Best TWAS P=1.92e-11 · Best GWAS P=1.68e-10 conditioned to 0.236
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Artery Aorta | GGCX | 0.23 | 0.22 | lasso | 6 | 0.23 | 5.5e-13 | 4.5 | 5.4 | 5.8e-08 | 0.61 | 0.86 | 0.14 | FALSE |
2 | GTEx | Artery Tibial | GGCX | 0.29 | 0.22 | enet | 14 | 0.24 | 6.3e-19 | 4.5 | 5.7 | 1.2e-08 | 0.62 | 0.98 | 0.02 | FALSE |
3 | GTEx | Colon Transverse | GGCX | 0.26 | 0.28 | lasso | 3 | 0.28 | 1.4e-13 | 4.5 | 5.1 | 2.8e-07 | 0.52 | 0.96 | 0.04 | FALSE |
4 | GTEx | Esophagus Gastroesophageal Junction | GGCX | 0.24 | 0.16 | lasso | 6 | 0.12 | 4.3e-05 | 4.6 | 5.2 | 1.5e-07 | 0.52 | 0.15 | 0.75 | FALSE |
5 | GTEx | Nerve Tibial | GGCX | 0.38 | 0.30 | lasso | 7 | 0.33 | 6.5e-24 | 4.5 | 5.5 | 3.4e-08 | 0.68 | 0.98 | 0.02 | FALSE |
6 | GTEx | Pancreas | VAMP5 | 0.29 | 0.09 | enet | 4 | 0.05 | 3.2e-03 | 6.4 | -6.3 | 3.9e-10 | -0.92 | 0.01 | 0.89 | FALSE |
7 | GTEx | Skin Sun Exposed Lower leg | GGCX | 0.15 | 0.11 | lasso | 3 | 0.18 | 7.9e-15 | 4.5 | 6.2 | 6.0e-10 | 0.78 | 0.05 | 0.95 | FALSE |
8 | GTEx | Testis | GGCX | 0.38 | 0.36 | enet | 25 | 0.40 | 8.6e-19 | 4.6 | 5.2 | 2.6e-07 | 0.65 | 0.86 | 0.14 | FALSE |
9 | GTEx | Thyroid | ELMOD3 | 0.10 | 0.01 | enet | 10 | 0.02 | 7.7e-03 | -2.9 | 5.1 | 3.1e-07 | 0.37 | 0.15 | 0.54 | FALSE |
10 | GTEx | Thyroid | GGCX | 0.30 | 0.17 | enet | 10 | 0.23 | 1.4e-17 | 4.5 | 5.7 | 9.3e-09 | 0.67 | 0.91 | 0.09 | FALSE |
11 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | VAMP8 | 0.06 | 0.01 | enet | 15 | 0.02 | 2.1e-02 | 6.1 | 6.4 | 1.5e-10 | 0.87 | 0.00 | 0.88 | FALSE |
12 | The Cancer Genome Atlas | Prostate Adenocarcinoma | GGCX | 0.04 | 0.02 | blup | 44 | 0.02 | 2.7e-03 | 6.0 | 6.7 | 1.9e-11 | 0.86 | 0.01 | 0.97 | TRUE |