0.5 2.8 -0.1 0.0 -0.9 0.2 0.0 -1.7 0.0 0.7 0.6
Had menopause 1.3 1.6 4.5 -1.1 1.3 -0.4 -0.9 -1.2 0.7 0.0 2.0 2.1
Had other major operations 1.3 1.6 4.0 0.9 -0.9 1.5 0.5 -2.0 1.5 0.0 1.6 1.2
Forced vital capacity (FVC) 1.0 3.7 7.5 2.0 -1.8 -0.1 2.0 1.7 -2.0 0.0 -2.7 -2.7
Heel bone mineral density (BMD) T-score, automated (right) 0.4 0.8 3.0 -1.1 1.1 -0.2 -0.8 0.3 0.1 0.0 1.1 1.7
Ever unenthusiastic/disinterested for a whole week 1.1 1.3 4.8 -0.7 0.7 -2.2 -0.6 -2.0 0.6 0.0 1.0 0.4
Qualifications: None of the above 0.5 1.1 4.5 1.4 -2.1 -0.7 1.2 0.3 0.1 0.0 -1.1 0.3
Financial difficulties in last 2 years 0.3 0.4 1.0 -0.5 0.4 0.4 -1.0 -0.8 -0.8 0.0 0.3 -0.6
Mouth/teeth dental problems 1.5 2.3 5.5 -2.2 2.3 2.0 -2.0 -1.2 -0.2 0.0 -0.4 -0.3
Heart attack 2.5 3.3 10.1 -2.5 3.2 1.5 -1.2 -0.7 0.4 0.0 1.8 2.4
Allergy 1.0 2.2 11.4 -1.3 0.5 -1.1 0.3 3.4 -0.3 0.0 -1.1 -2.0
Pain all over the body in last month 1.0 1.1 4.0 1.3 -1.2 -0.8 0.7 -2.0 0.2 0.0 -0.7 -1.2
Diabetes (self-reported) 1.2 1.9 4.9 -2.2 2.1 0.8 -1.7 -0.3 1.7 0.0 0.6 0.6
Hayfever/allergic rhinitis (self-reported) 0.5 0.7 2.0 0.8 -0.2 -0.7 0.8 -1.2 -0.2 0.0 1.1 1.4
Medication: Ramipril 1.5 1.9 4.6 -2.1 2.1 -0.5 -2.1 0.6 1.1 0.0 0.7 1.1
Medication: Simvastatin 1.0 1.4 7.0 -1.1 0.9 -0.8 -0.3 1.0 2.6 0.0 0.1 1.5
Fluid intelligence score 0.3 0.7 2.2 -0.7 0.4 0.6 -0.6 0.2 -1.5 0.0 -1.0 -1.3
Illnesses of siblings 0.8 1.1 3.8 1.3 -1.4 -0.6 1.4 0.7 1.9 0.0 -0.0 0.0
Neuroticism score 0.4 0.9 2.6 0.5 -0.6 -1.6 1.3 1.0 0.5 0.0 1.2 0.8
Weight 0.7 3.5 10.6 1.8 -2.6 -0.6 1.1 0.7 -0.8 0.0 -3.3 -2.8
Impedance of arm (right) 2.1 9.7 24.7 -4.5 5.0 0.5 -3.6 -1.7 -0.1 0.0 4.1 3.1
Arm fat percentage (right) 0.9 3.6 11.0 -3.2 2.1 0.9 -3.3 -0.5 -1.7 0.0 -1.4 -0.9
Trunk fat-free mass 2.6 14.8 36.0 5.9 -6.0 -1.9 4.4 1.7 -0.4 0.0 -4.4 -4.1
Hip circumference 0.4 1.6 7.0 -0.1 -0.5 -0.6 -0.6 0.8 -1.3 0.0 -2.7 -2.0
Time employed in main current job 0.2 0.2 0.5 -0.1 -0.2 0.6 -0.5 0.1 0.6 0.0 -0.7 -0.7
Alcohol intake versus 10 years previously 1.0 1.5 3.2 1.5 -1.7 -0.5 1.7 1.8 -0.5 0.0 -0.8 -1.1
Father’s age at death 1.6 2.1 5.4 -2.3 2.0 1.8 -2.3 0.3 0.1 0.0 0.9 0.7
Worrier / anxious feelings 0.8 1.6 4.8 1.1 -1.5 -1.1 2.0 2.2 0.3 0.0 -0.9 -0.1
Frequency of tiredness / lethargy in last 2 weeks 0.8 1.3 3.9 2.0 -1.3 0.1 1.7 0.3 -1.2 0.0 0.3 -1.2
