Best TWAS P=7.07e-11 · Best GWAS P=6.87e-09 conditioned to 0.266
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | The Cancer Genome Atlas | Breast Invasive Carcinoma | FLJ12825 | 0.32 | 0.29 | lasso | 5 | 0.32 | 1.7e-67 | -5.7 | -5.6 | 2.7e-08 | 0.87 | 0.00 | 1.00 | FALSE |
2 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | FLJ12825 | 0.35 | 0.21 | lasso | 5 | 0.26 | 5.5e-13 | -5.7 | -5.4 | 6.1e-08 | 0.86 | 0.00 | 1.00 | FALSE |
3 | The Cancer Genome Atlas | Esophageal Carcinoma | FLJ12825 | 0.12 | 0.05 | blup | 59 | 0.02 | 6.9e-02 | 4.1 | -6.5 | 7.1e-11 | 0.78 | 0.01 | 0.64 | TRUE |
4 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | FLJ12825 | 0.35 | 0.27 | lasso | 5 | 0.29 | 7.4e-33 | -5.7 | -5.7 | 1.3e-08 | 0.83 | 0.00 | 1.00 | FALSE |
5 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | FLJ12825 | 0.54 | 0.56 | enet | 12 | 0.57 | 2.5e-78 | -5.7 | -5.6 | 1.6e-08 | 0.85 | 0.00 | 1.00 | FALSE |
6 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | HOXC8 | 0.03 | 0.05 | enet | 5 | 0.04 | 2.4e-05 | -5.5 | 5.2 | 1.8e-07 | -0.19 | 0.00 | 0.99 | FALSE |
7 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | FLJ12825 | 0.52 | 0.36 | lasso | 4 | 0.37 | 2.1e-22 | -5.7 | -5.2 | 2.4e-07 | 0.79 | 0.00 | 1.00 | FALSE |
8 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | FLJ12825 | 0.35 | 0.23 | lasso | 2 | 0.21 | 8.8e-09 | -5.7 | -5.7 | 1.4e-08 | 0.84 | 0.00 | 1.00 | FALSE |
9 | The Cancer Genome Atlas | Stomach Adenocarcinoma | FLJ12825 | 0.18 | 0.11 | lasso | 3 | 0.16 | 1.4e-11 | 3.3 | -5.2 | 2.4e-07 | 0.83 | 0.01 | 0.99 | FALSE |
10 | The Cancer Genome Atlas | Stomach Adenocarcinoma | LOC100240734 | 0.06 | 0.01 | blup | 33 | 0.03 | 1.8e-03 | 2.5 | 5.7 | 1.4e-08 | -0.72 | 0.01 | 0.85 | FALSE |
11 | The Cancer Genome Atlas | Uterine Corpus Endometrial Carcinoma | FLJ12825 | 0.15 | 0.02 | lasso | 5 | 0.06 | 8.9e-03 | -5.5 | -6.2 | 4.4e-10 | 0.56 | 0.01 | 0.50 | FALSE |