Hub : Traits :

High blood pressure (mother)

40 significantly associated models · 10 unique genes.

Significant Loci

#	chr	p0	p1	# assoc genes	# joint genes	best TWAS P	best SNP P	cond SNP P	% var exp	joint genes
1	1	26428864	27820430	1	1	1.4e-07	3.5e-06	0.95800	100	PIGV
2	2	85818273	86365607	1	1	1.4e-07	1.4e-06	0.98900	100	ST3GAL5
3	10	103987875	105531761	1	1	2.4e-07	1.1e-07	1.00000	100	CNNM2
4	12	47671905	49061511	1	1	2.7e-08	1.1e-05	0.00045	36	TMEM106C
5	12	54158993	54760824	3	1	7.1e-11	6.9e-09	0.26600	96	FLJ12825
6	15	90712555	92135418	2	2	9.9e-22	1.4e-19	0.17900	98	FES
7	17	46303558	47688526	1	1	9.2e-08	7.7e-08	0.07450	89	UBE2Z

Pleiotropic Associations

Trait	chisq ratio	# genes⁺	# genes⁺⁺	% genes⁺⁺	corr	corr P	genes
Systolic Blood Pressure	22.92	7	3	6.7	0.91	1.7e-03	CNNM2 FES FLJ12825 PIGV ST3GAL5 TMEM106C UBE2Z
Vascular/heart problems diagnosed by doctor	20.87	5	4	8.9	-0.92	9.9e-03	CNNM2 FES FLJ12825 PIGV UBE2Z
High blood pressure	19.23	5	4	8.9	0.94	5.1e-03	CNNM2 FES FLJ12825 PIGV UBE2Z
Hypertension (Self-reported)	18.99	5	4	8.9	0.94	5.6e-03	CNNM2 FES FLJ12825 PIGV UBE2Z
Cardiovascular Disease	18.23	7	4	8.9	0.96	2.0e-04	CNNM2 FES FLJ12825 PIGV ST3GAL5 TMEM106C UBE2Z
Systolic blood pressure, automated reading	17.09	3	2	4.4	0.68	3.2e-01	CNNM2 FES PIGV
Medication: Blood pressure	14.78	4	1	2.2	0.98	2.9e-03	CNNM2 FES TMEM106C UBE2Z
Illnesses of mother	14.21	4	1	2.2	-1.00	3.4e-05	FES FLJ12825 PIGV UBE2Z
Medication: Blood pressure	14.05	3	3	6.7	0.96	3.6e-02	CNNM2 FES PIGV
Medication for cholesterol, blood pressure or diabetes	12.74	3	1	2.2	-0.99	1.4e-02	FES PIGV UBE2Z
Illnesses of father: High blood pressure	12.49	2	1	2.2	0.00	1.0e+00	FES FLJ12825
Diastolic blood pressure, automated reading	12.09	4	2	4.4	0.97	5.8e-03	CNNM2 FES PIGV UBE2Z
Illnesses of father: None of the above (group 1)	11.62	2	1	2.2	0.00	1.0e+00	CNNM2 FES
Illnesses of father: Heart disease	11.08	2	1	2.2	0.00	1.0e+00	CNNM2 FES
Medication: Atenolol	10.41	1	1	2.2	0.00	1.0e+00	FES
Angina (self-reported)	10.29	2	1	2.2	0.00	1.0e+00	CNNM2 FES
Schizophrenia (2018)	9.94	3	2	4.4	-0.66	3.4e-01	CNNM2 FES PIGV
Angina	9.79	1	1	2.2	0.00	1.0e+00	FES
Schizophrenia (2014)	9.78	3	2	4.4	-0.66	3.4e-01	CNNM2 FES PIGV
Bipolar Disorder or Schizophrenia	9.24	3	2	4.4	-0.68	3.2e-01	CNNM2 FES PIGV
High blood pressure (siblings)	9.05	2	1	2.2	0.00	1.0e+00	FES UBE2Z
