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chr13:114,302,502-115,106,996

Best TWAS P=2.89e-14 · Best GWAS P=1.49e-13 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adipose Subcutaneous	CDC16	0.17	0.17	lasso	4	0.19	3.6e-15	-7.3	-7.3	3.8e-13	0.99	0.01	0.99	FALSE
2	GTEx	Adipose Visceral Omentum	CDC16	0.12	0.11	lasso	4	0.09	1.5e-05	-7.3	-7.1	9.0e-13	0.98	0.01	0.99	FALSE
3	GTEx	Artery Aorta	CDC16	0.15	0.18	enet	10	0.17	1.6e-09	-7.3	-7.2	4.7e-13	0.97	0.01	0.99	FALSE
4	GTEx	Artery Coronary	CDC16	0.41	0.02	enet	5	0.02	6.9e-02	-5.5	-6.7	2.4e-11	0.91	0.02	0.94	FALSE
5	GTEx	Artery Tibial	CDC16	0.23	0.26	lasso	8	0.25	2.8e-19	-7.3	-7.3	2.9e-13	0.99	0.01	0.99	FALSE
6	GTEx	Brain Cerebellar Hemisphere	CDC16	0.17	0.10	lasso	9	0.17	3.5e-05	-7.3	-6.4	1.3e-10	0.92	0.02	0.97	FALSE
7	GTEx	Brain Cerebellum	CDC16	0.18	0.05	lasso	4	0.07	3.4e-03	-7.3	-7.3	3.2e-13	0.95	0.02	0.96	FALSE
8	GTEx	Brain Cortex	UPF3A	0.25	0.11	enet	13	0.10	1.2e-03	-6.6	5.8	7.5e-09	-0.58	0.08	0.12	FALSE
9	GTEx	Breast Mammary Tissue	CDC16	0.25	0.28	lasso	6	0.26	6.9e-14	-7.4	-7.3	3.9e-13	0.97	0.01	0.99	FALSE
10	GTEx	Breast Mammary Tissue (Male)	CDC16	0.23	0.08	enet	11	0.09	3.8e-03	-6.1	-6.6	3.6e-11	0.85	0.03	0.86	FALSE
11	GTEx	Breast Mammary Tissue (Female)	CDC16	0.25	0.22	enet	28	0.22	3.6e-07	-7.4	-7.3	3.7e-13	0.92	0.01	0.98	FALSE
12	GTEx	Breast Mammary Tissue (Female)	UPF3A	0.32	0.16	lasso	13	0.17	1.2e-05	-7.3	-6.8	1.2e-11	0.91	0.02	0.98	FALSE
13	GTEx	Cells EBV-transformed lymphocytes	CDC16	0.14	0.09	lasso	3	0.10	2.9e-04	-7.3	-7.4	1.7e-13	0.99	0.01	0.98	FALSE
14	GTEx	Cells Transformed fibroblasts	CDC16	0.17	0.13	lasso	6	0.15	4.6e-11	-7.3	-7.5	8.8e-14	0.98	0.01	0.99	FALSE
15	GTEx	Colon Sigmoid	UPF3A	0.15	0.10	lasso	8	0.08	8.3e-04	-7.3	-7.3	2.0e-13	0.97	0.02	0.97	FALSE
16	GTEx	Colon Transverse	CDC16	0.18	0.23	lasso	5	0.21	3.2e-10	-7.4	-7.3	2.8e-13	0.98	0.01	0.99	FALSE
17	GTEx	Colon Transverse	UPF3A	0.13	0.04	lasso	3	0.04	5.6e-03	-3.6	-5.7	1.5e-08	0.77	0.03	0.91	FALSE
18	GTEx	Esophagus Gastroesophageal Junction	CDC16	0.09	0.05	lasso	2	0.02	5.7e-02	-7.4	-7.4	1.4e-13	1.00	0.02	0.91	FALSE
19	GTEx	Esophagus Gastroesophageal Junction	UPF3A	0.20	0.07	lasso	6	0.06	4.5e-03	-7.3	-7.1	1.7e-12	0.99	0.01	0.95	FALSE
20	GTEx	Esophagus Mucosa	CDC16	0.35	0.46	lasso	6	0.46	1.0e-33	-7.4	-7.3	2.6e-13	1.00	0.01	0.99	FALSE
21	GTEx	Esophagus Muscularis	CDC16	0.12	0.09	lasso	6	0.13	3.2e-08	-6.2	-5.5	3.7e-08	0.88	0.01	0.99	FALSE
22	GTEx	Lung	CDC16	0.16	0.21	lasso	5	0.19	9.6e-15	-7.3	-7.3	2.6e-13	0.99	0.01	0.99	FALSE
23	GTEx	Muscle Skeletal	CDC16	0.05	0.06	lasso	1	0.05	9.2e-06	-7.3	-7.3	2.7e-13	0.99	0.01	0.99	FALSE
24	GTEx	Nerve Tibial	CDC16	0.23	0.23	enet	19	0.26	9.5e-19	-7.3	-7.2	5.3e-13	0.95	0.01	0.99	FALSE
25	GTEx	Pancreas	CDC16	0.09	0.14	lasso	3	0.06	1.8e-03	-7.3	-7.3	2.1e-13	1.00	0.01	0.97	FALSE
