Best TWAS P=7e-21 · Best GWAS P=2.44e-20 conditioned to 0.216
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | EIF2AK3 | 0.08 | 0.05 | lasso | 7 | 0.07 | 3.7e-09 | 8.30 | 7.2 | 4.6e-13 | 0.83 | 0.01 | 0.99 | FALSE |
| 2 | GTEx | Artery Tibial | AC062029.1 | 0.14 | 0.10 | enet | 11 | 0.12 | 1.3e-09 | 8.56 | 9.4 | 7.0e-21 | 0.94 | 0.00 | 1.00 | TRUE |
| 3 | GTEx | Cells Transformed fibroblasts | AC062029.1 | 0.07 | 0.08 | lasso | 3 | 0.07 | 3.0e-06 | 9.24 | 8.7 | 2.8e-18 | 0.98 | 0.00 | 1.00 | FALSE |
| 4 | GTEx | Lung | AC062029.1 | 0.08 | 0.00 | lasso | 5 | 0.01 | 2.5e-02 | -4.97 | 6.3 | 3.1e-10 | 0.57 | 0.06 | 0.22 | FALSE |
| 5 | GTEx | Nerve Tibial | RPIA | 0.10 | 0.03 | lasso | 10 | 0.04 | 1.3e-03 | 8.56 | 7.3 | 2.0e-13 | 0.80 | 0.05 | 0.34 | FALSE |
| 6 | ROSMAP | Brain Pre-frontal Cortex | RPIA | 0.05 | 0.05 | blup | 194 | 0.04 | 4.3e-06 | 8.30 | 5.4 | 6.0e-08 | 0.69 | 0.01 | 0.99 | FALSE |
| 7 | ROSMAP | Brain Pre-frontal Cortex | EIF2AK3 | 0.11 | 0.09 | lasso | 5 | 0.09 | 2.0e-11 | 9.24 | 8.7 | 4.7e-18 | 0.97 | 0.00 | 1.00 | FALSE |
| 8 | YFS | Blood | RPIA | 0.05 | 0.04 | lasso | 12 | 0.05 | 1.1e-14 | -5.67 | -6.0 | 2.6e-09 | -0.42 | 1.00 | 0.00 | FALSE |
| 9 | The Cancer Genome Atlas | Breast Invasive Carcinoma | RPIA | 0.05 | 0.02 | lasso | 3 | 0.02 | 2.6e-04 | -2.89 | 5.2 | 1.7e-07 | 0.66 | 0.01 | 0.90 | FALSE |
| 10 | The Cancer Genome Atlas | Brain Lower Grade Glioma | EIF2AK3 | 0.13 | 0.01 | enet | 17 | 0.02 | 4.0e-03 | 9.24 | 6.1 | 9.3e-10 | 0.71 | 0.00 | 0.94 | FALSE |
| 11 | The Cancer Genome Atlas | Thyroid Carcinoma | RPIA | 0.20 | 0.03 | enet | 11 | 0.14 | 1.5e-13 | 0.31 | 5.5 | 4.3e-08 | 0.64 | 0.02 | 0.98 | FALSE |