Falls in the last year 0.8 1.0 3.2 1.8 -1.3 0.8 0.7 -0.9 -1.2 0.0 0.1 -0.9
Hair/balding pattern: Pattern 3 1.2 1.8 3.3 1.8 -1.0 -0.3 1.8 1.6 1.8 0.0 -1.1 -1.3
Number of live births 0.2 0.3 1.6 0.2 -0.9 -0.2 0.1 -0.2 -1.2 0.0 -0.2 -0.2
Forced expiratory volume in 1-second (FEV1) 1.0 3.5 10.1 0.9 -0.8 -0.1 1.2 2.1 -2.4 0.0 -3.2 -2.9
Pulse rate 0.7 1.2 2.9 0.8 -0.6 -1.5 0.8 1.7 1.5 0.0 -0.8 -1.1
Happiness 2.2 2.7 6.3 1.6 -1.5 -2.2 1.5 -2.5 1.7 0.0 1.3 1.4
Noisy workplace 0.9 1.2 4.0 0.8 -0.6 -2.0 1.4 1.5 -0.9 0.0 -0.2 -0.7
Qualifications: A levels/AS levels or equivalent 1.0 2.3 5.8 -2.0 2.0 1.2 -2.4 -0.7 -1.6 0.0 1.4 0.3
Serious illness, injury or assault of a close relative in last 2 years 2.2 2.5 9.9 -1.4 3.1 -0.6 -1.4 0.5 -0.3 0.0 1.8 2.0
Mouth/teeth dental problems: Dentures 0.4 0.8 1.9 1.4 -1.2 -1.2 1.2 -0.3 -0.3 0.0 -0.3 0.5
Asthma 1.7 3.3 15.9 1.1 -0.4 0.2 0.1 -4.0 1.8 0.0 1.7 2.5
Medication: Ibuprofen (e.g. Nurofen) 3.2 4.0 11.9 3.0 -3.5 -1.0 3.0 0.3 -0.5 0.0 1.9 1.1
Medication: Cholesterol lowering 0.8 1.3 3.2 -1.6 1.7 0.9 -0.7 1.2 1.8 0.0 -0.2 0.2
Depression (self-reported) 1.5 1.8 4.4 -1.4 1.9 1.4 -1.7 -2.1 0.9 0.0 0.8 0.6
Medication: Lansoprazole 1.5 1.7 6.7 -1.0 0.7 0.9 -1.2 -0.3 -0.8 0.0 -2.6 -2.0
Prospective memory result 0.8 1.0 2.0 1.3 -0.4 -1.1 1.4 -0.4 1.0 0.0 1.1 1.2
Lung cancer (father) 0.2 0.2 0.8 -0.1 -0.3 -0.1 0.6 -0.3 0.9 0.0 0.2 0.4
Illnesses of mother 1.6 2.0 4.7 1.0 -1.5 -2.2 0.8 0.9 -0.6 0.0 -1.9 -2.2
Forced expiratory volume in 1-second (FEV1), Best measure 1.4 4.4 13.4 0.8 -0.8 0.2 1.0 2.0 -3.2 0.0 -3.7 -3.2
Pulse wave Arterial Stiffness index 0.8 1.0 3.6 -0.2 -0.1 1.0 -0.7 0.6 -1.6 0.0 -1.9 -0.6
Impedance of arm (left) 1.9 9.0 23.7 -4.3 4.9 0.1 -3.2 -1.0 0.7 0.0 4.3 2.9
Arm fat mass (right) 0.5 2.0 7.0 -1.1 0.1 0.4 -1.5 0.3 -1.6 0.0 -2.6 -2.2
Trunk predicted mass 2.7 15.4 37.0 6.0 -6.1 -2.0 4.5 1.7 -0.4 0.0 -4.5 -4.2
Standing height 1.4 14.2 42.1 6.5 -5.9 -2.8 5.7 1.6 1.6 0.0 -1.1 -2.1
Length of working week for main job 1.5 1.7 3.3 1.8 -1.7 -0.9 1.6 -1.5 1.4 0.0 1.0 0.4
Exposure to tobacco smoke at home 0.4 0.5 1.8 0.4 0.1 -0.5 0.2 -1.3 0.8 0.0 -1.1 -0.5
Breastfed as a baby 0.6 0.8 3.3 -0.6 0.5 0.5 0.5 1.3 1.8 0.0 0.7 0.8
Tense / ‘highly strung’ 0.6 1.0 2.4 1.1 -0.9 -1.2 0.9 1.5 0.6 0.0 -1.2 -0.6
