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chr18:11,968,117-13,822,256

Best TWAS P=2.55e-11 · Best GWAS P=1.27e-09 conditioned to 0.131

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	CEP192	0.13	0.13	lasso	6	0.14	1.1e-16	6.0	6.0	2.0e-09	0.97	0.02	0.98	FALSE
2	GTEx	Adipose Subcutaneous	CEP192	0.38	0.44	enet	24	0.48	1.3e-44	5.9	5.8	6.2e-09	0.96	0.03	0.97	FALSE
3	GTEx	Adipose Visceral Omentum	CEP192	0.38	0.35	lasso	4	0.43	3.0e-24	6.0	5.1	2.8e-07	0.95	0.02	0.98	FALSE
4	GTEx	Adrenal Gland	CEP192	0.44	0.56	lasso	2	0.56	9.6e-24	5.9	5.8	7.0e-09	0.98	0.03	0.97	FALSE
5	GTEx	Artery Aorta	CEP192	0.43	0.50	lasso	11	0.55	2.5e-35	5.9	5.9	3.0e-09	0.97	0.02	0.98	FALSE
6	GTEx	Artery Coronary	CEP192	0.32	0.35	lasso	5	0.33	8.2e-12	6.0	5.8	7.5e-09	0.97	0.02	0.98	FALSE
7	GTEx	Artery Tibial	CEP192	0.40	0.50	enet	29	0.54	7.3e-50	5.9	5.7	1.5e-08	0.96	0.02	0.97	FALSE
8	GTEx	Brain Caudate basal ganglia	CEP192	0.48	0.36	enet	19	0.36	4.2e-11	6.0	5.8	6.2e-09	0.97	0.02	0.98	FALSE
9	GTEx	Brain Cerebellar Hemisphere	CEP192	0.44	0.20	enet	22	0.26	2.2e-07	5.7	5.4	7.1e-08	0.92	0.03	0.97	FALSE
10	GTEx	Brain Cerebellum	CEP192	0.52	0.44	enet	31	0.52	5.6e-18	6.0	5.4	7.8e-08	0.91	0.02	0.98	FALSE
11	GTEx	Brain Cortex	CEP192	0.40	0.26	lasso	6	0.26	9.9e-08	6.0	5.7	9.5e-09	0.95	0.02	0.98	FALSE
12	GTEx	Brain Frontal Cortex BA9	SEH1L	0.29	-0.01	lasso	4	0.00	3.0e-01	5.6	5.5	3.3e-08	0.76	0.04	0.28	FALSE
13	GTEx	Brain Frontal Cortex BA9	CEP192	0.27	0.19	lasso	11	0.18	1.3e-05	5.7	5.9	3.7e-09	0.94	0.03	0.96	FALSE
14	GTEx	Brain Hypothalamus	SEH1L	0.26	0.21	lasso	2	0.13	6.6e-04	5.6	5.8	6.0e-09	0.96	0.03	0.86	FALSE
15	GTEx	Brain Hypothalamus	CEP192	0.35	0.33	enet	29	0.33	1.8e-08	5.9	5.1	2.6e-07	0.94	0.02	0.98	FALSE
16	GTEx	Brain Nucleus accumbens basal ganglia	CEP192	0.38	0.28	lasso	9	0.28	4.8e-08	6.0	5.3	1.2e-07	0.93	0.02	0.98	FALSE
17	GTEx	Brain Putamen basal ganglia	CEP192	0.50	0.39	lasso	5	0.36	2.4e-09	6.0	5.5	3.8e-08	0.95	0.02	0.98	FALSE
18	GTEx	Breast Mammary Tissue	CEP192	0.38	0.40	lasso	4	0.42	4.7e-23	5.9	6.0	1.9e-09	0.97	0.02	0.98	FALSE
19	GTEx	Breast Mammary Tissue (Male)	CEP192	0.58	0.26	lasso	11	0.30	1.3e-07	5.9	6.1	1.1e-09	0.93	0.02	0.97	FALSE
20	GTEx	Breast Mammary Tissue (Female)	CEP192	0.34	0.23	lasso	11	0.26	2.4e-08	5.9	5.3	1.4e-07	0.94	0.02	0.98	FALSE
21	GTEx	Cells EBV-transformed lymphocytes	SEH1L	0.18	0.13	lasso	4	0.08	1.3e-03	5.9	5.8	6.3e-09	0.93	0.03	0.82	FALSE
22	GTEx	Cells EBV-transformed lymphocytes	CEP76	0.17	-0.01	enet	30	0.02	7.7e-02	2.5	5.2	1.7e-07	0.20	0.08	0.12	FALSE
