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chr17:78,763,580-80,866,427

Best TWAS P=7.53e-21 · Best GWAS P=2.2e-19 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	DCXR	0.14	0.07	enet	17	0.10	3.4e-12	4.0	7.7	9.6e-15	-0.49	0.99	0.01	FALSE
2	CommonMind	Brain Pre-frontal Cortex	LRRC45	0.09	0.10	enet	7	0.10	1.2e-11	-9.0	8.9	5.4e-19	-0.99	0.00	1.00	FALSE
3	CommonMind	Brain Pre-frontal Cortex	MYADML2	0.52	0.43	enet	15	0.45	3.6e-60	-7.2	-7.3	2.3e-13	0.56	1.00	0.00	FALSE
4	CommonMind	Brain Pre-frontal Cortex	STRA13	0.45	0.38	lasso	4	0.40	1.6e-51	-5.6	5.9	3.9e-09	-0.78	1.00	0.00	FALSE
5	GTEx	Adipose Subcutaneous	LRRC45	0.23	0.06	lasso	3	0.05	1.0e-04	-9.0	9.4	7.5e-21	-0.99	0.00	1.00	TRUE
6	GTEx	Adipose Subcutaneous	STRA13	0.28	0.26	lasso	3	0.26	5.0e-21	-5.6	5.6	2.0e-08	-0.77	1.00	0.00	FALSE
7	GTEx	Adipose Subcutaneous	RP11-1376P16.2	0.06	0.04	enet	10	0.03	3.5e-03	-5.7	5.8	5.4e-09	-0.19	0.85	0.02	TRUE
8	GTEx	Adipose Visceral Omentum	LRRC45	0.18	0.03	enet	12	0.10	9.0e-06	-9.0	7.6	4.0e-14	-0.89	0.00	0.99	FALSE
9	GTEx	Adipose Visceral Omentum	STRA13	0.18	0.15	lasso	4	0.14	8.0e-08	-5.6	-5.6	2.0e-08	0.76	0.88	0.03	FALSE
10	GTEx	Artery Aorta	DCXR	0.34	0.17	enet	25	0.21	1.4e-11	4.4	5.9	3.2e-09	-0.28	1.00	0.00	FALSE
11	GTEx	Artery Coronary	LRRC45	0.18	0.00	enet	22	0.00	3.8e-01	-4.6	6.0	1.6e-09	-0.49	0.03	0.42	FALSE
12	GTEx	Artery Tibial	LRRC45	0.09	0.07	lasso	4	0.04	2.0e-04	-9.0	8.7	2.5e-18	-0.94	0.00	1.00	FALSE
13	GTEx	Artery Tibial	CCDC57	0.08	0.03	enet	7	0.05	5.8e-05	-5.7	6.8	9.5e-12	-0.37	0.69	0.07	FALSE
14	GTEx	Brain Caudate basal ganglia	CCDC57	0.14	0.16	lasso	5	0.10	8.3e-04	5.2	5.4	6.5e-08	-0.23	0.57	0.03	FALSE
15	GTEx	Brain Cerebellar Hemisphere	CCDC57	0.36	0.35	lasso	2	0.34	1.9e-09	-5.9	5.9	4.8e-09	-0.23	0.99	0.00	FALSE
16	GTEx	Brain Cerebellum	CCDC57	0.40	0.44	lasso	21	0.42	7.1e-14	-5.9	5.9	3.8e-09	-0.24	1.00	0.00	FALSE
17	GTEx	Brain Cerebellum	RP11-1376P16.2	0.15	0.19	lasso	2	0.16	2.3e-05	-5.8	5.8	5.4e-09	-0.24	0.69	0.04	FALSE
18	GTEx	Breast Mammary Tissue	CCDC57	0.14	0.07	lasso	6	0.07	2.6e-04	4.1	5.2	2.3e-07	-0.23	0.74	0.02	FALSE
19	GTEx	Cells Transformed fibroblasts	LRRC45	0.08	0.08	enet	3	0.08	2.6e-06	-9.0	9.1	1.2e-19	-0.98	0.00	1.00	FALSE
20	GTEx	Cells Transformed fibroblasts	STRA13	0.19	0.23	lasso	1	0.22	4.9e-16	-5.6	5.6	2.5e-08	-0.76	1.00	0.00	FALSE
21	GTEx	Cells Transformed fibroblasts	CCDC57	0.19	0.25	lasso	4	0.29	3.3e-22	5.3	5.4	7.8e-08	-0.22	1.00	0.00	FALSE
22	GTEx	Cells Transformed fibroblasts	RP11-1376P16.2	0.09	0.06	lasso	4	0.07	8.1e-06	5.6	6.1	9.7e-10	-0.29	0.98	0.00	FALSE
23	GTEx	Esophagus Gastroesophageal Junction	STRA13	0.20	0.14	enet	4	0.16	3.1e-06	-5.9	6.2	6.2e-10	-0.76	0.38	0.46	FALSE