Seen doctor (GP) for nerves, anxiety, tension or depression 0.2 0.4 1.7 0.7 0.3 -0.3 0.2 -1.3 -0.5 0.0 0.5 -0.7
Hair/balding pattern: Pattern 4 0.3 0.6 1.3 -1.1 0.4 -1.2 -0.9 -0.2 0.9 0.0 0.7 0.9
Birth weight of first child 0.7 1.3 2.4 1.0 -1.1 -0.2 1.4 1.5 -0.8 0.0 -1.5 -1.3
Peak expiratory flow (PEF) 0.1 0.2 0.8 -0.4 0.7 0.9 -0.2 0.6 -0.0 0.0 -0.6 0.1
Pulse wave reflection index 1.8 2.2 8.6 -0.6 0.6 2.9 -1.0 -1.0 -2.2 0.0 -2.0 -0.7
Ever highly irritable/argumentative for 2 days 1.2 1.4 5.0 0.9 -1.0 -0.1 0.1 -1.3 0.8 0.0 2.2 1.9
Loud music exposure frequency 1.1 1.2 3.5 1.9 -1.5 -1.0 1.4 -0.2 -1.3 0.0 -0.1 -0.9
Qualifications: O levels/GCSEs or equivalent 0.6 1.0 3.0 -0.5 1.2 1.6 -1.0 0.7 -1.7 0.0 0.2 -0.6
Mouth/teeth dental problems: Bleeding gums 1.0 1.2 3.8 0.2 -1.1 -0.8 0.3 1.0 -2.0 0.0 -1.1 -1.7
Blood clot in the leg (DVT) 0.7 0.9 3.0 1.7 -1.2 -1.2 1.3 -0.6 -0.4 0.0 0.1 -0.3
Medication: Paracetamol 0.9 1.5 4.1 2.0 -1.6 -1.7 1.5 0.5 0.0 0.0 0.9 0.9
Headache pain in last month 1.1 1.9 6.5 2.5 -2.4 -1.4 1.7 0.0 -0.2 0.0 0.3 -0.7
Medication for cholesterol, blood pressure or diabetes 1.4 2.3 5.8 2.4 -2.4 -0.8 1.6 0.1 -2.2 0.0 -0.6 -0.7
Glaucoma (self-reported) 1.2 1.5 4.5 1.2 -1.7 -2.1 1.1 0.6 1.6 0.0 -0.4 -0.5
Gout (self-reported) 0.8 1.1 3.3 -1.3 1.3 1.8 -1.4 0.2 0.2 0.0 -0.7 -0.4
Hypothyroidism/myxoedema (self-reported) 0.3 0.6 1.9 -1.4 1.3 -0.5 -0.7 -1.0 -0.4 0.0 0.3 0.3
Medication: Amlodipine 2.1 3.0 7.9 -2.6 2.3 -0.5 -2.8 -1.6 1.0 0.0 1.1 1.2
Medication: Ventolin 100micrograms inhaler 0.4 0.5 1.7 0.7 -0.5 0.4 0.5 -0.1 1.3 0.0 1.0 0.9
Birth weight 0.2 0.5 0.8 0.9 -0.8 0.7 0.9 0.8 -0.5 0.0 0.7 0.2
Chronic bronchitis/emphysema (mother) 2.7 3.2 6.6 2.4 -2.1 -2.0 1.2 -2.6 1.2 0.0 1.1 1.9
High blood pressure (siblings) 1.6 2.3 5.6 -2.3 2.4 -0.4 -2.2 -0.8 -1.8 0.0 0.2 -0.0
Forced vital capacity (FVC), Best measure 1.6 5.7 14.3 2.2 -2.1 0.4 1.8 1.5 -3.1 0.0 -3.8 -3.5
Body fat percentage 0.6 2.5 8.2 -2.9 1.7 0.9 -2.8 -0.5 -0.6 0.0 -1.1 -0.7
Leg fat percentage (right) 0.4 1.3 4.7 -1.4 0.2 0.8 -1.4 -0.2 -0.9 0.0 -2.2 -1.3
Arm fat-free mass (right) 2.4 12.4 32.3 5.0 -5.7 -1.1 3.8 1.7 -0.5 0.0 -4.3 -4.2
Exposure to tobacco smoke outside home 1.0 1.4 3.2 1.4 -1.7 0.6 1.0 0.7 -0.1 0.0 -1.8 -1.6
Comparative body size at age 10 1.0 2.9 8.2 -2.9 2.4 1.4 -2.5 0.2 -1.8 0.0 -0.6 -0.8