Medication: Aspirin	9.01	2	1	2.2	0.00	1.0e+00	FES UBE2Z
Birth weight of first child	8.74	2	1	2.2	0.00	1.0e+00	CNNM2 FES
Medication: Aspirin	8.68	2	1	2.2	0.00	1.0e+00	FES UBE2Z
Medication: Bendroflumethiazide	8.29	2	1	2.2	0.00	1.0e+00	FES PIGV
Medication: Simvastatin	7.87	3	1	2.2	0.98	2.4e-02	FES PIGV UBE2Z
Medication: Cholesterol lowering	7.62	2	1	2.2	0.00	1.0e+00	FES PIGV
Medication for cholesterol	7.57	3	0	0.0	-0.60	4.0e-01	CNNM2 FES PIGV
Medication: Amlodipine	7.50	2	1	2.2	0.00	1.0e+00	FES UBE2Z
Heart attack	6.79	1	1	2.2	0.00	1.0e+00	FES
Heart attack/myocardial infarction (self-reported)	6.59	1	1	2.2	0.00	1.0e+00	FES
Coronary Artery Disease (CAD)	6.15	2	0	0.0	0.00	1.0e+00	CNNM2 UBE2Z
Illnesses of siblings	6.02	2	1	2.2	0.00	1.0e+00	FES UBE2Z
Birth weight	5.72	2	2	4.4	0.00	1.0e+00	CNNM2 FES
Father's age at death	5.67	1	1	2.2	0.00	1.0e+00	FES
Heart disease (siblings)	5.52	2	0	0.0	0.00	1.0e+00	CNNM2 FES
Impedance of leg (right)	5.34	5	3	6.7	0.36	4.9e-01	CNNM2 FES FLJ12825 TMEM106C UBE2Z
Sensitivity / hurt feelings	5.32	2	1	2.2	0.00	1.0e+00	FES UBE2Z
High cholesterol (Self-reported)	5.32	2	1	2.2	0.00	1.0e+00	FES PIGV
Medication: Lisinopril	5.21	2	0	0.0	0.00	1.0e+00	FES PIGV
Medication: Ramipril	5.07	1	0	0.0	0.00	1.0e+00	FES
Impedance of leg (left)	4.92	5	2	4.4	0.34	5.1e-01	CNNM2 FES FLJ12825 TMEM106C UBE2Z
Breastfed as a baby	4.57	1	0	0.0	0.00	1.0e+00	FES
Cholesterol lowering medication	4.41	1	1	2.2	0.00	1.0e+00	PIGV
Heart disease (mother)	4.21	1	0	0.0	0.00	1.0e+00	FES
Number of treatments/medications taken	4.18	1	0	0.0	0.00	1.0e+00	FES
Neuroticism	3.86	2	1	2.2	0.00	1.0e+00	CNNM2 FES
Worry (Nagel 2018)	3.80	1	1	2.2	0.00	1.0e+00	CNNM2
Medication: Atorvastatin	3.80	1	0	0.0	0.00	1.0e+00	PIGV
Alcohol usually taken with meals	3.69	1	0	0.0	0.00	1.0e+00	FES
Schizophrenia vs Biploar Disorder	3.59	2	0	0.0	0.00	1.0e+00	CNNM2 UBE2Z
Pulse wave peak to peak time	3.54	1	0	0.0	0.00	1.0e+00	FES
Handedness (chirality/laterality): Left-handed	3.41	1	0	0.0	0.00	1.0e+00	FES
Number of incorrect matches in round	3.40	1	0	0.0	0.00	1.0e+00	FES
Breast Cancer	3.25	1	0	0.0	0.00	1.0e+00	FES
Impedance of whole body	3.25	5	2	4.4	0.27	6.6e-01	CNNM2 FES FLJ12825 TMEM106C UBE2Z
Pulse wave Arterial Stiffness index	3.23	1	0	0.0	0.00	1.0e+00	FES
Age started oral contraceptive pill	3.18	1	0	0.0	0.00	1.0e+00	FES
