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chr12:131,872,850-133,318,989

Best TWAS P=9.52e-10 · Best GWAS P=3.4e-09 conditioned to 0.676

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	DDX51	0.32	0.53	lasso	4	0.54	3.4e-78	5.7	5.7	1.0e-08	0.99	0.01	0.99	FALSE
2	GTEx	Adipose Subcutaneous	DDX51	0.16	0.05	lasso	2	0.05	1.2e-04	5.3	5.2	1.5e-07	0.80	0.13	0.58	FALSE
3	GTEx	Adipose Subcutaneous	EP400NL	0.31	0.25	enet	28	0.26	1.2e-21	4.7	-5.2	2.2e-07	-0.83	0.78	0.21	FALSE
4	GTEx	Artery Aorta	EP400NL	0.42	0.32	lasso	7	0.37	2.3e-21	4.7	-5.2	2.3e-07	-0.92	0.03	0.97	FALSE
5	GTEx	Artery Coronary	EP400NL	0.26	0.13	lasso	5	0.14	1.7e-05	5.8	-5.7	1.2e-08	-0.96	0.02	0.98	FALSE
6	GTEx	Cells EBV-transformed lymphocytes	DDX51	0.45	0.33	lasso	5	0.30	2.2e-10	5.2	5.1	3.0e-07	0.79	0.16	0.83	FALSE
7	GTEx	Cells Transformed fibroblasts	DDX51	0.44	0.34	enet	37	0.46	1.6e-37	5.2	5.2	2.5e-07	0.90	0.02	0.98	FALSE
8	GTEx	Cells Transformed fibroblasts	EP400NL	0.38	0.30	enet	29	0.37	3.8e-29	5.7	-5.5	4.9e-08	-0.96	0.01	0.99	FALSE
9	GTEx	Cells Transformed fibroblasts	RP13-977J11.5	0.25	0.15	lasso	10	0.16	7.5e-12	4.7	-5.4	6.4e-08	-0.83	0.09	0.91	FALSE
10	GTEx	Colon Sigmoid	RP13-977J11.5	0.15	0.11	lasso	4	0.14	1.8e-05	4.3	-5.4	7.2e-08	-0.71	0.04	0.84	FALSE
11	GTEx	Colon Transverse	EP400NL	0.31	0.11	enet	10	0.17	2.2e-08	4.7	-5.2	1.5e-07	-0.91	0.03	0.97	FALSE
12	GTEx	Esophagus Mucosa	EP400NL	0.29	0.22	lasso	6	0.33	1.9e-22	5.8	-5.7	1.2e-08	-0.92	0.01	0.99	FALSE
13	GTEx	Lung	EP400NL	0.34	0.27	lasso	7	0.27	1.6e-20	4.7	-5.2	1.9e-07	-0.88	0.66	0.34	FALSE
14	GTEx	Muscle Skeletal	DDX51	0.19	0.18	lasso	2	0.18	3.2e-17	5.2	5.2	2.0e-07	0.79	0.20	0.80	FALSE
15	GTEx	Nerve Tibial	EP400NL	0.35	0.27	lasso	6	0.29	1.5e-20	4.7	-5.3	1.4e-07	-0.91	0.26	0.74	FALSE
16	GTEx	Pancreas	EP400NL	0.43	0.29	lasso	6	0.37	1.6e-16	5.8	-5.7	1.2e-08	-0.95	0.01	0.99	FALSE
17	GTEx	Skin Sun Exposed Lower leg	EP400NL	0.33	0.17	enet	41	0.26	2.4e-21	5.7	-5.7	1.2e-08	-0.86	0.01	0.99	FALSE
18	GTEx	Small Intestine Terminal Ileum	EP400NL	0.22	0.16	lasso	6	0.09	4.3e-03	5.8	-5.8	8.6e-09	-0.97	0.02	0.91	FALSE
19	GTEx	Spleen	EP400NL	0.57	0.23	lasso	7	0.30	2.6e-08	4.7	-5.2	1.6e-07	-0.88	0.04	0.95	FALSE
20	GTEx	Spleen	RP13-977J11.5	0.52	0.04	enet	32	0.22	2.5e-06	5.8	-5.5	4.2e-08	-0.55	0.02	0.68	FALSE
21	GTEx	Stomach	EP400NL	0.29	0.12	lasso	6	0.13	8.5e-07	5.8	-5.7	1.5e-08	-0.95	0.02	0.98	FALSE
22	GTEx	Thyroid	EP400NL	0.37	0.38	lasso	3	0.43	4.2e-36	5.8	-5.8	6.4e-09	-0.97	0.01	0.99	FALSE
23	GTEx	Vagina	EP400NL	0.42	0.17	lasso	4	0.21	1.2e-05	4.5	-5.5	4.7e-08	-0.89	0.02	0.95	FALSE