Number of full brothers 1.7 2.1 5.3 2.3 -1.7 -0.3 2.3 0.4 -0.5 0.0 -1.6 -1.7
Worry too long after embarrassment 1.2 2.0 6.4 1.5 -1.5 -0.9 2.5 2.3 -0.2 0.0 0.4 -0.7
Seen a psychiatrist for nerves, anxiety, tension or depression 1.2 1.6 5.4 0.5 1.0 0.0 -0.2 -2.3 1.2 0.0 1.8 1.7
Wheeze or whistling in the chest in last year 1.5 2.7 6.6 2.3 -0.5 -0.6 0.9 -2.6 1.2 0.0 1.7 2.5
Number of children fathered 0.5 0.6 1.8 -1.0 1.4 0.3 -0.3 1.0 -0.4 0.0 -0.7 -0.9
Reason for reducing amount of alcohol drunk: Health precaution 0.9 1.0 4.3 0.3 -0.9 -0.1 0.1 -1.8 2.1 0.0 0.4 1.0
Age at first live birth 1.1 1.9 4.2 -1.7 1.9 0.6 -1.0 -0.7 1.6 0.0 2.0 1.2
Pulse wave peak to peak time 0.7 0.9 3.0 0.3 -0.1 -1.1 0.8 -0.6 1.5 0.0 1.7 0.4
Health satisfaction 0.5 0.7 2.0 -0.2 0.4 -1.0 0.1 -1.4 1.4 0.0 0.5 0.9
Shortness of breath walking on level ground 0.3 0.3 1.3 -0.0 -0.3 -1.1 0.3 -0.9 0.3 0.0 0.5 -0.3
Qualifications: College or University degree 2.1 6.6 16.6 -4.1 3.8 3.4 -3.9 -0.3 -0.2 0.0 -1.2 -0.5
Eye problems/disorders: None of the above 0.8 0.9 2.5 1.2 -1.5 0.8 0.4 -1.6 -0.7 0.0 0.3 0.9
Mouth/teeth dental problems: Loose teeth 0.2 0.2 0.7 -0.5 0.4 0.4 -0.5 0.9 0.1 0.0 -0.2 -0.1
Emphysema/chronic bronchitis 1.8 2.1 9.0 -0.2 0.3 0.1 0.8 -1.6 1.6 0.0 3.0 1.9
Medication for pain relief, constipation, heartburn 1.1 1.8 5.1 -1.1 1.6 1.3 -1.1 0.5 -0.4 0.0 -2.3 -2.1
Neck or shoulder pain in last month 1.1 1.6 3.9 2.0 -2.0 -1.3 1.5 -0.0 1.5 0.0 0.3 0.6
Medication: Blood pressure 1.9 3.4 9.0 -2.9 3.0 0.2 -2.2 -1.0 2.5 0.0 0.9 0.6
Angina (self-reported) 1.0 1.3 6.4 -2.5 1.9 0.4 -0.9 -0.8 -0.7 0.0 0.0 -0.1
Migraine (self-reported) 0.7 0.9 3.6 0.9 -1.9 0.4 0.9 0.2 -0.7 0.0 -1.3 -0.4
Medication: Ibuprofen 2.9 3.4 10.6 2.8 -3.2 -0.7 2.8 -0.1 -0.3 0.0 1.6 1.2
Medication: Allopurinol 0.5 0.6 1.8 -1.3 1.1 1.1 -1.0 0.5 0.4 0.0 0.1 0.1
Medication: Omeprazole 0.2 0.3 1.0 -0.1 -0.4 0.4 -0.0 0.8 1.0 0.0 -0.7 0.2
Medication: Seretide 50 evohaler 0.9 1.1 2.7 1.0 -0.9 -0.7 1.0 -1.7 1.4 0.0 1.3 0.4
Mean time to correctly identify matches 0.2 0.3 1.6 0.3 -0.6 0.3 0.3 -0.7 1.3 0.0 -0.1 -0.1
Heart disease (mother) 0.8 1.0 3.6 1.9 -1.6 -0.5 1.4 0.5 0.6 0.0 0.3 0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria 2.4 2.9 15.0 0.6 -0.1 0.1 0.9 -0.6 3.9 0.0 1.8 2.5