26	GTEx	Prostate	CDC16	0.17	0.16	lasso	3	0.11	1.4e-03	-7.4	-7.4	2.0e-13	1.00	0.01	0.94	FALSE
27	GTEx	Skin Not Sun Exposed Suprapubic	CDC16	0.35	0.42	enet	33	0.45	7.9e-27	-7.3	-7.0	2.0e-12	0.96	0.01	0.99	FALSE
28	GTEx	Skin Sun Exposed Lower leg	CDC16	0.31	0.33	lasso	7	0.33	4.1e-28	-7.3	-7.2	4.6e-13	0.98	0.01	0.99	FALSE
29	GTEx	Spleen	CDC16	0.25	0.19	lasso	7	0.21	4.9e-06	-7.3	-7.0	1.9e-12	0.98	0.02	0.97	FALSE
30	GTEx	Stomach	CDC16	0.12	0.06	enet	23	0.08	1.6e-04	-7.3	-5.8	7.1e-09	0.87	0.02	0.98	FALSE
31	GTEx	Testis	CDC16	0.32	0.30	enet	26	0.35	4.4e-16	-7.4	-7.6	4.0e-14	0.94	0.01	0.99	FALSE
32	GTEx	Thyroid	CDC16	0.12	0.13	lasso	2	0.11	8.2e-09	-7.3	-7.3	3.9e-13	1.00	0.01	0.99	FALSE
33	GTEx	Whole Blood	CDC16	0.31	0.20	lasso	5	0.20	4.4e-18	-7.3	-7.2	5.2e-13	0.98	0.01	0.99	FALSE
34	METSIM	Adipose	CDC16	0.18	0.27	enet	18	0.26	6.6e-39	-7.3	-7.0	2.3e-12	0.96	0.01	0.99	FALSE
35	NTR	Blood	CDC16	0.10	0.20	bslmm	209	0.20	3.1e-63	-7.3	-7.3	2.5e-13	1.00	0.01	0.99	FALSE
36	YFS	Blood	CDC16	0.28	0.54	enet	30	0.55	1.1e-220	-7.3	-7.1	1.3e-12	0.99	0.02	0.98	FALSE
37	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	CDC16	0.08	0.11	lasso	5	0.12	4.3e-10	-7.3	-7.2	5.2e-13	0.99	0.01	0.99	FALSE
38	The Cancer Genome Atlas	Breast Invasive Carcinoma	CDC16	0.01	0.01	blup	49	0.01	1.1e-03	-7.3	-7.1	1.1e-12	0.97	0.01	0.96	FALSE
39	The Cancer Genome Atlas	Colon Adenocarcinoma	CDC16	0.06	0.04	lasso	5	0.03	5.9e-03	-6.6	-7.3	3.1e-13	0.88	0.02	0.91	FALSE
40	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	CDC16	0.05	0.08	lasso	4	0.08	7.2e-09	-7.3	-7.2	4.2e-13	0.99	0.01	0.99	FALSE
41	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	CDC16	0.05	0.04	blup	49	0.05	2.0e-06	-7.3	-7.5	8.9e-14	0.95	0.01	0.99	FALSE
42	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	CDC16	0.04	0.01	blup	49	0.03	7.7e-03	-7.4	-7.0	2.0e-12	0.96	0.01	0.95	FALSE
43	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	CDC16	0.03	0.04	lasso	3	0.04	1.3e-05	-6.5	-7.4	1.6e-13	0.90	0.02	0.98	FALSE
44	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	CDC16	0.11	0.09	blup	49	0.09	1.8e-04	-7.3	-7.5	6.4e-14	0.98	0.01	0.97	FALSE
45	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	CDC16	0.07	0.03	blup	49	0.05	6.3e-03	-7.3	-6.9	4.8e-12	0.93	0.01	0.87	FALSE
46	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	UPF3A	0.10	0.09	lasso	1	0.08	3.8e-04	-6.5	-6.5	9.7e-11	0.76	0.02	0.53	FALSE
47	The Cancer Genome Atlas	Prostate Adenocarcinoma	CDC16	0.08	0.07	blup	49	0.08	1.2e-08	-6.3	-6.8	1.3e-11	0.90	0.02	0.98	FALSE
48	The Cancer Genome Atlas	Prostate Adenocarcinoma	UPF3A	0.14	0.06	blup	32	0.10	3.9e-10	-6.5	-5.3	1.4e-07	0.70	0.20	0.80	FALSE
49	The Cancer Genome Atlas	Thyroid Carcinoma	CDC16	0.06	0.09	lasso	3	0.09	3.3e-09	-7.3	-7.6	2.9e-14	0.98	0.01	0.99	TRUE
50	The Cancer Genome Atlas	Thyroid Carcinoma	UPF3A	0.14	0.11	enet	9	0.15	1.7e-14	-6.5	-5.7	1.5e-08	0.77	0.06	0.94	FALSE