Nervous feelings	3.09	1	1	2.2	0.00	1.0e+00	CNNM2
Major Depression (MDD)	2.96	1	0	0.0	0.00	1.0e+00	CNNM2
Neuroticism (Nagel 2018)	2.95	2	0	0.0	0.00	1.0e+00	CNNM2 FES
HDL Cholesterol	2.87	1	0	0.0	0.00	1.0e+00	PIGV
Risk taking	2.87	1	0	0.0	0.00	1.0e+00	FES
Body Mass Index (BMI) (2010)	2.83	1	0	0.0	0.00	1.0e+00	CNNM2
BMI	2.80	2	2	4.4	0.00	1.0e+00	CNNM2 UBE2Z
Worrier / anxious feelings	2.80	1	1	2.2	0.00	1.0e+00	CNNM2
Number of live births	2.72	1	0	0.0	0.00	1.0e+00	FES
Neuroticism score	2.67	2	0	0.0	0.00	1.0e+00	CNNM2 UBE2Z
Bipolar Disorder (2018)	2.60	1	0	0.0	0.00	1.0e+00	FES
Medication: Allopurinol	2.59	1	0	0.0	0.00	1.0e+00	PIGV
Smoking Status	2.57	1	0	0.0	0.00	1.0e+00	FES
Type 2 Diabetes (T2D) (2018)	2.53	1	0	0.0	0.00	1.0e+00	UBE2Z
Arm fat percentage (right)	2.53	2	1	2.2	0.00	1.0e+00	CNNM2 UBE2Z
Leg predicted mass (right)	2.51	2	1	2.2	0.00	1.0e+00	CNNM2 FES
Height	2.48	4	3	6.7	-0.86	6.1e-02	CNNM2 FES PIGV UBE2Z
Leg fat-free mass (right)	2.47	2	1	2.2	0.00	1.0e+00	CNNM2 FES
Diabetes (father)	2.45	1	0	0.0	0.00	1.0e+00	UBE2Z
Tense / 'highly strung'	2.41	1	0	0.0	0.00	1.0e+00	CNNM2
Gout (self-reported)	2.37	1	0	0.0	0.00	1.0e+00	PIGV
Blood White Count	2.36	3	1	2.2	0.58	4.2e-01	CNNM2 FES FLJ12825
Hand grip strength (left)	2.34	1	0	0.0	0.00	1.0e+00	FES
Leg fat-free mass (left)	2.33	2	1	2.2	0.00	1.0e+00	CNNM2 FES
Mean time to correctly identify matches	2.33	1	0	0.0	0.00	1.0e+00	FES
Arm fat percentage (left)	2.33	2	1	2.2	0.00	1.0e+00	CNNM2 UBE2Z
Body mass index (BMI)	2.32	2	2	4.4	0.00	1.0e+00	CNNM2 UBE2Z
Allergy	2.31	1	0	0.0	0.00	1.0e+00	FES
Impedance of arm (right)	2.31	3	1	2.2	0.00	1.0e+00	CNNM2 FLJ12825 TMEM106C
Diabetes diagnosed by doctor	2.31	1	0	0.0	0.00	1.0e+00	UBE2Z
Headache pain in last month	2.30	1	0	0.0	0.00	1.0e+00	FES
Leg predicted mass (left)	2.24	2	1	2.2	0.00	1.0e+00	CNNM2 FES
Worry too long after embarrassment	2.24	1	0	0.0	0.00	1.0e+00	UBE2Z
Respiratory disease	2.18	1	0	0.0	0.00	1.0e+00	FES
Impedance of arm (left)	2.17	3	1	2.2	0.00	1.0e+00	CNNM2 FLJ12825 TMEM106C
Allergy or Eczema	2.15	1	0	0.0	0.00	1.0e+00	FES
Diabetes (self-reported)	2.13	1	0	0.0	0.00	1.0e+00	UBE2Z
Mineral and other dietary supplements	2.12	1	0	0.0	0.00	1.0e+00	FES
Average weekly champagne plus white wine intake	2.12	1	0	0.0	0.00	1.0e+00	UBE2Z
Lung FEV1/FVC ratio	2.09	1	1	2.2	0.00	1.0e+00	FLJ12825