24	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	DDX51	0.06	0.06	blup	42	0.07	1.7e-06	5.2	5.6	2.4e-08	0.96	0.01	0.99	FALSE
25	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	EP400NL	0.05	0.08	lasso	3	0.08	5.2e-07	5.4	-5.4	5.6e-08	-0.90	0.02	0.98	FALSE
26	The Cancer Genome Atlas	Breast Invasive Carcinoma	DDX51	0.05	0.06	blup	43	0.08	1.3e-16	5.7	5.3	1.4e-07	0.92	0.01	0.99	FALSE
27	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	DDX51	0.05	0.02	blup	43	0.03	1.5e-02	5.8	6.1	9.5e-10	0.94	0.01	0.76	TRUE
28	The Cancer Genome Atlas	Colon Adenocarcinoma	DDX51	0.05	0.04	lasso	2	0.05	8.1e-04	4.3	5.5	3.7e-08	0.86	0.02	0.89	FALSE
29	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	EP400NL	0.05	0.05	lasso	5	0.06	1.3e-07	4.7	-5.5	4.0e-08	-0.90	0.02	0.98	FALSE
30	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	DDX51	0.08	0.03	blup	43	0.05	9.4e-04	3.2	5.8	4.9e-09	0.94	0.02	0.92	FALSE
31	The Cancer Genome Atlas	Brain Lower Grade Glioma	EP400NL	0.05	0.06	blup	60	0.07	4.1e-08	5.9	-5.5	3.0e-08	-0.96	0.01	0.99	FALSE
32	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	DDX51	0.11	0.11	lasso	5	0.09	5.6e-05	5.8	5.7	1.3e-08	0.99	0.01	0.99	FALSE
33	The Cancer Genome Atlas	Lung Adenocarcinoma	DDX51	0.06	0.09	lasso	4	0.09	9.9e-11	5.8	5.8	7.5e-09	0.99	0.01	0.99	FALSE
34	The Cancer Genome Atlas	Lung Adenocarcinoma	EP400NL	0.06	0.06	blup	60	0.05	8.4e-07	5.7	-5.3	1.0e-07	-0.93	0.01	0.99	FALSE
35	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	DDX51	0.05	0.09	lasso	6	0.07	1.7e-08	5.7	5.9	4.0e-09	0.98	0.01	0.99	FALSE
36	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	EP400NL	0.04	0.02	blup	60	0.03	2.4e-04	5.2	-5.9	3.6e-09	-0.92	0.02	0.97	FALSE
37	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	DDX51	0.05	0.09	lasso	7	0.08	5.0e-06	5.8	5.8	7.3e-09	0.99	0.01	0.99	FALSE
38	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	EP400NL	0.08	0.08	blup	60	0.08	2.6e-06	5.2	-5.6	2.6e-08	-0.98	0.02	0.98	FALSE
39	The Cancer Genome Atlas	Prostate Adenocarcinoma	DDX51	0.08	0.11	blup	45	0.11	1.3e-11	5.8	5.7	1.2e-08	0.96	0.01	0.99	FALSE
40	The Cancer Genome Atlas	Rectum Adenocarcinoma	DDX51	0.16	0.00	blup	42	0.08	6.3e-03	5.2	5.5	2.9e-08	0.86	0.02	0.43	FALSE
41	The Cancer Genome Atlas	Soft Tissue Sarcoma	DDX51	0.05	0.03	blup	42	0.03	4.2e-03	5.7	5.9	3.4e-09	0.94	0.02	0.97	FALSE
42	The Cancer Genome Atlas	Stomach Adenocarcinoma	EP400NL	0.08	0.04	blup	60	0.08	2.8e-06	5.9	-5.7	1.3e-08	-0.93	0.01	0.99	FALSE
43	The Cancer Genome Atlas	Thyroid Carcinoma	DDX51	0.11	0.11	blup	42	0.10	3.5e-10	5.8	5.4	8.1e-08	0.94	0.01	0.99	FALSE