Whole body fat mass 0.3 1.4 5.0 -1.0 0.0 0.3 -1.4 0.1 -1.0 0.0 -2.2 -1.9
Leg fat mass (right) 0.5 1.8 8.1 -0.3 -0.8 0.5 -0.7 0.3 -1.2 0.0 -2.8 -2.3
Arm predicted mass (right) 2.5 12.7 32.6 5.1 -5.7 -1.1 3.8 1.5 -0.4 0.0 -4.4 -4.2
Pulse rate, automated reading 0.5 1.7 4.0 0.8 -1.8 -1.1 0.8 2.0 0.2 0.0 -1.9 -1.4
Alcohol intake frequency. 0.4 1.0 2.5 0.6 -1.3 0.7 1.2 1.6 -0.7 0.0 -0.8 -1.3
Comparative height size at age 10 0.8 4.5 10.6 3.2 -3.1 0.2 2.7 2.0 -1.4 0.0 -1.4 -2.1
Number of full sisters 0.6 0.7 1.6 1.1 -1.3 1.1 0.9 -0.6 -1.2 0.0 -0.5 -0.1
Suffer from ‘nerves’ 0.7 1.1 3.3 1.8 -1.4 -0.9 1.6 -0.9 0.7 0.0 -0.6 0.0
Overall health rating 0.2 0.5 1.3 0.9 -0.8 -0.3 0.4 -0.2 -1.1 0.0 -1.1 0.0
Chest pain or discomfort 1.3 1.9 5.3 2.3 -2.2 -0.9 1.9 -1.4 0.7 0.0 0.0 -0.2
Had major operations 0.5 0.6 2.9 -0.5 1.0 -0.1 -0.5 -0.5 1.7 0.0 0.8 0.6
Age at last live birth 1.3 1.9 7.8 -0.7 0.7 0.7 0.2 -0.9 1.6 0.0 2.8 2.0
Family relationship satisfaction 1.5 1.9 7.1 -0.7 1.3 0.7 -1.2 -2.7 0.7 0.0 1.9 1.4
Leg pain on walking 1.3 1.7 8.7 -1.3 1.4 -0.2 -1.5 -2.9 0.1 0.0 0.7 -0.2
Qualifications: NVQ or HND or HNC or equivalent 2.0 2.4 8.0 1.4 -1.9 -2.8 1.9 0.3 -0.4 0.0 1.7 1.1
Commuting to job workplace: Car/motor vehicle 0.9 1.1 2.4 0.9 -0.9 0.1 1.2 -0.4 1.4 0.0 1.5 1.5
Illness, injury, bereavement, stress in last 2 years 0.3 0.4 1.0 -0.0 -0.7 0.5 0.5 0.6 1.0 0.0 0.6 1.0
Medication: Aspirin 2.3 3.0 8.2 -2.9 2.3 -0.0 -1.8 -0.7 -0.0 0.0 1.9 2.5
Supplements: Vitamin C 0.7 0.9 3.4 0.3 0.3 -1.2 0.4 0.0 1.9 0.0 1.2 1.0
Knee pain experienced in last month 1.2 1.9 4.4 -2.1 1.8 -1.4 -1.3 0.9 -2.1 0.0 -0.6 -0.7
Hypertension (Self-reported) 1.4 3.9 11.4 -2.8 3.4 0.0 -3.4 -1.9 0.5 0.0 0.7 0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.7 0.8 3.7 -0.3 1.0 1.1 -0.1 0.7 -0.3 0.0 -1.9 -0.9
Illnesses of father: Heart disease 0.1 0.1 0.5 0.3 -0.3 -0.3 0.6 0.3 -0.1 0.0 0.3 0.7
Illnesses of siblings: Diabetes 0.7 0.9 2.7 -0.1 0.1 1.3 0.3 -1.6 -0.0 0.0 1.5 1.0
Smoking status: Previous 0.4 0.6 2.5 -0.8 0.7 -1.6 -0.4 -0.7 0.4 0.0 1.0 -0.3
Forced expiratory volume in 1-second (FEV1), predicted 2.1 4.3 12.2 3.5 -3.2 -1.3 3.3 0.0 0.2 0.0 1.7 0.9
Whole body fat-free mass 1.9 11.1 26.4 4.8 -5.1 -1.3 3.6 1.6 -0.7 0.0 -4.1 -4.0
Leg fat-free mass (right) 1.0 5.1 12.0 3.2 -3.5 -0.7 2.0 0.9 -0.6 0.0 -3.0 -3.1