Frequency of tenseness / restlessness in last 2 weeks	2.08	1	0	0.0	0.00	1.0e+00	CNNM2
Seen a psychiatrist for nerves, anxiety, tension or depression	2.06	1	0	0.0	0.00	1.0e+00	CNNM2
Blood Platelet Count	2.05	4	3	6.7	0.24	7.6e-01	FLJ12825 PIGV TMEM106C UBE2Z
Blood Red Count	2.03	4	2	4.4	-0.32	6.8e-01	CNNM2 FES ST3GAL5 TMEM106C
Lung FVC	2.03	2	1	2.2	0.00	1.0e+00	CNNM2 FLJ12825
Sitting height	2.03	3	1	2.2	0.00	1.0e+00	FES PIGV UBE2Z
Comparative height size at age 10	2.03	4	0	0.0	-0.70	3.0e-01	CNNM2 FES PIGV UBE2Z
Standing height	1.96	2	1	2.2	0.00	1.0e+00	PIGV UBE2Z
Frequency of tiredness / lethargy in last 2 weeks	1.92	1	0	0.0	0.00	1.0e+00	UBE2Z
Ever smoked	1.91	1	0	0.0	0.00	1.0e+00	FES
Asthma (self-reported)	1.89	1	0	0.0	0.00	1.0e+00	FES
LDL Cholesterol	1.84	1	0	0.0	0.00	1.0e+00	PIGV
Asthma	1.83	1	0	0.0	0.00	1.0e+00	FES
Arm fat mass (right)	1.82	2	0	0.0	0.00	1.0e+00	CNNM2 UBE2Z
Hayfever, allergic rhinitis or eczema	1.78	1	0	0.0	0.00	1.0e+00	FES
Whole body fat-free mass	1.78	3	1	2.2	0.00	1.0e+00	CNNM2 FES TMEM106C
Whole body water mass	1.77	2	1	2.2	0.00	1.0e+00	CNNM2 FES
Arm fat mass (left)	1.77	2	0	0.0	0.00	1.0e+00	CNNM2 UBE2Z
Fed-up feelings	1.69	1	0	0.0	0.00	1.0e+00	UBE2Z
Basal metabolic rate	1.65	2	1	2.2	0.00	1.0e+00	CNNM2 FES
Hair/balding pattern: Pattern 4	1.64	1	0	0.0	0.00	1.0e+00	FES
Migraine (self-reported)	1.63	1	0	0.0	0.00	1.0e+00	CNNM2
Trunk fat-free mass	1.62	2	0	0.0	0.00	1.0e+00	CNNM2 TMEM106C
Deep venous thrombosis (DVT) (self-reported)	1.62	1	0	0.0	0.00	1.0e+00	PIGV
Peak expiratory flow (PEF)	1.61	1	0	0.0	0.00	1.0e+00	UBE2Z
Trunk predicted mass	1.60	2	0	0.0	0.00	1.0e+00	CNNM2 TMEM106C
Waist Hip Ratio (WHR)	1.59	1	1	2.2	0.00	1.0e+00	FLJ12825
Forced vital capacity (FVC)	1.49	2	0	0.0	0.00	1.0e+00	FLJ12825 UBE2Z
Blood clot in the leg (DVT)	1.47	1	0	0.0	0.00	1.0e+00	PIGV
Blood Eosinophil Count	1.45	3	2	4.4	0.00	1.0e+00	PIGV ST3GAL5 UBE2Z
Trunk fat percentage	1.44	3	0	0.0	0.00	1.0e+00	CNNM2 FLJ12825 UBE2Z
Alcohol intake frequency.	1.43	1	0	0.0	0.00	1.0e+00	UBE2Z
Suffer from 'nerves'	1.42	1	0	0.0	0.00	1.0e+00	CNNM2
Body fat percentage	1.41	2	0	0.0	0.00	1.0e+00	FLJ12825 UBE2Z
Trunk fat mass	1.40	1	0	0.0	0.00	1.0e+00	CNNM2
Whole body fat mass	1.40	2	0	0.0	0.00	1.0e+00	CNNM2 UBE2Z
Irritable Bowel Disease (IBD)	1.38	1	0	0.0	0.00	1.0e+00	FES
Waist circumference	1.36	1	0	0.0	0.00	1.0e+00	CNNM2
