TWAS
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Traits
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Traits
:
Forced expiratory volume in 1-second (FEV1), Best measure
:
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→
chr10:95,379,543-96,818,402
Best TWAS P=3.43e-08 · Best GWAS P=1.37e-07 conditioned to 0.597
95.4M
95.6M
95.8M
96M
96.2M
96.4M
96.6M
96.8M
0
2
4
6
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
3
GTEx
Skin Not Sun Exposed Suprapubic
NOC3L
0.32
0.21
enet
31
0.23
8.2e-13
-4.9
-5.5
3.4e-08
0.92
0.02
0.98
TRUE
4
METSIM
Adipose
NOC3L
0.10
0.10
lasso
7
0.11
3.3e-16
-5.2
-5.3
1.1e-07
0.94
0.01
0.98
FALSE
2
GTEx
Nerve Tibial
NOC3L
0.17
0.20
lasso
5
0.20
6.0e-14
-5.3
-5.3
1.2e-07
0.99
0.01
0.99
FALSE
1
GTEx
Esophagus Muscularis
NOC3L
0.11
0.10
lasso
7
0.10
1.7e-06
-4.6
-5.1
2.7e-07
0.91
0.02
0.98
FALSE