Arm fat percentage (left) 0.9 3.6 11.2 -3.3 2.2 0.9 -3.2 -0.4 -1.4 0.0 -1.4 -1.1
Average weekly red wine intake 1.1 1.6 4.2 -2.0 2.0 1.0 -2.0 0.5 -0.7 0.0 -0.2 0.1
Handedness (chirality/laterality): Left-handed 0.3 0.4 2.1 -0.4 1.4 0.1 -0.3 -0.4 -0.2 0.0 -0.1 1.0
Mood swings 1.0 1.7 7.1 0.8 -0.8 -2.7 1.6 1.1 -1.2 0.0 0.9 1.0
Loneliness, isolation 0.4 0.5 3.1 0.1 0.1 -1.8 0.0 0.9 -0.6 0.0 -0.3 -0.1
Long-standing illness, disability or infirmity 1.2 1.8 3.5 -1.9 1.7 1.3 -1.5 -0.8 1.8 0.0 0.9 1.0
Ever had bowel cancer screening 1.1 1.3 4.9 -1.3 0.8 0.7 -1.1 -0.3 2.2 0.0 0.8 1.6
Diabetes diagnosed by doctor 0.7 1.1 3.7 -1.2 1.1 1.0 -0.9 -0.4 1.9 0.0 0.8 0.9
Ever had stillbirth, spontaneous miscarriage or termination 1.8 1.9 4.7 2.2 -1.7 -1.0 1.9 0.4 -0.3 0.0 -1.0 -1.8
Friendships satisfaction 1.0 1.2 3.4 0.6 -0.9 -0.1 -0.0 -1.1 -1.9 0.0 -1.7 -1.5
Qualifications: nursing, teaching 2.9 4.4 10.8 -3.2 2.8 -0.0 -3.3 -0.6 1.4 0.0 2.5 1.5
Commuting to job workplace: Walk 0.2 0.2 0.7 -0.2 0.6 0.4 -0.3 -0.8 -0.5 0.0 0.8 -0.1
Eye problems/disorders: Cataract 0.6 0.7 2.8 -1.7 1.0 -0.9 -1.0 -0.1 0.2 0.0 -0.5 -0.7
Mouth/teeth dental problems: Mouth ulcers 2.2 3.5 10.4 3.1 -2.4 -1.2 3.2 1.3 1.4 0.0 1.0 0.1
Medication for cholesterol 2.2 3.3 9.1 3.0 -2.8 -2.3 2.4 -0.2 1.3 0.0 -0.1 0.3
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.3 0.3 1.9 -0.5 0.0 0.2 -0.5 -1.4 0.5 0.0 -0.0 -0.2
Back pain experienced in last month 0.8 1.2 1.8 1.0 -1.4 -1.2 1.1 1.2 1.1 0.0 -0.6 -1.3
Mineral and other dietary supplements 0.5 0.7 2.0 1.2 -0.8 -0.6 0.7 1.0 -1.4 0.0 -0.6 -0.7
Breast cancer (self-reported) 2.1 2.5 6.6 1.8 -1.7 -0.6 1.0 -2.4 2.6 0.0 0.9 1.5
Asthma (self-reported) 1.5 2.9 14.7 0.8 -0.2 0.2 0.1 -3.8 1.6 0.0 1.8 2.2
Osteoporosis (self-reported) 1.2 1.4 8.1 0.9 -0.3 -0.4 1.3 -0.2 2.9 0.0 1.1 1.0
Osteoarthritis (self-reported) 0.3 0.4 1.7 -0.2 0.7 -0.6 -0.1 0.4 1.3 0.0 0.3 0.9
Medication: Aspirin 2.2 2.9 8.4 -2.9 2.3 0.3 -2.0 -0.7 -0.1 0.0 1.9 2.1
Medication: Gliclazide 0.7 0.8 3.3 1.1 -0.5 0.8 1.1 -0.1 1.8 0.0 0.4 0.6
Illnesses of father: None of the above (group 1) 0.3 0.4 1.5 1.2 -0.6 0.3 0.8 0.3 0.2 0.0 -0.6 -0.4
Smoking status: Current 0.7 1.2 4.8 2.2 -0.5 -0.4 0.9 -1.4 -1.0 0.0 0.6 1.2
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.0 2.1 10.7 0.7 -0.1 1.2 0.9 0.9 -0.9 0.0 -3.3 -2.0