Weight	1.36	1	1	2.2	0.00	1.0e+00	CNNM2
Leg fat mass (right)	1.34	2	0	0.0	0.00	1.0e+00	CNNM2 UBE2Z
Leg fat mass (left)	1.32	2	0	0.0	0.00	1.0e+00	CNNM2 UBE2Z
Leg fat percentage (right)	1.30	2	0	0.0	0.00	1.0e+00	FLJ12825 UBE2Z
Overall health rating	1.30	1	0	0.0	0.00	1.0e+00	UBE2Z
Leg fat percentage (left)	1.29	2	0	0.0	0.00	1.0e+00	FLJ12825 UBE2Z
Comparative body size at age 10	1.24	1	0	0.0	0.00	1.0e+00	CNNM2
Arm predicted mass (left)	1.24	2	0	0.0	0.00	1.0e+00	CNNM2 TMEM106C
Arm predicted mass (right)	1.23	2	0	0.0	0.00	1.0e+00	CNNM2 TMEM106C
Arm fat-free mass (left)	1.23	2	0	0.0	0.00	1.0e+00	CNNM2 TMEM106C
Arm fat-free mass (right)	1.21	2	0	0.0	0.00	1.0e+00	CNNM2 TMEM106C
Intelligence (Savage-Jansen 2018)	1.19	1	0	0.0	0.00	1.0e+00	UBE2Z
Crohns Disease (2017)	1.19	1	0	0.0	0.00	1.0e+00	FES
Forced vital capacity (FVC), Best measure	1.06	1	0	0.0	0.00	1.0e+00	UBE2Z
Pulse rate, automated reading	1.01	1	0	0.0	0.00	1.0e+00	CNNM2
Heel T-Score	0.99	3	0	0.0	0.00	1.0e+00	CNNM2 FLJ12825 TMEM106C
Hip circumference	0.96	1	0	0.0	0.00	1.0e+00	CNNM2
Forced expiratory volume in 1-second (FEV1)	0.96	1	0	0.0	0.00	1.0e+00	UBE2Z
Qualifications: None of the above	0.90	1	0	0.0	0.00	1.0e+00	UBE2Z
Qualifications: College or University degree	0.89	1	0	0.0	0.00	1.0e+00	UBE2Z
Hair Pigment	0.46	2	1	2.2	0.00	1.0e+00	FES PIGV

Associations by panel

study	tissue	# hits	% hits/tests	avg chisq
GTEx	Artery Aorta	0	0.000	1.5
GTEx	Brain Cortex	1	0.097	1.5
GTEx	Cells Transformed fibroblasts	1	0.024	1.5
GTEx	Colon Transverse	0	0.000	1.5
GTEx	Heart Left Ventricle	0	0.000	1.5
GTEx	Pancreas	0	0.000	1.5
GTEx	Pituitary	0	0.000	1.5
GTEx	Prostate	0	0.000	1.5
GTEx	Small Intestine Terminal Ileum	0	0.000	1.5
GTEx	Thyroid	1	0.025	1.5
GTEx	Vagina	0	0.000	1.5
The Cancer Genome Atlas	Colon Adenocarcinoma	1	0.048	1.5
The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	2	0.073	1.5
The Cancer Genome Atlas	Stomach Adenocarcinoma	3	0.178	1.5
GTEx	Adipose Subcutaneous	0	0.000	1.4
GTEx	Adipose Visceral Omentum	1	0.049	1.4
GTEx	Adrenal Gland	0	0.000	1.4
GTEx	Artery Coronary	0	0.000	1.4
GTEx	Artery Tibial	1	0.027	1.4
GTEx	Brain Caudate basal ganglia	0	0.000	1.4
GTEx	Brain Cerebellar Hemisphere	0	0.000	1.4
GTEx	Brain Cerebellum	0	0.000	1.4
GTEx	Brain Frontal Cortex BA9	0	0.000	1.4
GTEx	Brain Hypothalamus	0	0.000	1.4
GTEx	Breast Mammary Tissue	0	0.000	1.4
