Best TWAS P=1.58e-18 · Best GWAS P=1.49e-17 conditioned to 8.89e-16
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | CTD-3076O17.1 | 0.22 | 0.05 | lasso | 6 | 0.04 | 2.9e-04 | -4.25 | -5.9 | 3.3e-09 | 0.05 | 0.75 | 0.08 | FALSE |
| 2 | GTEx | Adipose Visceral Omentum | CTD-3076O17.1 | 0.21 | 0.00 | lasso | 6 | 0.00 | 6.2e-01 | -5.95 | -8.8 | 1.6e-18 | 0.01 | 0.08 | 0.35 | TRUE |
| 3 | GTEx | Colon Sigmoid | CTD-3076O17.1 | 0.25 | 0.15 | lasso | 5 | 0.09 | 3.5e-04 | -6.01 | -5.9 | 4.0e-09 | 0.03 | 0.16 | 0.35 | FALSE |
| 4 | GTEx | Esophagus Mucosa | CTD-3076O17.1 | 0.28 | 0.10 | lasso | 6 | 0.11 | 4.7e-08 | -5.83 | -5.2 | 2.4e-07 | 0.03 | 0.93 | 0.07 | TRUE |
| 5 | GTEx | Heart Atrial Appendage | ADAMTS17 | 0.22 | 0.00 | lasso | 4 | 0.09 | 9.6e-05 | -2.75 | -5.2 | 2.1e-07 | 0.07 | 0.10 | 0.18 | FALSE |
| 6 | GTEx | Lung | CTD-3076O17.1 | 0.15 | 0.09 | enet | 13 | 0.09 | 2.8e-07 | -5.83 | -5.5 | 4.3e-08 | 0.02 | 0.92 | 0.07 | FALSE |
| 7 | GTEx | Pancreas | CTD-3076O17.1 | 0.24 | 0.11 | enet | 6 | 0.11 | 2.7e-05 | -5.88 | -5.7 | 1.0e-08 | 0.01 | 0.48 | 0.11 | FALSE |
| 8 | GTEx | Testis | ADAMTS17 | 0.30 | 0.24 | lasso | 2 | 0.22 | 6.7e-10 | -5.93 | -6.0 | 2.5e-09 | 0.02 | 0.90 | 0.09 | FALSE |
| 9 | GTEx | Testis | TARSL2 | 0.20 | 0.00 | enet | 26 | 0.10 | 2.6e-05 | 0.85 | -5.2 | 2.3e-07 | -0.17 | 0.11 | 0.13 | TRUE |
| 10 | GTEx | Testis | CTD-3076O17.1 | 0.45 | 0.17 | enet | 19 | 0.14 | 1.0e-06 | -5.93 | -5.8 | 5.0e-09 | 0.03 | 0.79 | 0.13 | FALSE |
| 11 | The Cancer Genome Atlas | Brain Lower Grade Glioma | LRRK1 | 0.07 | 0.05 | lasso | 3 | 0.04 | 1.3e-05 | -5.04 | -5.5 | 3.0e-08 | 0.06 | 0.06 | 0.91 | TRUE |