24	GTEx	Esophagus Mucosa	STRA13	0.19	0.14	lasso	2	0.12	2.8e-08	-5.6	5.6	1.9e-08	-0.76	0.95	0.04	FALSE
25	GTEx	Esophagus Mucosa	CCDC57	0.13	0.10	lasso	2	0.08	2.9e-06	-5.9	5.8	5.5e-09	-0.25	0.98	0.00	FALSE
26	GTEx	Esophagus Mucosa	RP11-1376P16.2	0.06	0.04	lasso	9	0.00	1.5e-01	-5.9	5.9	3.1e-09	-0.23	0.34	0.03	FALSE
27	GTEx	Esophagus Muscularis	STRA13	0.40	0.33	lasso	2	0.32	4.2e-20	-5.6	5.6	2.6e-08	-0.76	1.00	0.00	FALSE
28	GTEx	Esophagus Muscularis	DCXR	0.18	0.08	lasso	5	0.05	9.2e-04	4.4	5.9	3.0e-09	-0.35	0.18	0.75	FALSE
29	GTEx	Heart Atrial Appendage	LRRC45	0.19	0.06	enet	9	0.12	6.7e-06	-6.6	8.9	5.3e-19	-0.88	0.01	0.99	FALSE
30	GTEx	Heart Atrial Appendage	STRA13	0.25	0.15	enet	4	0.16	1.2e-07	-5.9	6.7	1.9e-11	-0.83	0.17	0.81	FALSE
31	GTEx	Heart Atrial Appendage	CCDC57	0.20	0.14	enet	23	0.14	5.5e-07	-5.9	5.7	1.0e-08	-0.27	0.99	0.00	TRUE
32	GTEx	Lung	STRA13	0.16	0.16	lasso	3	0.15	1.2e-11	-5.6	5.6	2.0e-08	-0.79	0.94	0.06	FALSE
33	GTEx	Lung	CCDC57	0.11	0.08	enet	18	0.05	8.4e-05	5.7	6.0	2.4e-09	-0.24	1.00	0.00	FALSE
34	GTEx	Lung	RP11-1376P16.2	0.06	0.02	lasso	5	0.02	8.4e-03	5.5	5.7	1.4e-08	-0.22	0.24	0.04	FALSE
35	GTEx	Muscle Skeletal	STRA13	0.20	0.09	lasso	6	0.10	5.4e-10	-5.6	5.4	6.4e-08	-0.79	0.92	0.08	FALSE
36	GTEx	Muscle Skeletal	FASN	0.04	0.05	enet	5	0.03	3.1e-04	-5.9	5.9	3.1e-09	-0.24	0.92	0.00	FALSE
37	GTEx	Nerve Tibial	STRA13	0.18	0.17	enet	2	0.12	1.4e-08	-5.6	5.6	2.5e-08	-0.76	0.99	0.01	FALSE
38	GTEx	Nerve Tibial	DCXR	0.19	0.06	enet	20	0.10	1.4e-07	4.0	6.6	4.6e-11	-0.24	0.74	0.16	FALSE
39	GTEx	Ovary	CCDC57	0.39	0.30	enet	13	0.42	2.2e-11	3.5	5.2	1.9e-07	-0.24	0.93	0.01	FALSE
40	GTEx	Pituitary	RFNG	0.21	0.02	lasso	5	0.05	2.4e-02	-4.1	-5.9	4.2e-09	0.37	0.06	0.08	TRUE
41	GTEx	Prostate	CCDC57	0.20	0.17	lasso	3	0.15	1.6e-04	4.2	5.5	3.1e-08	-0.24	0.33	0.18	FALSE
42	GTEx	Skin Not Sun Exposed Suprapubic	STRA13	0.23	0.18	enet	5	0.10	6.6e-06	-5.6	5.8	8.1e-09	-0.77	0.95	0.04	FALSE
43	GTEx	Skin Not Sun Exposed Suprapubic	DCXR	0.12	0.00	enet	13	0.00	2.3e-01	4.2	7.2	8.9e-13	-0.42	0.08	0.16	FALSE
44	GTEx	Skin Not Sun Exposed Suprapubic	CCDC57	0.11	0.05	enet	6	0.04	2.3e-03	4.2	5.2	2.1e-07	-0.24	0.47	0.07	FALSE
45	GTEx	Skin Sun Exposed Lower leg	STRA13	0.12	0.13	lasso	3	0.12	7.9e-10	-5.6	5.5	3.0e-08	-0.76	0.85	0.14	FALSE
46	GTEx	Skin Sun Exposed Lower leg	DCXR	0.08	0.11	lasso	7	0.09	4.6e-08	4.2	5.6	2.7e-08	-0.22	1.00	0.00	FALSE
47	GTEx	Skin Sun Exposed Lower leg	CCDC57	0.18	0.15	lasso	5	0.22	3.0e-18	4.2	5.6	2.7e-08	-0.24	1.00	0.00	FALSE
48	GTEx	Stomach	CCDC57	0.11	0.09	lasso	3	0.10	2.0e-05	5.6	5.6	2.2e-08	-0.25	0.80	0.01	FALSE