GTEx	Breast Mammary Tissue (Male)	0	0.000	1.4
GTEx	Breast Mammary Tissue (Female)	0	0.000	1.4
GTEx	Cells EBV-transformed lymphocytes	0	0.000	1.4
GTEx	Colon Sigmoid	0	0.000	1.4
GTEx	Esophagus Gastroesophageal Junction	0	0.000	1.4
GTEx	Esophagus Mucosa	0	0.000	1.4
GTEx	Esophagus Muscularis	1	0.031	1.4
GTEx	Heart Atrial Appendage	0	0.000	1.4
GTEx	Liver	0	0.000	1.4
GTEx	Lung	1	0.035	1.4
GTEx	Muscle Skeletal	1	0.035	1.4
GTEx	Nerve Tibial	0	0.000	1.4
GTEx	Ovary	0	0.000	1.4
GTEx	Skin Not Sun Exposed Suprapubic	0	0.000	1.4
GTEx	Skin Sun Exposed Lower leg	1	0.027	1.4
GTEx	Spleen	0	0.000	1.4
GTEx	Stomach	0	0.000	1.4
GTEx	Testis	0	0.000	1.4
GTEx	Uterus	0	0.000	1.4
GTEx	Whole Blood	0	0.000	1.4
METSIM	Adipose	1	0.022	1.4
NTR	Blood	0	0.000	1.4
ROSMAP	Brain Pre-frontal Cortex	1	0.023	1.4
CommonMind	Brain Pre-frontal Cortex	1	0.019	1.4
The Cancer Genome Atlas	Bladder Urothelial Carcinoma	1	0.060	1.4
The Cancer Genome Atlas	Breast Invasive Carcinoma	2	0.045	1.4
The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	2	0.182	1.4
The Cancer Genome Atlas	Esophageal Carcinoma	1	0.146	1.4
The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	3	0.073	1.4
The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	1	0.049	1.4
The Cancer Genome Atlas	Brain Lower Grade Glioma	0	0.000	1.4
The Cancer Genome Atlas	Lung Adenocarcinoma	1	0.034	1.4
The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	1	0.040	1.4
The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	1	0.063	1.4
The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	1	0.075	1.4
The Cancer Genome Atlas	Prostate Adenocarcinoma	2	0.043	1.4
The Cancer Genome Atlas	Skin Cutaneous Melanoma	0	0.000	1.4
The Cancer Genome Atlas	Testicular Germ Cell Tumors	1	0.078	1.4
The Cancer Genome Atlas	Thyroid Carcinoma	1	0.019	1.4
GTEx	Brain Hippocampus	0	0.000	1.3
GTEx	Brain Nucleus accumbens basal ganglia	0	0.000	1.3
GTEx	Brain Putamen basal ganglia	0	0.000	1.3
YFS	Blood	2	0.043	1.3
The Cancer Genome Atlas	Glioblastoma Multiforme	1	0.098	1.3
The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	0	0.000	1.3
The Cancer Genome Atlas	Pancreatic Adenocarcinoma	0	0.000	1.3
The Cancer Genome Atlas	Soft Tissue Sarcoma	0	0.000	1.3
The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	1	0.197	1.3
The Cancer Genome Atlas	Rectum Adenocarcinoma	0	0.000	1.2