23	GTEx	Cells EBV-transformed lymphocytes	CEP192	0.52	0.34	lasso	5	0.36	1.6e-12	5.9	6.2	5.4e-10	0.92	0.03	0.97	FALSE
24	GTEx	Cells Transformed fibroblasts	SEH1L	0.10	0.03	enet	18	0.04	7.8e-04	5.9	5.7	1.2e-08	0.63	0.04	0.93	FALSE
25	GTEx	Cells Transformed fibroblasts	CEP192	0.32	0.32	enet	39	0.39	2.7e-31	6.0	5.8	5.8e-09	0.93	0.02	0.98	FALSE
26	GTEx	Colon Transverse	CEP192	0.45	0.54	lasso	8	0.57	1.2e-32	5.9	5.5	4.8e-08	0.96	0.02	0.97	FALSE
27	GTEx	Esophagus Gastroesophageal Junction	CEP192	0.38	0.39	lasso	4	0.39	4.7e-15	5.9	6.0	1.9e-09	0.97	0.02	0.98	FALSE
28	GTEx	Esophagus Mucosa	SEH1L	0.09	0.02	enet	25	0.03	2.4e-03	-5.0	5.1	3.0e-07	0.50	0.11	0.71	FALSE
29	GTEx	Esophagus Mucosa	CEP192	0.39	0.51	enet	29	0.52	7.4e-40	5.9	5.7	1.3e-08	0.95	0.02	0.98	FALSE
30	GTEx	Esophagus Muscularis	CEP192	0.39	0.46	lasso	9	0.52	2.1e-36	6.0	5.7	1.5e-08	0.97	0.02	0.98	FALSE
31	GTEx	Heart Atrial Appendage	CEP192	0.29	0.28	lasso	5	0.26	4.3e-12	5.9	5.5	4.6e-08	0.96	0.02	0.98	FALSE
32	GTEx	Heart Left Ventricle	CEP192	0.24	0.06	lasso	4	0.09	1.4e-05	5.9	6.3	2.9e-10	0.91	0.02	0.98	FALSE
33	GTEx	Lung	SEH1L	0.13	0.09	lasso	9	0.09	2.9e-07	6.0	5.2	1.7e-07	0.95	0.02	0.98	FALSE
34	GTEx	Lung	CEP192	0.32	0.29	lasso	7	0.34	3.8e-27	5.9	5.8	7.6e-09	0.97	0.03	0.97	FALSE
35	GTEx	Muscle Skeletal	CEP192	0.10	0.07	lasso	3	0.07	3.1e-07	5.9	5.5	4.3e-08	0.97	0.02	0.98	FALSE
36	GTEx	Nerve Tibial	CEP192	0.44	0.52	lasso	12	0.55	3.1e-46	5.9	5.8	7.2e-09	0.97	0.02	0.98	FALSE
37	GTEx	Ovary	CEP192	0.43	0.42	enet	25	0.43	6.5e-12	5.9	5.9	3.2e-09	0.96	0.02	0.98	FALSE
38	GTEx	Pancreas	CEP192	0.44	0.37	lasso	8	0.44	3.1e-20	5.9	5.1	2.9e-07	0.95	0.03	0.97	FALSE
39	GTEx	Prostate	CEP192	0.57	0.59	enet	23	0.66	1.8e-21	5.9	5.6	2.5e-08	0.96	0.02	0.98	FALSE
40	GTEx	Skin Not Sun Exposed Suprapubic	CEP192	0.34	0.35	enet	20	0.40	1.6e-23	6.0	5.4	8.5e-08	0.95	0.02	0.98	FALSE
41	GTEx	Skin Sun Exposed Lower leg	CEP192	0.34	0.36	lasso	3	0.38	3.5e-33	5.9	5.9	3.5e-09	0.97	0.03	0.97	FALSE
42	GTEx	Spleen	CEP192	0.54	0.52	lasso	5	0.49	2.8e-14	5.9	5.9	3.8e-09	0.97	0.03	0.97	FALSE
43	GTEx	Stomach	CEP192	0.37	0.44	lasso	5	0.43	1.5e-22	5.9	6.0	2.1e-09	0.97	0.03	0.97	FALSE
44	GTEx	Thyroid	CEP192	0.37	0.48	lasso	7	0.52	3.2e-46	5.9	5.9	2.9e-09	0.97	0.02	0.98	FALSE
45	GTEx	Uterus	CEP192	0.52	0.43	lasso	6	0.41	1.7e-09	5.9	6.1	7.9e-10	0.97	0.02	0.97	FALSE
46	GTEx	Vagina	CEP192	0.51	0.31	lasso	4	0.37	2.3e-09	5.9	6.1	1.2e-09	0.94	0.02	0.98	FALSE
47	GTEx	Whole Blood	CEP192	0.17	0.16	enet	15	0.17	3.7e-15	5.9	5.7	9.3e-09	0.97	0.02	0.98	FALSE
48	METSIM	Adipose	CEP192	0.19	0.32	lasso	5	0.32	1.0e-48	6.0	5.8	5.0e-09	0.98	0.03	0.97	FALSE
