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chr16:80,779,331-82,901,701

Best TWAS P=7.58e-14 · Best GWAS P=1.99e-11 conditioned to 0.937

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	MPHOSPH6	0.30	0.24	lasso	8	0.23	2.1e-27	6.6	-6.1	1.2e-09	-0.79	0.02	0.98	FALSE
2	GTEx	Adipose Subcutaneous	MPHOSPH6	0.15	0.08	enet	8	0.09	5.1e-08	6.7	5.9	4.4e-09	0.85	0.01	0.99	FALSE
3	GTEx	Adipose Visceral Omentum	MPHOSPH6	0.32	0.14	lasso	4	0.17	3.5e-09	6.6	6.8	1.1e-11	0.95	0.01	0.99	FALSE
4	GTEx	Adrenal Gland	MPHOSPH6	0.34	0.25	lasso	3	0.26	8.4e-10	6.7	6.6	4.6e-11	0.94	0.01	0.99	FALSE
5	GTEx	Artery Aorta	MPHOSPH6	0.32	0.15	lasso	6	0.17	7.8e-10	6.7	6.5	6.9e-11	0.92	0.01	0.99	FALSE
6	GTEx	Artery Tibial	MPHOSPH6	0.36	0.24	enet	9	0.27	1.9e-21	6.7	6.9	5.9e-12	0.94	0.01	0.99	FALSE
7	GTEx	Brain Cerebellar Hemisphere	MPHOSPH6	0.49	0.30	enet	12	0.31	8.5e-09	6.7	6.3	3.2e-10	0.96	0.01	0.99	FALSE
8	GTEx	Brain Cerebellum	MPHOSPH6	0.40	0.36	enet	10	0.39	1.8e-12	4.4	5.8	7.1e-09	0.94	0.02	0.98	FALSE
9	GTEx	Cells Transformed fibroblasts	CMIP	0.20	0.05	lasso	6	0.07	1.0e-05	-4.9	-7.1	1.4e-12	-0.27	0.38	0.61	FALSE
10	GTEx	Colon Transverse	MPHOSPH6	0.21	0.16	lasso	3	0.17	1.4e-08	6.7	6.8	8.3e-12	0.96	0.01	0.99	FALSE
11	GTEx	Esophagus Gastroesophageal Junction	MPHOSPH6	0.43	0.19	enet	30	0.19	1.8e-07	6.6	5.4	6.8e-08	0.83	0.01	0.98	FALSE
12	GTEx	Esophagus Muscularis	MPHOSPH6	0.36	0.23	lasso	7	0.20	1.7e-12	6.7	6.7	1.7e-11	0.96	0.01	0.99	FALSE
13	GTEx	Heart Atrial Appendage	MPHOSPH6	0.33	0.19	enet	27	0.21	5.4e-10	6.7	6.0	1.8e-09	0.88	0.01	0.99	FALSE
14	GTEx	Heart Left Ventricle	MPHOSPH6	0.28	0.24	lasso	3	0.24	8.9e-13	6.7	6.7	1.6e-11	0.96	0.01	0.99	FALSE
15	GTEx	Lung	MPHOSPH6	0.16	0.10	lasso	4	0.11	8.3e-09	6.7	6.8	7.8e-12	0.97	0.01	0.99	FALSE
16	GTEx	Muscle Skeletal	MPHOSPH6	0.27	0.19	lasso	7	0.23	1.4e-22	6.7	6.6	4.7e-11	0.95	0.01	0.99	FALSE
17	GTEx	Nerve Tibial	MPHOSPH6	0.40	0.22	lasso	7	0.28	1.0e-19	6.7	6.5	6.0e-11	0.94	0.01	0.99	FALSE
18	GTEx	Pancreas	MPHOSPH6	0.25	0.14	enet	15	0.15	9.2e-07	6.7	7.5	7.6e-14	0.89	0.01	0.99	TRUE
19	GTEx	Stomach	MPHOSPH6	0.41	0.10	lasso	7	0.09	3.5e-05	6.6	7.1	1.6e-12	0.92	0.01	0.99	FALSE
20	GTEx	Testis	MPHOSPH6	0.52	0.32	lasso	11	0.35	2.0e-16	6.7	6.7	2.4e-11	0.93	0.01	0.99	FALSE
21	GTEx	Thyroid	MPHOSPH6	0.31	0.21	lasso	4	0.26	4.7e-20	6.6	6.8	9.9e-12	0.94	0.01	0.99	FALSE
22	METSIM	Adipose	MPHOSPH6	0.12	0.07	bslmm	741	0.08	2.0e-11	6.6	7.0	2.1e-12	0.92	0.01	0.99	FALSE
23	NTR	Blood	MPHOSPH6	0.10	0.08	lasso	6	0.09	2.7e-26	4.5	5.5	4.9e-08	0.74	1.00	0.00	FALSE
24	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	MPHOSPH6	0.14	0.15	lasso	6	0.15	7.0e-17	6.6	6.5	1.0e-10	0.88	0.01	0.99	FALSE
25	The Cancer Genome Atlas	Lung Adenocarcinoma	MPHOSPH6	0.04	0.01	blup	90	0.02	2.2e-03	4.4	5.1	2.7e-07	0.61	0.05	0.44	FALSE
26	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	MPHOSPH6	0.13	0.09	lasso	2	0.12	2.4e-05	4.4	5.7	1.0e-08	0.88	0.03	0.91	FALSE
27	The Cancer Genome Atlas	Thyroid Carcinoma	MPHOSPH6	0.18	0.16	lasso	3	0.16	5.1e-15	6.7	6.8	8.1e-12	0.98	0.01	0.99	FALSE