49	GTEx	Thyroid	STRA13	0.40	0.34	lasso	5	0.34	2.3e-26	-5.6	5.8	8.1e-09	-0.77	1.00	0.00	FALSE
50	GTEx	Thyroid	ASPSCR1	0.23	0.15	enet	19	0.09	1.2e-07	-6.8	7.0	2.5e-12	-0.65	0.99	0.01	FALSE
51	GTEx	Thyroid	DUS1L	0.07	0.05	lasso	5	0.02	7.1e-03	5.6	6.9	6.7e-12	-0.41	0.32	0.56	TRUE
52	GTEx	Thyroid	DCXR	0.35	0.20	lasso	5	0.30	5.1e-23	4.2	6.5	6.4e-11	-0.26	1.00	0.00	FALSE
53	GTEx	Whole Blood	FASN	0.06	0.00	enet	30	0.01	4.0e-02	4.1	-6.2	4.7e-10	0.22	0.24	0.05	FALSE
54	YFS	Blood	ASPSCR1	0.11	0.07	lasso	9	0.06	7.9e-20	-8.1	8.8	1.6e-18	-0.77	0.05	0.95	FALSE
55	YFS	Blood	FASN	0.08	0.09	lasso	10	0.13	4.8e-41	3.7	-5.2	1.5e-07	0.24	1.00	0.00	FALSE
56	The Cancer Genome Atlas	Colon Adenocarcinoma	LRRC45	0.08	0.07	lasso	3	0.04	1.4e-03	-5.9	6.1	8.6e-10	-0.74	0.12	0.50	FALSE
57	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	LRRC45	0.02	0.03	blup	36	0.02	1.5e-03	-9.0	9.2	2.3e-20	-0.93	0.00	0.93	FALSE
58	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	PYCR1	0.02	0.01	blup	9	0.01	1.1e-02	-7.2	7.8	9.0e-15	-0.63	0.00	0.68	FALSE
59	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	STRA13	0.05	0.04	blup	33	0.05	5.0e-06	-9.0	7.0	3.5e-12	-0.87	0.00	1.00	FALSE
60	The Cancer Genome Atlas	Brain Lower Grade Glioma	LRRC45	0.05	0.07	lasso	6	0.06	9.5e-08	-9.0	8.7	3.3e-18	-0.97	0.00	1.00	FALSE
61	The Cancer Genome Atlas	Brain Lower Grade Glioma	MYADML2	0.03	0.03	blup	10	0.03	1.1e-04	-7.5	-7.6	3.0e-14	0.63	0.02	0.90	FALSE
62	The Cancer Genome Atlas	Brain Lower Grade Glioma	NOTUM	0.06	0.02	enet	2	0.02	4.7e-03	-6.6	-7.7	1.9e-14	0.59	0.02	0.17	FALSE
63	The Cancer Genome Atlas	Brain Lower Grade Glioma	RFNG	0.06	0.04	lasso	5	0.03	1.1e-04	-5.7	-5.7	1.2e-08	0.22	0.24	0.03	FALSE
64	The Cancer Genome Atlas	Brain Lower Grade Glioma	STRA13	0.06	0.07	blup	33	0.07	3.3e-08	-5.6	6.7	1.9e-11	-0.81	0.01	0.99	FALSE
65	The Cancer Genome Atlas	Lung Adenocarcinoma	NPB	0.03	0.01	enet	3	0.01	1.1e-02	-6.8	6.6	3.3e-11	-0.55	0.00	0.68	FALSE
66	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	LRRC45	0.10	0.02	blup	35	0.04	8.0e-03	-7.1	9.1	1.1e-19	-0.84	0.01	0.48	FALSE
67	The Cancer Genome Atlas	Prostate Adenocarcinoma	STRA13	0.05	0.03	lasso	3	0.02	1.8e-03	-9.0	9.0	2.3e-19	-1.00	0.00	0.98	FALSE
68	The Cancer Genome Atlas	Thyroid Carcinoma	BAIAP2	0.17	0.06	lasso	6	0.14	2.9e-13	2.6	-5.3	1.2e-07	0.01	0.18	0.76	TRUE
69	The Cancer Genome Atlas	Thyroid Carcinoma	CCDC57	0.08	0.02	blup	73	0.03	9.9e-04	-6.0	-5.8	4.8e-09	0.24	0.04	0.92	FALSE
70	The Cancer Genome Atlas	Thyroid Carcinoma	DCXR	0.09	0.03	blup	38	0.09	9.5e-09	4.2	7.8	6.8e-15	-0.51	0.15	0.84	FALSE
71	The Cancer Genome Atlas	Thyroid Carcinoma	STRA13	0.07	0.12	lasso	6	0.10	3.2e-10	-5.5	6.5	7.1e-11	-0.88	0.02	0.98	FALSE