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chr14:91,553,016-93,268,359

Best TWAS P=7.5e-11 · Best GWAS P=6.66e-10 conditioned to 0.0021

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adipose Subcutaneous	ATXN3	0.19	0.17	lasso	5	0.17	1.7e-13	-5.5	-5.7	1.6e-08	0.72	0.16	0.84	FALSE
2	GTEx	Adipose Subcutaneous	RP11-529H20.5	0.14	0.16	lasso	3	0.15	3.0e-12	-5.5	-6.0	1.7e-09	0.83	0.16	0.84	FALSE
3	GTEx	Adipose Subcutaneous	RP11-529H20.6	0.16	0.26	lasso	2	0.26	4.8e-21	-5.7	-5.7	1.4e-08	0.72	0.09	0.91	FALSE
4	GTEx	Adipose Visceral Omentum	ATXN3	0.19	0.14	lasso	6	0.12	7.0e-07	-5.7	-5.6	1.7e-08	0.72	0.12	0.88	FALSE
5	GTEx	Adipose Visceral Omentum	RP11-529H20.5	0.19	0.05	lasso	6	0.08	9.9e-05	-5.7	-5.4	7.4e-08	0.80	0.10	0.90	FALSE
6	GTEx	Adipose Visceral Omentum	RP11-529H20.6	0.26	0.29	lasso	4	0.28	1.1e-14	-5.8	-5.7	1.5e-08	0.73	0.10	0.90	FALSE
7	GTEx	Adrenal Gland	RP11-529H20.6	0.22	0.21	lasso	7	0.18	4.8e-07	-5.7	-5.3	1.1e-07	0.71	0.10	0.89	FALSE
8	GTEx	Artery Aorta	RP11-529H20.6	0.20	0.14	lasso	4	0.18	6.4e-10	-5.7	-5.4	6.7e-08	0.71	0.14	0.86	FALSE
9	GTEx	Artery Coronary	ATXN3	0.21	0.20	lasso	2	0.24	1.4e-08	-5.7	-5.5	2.9e-08	0.64	0.12	0.87	FALSE
10	GTEx	Artery Tibial	ATXN3	0.13	0.11	lasso	3	0.10	5.8e-08	-5.5	-5.5	3.6e-08	0.85	0.22	0.77	FALSE
11	GTEx	Artery Tibial	RP11-529H20.5	0.07	0.00	lasso	4	0.00	4.7e-01	-6.0	-6.1	1.1e-09	0.95	0.02	0.88	FALSE
12	GTEx	Artery Tibial	RP11-529H20.6	0.20	0.22	lasso	8	0.22	2.3e-17	-5.7	-5.7	1.4e-08	0.72	0.14	0.86	FALSE
13	GTEx	Breast Mammary Tissue	ATXN3	0.20	0.24	lasso	8	0.23	3.5e-12	-5.7	-5.7	1.3e-08	0.74	0.14	0.86	FALSE
14	GTEx	Breast Mammary Tissue	RP11-529H20.6	0.20	0.23	enet	13	0.27	3.5e-14	-5.7	-5.6	2.1e-08	0.75	0.11	0.89	FALSE
15	GTEx	Breast Mammary Tissue (Female)	ATXN3	0.18	0.04	lasso	4	0.03	3.3e-02	-5.5	-5.6	1.7e-08	0.84	0.10	0.80	FALSE
16	GTEx	Breast Mammary Tissue (Female)	RP11-529H20.6	0.22	0.13	lasso	3	0.09	1.5e-03	-5.7	-5.1	2.8e-07	0.71	0.09	0.88	FALSE
17	GTEx	Cells EBV-transformed lymphocytes	RP11-529H20.6	0.41	0.30	lasso	2	0.28	6.9e-10	-5.7	-5.8	7.3e-09	0.70	0.14	0.86	FALSE
18	GTEx	Cells Transformed fibroblasts	ATXN3	0.14	0.10	lasso	9	0.09	6.0e-07	-5.5	-5.6	2.2e-08	0.72	0.15	0.84	FALSE