Whole body water mass 2.0 11.4 26.7 4.9 -5.2 -1.2 3.6 1.6 -0.7 0.0 -4.2 -4.1
Leg predicted mass (right) 1.0 5.2 12.3 3.2 -3.5 -0.7 2.1 0.8 -0.7 0.0 -3.0 -3.1
Arm fat mass (left) 0.5 1.9 6.3 -1.1 -0.1 0.6 -1.3 0.1 -1.5 0.0 -2.5 -2.3
Number of self-reported non-cancer illnesses 1.4 2.5 6.0 -1.3 1.5 1.4 -0.6 -1.5 2.5 0.0 1.9 2.0
Average weekly champagne plus white wine intake 0.6 0.8 3.3 -0.8 0.7 0.6 -0.2 1.8 1.4 0.0 -0.6 -0.5
Miserableness 0.5 0.9 3.0 0.5 -0.8 -1.7 0.2 -0.4 -0.6 0.0 1.3 1.4
Guilty feelings 0.6 0.9 4.8 0.8 -0.2 -0.1 1.2 0.8 0.2 0.0 2.2 0.6
Wears glasses or contact lenses 0.9 1.0 2.9 -1.7 1.5 0.5 -1.2 -0.9 -1.2 0.0 -0.2 -0.1
Ever taken oral contraceptive pill 1.0 1.1 3.1 1.8 -1.5 -0.8 1.5 -0.0 1.0 0.0 0.6 -0.7
Hearing aid user 0.6 0.6 2.5 -0.1 0.1 -1.6 -0.1 -1.3 1.2 0.0 -0.3 0.2
Mother’s age at death 2.6 3.2 10.6 -3.2 3.1 1.0 -2.8 0.1 -0.0 0.0 0.2 -0.1
Financial situation satisfaction 0.5 0.7 1.6 1.3 -1.1 -1.2 0.7 -0.8 -0.6 0.0 0.3 -0.4
Tinnitus: Yes, now most or all of the time 0.4 0.5 2.1 0.1 -0.7 0.8 0.8 0.0 0.6 0.0 -1.4 -0.7
Commuting to job workplace: Public transport 0.6 0.7 2.8 -0.7 0.1 0.0 -0.5 0.1 -1.7 0.0 -1.4 -1.0
Eye problems/disorders: Glaucoma 0.8 0.9 4.1 0.1 -0.4 -2.0 0.1 1.4 1.4 0.0 0.1 -0.3
Medication: Blood pressure 1.8 3.5 11.2 -2.8 2.9 0.4 -3.3 -1.6 -1.0 0.0 0.3 0.4
Pain type(s) experienced in last month: Hip pain 0.4 0.5 2.2 0.3 -0.3 -1.5 0.8 -0.2 1.1 0.0 0.3 0.5
Supplements: Fish oil (including cod liver oil) 0.4 0.5 2.2 -0.8 0.6 0.2 -0.1 -0.7 1.5 0.0 0.6 0.5
High cholesterol (Self-reported) 0.7 1.2 3.1 -1.8 1.3 1.2 -0.3 1.6 1.4 0.0 -0.3 0.1
Medication: Bendroflumethiazide 0.9 1.4 4.5 -1.4 1.7 1.5 -2.1 -0.7 0.0 0.0 -0.4 0.2
Medication: Paracetamol 0.4 0.7 3.2 1.2 -0.6 -1.8 0.6 0.4 -0.5 0.0 0.6 0.4
Medication: Lisinopril 0.6 0.8 3.0 -0.2 -0.0 0.0 -0.5 -0.4 -1.7 0.0 -0.9 -1.7
Medication: Atorvastatin 2.1 2.6 10.0 -3.2 2.5 0.5 -1.9 0.0 0.7 0.0 1.5 0.5
Illnesses of father: High blood pressure 0.5 0.6 1.7 0.1 0.6 -0.4 0.4 1.3 -1.0 0.0 -0.8 -1.1
Alcohol drinker status: Never 0.3 0.4 1.0 -1.0 1.0 0.8 -0.3 -0.6 -0.6 0.0 -0.0 -0.5
Ever smoked 0.1 0.2 0.5 0.4 0.7 -0.4 0.2 -0.2 0.6 0.0 0.7 -0.4
Basal metabolic rate 1.7 9.2 21.7 4.2 -4.7 -1.1 3.0 1.4 -0.8 0.0 -4.0 -3.8
Leg fat percentage (left) 0.4 1.5 4.2 -1.6 0.4 1.3 -1.7 -0.4 -0.6 0.0 -2.1 -1.1