49	YFS	Blood	SEH1L	0.04	0.02	blup	393	0.02	7.6e-08	-5.0	5.5	3.6e-08	0.57	0.79	0.20	FALSE
50	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	CEP192	0.07	0.09	lasso	2	0.09	9.4e-08	6.1	6.1	1.3e-09	0.94	0.02	0.98	FALSE
51	The Cancer Genome Atlas	Breast Invasive Carcinoma	CEP192	0.06	0.13	enet	9	0.13	3.4e-26	5.9	6.0	2.6e-09	0.97	0.03	0.97	FALSE
52	The Cancer Genome Atlas	Breast Invasive Carcinoma	SEH1L	0.02	0.01	lasso	3	0.02	2.5e-04	-4.8	5.5	4.4e-08	0.52	0.16	0.45	FALSE
53	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	CEP192	0.16	0.20	lasso	4	0.19	1.6e-09	5.9	5.9	3.6e-09	0.95	0.02	0.98	FALSE
54	The Cancer Genome Atlas	Colon Adenocarcinoma	CEP192	0.06	0.05	blup	84	0.04	1.5e-03	5.7	6.6	4.2e-11	0.93	0.03	0.91	FALSE
55	The Cancer Genome Atlas	Glioblastoma Multiforme	CEP192	0.24	0.13	blup	84	0.13	7.9e-05	5.9	5.4	8.2e-08	0.89	0.02	0.96	FALSE
56	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	CEP192	0.21	0.31	lasso	4	0.31	1.0e-35	5.9	5.8	6.7e-09	0.97	0.03	0.97	FALSE
57	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SEH1L	0.03	0.01	blup	60	0.01	4.0e-02	-5.2	6.3	3.0e-10	0.68	0.02	0.30	FALSE
58	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	CEP192	0.30	0.33	lasso	2	0.33	1.8e-19	6.0	5.8	6.5e-09	0.98	0.02	0.98	FALSE
59	The Cancer Genome Atlas	Brain Lower Grade Glioma	CEP192	0.27	0.38	blup	84	0.38	1.5e-45	5.9	5.3	9.7e-08	0.95	0.02	0.98	FALSE
60	The Cancer Genome Atlas	Brain Lower Grade Glioma	SEH1L	0.05	0.00	blup	60	0.01	1.0e-02	5.9	6.7	2.5e-11	0.76	0.01	0.59	TRUE
61	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	CEP192	0.11	0.16	lasso	3	0.16	7.6e-08	6.1	6.2	7.6e-10	0.95	0.02	0.98	FALSE
62	The Cancer Genome Atlas	Lung Adenocarcinoma	CEP192	0.09	0.14	blup	85	0.14	8.4e-16	6.0	5.2	2.2e-07	0.95	0.02	0.98	FALSE
63	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	CEP192	0.09	0.07	blup	84	0.09	2.1e-06	5.6	5.3	9.2e-08	0.93	0.03	0.97	FALSE
64	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	CEP192	0.12	0.06	blup	84	0.08	2.0e-04	5.7	6.2	6.3e-10	0.96	0.02	0.97	FALSE
65	The Cancer Genome Atlas	Prostate Adenocarcinoma	CEP192	0.33	0.49	lasso	5	0.49	1.0e-57	5.9	5.9	2.9e-09	0.96	0.02	0.98	FALSE
66	The Cancer Genome Atlas	Soft Tissue Sarcoma	CEP192	0.10	0.07	blup	84	0.08	1.2e-05	5.9	5.5	4.8e-08	0.96	0.02	0.97	FALSE
67	The Cancer Genome Atlas	Stomach Adenocarcinoma	CEP192	0.07	0.04	blup	84	0.07	1.7e-05	5.7	5.5	3.8e-08	0.96	0.02	0.97	FALSE
68	The Cancer Genome Atlas	Thyroid Carcinoma	CEP192	0.36	0.53	enet	19	0.54	2.6e-61	5.9	5.7	1.0e-08	0.96	0.02	0.98	FALSE