19	GTEx	Cells Transformed fibroblasts	TRIP11	0.09	0.04	lasso	2	0.00	3.8e-01	-5.7	-5.9	4.7e-09	0.70	0.08	0.65	FALSE
20	GTEx	Cells Transformed fibroblasts	RP11-529H20.5	0.10	0.13	lasso	11	0.12	3.1e-09	-5.5	-5.6	2.7e-08	0.72	0.16	0.84	FALSE
21	GTEx	Cells Transformed fibroblasts	RP11-529H20.6	0.27	0.26	lasso	6	0.24	3.1e-18	-5.7	-5.7	9.7e-09	0.74	0.14	0.86	FALSE
22	GTEx	Colon Sigmoid	RP11-529H20.6	0.24	0.24	lasso	3	0.27	4.8e-10	-5.7	-5.4	7.2e-08	0.71	0.13	0.87	FALSE
23	GTEx	Esophagus Mucosa	RP11-529H20.6	0.13	0.11	lasso	10	0.13	7.9e-09	-5.7	-6.0	1.8e-09	0.87	0.07	0.93	FALSE
24	GTEx	Esophagus Muscularis	ATXN3	0.16	0.17	lasso	5	0.17	2.0e-10	-5.5	-5.7	1.5e-08	0.79	0.16	0.84	FALSE
25	GTEx	Esophagus Muscularis	RP11-529H20.6	0.21	0.24	lasso	2	0.22	9.2e-14	-5.5	-5.5	3.0e-08	0.72	0.17	0.83	FALSE
26	GTEx	Heart Atrial Appendage	RP11-529H20.6	0.27	0.20	lasso	5	0.18	2.5e-08	-5.7	-5.5	3.5e-08	0.71	0.13	0.87	FALSE
27	GTEx	Heart Left Ventricle	TC2N	0.13	0.10	enet	15	0.10	6.5e-06	4.8	5.3	8.9e-08	0.13	0.51	0.43	FALSE
28	GTEx	Lung	RP11-529H20.6	0.08	0.05	enet	15	0.05	1.8e-04	-5.7	-5.7	1.4e-08	0.83	0.10	0.89	FALSE
29	GTEx	Muscle Skeletal	ATXN3	0.04	0.04	lasso	5	0.04	1.2e-04	-5.5	-5.5	3.2e-08	0.76	0.12	0.84	FALSE
30	GTEx	Muscle Skeletal	TRIP11	0.05	0.04	lasso	6	0.03	7.9e-04	-5.6	-5.2	1.8e-07	0.72	0.12	0.83	FALSE
31	GTEx	Muscle Skeletal	RP11-529H20.6	0.11	0.06	lasso	2	0.06	2.9e-06	-5.7	-5.7	9.1e-09	0.72	0.11	0.88	FALSE
32	GTEx	Nerve Tibial	ATXN3	0.30	0.29	lasso	4	0.29	1.6e-20	-5.5	-5.2	1.5e-07	0.72	0.18	0.82	FALSE
33	GTEx	Nerve Tibial	TRIP11	0.21	0.14	lasso	6	0.11	3.7e-08	-5.5	-5.5	3.7e-08	0.73	0.18	0.82	FALSE
34	GTEx	Nerve Tibial	RP11-529H20.5	0.28	0.26	lasso	5	0.25	9.2e-18	-5.5	-5.5	3.0e-08	0.73	0.18	0.82	FALSE
35	GTEx	Nerve Tibial	RP11-529H20.6	0.29	0.30	lasso	4	0.29	4.4e-21	-5.5	-5.6	2.2e-08	0.72	0.16	0.84	FALSE
36	GTEx	Ovary	ATXN3	0.32	0.18	lasso	8	0.18	2.9e-05	-5.5	-5.2	1.9e-07	0.72	0.10	0.80	FALSE
37	GTEx	Ovary	RP11-529H20.5	0.24	0.10	lasso	5	0.11	1.2e-03	-5.5	-5.4	7.2e-08	0.74	0.05	0.82	FALSE
38	GTEx	Ovary	RP11-529H20.6	0.20	0.23	lasso	4	0.18	4.3e-05	-5.7	-5.8	5.8e-09	0.76	0.06	0.86	FALSE
39	GTEx	Pituitary	ATXN3	0.33	0.03	lasso	2	0.03	4.7e-02	-5.7	-6.0	2.3e-09	0.75	0.10	0.64	FALSE