Arm fat-free mass (left) 2.4 12.3 32.3 5.1 -5.7 -0.9 3.8 1.3 -0.7 0.0 -4.4 -4.0
Number of operations (self-reported) 0.8 1.2 4.6 -0.6 1.0 -0.2 -0.5 -1.8 2.1 0.0 1.2 0.2
Average weekly beer plus cider intake 0.7 1.1 2.3 1.5 -0.6 -1.5 1.1 0.5 1.0 0.0 0.9 1.1
Irritability 0.2 0.3 1.7 -0.0 -0.3 -1.3 0.2 0.0 0.4 0.0 0.9 0.6
Risk taking 0.2 0.3 1.3 0.4 -1.1 1.0 0.2 -0.3 -0.6 0.0 -0.0 0.5
Ever had prostate specific antigen (PSA) test 0.5 0.6 2.7 -0.2 0.6 0.2 0.2 -0.3 1.6 0.0 1.4 0.0
Fractured/broken bones in last 5 years 0.8 1.1 2.3 1.3 -1.5 0.8 1.1 -1.3 0.1 0.0 1.1 0.9
Age started oral contraceptive pill 1.8 2.3 6.6 -2.6 2.5 1.2 -2.3 0.5 0.6 0.0 0.5 0.5
Diastolic blood pressure, automated reading 0.2 0.7 1.6 -0.8 0.7 -1.2 -0.9 0.7 -0.1 0.0 -1.0 -1.2
Ever depressed for a whole week 0.6 0.8 1.4 -1.2 1.0 0.9 -1.1 -0.1 -1.1 0.0 -0.1 -1.2
Unable to work because of sickness or disability 0.6 0.8 3.4 1.3 -1.0 0.2 1.8 0.7 -0.4 0.0 -0.0 -0.3
Commuting to job workplace: Cycle 0.6 0.7 2.8 -1.3 0.7 -0.3 -0.9 1.7 0.1 0.0 0.7 -0.5
Myopia 0.4 0.5 1.7 -0.1 -0.6 1.0 -0.3 0.0 -0.9 0.0 -0.9 -1.3
Vascular/heart problems diagnosed by doctor 1.2 3.3 9.8 2.8 -2.9 -0.2 3.1 1.8 0.0 0.0 -0.2 -0.3
Cholesterol lowering medication 1.0 1.4 5.9 -2.4 1.6 0.2 -0.3 1.1 1.5 0.0 0.4 0.7
Medication: Omeprazole (e.g. Zanprol) 0.4 0.5 2.9 -0.4 -0.3 0.5 -0.2 0.5 1.7 0.0 -0.2 0.8
Pain experienced in last month 1.6 2.6 7.5 -2.4 1.9 2.7 -2.1 -0.0 -1.4 0.0 -0.2 0.2
Supplements: Calcium 0.2 0.2 1.0 0.3 0.2 0.6 0.6 0.2 1.0 0.0 0.3 0.5
Basal cell carcinoma (self-reported) 0.3 0.3 1.5 -0.2 0.3 -0.5 0.0 0.1 1.2 0.0 0.9 -0.1
Heart attack/myocardial infarction (self-reported) 2.2 2.9 8.8 -2.3 3.0 1.6 -1.1 -0.7 0.4 0.0 1.6 2.3
Deep venous thrombosis (DVT) (self-reported) 0.6 0.8 2.2 1.5 -0.9 -1.4 1.0 -0.9 -0.7 0.0 -0.1 -0.4
Heart disease (siblings) 0.7 0.8 2.1 0.8 -0.6 1.5 0.7 0.9 -0.2 0.0 -1.1 -1.3
Alcohol drinker status: Previous 0.4 0.5 1.3 0.3 -0.9 1.1 0.5 -1.1 0.2 0.0 0.0 -0.8
Pack years of smoking 0.8 1.2 3.9 -0.2 0.1 2.0 -0.2 -0.8 -1.2 0.0 -1.4 -1.6
Impedance of whole body 1.1 5.7 16.0 -3.0 3.3 0.6 -2.1 -0.7 0.9 0.0 4.0 3.1
Leg fat mass (left) 0.4 1.7 7.2 -0.4 -0.7 0.8 -0.8 0.1 -1.1 0.0 -2.7 -2.2
Arm predicted mass (left) 2.4 12.0 31.3 5.0 -5.6 -0.8 3.7 1.3 -0.8 0.0 -4.4 -4.0