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chr14:75,343,027-77,117,550

Best TWAS P=1.97e-12 · Best GWAS P=2.61e-11 conditioned to 0.164

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	TTLL5	0.13	0.15	lasso	10	0.19	1.2e-22	5.3	-6.4	2.1e-10	-0.82	0.72	0.28	FALSE
2	GTEx	Adipose Subcutaneous	TTLL5	0.13	0.10	lasso	4	0.11	2.2e-09	5.4	-5.9	3.8e-09	-0.73	0.52	0.48	FALSE
3	GTEx	Artery Aorta	TTLL5	0.09	0.11	lasso	3	0.07	1.1e-04	5.8	-6.0	2.7e-09	-0.62	0.47	0.40	FALSE
4	GTEx	Artery Tibial	TTLL5	0.09	0.05	lasso	4	0.05	1.3e-04	5.0	-5.4	8.3e-08	-0.70	0.69	0.21	FALSE
5	GTEx	Brain Cerebellar Hemisphere	TTLL5	0.19	0.06	lasso	2	0.02	9.7e-02	5.7	-5.8	6.3e-09	-0.48	0.10	0.35	FALSE
6	GTEx	Brain Cortex	TTLL5	0.23	0.09	lasso	13	0.07	5.9e-03	6.6	-7.0	2.5e-12	-0.91	0.04	0.85	FALSE
7	GTEx	Cells Transformed fibroblasts	TTLL5	0.09	0.09	lasso	6	0.11	1.6e-08	5.3	-5.7	1.0e-08	-0.82	0.52	0.48	FALSE
8	GTEx	Cells Transformed fibroblasts	FLVCR2	0.21	0.16	lasso	8	0.17	1.2e-12	6.3	6.2	6.3e-10	0.89	0.06	0.94	FALSE
9	GTEx	Cells Transformed fibroblasts	AC007182.6	0.18	0.20	lasso	7	0.18	2.1e-13	6.3	6.3	3.1e-10	0.89	0.08	0.92	FALSE
10	GTEx	Esophagus Gastroesophageal Junction	TTLL5	0.16	0.03	lasso	3	0.01	1.2e-01	5.2	-5.3	1.2e-07	-0.75	0.13	0.63	FALSE
11	GTEx	Esophagus Mucosa	TTLL5	0.11	0.00	lasso	5	0.00	2.4e-01	5.1	-5.5	4.5e-08	-0.74	0.22	0.43	FALSE
12	GTEx	Lung	TTLL5	0.15	0.08	enet	17	0.11	9.0e-09	5.4	-5.9	4.8e-09	-0.74	0.72	0.28	FALSE
13	METSIM	Adipose	TTLL5	0.12	0.01	blup	624	0.05	2.1e-07	4.8	-5.4	5.7e-08	-0.53	0.36	0.37	FALSE
14	YFS	Blood	TTLL5	0.04	0.04	lasso	6	0.03	1.4e-10	4.4	-5.5	2.9e-08	-0.54	0.99	0.01	FALSE
15	The Cancer Genome Atlas	Breast Invasive Carcinoma	TTLL5	0.01	0.02	enet	7	0.02	3.6e-05	5.8	-7.0	3.2e-12	-0.80	0.04	0.87	FALSE
16	The Cancer Genome Atlas	Colon Adenocarcinoma	TTLL5	0.07	0.04	blup	121	0.06	2.4e-04	6.6	-6.4	2.1e-10	-0.92	0.03	0.96	FALSE
17	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	TTLL5	0.04	0.02	blup	121	0.04	1.1e-05	5.9	-6.3	2.7e-10	-0.79	0.24	0.75	FALSE
18	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	TTLL5	0.04	0.03	blup	121	0.04	2.8e-05	5.0	-5.9	3.5e-09	-0.73	0.69	0.24	FALSE
19	The Cancer Genome Atlas	Lung Adenocarcinoma	TTLL5	0.03	0.01	blup	122	0.02	3.2e-03	5.7	-7.0	2.0e-12	-0.84	0.05	0.88	TRUE
20	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	TTLL5	0.02	0.01	blup	121	0.02	2.5e-03	5.7	-6.9	4.4e-12	-0.86	0.05	0.58	FALSE
21	The Cancer Genome Atlas	Prostate Adenocarcinoma	TTLL5	0.03	0.03	lasso	3	0.02	1.6e-03	4.9	-5.2	2.4e-07	-0.62	0.06	0.69	FALSE
22	The Cancer Genome Atlas	Thyroid Carcinoma	TTLL5	0.06	0.05	blup	121	0.05	6.3e-06	4.7	-6.0	1.8e-09	-0.79	0.92	0.08	FALSE