40	GTEx	Pituitary	RP11-529H20.5	0.37	0.14	enet	7	0.07	6.3e-03	-6.1	-6.0	2.5e-09	0.79	0.04	0.85	FALSE
41	GTEx	Prostate	RP11-529H20.6	0.28	0.00	lasso	5	0.05	2.5e-02	-5.7	-6.5	7.5e-11	0.59	0.09	0.44	TRUE
42	GTEx	Small Intestine Terminal Ileum	RP11-529H20.6	0.36	0.32	lasso	8	0.26	1.8e-06	-5.8	-5.4	5.5e-08	0.70	0.11	0.86	FALSE
43	GTEx	Spleen	RP11-529H20.5	0.31	0.15	lasso	3	0.18	2.3e-05	-6.1	-5.8	5.7e-09	0.80	0.04	0.78	FALSE
44	GTEx	Stomach	ATXN3	0.24	0.09	lasso	3	0.11	5.0e-06	-5.7	-5.7	1.2e-08	0.78	0.14	0.86	FALSE
45	GTEx	Stomach	RP11-529H20.5	0.19	0.12	enet	32	0.12	2.2e-06	-5.7	-5.2	2.6e-07	0.73	0.09	0.90	FALSE
46	GTEx	Stomach	RP11-529H20.6	0.20	0.27	lasso	4	0.25	2.5e-12	-5.5	-5.6	1.8e-08	0.72	0.14	0.86	FALSE
47	GTEx	Testis	TRIP11	0.10	0.05	lasso	4	0.02	3.5e-02	-5.7	-5.6	2.1e-08	0.72	0.06	0.82	FALSE
48	GTEx	Testis	RP11-529H20.5	0.19	0.05	lasso	10	0.05	4.2e-03	-5.5	-6.1	1.0e-09	0.83	0.04	0.94	FALSE
49	GTEx	Testis	RP11-529H20.6	0.23	0.23	lasso	3	0.22	4.9e-10	-5.7	-5.7	1.1e-08	0.71	0.14	0.86	FALSE
50	GTEx	Thyroid	RP11-529H20.6	0.17	0.18	lasso	2	0.17	9.6e-13	-5.7	-5.7	1.2e-08	0.73	0.11	0.89	FALSE
51	GTEx	Whole Blood	RP11-529H20.5	0.13	0.09	lasso	5	0.08	1.2e-07	-6.1	-6.1	1.3e-09	0.82	0.01	0.99	FALSE
52	GTEx	Whole Blood	RP11-529H20.6	0.15	0.13	lasso	4	0.16	3.8e-14	-5.7	-6.2	7.7e-10	0.80	0.07	0.93	FALSE
53	METSIM	Adipose	TRIP11	0.05	0.04	enet	13	0.02	3.8e-04	-6.1	-5.5	3.5e-08	0.89	0.01	0.99	FALSE
54	The Cancer Genome Atlas	Colon Adenocarcinoma	TRIP11	0.04	0.01	blup	70	0.01	4.4e-02	4.5	-6.0	2.3e-09	0.82	0.03	0.48	FALSE
55	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	TRIP11	0.02	0.02	lasso	1	0.01	1.1e-02	-5.7	-5.7	1.4e-08	0.72	0.07	0.56	FALSE
56	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	TC2N	0.17	0.12	blup	83	0.12	2.1e-05	-5.5	5.7	1.1e-08	0.06	0.03	0.94	FALSE
57	The Cancer Genome Atlas	Skin Cutaneous Melanoma	TC2N	0.20	0.04	enet	18	0.04	2.4e-02	3.0	5.2	1.9e-07	0.16	0.02	0.27	FALSE
58	The Cancer Genome Atlas	Thyroid Carcinoma	TC2N	0.07	0.06	enet	10	0.06	2.8e-06	-5.5	5.7	9.7e-09	0.03	0.01	0.99	TRUE
59	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	TRIP11	0.14	0.04	blup	70	0.09	1.6e-03	-4.5	-5.9	3.1e-09	0.90	0.03	0.61	FALSE